Patents Assigned to University
  • Patent number: 7550141
    Abstract: Disclosed is the surprising discovery that aminophospholipids, such as phosphatidylserine and phosphatidylethanolamine, are specific, accessible and stable markers of the luminal surface of tumor blood vessels. The present invention thus provides aminophospholipid-targeted diagnostic and therapeutic constructs for use in tumor intervention. Antibody-therapeutic agent conjugates and constructs that bind to aminophospholipids are particularly provided, as are methods of specifically delivering therapeutic agents, including toxins and coagulants, to the stably-expressed aminophospholipids of tumor blood vessels, thereby inducing thrombosis, necrosis and tumor regression.
    Type: Grant
    Filed: November 12, 2004
    Date of Patent: June 23, 2009
    Assignee: Board of Regents, The University of Texas System
    Inventors: Philip E. Thorpe, Sophia Ran, Rolf A. Brekken
  • Patent number: 7550577
    Abstract: The present invention provides a polynucleotide comprising all or a part of the nucleotide sequence identified as SEQ ID NO:1 that regulates transcription of the human high-affinity IgE receptor (Fc?FI) ?-chain gene, and a method for regulating transcription of the Fc?FI ?-chain gene which comprises the step of promoting binding between a transcription regulatory complex containing MZF-1 and the transcription regulatory region of the Fc?FI ?-chain gene that contains the nucleotide sequence identified as SEQ ID NO: 1. In addition, the present invention provides a screening method and a kit therefor that utilizes the method for regulating transcription of the Fc?FI ?-chain gene having the step of promoting binding between a transcription regulatory complex containing MZF-1 and the transcription regulatory region of the Fc?FI ?-chain gene that contains the nucleotide sequence identified as SEQ ID NO:1, thereby enabling development of a novel agent for the prevention and treatment of allergic diseases.
    Type: Grant
    Filed: June 4, 2003
    Date of Patent: June 23, 2009
    Assignee: Nihon University
    Inventors: Chisei Ra, Kyoko Takahashi
  • Patent number: 7550268
    Abstract: Methods, systems and kits are provided for detecting and quantifying multiple immunogens in a sample via consecutive addition of quantifiable extenders to immunogen bound complexes of immunogen binding agent attached to a DNA containing an RNA polymerase promoter.
    Type: Grant
    Filed: July 28, 2006
    Date of Patent: June 23, 2009
    Assignee: Trustees of the University of Pennsylvania
    Inventor: James Eberwine
  • Patent number: 7550281
    Abstract: Disclosed is a novel recombinant Bacillus bacterial strain constructed by genetic engineering which has high productivity of aipha-amylase. The Bacillus strain comprises an alpha-amylase gene inserted in the Bacillus chromosome under transcriptional control of a phage promoter. An efficient process for the rapid production of large amounts of alpha-amylase is also disclosed.
    Type: Grant
    Filed: August 7, 2002
    Date of Patent: June 23, 2009
    Assignee: The Hong Kong Polytechnic University
    Inventors: Yun Chung Leung, Wai Hung Lo, Jeffery Errington
  • Patent number: 7549427
    Abstract: A novel nanocatalyst is disclosed containing titanium oxide, iron oxide, and calcium oxide. The catalyst comprises a layer of iron oxide in the gamma form supported on a titanium oxide core. Addition of calcium cations helps to stabilize the iron oxide in the gamma form. The iron oxide layer is on the order of a few nanometers thick on the surface of the titanium oxide core, in an “egg-in-shell” structure. The nanocatalyst is highly active in promoting the oxidation of compounds such as hydroquinone, catechol, other hydrocarbons, chlorinated phenols, and carbon monoxide, even at moderately elevated temperatures. The catalyst remains active in a pyrolytic environment for extended periods of time, and possesses high redox cycling potential. The efficiency of the catalyst is not strongly affected by coking in a combustion environment.
