Abstract: Methods and compositions for nuclear delivery and transcriptional repression employ a cell-penetrant MeCP2 fusion protein.

Abstract: In some embodiments of the invention, a millimeter wave (mmWave) backscatter network node includes a frequency scanning antenna (FSA) having at least one port, the FSA including an array of emitting elements such that, given an incoming signal resulting in emitting signal from the emitting elements, the direction in which emitting signals combine constructively changes with the frequency of the incoming signal, and a radio frequency (RF) signal processing unit configured to measure strength and determine frequency of a received signal that is received by a first port of the FSA.

Abstract: Methods are disclosed for generating a target mean arterial pressure (MAP) for a patient during a surgery. In some implementations, the disclosed methods include calculating the target MAP based on the age, biological sex, emergent surgery status, and American Society of Anesthesiology (ASA) physical status (PS) class of the patient, and a predetermined intraoperative hypotension (IOH) risk benchmark. Treating the patient to maintain a MAP at or above the target MAP during the surgery reduces a risk of IOH during the surgery, a risk of administering an unnecessary therapy to avoid IOH during the surgery; and a risk of not administering a therapeutic MAP-decreasing action during the surgery. In some implementations, the method further comprises conducting the surgery on the patient and treating the patient to maintain the MAP of the patient at or above the target MAP during the surgery. Also provided are systems for implementing the disclosed methods.

Abstract: A naked-eye three-dimensional (3D) display device (600) is provided. The naked-eye 3D display device (600) comprises: a display component (610), comprising an array of display units (110); and a viewing angle regulator (620), comprising an array of microprism blocks (120, 620-1, 620-2, 620-3, 620-4, 620-5, 620-6). The microprism blocks (120, 620-1, 620-2, 620-3, 620-4, 620-5, 620-6) are divided into a plurality of groups, and an angle combination of a first angle (?1) and a second angle (?2) of each of the microprism blocks (120, 620-1, 620-2, 620-3, 620-4, 620-5, 620-6) is preset so that outgoing lights of the same group of microprism blocks converge into the same viewpoint, and outgoing lights of different groups of microprism blocks converge into different viewpoints. Hence, a plurality of different viewpoints are formed by setting angles of inclined surfaces of the microprism blocks (120, 620-1, 620-2, 620-3, 620-4, 620-5, 620-6), thereby seeing different 3D display effects from different viewing angles.

Abstract: A nanohybrid material includes a plurality of gold nanohybrid particles having formula (I). The gold nanohybrid particles have a gold nanoparticle (AuNPs) core and a shell of at least one fatty acid derivative at least partially disposed around the AuNPs core. The AuNPs core has a cuboidal shape and an average particle size of 20 to 60 nanometers (nm). Each R1, and R2 are independently selected from the group consisting of a hydrgon atom, and a fatty acid hydrocarbon chain having 16 to 22 carbon atoms. R3 is selected from the group consisting of a hydrogen atom, an alkyl, an alkoxy, an optionally substituted alkoxy having 1 to 10 carbon atoms, and an optionally substituted alkoxyalky.

Abstract: Compositions and methods are provided including a plurality of analyte detection agents, each analyte detection agent includes a labile tag operatively coupled to the analyte detection agent, each labile tag includes a signal that is different from each other labile tag and each analyte detection agent targeting a different analyte.

Abstract: A low-energy consumption electrocatalytic method for electrosynthesis of hydrogen peroxide coupled with oxidation upcycling of PET plastics is provided. The method includes ball-milling a waste polyethylene terephthalate (PET) plastic into powder, depolymerizing in alkali solution, and then using the transition metal catalyst and carbon-based material as anode and cathode in the circulating electrolytic cell, under the applied voltage, the cathode undergoes an oxygen reduction reaction to generate hydrogen peroxide, and the anode undergoes an oxidation reaction to upgrade ethylene glycol to formic acid. Products of terephthalic acid and potassium diformate are obtained by adjusting the pH and vacuum distillation of the anode electrolyte. The sodium perborate product or benzoyl peroxide product can be prepared in the cathode electrolyte.

Abstract: Methods and devices for determining a mass concentration of an airborne or respirable species in real time are provided. Methods can include drawing in a particulate species through an inlet and into a chamber of a resonator of a monitoring device and directing a laser beam into the chamber of the resonator and toward the particulate species such that the particulate species absorbs energy from the laser beam and transmits heat to the surrounding air within the chamber of the resonator. A power of the laser beam as it leaves the resonator and a sound pressure within the chamber of the resonator can be determined. Determining a mass concentration of the particulate species based on a ratio of the measured sound pressure and power of the laser beam, and whether the mass concentration of the particulate species exceeds a threshold concentration can be achieved.

Abstract: An operation training system for ultrasound includes a sensing device, a data processing device and a display device. The sensing device is configured to sense a hand movement signal and a voice signal. The data processing device is configured to analyze the hand movement signal, control the virtual hand to move the virtual probe in the virtual scene and perform virtual ultrasound detection, and generate an answer content corresponding to the voice signal based on the question-and-answer model. The display device is configured to display the virtual scene and play the answer content.

Abstract: A differential pressure flow meter has a fluid restriction unit and a differential pressure transducer. The fluid restriction unit includes an upstream compartment, a downstream compartment, and an orifice element having a centric bore. The orifice element is located at a junction face of the upstream and downstream compartments. The differential pressure transducer includes a diaphragm compartment having a first sensor coupled to a high-pressure side diaphragm and a second sensor coupled to a low-pressure side diaphragm. The diaphragm compartment is disposed within a chamber having a high-pressure compartment and the low-pressure compartment. The high-pressure compartment is in fluid communication with the upstream compartment via a first fluid outlet port and the low-pressure compartment is in fluid communication with the downstream compartment via a second fluid outlet port.

