Abstract: Mesothelin can be used as an immunotherapeutic target. It induces a cytolytic T cell response. Portions of mesothelin which induce such responses are identified. Vaccines can be either polynucleotide- or polypeptide-based. Carriers for raising a cytolytic T cell response include bacteria and viruses. A mouse model for testing vaccines and other anti-tumor therapeutics and prophylactics comprises a strongly mesothelin-expressing, transformed peritoneal cell line.
Type:
Application
Filed:
September 15, 2008
Publication date:
June 25, 2009
Applicant:
The Johns Hopkins University
Inventors:
Elizabeth Jaffee, Tzyy-Choou Wu, Chien-Fu Hung, Ralph Hruban
Abstract: A method of providing microelectromechanical structures (MEMS) that are compatible with silicon CMOS electronics is provided. The method provides for processing and manufacturing is steps limiting a maximum exposure of an integrated circuit upon which the MEMS is manufactured during MEMS manufacturing to below a temperature wherein CMOS circuitry is adversely affected, for example below 400° C., and sometimes to below 300° C. or 250° C., thereby allowing direct manufacturing of the MEMS devices onto electronic integrated circuits, such as Si CMOS circuits.
Type:
Application
Filed:
December 22, 2008
Publication date:
June 25, 2009
Applicant:
The Royal Institution for the Advancement of Learning/McGill University
Inventors:
Frederic NABKI, Mourad EL-GAMAL, Tomas A. DUSATKO, Srikar VENGALLATORE
Abstract: Lipophilic compounds extracted from cell growth mediums, particularly lysophospholipids are used to solubilize single-walled nanotubes. The naturally occurring lysophospholipids were found to readily bond to the exterior wall of the single-walled nanotubes to enhance the biocompatibility of the single-walled nanotubes in therapeutic and diagnostic conditions. The solubilization protocol is simple, highly efficient, and results in a population of coated single-walled nanotubes which are highly stable.
Abstract: The present invention relates to immunogenic but non-depositing-forming polypeptides or peptides homologous to amyloid ?, prion, amylin or ?-synuclein which can be used alone or conjugated to an immunostimulatory molecule in an immunizing composition for inducing an immune response to amyloid ? peptides and amyloid deposits, to prion protein and prion deposits, to amylin and amylin deposits, to ?-synuclein and deposits containing ?-synuclein, or to polyglutamine repeats and deposits of proteins containing polyglutamine repeats. Described are also antibodies directed against such peptides, their generation, and their use in methods of passive immunization to such peptides and deposits.
Type:
Application
Filed:
December 19, 2008
Publication date:
June 25, 2009
Applicant:
New York University
Inventors:
Blas Frangione, Thomas Wisniewski, Einar M. Sigurdsson
Abstract: A touch panel includes a first conductive layer, a second conductive layer and a capacitive sensing member. The first conductive layer includes a plurality of first conductive lines. The second conductive layer separated from the first conductive layer includes a plurality of second conductive lines. One of the plurality of conductive lines is located above the other plurality of conductive lines. The capacitive sensing member is connected to the first conductive lines. At least one of the first and second pluralities of conductive lines includes carbon nanotube wires. The carbon nanotube wires each include a plurality of carbon nanotubes. Further, a display device using the above-described touch panel is also included.
Type:
Application
Filed:
September 29, 2008
Publication date:
June 25, 2009
Applicants:
Tsinghua University, HON HAI Precision Industry CO., LTD.
Abstract: A device for inspecting a soldering spot in a storage battery includes a power supply unit and an inspecting unit. The power supply unit outputs a test power signal to be applied to the soldering spot. The inspecting unit includes first and second inspecting terminals, and a control module. The first and second inspecting terminals are adapted to be connected electrically to the soldering spot so as to detect response of the soldering spot to application of the test power signal by the power supply unit. The control module determines if a detected response of the soldering spot as detected through the first and second inspecting terminals falls within a predetermined range configured in the control module, generates an indication signal if the detected response falls outside the predetermined range, and generates an inspection result corresponding to the detected response.