    Type: Grant
    Filed: July 13, 2005
    Date of Patent: June 23, 2009
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Harold B. Dellinger, Slawomir M. Lomnicki
  • Patent number: 7550165
    Abstract: An apparatus and method of peeling produce is described comprising adding an electrically conductive fluid and a produce having a peel to a container and subjecting the fluid and the produce to an electrical field to produce a current sufficient to rupture the peel from the produce.
    Type: Grant
    Filed: June 9, 2004
    Date of Patent: June 23, 2009
    Assignee: The Ohio State University Research Foundation
    Inventors: Sudhir Sastry, Pisit Wongsa-Ngasri
  • Patent number: 7550395
    Abstract: A method for locally controlling an electrical potential of a semiconductor structure or device, and hence locally controlling lateral and/or vertical photoelectrochemical (PEC) etch rates, by appropriate placement of electrically resistive layers or layers that impede electron flow within the semiconductor structure, and/or by positioning a cathode in contact with specific layers of the semiconductor structure during PEC etching.
    Type: Grant
    Filed: October 31, 2005
    Date of Patent: June 23, 2009
    Assignee: The Regents of the University of California
    Inventors: Evelyn L. Hu, Shuji Nakamura, Elaine D. Haberer, Rajat Sharma
  • Patent number: 7551826
    Abstract: An integrated circuit is provided with a photonic device and a spot-size converter waveguide device integrated on a common substrate. The spot-size converter waveguide device provides for transformation between a larger spot-size and a smaller spot-size corresponding to the photonic device. The spot-size converter waveguide device includes at least one of a bottom mirror and top mirror, which provide highly-reflective lower and upper cladding, respectively, for vertical confinement of light propagating through the waveguide device. The top mirror overlies opposing sidewalls of the spot-converter waveguide device, which provide highly-reflective sidewall cladding for lateral confinement of light propagating through the waveguide device. Advantageously, the highly-reflective lower cladding provided by the bottom mirror limits optical loss of the waveguide device. Similarly, the highly-reflective upper cladding and sidewall cladding provided by the top mirror limits optical loss of the waveguide device.
    Type: Grant
    Filed: June 26, 2007
    Date of Patent: June 23, 2009
    Assignees: The University of Connecticut, Opel, Inc.
    Inventor: Geoff W. Taylor
  • Patent number: 7550529
    Abstract: Graphite nanoplatelets of expanded graphite and composites and products produced therefrom are described. The preferred method of expanding the graphite is by microwaves or other radiofrequency wave treatment of intercalated graphite. The expanded graphite is preferably then crushed to nanometer (substantially all 200 microns or less). The expanded graphite is used in polymer composites. The expanded graphite is particularly useful for batteries, anodes and fuel cells.
    Type: Grant
    Filed: February 27, 2006
    Date of Patent: June 23, 2009
    Assignee: Board of Trustees of Michigan State University
    Inventors: Lawrence T. Drzal, Hiroyuki Fukushima
  • Patent number: 7550429
    Abstract: A biologically active lipid mobilising agent for use in therapy is disclosed which has the properties and characteristics of a Zn-?2-glycoprotein, or of a fragment thereof having an apparent molecular mass Mr greater than 6.0 kDa as determined by gel exclusion chromatography. Methods of isolation and purification from biological material are also disclosed together with uses of the material for making up pharmaceutical compositions, especially pharmaceutical compositions useful for treating mammals to achieve weight reduction or for controlling obesity. In addition, uses of the material for developing diagnostic agents and for identifying inhibitors of lipolytic activity for therapeutic purposes are disclosed.
    Type: Grant
    Filed: August 16, 2004
    Date of Patent: June 23, 2009
    Assignee: Aston University
    Inventors: Michael J. Tisdale, Penio T. Todorov
  • Patent number: 7550907
    Abstract: A field emission element (100) includes an elongated solid body (110), a carbon nanotube yarn (112) and an electrically conductive adhesive agent (114). The carbon nanotube yarn wraps round the elongated solid body. The electrically conductive adhesive agent is applied between the elongated solid body and the carbon nanotube yarn, and the electrically conductive adhesive agent is configured for fixing the carbon nanotube yarn to the elongated solid body. The substantially all of carbon nanotube yarn is entirely adhered on a peripheral surface of the elongated solid body.
