Abstract: Disclosed herein is a multilayer film comprising two or more layers of polyelectrolytes, wherein adjacent layers comprise oppositely charged polyelectrolytes. A first layer polyelectrolye comprises a composite polypeptide comprising one or more surface adsorption regions covalently linked to one or more functional regions forming a single polypeptide chain. The surface adsorption regions comprise one or more amino acid sequence motifs consisting of 5 to 15 amino acid residues. The one or more functional regions comprise 3 to about 250 amino acid residues.

Abstract: The present invention discloses a sensing device, wherein a hemispherical container containing a liquid dielectric, and the hemispherical container has more than two pairs of electrodes, and the liquid dielectric can trigger the conduction states of the electrodes. A corrosion-resistant material envelops the container. A precision valve is arranged in the container and used to adjust the level of the liquid dielectric and the sensitivity of the sensing device. A buffer necking part is also arranged in the container and used to prevent from non-expected vibration-induced contact between the electrodes and the liquid dielectric. A leakage-proof detection device envelops the hemispherical container, the liquid dielectric, the precision valve, and the buffer necking part and functions to prevent from the leakage of the liquid dielectric. Thus, the present invention can provide an adjustable multi-directional tilt-sensing device for level control.

Abstract: This invention provides isolated nucleic acids encoding polypeptides comprising amino acid sequences of streptococcal matrix adhesion (Ema) polypeptides. The invention provides nucleic acids encoding Group B streptococcal Ema polypeptides EmaA, EmaB, EmaC, EmaD and EmaE. The present invention provides isolated polypeptides comprising amino acid sequences of Group B streptococcal polypeptides EmaA, EmaB, EmaC, EmaD and EmaE, including analogs, variants, mutants, derivatives and fragments thereof. Ema homologous polypeptides from additional bacterial species, including S. pneumoniae, S. pyogenes, E. faecalis and C. diptheriae are also provided. Antibodies to the Ema polypeptides and immunogenic fragments thereof are also provided. The present invention relates to the identification and prevention of infections by virulent forms of streptococci.

Abstract: The present invention is directed to novel thalidomide derivative compounds that have activity as anti-angiogenic compounds. More particularly the compounds have the general structure: where R1 is selected from the group consisting of H, halo, alkyl, haloalkyl, —NH2, hydroxy and alkoxy; R2 is selected from the group consisting of optionally substituted bicyclic, optionally substituted aryl, and R6 is H, or C1-C8 alkyl; R19 is optionally substituted aryl; and m is 0-6.

Abstract: A sensor to detect particulate matter. The sensor includes a first rigid tube, a second rigid tube, a detection surface electrode, and a bias surface electrode. The second rigid tube is mounted substantially parallel to the first rigid tube. The detection surface electrode is disposed on an outer surface of the first rigid tube. The detection surface electrode is disposed to face the second rigid tube. The bias surface electrode is disposed on an outer surface of the second rigid tube. The bias surface electrode is disposed to face the detection surface electrode on the first rigid tube. An air gap exists between the detection surface electrode and the bias surface electrode to allow particulate matter within an exhaust stream to flow between the detection and bias surface electrodes.

Abstract: The water rocket engine with a two-phase nozzle includes a water rocket propulsion system having a reservoir, and a nozzle assembly disposed along a central longitudinal axis therein, the nozzle assembly comprising an inverted cup shaped fluid capture vessel having a substantially concave sidewall and extending away from an elongated tube. Open lower portion of the fluid capture vessel forms a fluid inlet. The elongated tube has a concave shaped side wall that forms a nozzle gas inlet at an upper portion of the tube, a nozzle outlet at a lower portion of the tube, and a passageway disposed between the tube upper portion and the tube lower portion. Within the confines of the capture vessel, fluid injection holes are disposed in the tube sidewall to provide fluid intake into the nozzle passageway where fluid and gas combine to form a two phase propellant.

Abstract: A conditional active shape model wherein a training set of images of objects in a class of objects to be identified, such as vascular cross-sections, is supplemented with training observations of at least one second characteristic of the object. A conditional mean shape of the objects is calculated, conditioned on the second characteristic, thereby reducing the size of the probable search space for the shape. A conditional covariance matrix of the shapes is calculated, conditioned on the second characteristic, and the eigenvectors of the conditional covariance matrix corresponding to largest eigenvalues are calculated. The conditional mean shape, and the eigenvalues and eigenvectors of the conditional covariance matrix are then used in an active shape model to identify the shapes of objects in subsequent images.

Abstract: Gene expression profiling between normal B cells/plasma cells and multiple myeloma cells revealed four distinct subgroups of multiple myeloma plasma cells that have significant correlation with clinical characteristics known to be associated with poor prognosis. Diagnosis for multiple myeloma (and possibly monoclonal gammopathy of undetermined significance) based on differential expression of 14 genes, as well as prognostics for the four subgroups of multiple myeloma based on the expression of 24 genes were also established. Gene expression profiling also allows placing multiple myeloma into a developmental schema parallel to that of normal plasma cell differentiation. The development of a gene expression- or developmental stage-based classification system for multiple myeloma would lead to rational design of more accurate and sensitive diagnostics, prognostics and tumor-specific therapies for multiple myeloma.