Type:
Application
Filed:
December 19, 2007
Publication date:
June 25, 2009
Applicants:
Department of Electrical Engineering, National Chang-Hua University of Education
Abstract: A peptide comprising an amino acid sequence as set forth in SEQ ID NO: 2, 4, 6, 8, 10 or 12 is provided. The peptide being at least 6 and no more than 50 amino acid residues in length. Also provided are therapeutic applications using such peptides.
Type:
Application
Filed:
November 28, 2008
Publication date:
June 25, 2009
Applicant:
Ramot At Tel Aviv University Ltd.
Inventors:
Britta Hardy, Alexander Battler, Annat Raiter, Ran Kornowski, Chana Weiss
Abstract: A photoactive aromatic polymer having high fluorescence, including an aromatic compound as a backbone, through the polymerization of aromatic polycyclic monomers and a photoactive aromatic polymer having high conductivity and fluorescence even in a state in which the photoactive aromatic polymer is formed into a thin film.
Type:
Application
Filed:
April 24, 2007
Publication date:
June 25, 2009
Applicant:
Industry-Academic Cooperation Foundation, Yonsei University
Abstract: An exemplary method for making a touch panel includes the steps of: providing a flexible substrate; fabricating a carbon nanotube film; laying the carbon nanotube film to form a carbon nanotube layer stacked on the flexible substrate; heat-pressing the carbon nanotube layer of the flexible substrate; and separately forming at least two electrodes on a surface of the carbon nanotube layer, thereby forming the touch panel.
Type:
Application
Filed:
September 29, 2008
Publication date:
June 25, 2009
Applicants:
Tsinghua University, HON HAI Precision Industry CO., LTD.
Abstract: A method and apparatus is provided for measuring the oxygen transmission rate (OTR) of a material, such as a perforated film packaging material. The method and apparatus can use a fiber optic oxygen sensor that does not consume oxygen and does do not require any flowing gas during measurement of the OTR.
Type:
Application
Filed:
December 15, 2008
Publication date:
June 25, 2009
Applicant:
University of Florida Research Foundation, Inc.
Abstract: A touch panel includes a first electrode plate, and a second electrode plate separated from the first electrode plate. The first electrode plate includes a first substrate, a first conductive layer, and at least two electrodes. The second electrode plate includes a second substrate, a second conductive layer, and at least two electrodes. At least one of the first and second conductive layers includes a plurality of carbon nanotube wire-like structures. Two ends of each carbon nanotube wire-like structure are connected with two of the electrodes. A display device adopting the touch panel includes the touch panel and a display element.
Type:
Application
Filed:
September 29, 2008
Publication date:
June 25, 2009
Applicants:
Tsinghua University, HON HAI Precision Industry CO., LTD.
Abstract: Systems and methods for camera-based fingertip tracking are disclosed. One such method includes identifying at least one location of a fingertip in at least one of the video frames, and mapping the location to a user input based on the location of the fingertip relative to a virtual user input device.
Type:
Application
Filed:
December 19, 2008
Publication date:
June 25, 2009
Applicant:
University of Central Florida Research Foundation
Abstract: Stress test analysis is facilitated through the acquired and manipulated use of a sequence of volumetric data regarding the heart (and may particularly comprise the left ventricle) for the assessment of the health state of the heart. Several provided and illustrated examples specifically relate to ultrasound volumetric data, but the volumetric data may be obtained through the use of any imaging modality (e.g., CT, MRI, X-ray, PET, SPECT, etc.) or combination thereof, and may be used to compute one or more functional quantitative metrics (e.g., ejection fraction.) The volumetric data may also be used to render one or more views of the heart, and particularly of the left ventricle. This disclosure relates to these and other uses of such volumetric data, and to some various implementations thereof, such as methods, systems, and graphical user interfaces.
Abstract: The present invention concerns a quantitative in situ assessment of mean telomere length, particularly in relation to nuclear area, for the diagnosis and/or prognosis of cancer. In particular aspects, the methods and compositions regard diagnosis and/or prognosis of bladder cancer, urothelial cancer, lung cancer, and lymphoma.