Abstract: A method for treating autoimmune and/or inflammatory disease includes a step of identifying a subject exhibiting symptoms of autoimmune and/or inflammatory disease administering a fasting mimicking diet. The fasting mimicking diet provides the subject with at most 50% to 75% of the subject's normal caloric intake. A probiotic composition for gastrointestinal autoimmune and/or inflammatory disease Bacteroides acidifaciens, Bifidobacterium choerinum, and combinations thereof is also provided.

Abstract: A system implements a modeling (ClassGP) and an optimization (ClassBO) framework that models heterogeneous functions with knowledge of individual partitions within classes, i.e., heterogeneous functions including non-stationary functions which can be divided into locally stationary functions over partitions of input space with an active stationary function in each partition. The framework constructs a class likelihood for the class by combining log marginal likelihoods associated with each partition of the plurality of partitions within the class. The framework aims to improve analysis of systems that are characterized by a discrete and finite number of “classes” of behaviors.

Abstract: Systems, processes and devices are provided for laser-based manufacturing of resonators and MEMS devices from bulk material including optically transparent material. Processes include digital marking of resonator structures in bulk material through non-linear interaction of ultrafast laser beam inscribing and material. The resonator structure may be defined and released through selective wet etching of the laser-modified areas, utilizing a combination of basic and acidic aqueous solutions. Processes can also include hydrofluoric thinning prior to wet etching to prevent laser surface damages. Systems and processes can pattern and fabricate resonator structures and concentricring structures. Embodiments provide miniaturized vibratory sensors from low loss material, such as fused silica and quartz, with an improved resolution and accuracy of measurements for inertial sensing, time referencing, bio-sensing and acoustic sensing.

Abstract: A precursor is made of a polymer or the polymer and a high-temperature material. The polymer includes at least one of silicone material, cellulose, hydrogel, and acrylic acid ammonium salt polymer. The silicone material is silicone rubber, and the high-temperature material includes one of ceramics, glass, metal, diamond, and high-temperature composite material.

Abstract: The present invention relates to PHOTORESIST COMPOSITIONS AND METHODS OF FORMING PATTERNS USING A PHOTORESIST COMPOSITION. Disclosed is a photoresist composition including an organometallic compound including a ring including a metal, a first heteroatom coordinated to the metal, and a second heteroatom covalently bonded to the metal, and an aromatic ring substituted or fused to the ring; and a solvent.

Abstract: Provided is a method of generating stepwise purified sentences using a deep learning-based interactive model. The method includes receiving input sentences by a user's terminal, detecting malicious words in the input sentences, and generating a plurality of stagewise purified sentences using a plurality of types of purification including purification of the malicious words according to stepwise sentence purification, by a language purification model part of a stepwise purified sentence generation system, and presenting, by the terminal, the plurality of stepwise purified sentences to a user to allow the user to select one of the plurality of stepwise purified sentences, and transmitting, by the terminal, the selected stepwise purified sentence to the stepwise purified sentence generation system to determine a final purified sentence.

Abstract: A memory fault information pre-analysis according to the present disclosure includes a fault monitor, a fault counter, a must monitor, and a fault address collector, the fault memory receives fault data configured by a row address and a column address of a memory and stores a location where fault information about the fault data is stored in the fault counter, the must monitor, and the fault address collector, the fault counter stores a number of faults in a fault row and a fault column of the memory, the must monitor stores must fault information, and the fault address collector stores a row address and a column address of the fault data and whether it is a pivot fault.

Abstract: A portable pupillometer for evaluating one or more pupils of a subject includes an optical assembly to stimulate the one or more pupils. The optical assembly has a light source to deliver a stimulus to the one or more pupils and a detector to capture images of the one or more pupils during delivery of the stimulus. A control device is coupled to the optical assembly, which has a controller to perform a plurality of operations in accordance with instructions stored in a digital memory. The plurality of operations includes: obtaining pupillary light reflex data comprising a plurality of Pupillary Light Reflex metrics during stimulation of the one or more pupils; analyzing the pupillary light reflex data based on one or more characteristics of the subject; determining a probability of a concussion injury suffered by the subject; and outputting the probability to a user of the pupillometer.

Abstract: An imaging apparatus may include a light source emitting linear light, a light reflector configured to reflect the linear light incident from the light source unit, a first filter configured to filter the linear light reflected from the light reflector, a light transmission reflector configured to reflect the linear light passing through the first filter toward an object and transmit light incident from the object, a second filter configured to filter the light that has passed through the light transmission reflector after being incident from the object, and a camera configured to capture the light passing through the second filter.

Abstract: A control system includes a target spacecraft and a swarm of chaser spacecraft. Each chaser spacecraft is controlled to follow a corresponding computed trajectory. The system also includes at least one computing device that executes a nested genetic algorithm. The nested genetic algorithm includes multiple guidance genetic algorithms and an outer genetic algorithm. Characteristically, each chaser spacecraft has an associated guidance genetic algorithm that determines a computed trajectory for the chaser spacecraft associated therewith. Advantageously, the outer genetic algorithm checks for collisions and is configured to alter one or more computed trajectories to avoid collisions.