Abstract: A method for ionizing and desorbing a sample for analysis includes energizing a first and second electrode to produce a glow discharge at atmospheric pressure. The method further includes supplying a carrier gas to at least a portion of the glow discharge to create effluents thereof. The method further includes conducting the effluents of the glow discharge to the sample to ionize and desorb the sample for analysis. An associated apparatus is also disclosed.

Abstract: A computer-based method that allows automated measurement of a number of metrics that likely reflect the quality of a colonoscopic procedure. The method is based on analysis of a digitized video file created during colonoscopy, and produces information regarding insertion time, withdrawal time, images at the time of maximal intubation, the time and ratio of clear versus blurred or non-informative images, and a first estimate of effort performed by the endoscopist. As these metrics can be obtained automatically, the method allows future quality control in the day-to-day medical practice setting on a large scale. In addition, the method can be adapted to other healthcare procedures. The method may be useful to assess progress during colonoscopy training, or as part of endoscopic skills assessment evaluations.

Abstract: Methods for screening compounds for their activity as a protein kinase A modulators are provided. The methods are based on fluorescence polarization of peptide probes to identify drug candidates that act by activating or inhibiting the catalytic function of PKA. In certain embodiments, the methods are adapted for high throughput screening.

Abstract: The present invention provides a system for site-specific directed gene insertion of desired genes or foreign DNA into cellular genomes. The system includes novel vectors for integrating DNA into the genome of different hosts. Methods of using the vectors and transformed hosts are described.

Abstract: An anatomical data registration device may include a dental device. The dental device may configurable to be subject-specific. A dental device may be positionable in a substantially fixed spatial relationship relative to a portion of the subject. An anatomical data registration device may include one or more radiopaque markers. At least one of the radiopaque markers may be positioned in the dental device. The radiopaque marker may be configured to facilitate alignment of two or more images of the portion of the subject. The data registration device may be positionable within a subject's mouth.

Abstract: Acene-based compounds that can be used to prepare n-type semiconductor materials are provided with processes for preparing the same. Composites and electronic devices including n-type semiconductor materials prepared from these compounds also are provided.

Abstract: The present invention provides novel dystrophin mini/micro-genes that retain the essential biological functions of a full-length dystrophin gene. More particularly, the present invention provides to a series of synthetic mini/micro-dystrophin genes capable of restoring neuronal nitric oxide synthase (nNOS) to the sarcolemma. A method as well as a pharmaceutical composition for treatment of Duchenne Muscular Dystrophy (DMD), Becker Muscular Dystrophy (BMD), and X-linked Dilated Cardiomyopathy (XLDC) are also provided.

Abstract: A power amplifier includes a bipolar transistor and a self-adaptive bias network situated between an RF input and the base of the bipolar transistor. The self-adaptive bias network suppresses the low frequency even-order intermodulation components. The self-adaptive bias network stabilizes a DC bias voltage to provide a substantially constant base-emitter voltage and provides an increased DC base current with increased input power when the power amplifier is operating within the nonlinear region.

Abstract: A peptide having a sequence which satisfies all of the following requirements (I) to (V) and has an activity of stimulating an immune cell: (I) the number of constituent amino acid residues is 12 to 36; (II) the sequence is amphipathic; (III) the charge of the whole molecule is +2 or more; (IV) when constituent amino acid residues are arranged so as to form an a-helical structure, a side chain of any aromatic amino acid residue is not located between side chains of at least two positively charged amino acid residues on a side where hydrophilic amino acid residues are located; and (V) the sequence contains an amino acid residue which serves as a cleavage point for a mitochondrial processing enzyme.

Abstract: An information retrieval system for automatically retrieving information related to the context of an active task being manipulated by a user. The system observes the operation of the active task and user interactions, and utilizes predetermined criteria to generate a context representation of the active task that are relevant to the context of the active task. The information retrieval system then processes the context representation to generate queries or search terms for conducting an information search. The information retrieval system reorders the terms in a query so that they occur in a meaningful order as they naturally occur in a document or active task being manipulated by the user. Furthermore, the information retrieval system may access a user profile to retrieve information related to the user, and the select information sources or transform search terms based on attributes related to the user, such as the users occupation, position in a company, major in school, etc.

Abstract: A serotonin reuptake inhibitor which can be used in the treatment of depression and which has a decreased occurrence of unwanted side effects. The serotonin reuptake inhibitors are bi-functional organic molecules which combine serotonin transporter reuptake inhibition with serotonin (5-HT, such as 5-HT2A) receptor antagonism in one molecular entity. The serotonin-selective reuptake inhibitor (SSRI) homologue portion of the molecule shows an affinity to the serotonin reuptake transporter (SERT) and has antidepressant properties. The piperazine or piperidine portion of the molecule demonstrates an affinity to 5-HT receptors and restores the undesired side effects of SSRIs.

Abstract: A respective intensity gradient of a first spatially aligned pixel in each frame of a sequence of images is multiplied by a respective intensity or function thereof of a second pixel in the new frame, this being done for all pixels in the set and the resulting products being summed. This is repeated so that in one of the sums the first and second pixels have identical locations in the respective frames and where in each additional sum the second pixel is shifted by a non-zero shift relative to its location in other sums. The transformation is computed using intensity and gradient values of the image frames in the sequence and the sums. Weighted averages of at least two of the sums are stored and used together with the intensity and gradient values of the frames in the sequence to re-compute the transformation.