Type:
Application
Filed:
August 31, 2005
Publication date:
June 25, 2009
Applicant:
Board of Regents, The University of Texas System
Inventors:
Ruth L. Katz, Jun Gu, Abha Khanna, Ricardo Fernandez
Abstract: Ultraviolet light reactive alternative cellular energy pigments (ACE-pigments) are produced in response to certain types of viral infections, and in other pathological circumstances. ACE-pigments have energy transducing activities, and in particular have the capacity to convert various forms of physical energies, such as electromagnetic radiations, magnetic force and sound frequencies, into chemical energy (both reducing and oxidizing). They are thought to play a metabolic supportive role in the virus infected cells. ACE-pigments can be eliminated from the body through the skin and can also be found in and attached to hair. A method is described for collecting ACE-pigments from the skin and bodily fluids of a patient and viewing the ACE pigments using ultraviolet light in the presence of a dye such as neutral red, which enhances their ultraviolet (UV) induced fluorescence.
Type:
Application
Filed:
December 24, 2007
Publication date:
June 25, 2009
Applicant:
MI Hope Inc. dba Progressive University
Abstract: The present invention is directed to compositions and methods for preventing or inhibiting biofilm formation on a solid substrate comprising an antimicrobial agent and a biofilm-degrading enzyme embedded in a matrix material.
Type:
Application
Filed:
December 22, 2008
Publication date:
June 25, 2009
Applicant:
University of Louisville Research Foundation
Abstract: In accordance with one embodiment of the present disclosure, a prosthetic valve is provided. The prosthetic valve includes an annulus, a pair of leaflets, and a pair of support elements. The annulus has a generally saddle-shape formed by a movable pair of first portions separated from each other by a movable pair of second portions. The pair of leaflets extend from the annulus and are separated from each other by the pair of support elements. The first portions of the annulus and the second portions of the annulus are configured to move back and forth from being generally concave to being generally convex such that any movement of the first portions of the annulus occurs at generally the same time as any movement of the second portions of the annulus.
Abstract: An exemplary touch panel includes a first electrode plate and a second electrode plate separated from the first electrode plate. The first electrode plate includes a first substrate and a first conductive layer disposed on a lower surface of the first substrate. The second electrode plate includes a second substrate and a second conductive layer disposed on an upper surface of the second substrate. Each of the first conductive layer and the second conductive layer includes a plurality of spaced carbon nanotube structures. A display device incorporates the touch panel and also includes a display element adjacent to the touch panel.
Type:
Application
Filed:
September 29, 2008
Publication date:
June 25, 2009
Applicants:
Tsinghua University, HON HAI Precision Industry CO., LTD.
Abstract: Methods of increasing tolerance of a plant to stress are provided. According to an exemplary aspect a method of increasing tolerance of a plant to a biotic stress is provided. The method comprising expressing within the plant an exogenous thereby increasing the tolerance of the plant to the biotic stress. Also provided are nucleic acid constructs and transgenic plants comprising same.
Type:
Application
Filed:
April 29, 2007
Publication date:
June 25, 2009
Applicant:
Yissum Research Development Company of the Hebrew University of Jerusalem
Inventors:
Alexander Vainstein, Elena Shklarman, Yael Leitner-Dagan
Abstract: The present invention relates to compositions comprising acyltransferase nucleic acid molecules for altering lipids on the surface of plants, and related methods. In particular, the present invention provides compositions and methods for increasing the amount of free fatty acids, acylglycerols, and other lipids on the surface of a plant. In a preferred embodiment, the present invention relates to increasing activity of a GPAT acyltransferase for altering lipid on the plant surface, for increasing surface lipids, for enhancing environmental stress tolerance, increasing resistance to biotic stress, and providing novel plant lipids for commercial products. In further embodiments, the present invention relates to using an Arabidopsis thaliana GPAT acyltransferase for altering lipid compounds on the surface of a plant.
Type:
Application
Filed:
June 22, 2007
Publication date:
June 25, 2009
Applicant:
The Board of Trustees Operating Michigan State University
Inventors:
Yonghua Li, Fred Beisson, Mike Pollard, John Ohlrogge