    Type: Grant
    Filed: August 11, 2006
    Date of Patent: June 23, 2009
    Assignees: Tsinghua University, Hon Hai Precision Industry Co., Ltd.
    Inventors: Kai-Li Jiang, Peng Liu, Yang Wei, Xiao-Bo Zhang, Shou-Shan Fan
  • Patent number: 7550681
    Abstract: This invention discloses a method and apparatus for measuring the weight of a CNC workpiece. As the weight of the workpiece on a loading platform increases, the loading of a driving module which drives the loading platform in constant speed increases accordingly. On the contrary, as the weight of the workpiece on the loading platform decreases, the loading of the driving module which drives the loading platform in constant speed also decreases. This invention determines the weight of the workpiece on the loading platform by measuring the electrical signal which drives the driving module and utilizing a calibration curve data in a preconfigured database.
    Type: Grant
    Filed: May 25, 2007
    Date of Patent: June 23, 2009
    Assignee: Chung Yuan Christian University
    Inventors: Shih-Ming Wang, Ming-Hua Li
  • Patent number: 7550557
    Abstract: Disclosed herein are multilayer films comprising two or more layers of polyelectrolytes, wherein adjacent layers comprise oppositely charged polyelectrolytes. A first layer polypeptide comprising one or more first amino acid sequence motifs, wherein the one or more first amino acid sequence motifs has a length of 5 to 15 amino acids residues, and wherein the balance of charge in the first amino acid sequence motif at pH 7 is greater than or equal to approximately one-half of the length of the first amino acid sequence motif, wherein the first layer polypeptide is not a homopolymer. Further, a second layer comprises second layer polyelectrolyte comprising a nonprotein polyelectrolyte having a charge opposite that of the first layer polypeptide.
    Type: Grant
    Filed: October 25, 2006
    Date of Patent: June 23, 2009
    Assignee: Louisiana Tech University Foundation, Inc.
    Inventor: Donald T. Haynie
  • Patent number: 7550512
    Abstract: The present invention provides a polyethylene glycol derivative having sugar residue-containing side chains and carboxyl group-containing side chains, and a method of preparing the same. The present invention also provides a carrier for drug delivery systems and a carrier for gene transfer, both comprising the polyethylene glycol derivative.
    Type: Grant
    Filed: June 3, 2004
    Date of Patent: June 23, 2009
    Assignees: Keio University, NOF Corporation
    Inventors: Toshinori Sato, Yoshiyuki Koyama, Tetsuji Yamaoka
  • Patent number: 7550752
    Abstract: Treatment planning methods are provided that determine the variability of relative biological effectiveness (RBE) along a beam line and calculate, among other things, what intensity of hadron beam such as a proton or a carbon ion beam should be applied to achieve a desired biological dose at treatment site of a patient afflicted with a medical condition. Typically, three or four RBE values at three or four corresponding spacially-dispersed intervals along the beam line are calculated. In one embodiment, two RBE values for the spread-out Bragg peak (SOBP) region of the treatment site; one for the proximal section and one for the declining distal section is calculated. A third and different RBE value may be determined for the distal edge region of the SOBP. A fourth value may also be calculated for a pre-SOBP region.
    Type: Grant
    Filed: March 27, 2007
    Date of Patent: June 23, 2009
    Assignee: Hampton University
    Inventors: Cynthia E. Keppel, Richard A. Britten, Vahagn R. Nazaryan
  • Patent number: 7550521
    Abstract: A method of manufacturing thermosets such as epoxy resins includes adding expandable hollow microspheres, which expand with temperature as shown in the accompanying graph, to the base thermoset components in the liquid phase and applying heat treatment to the mixture so formed causing the micropsheres to expand during or after curing of the thermoset. This results in a toughening mechanism caused by compressive residual stress around the microspheres which significantly increases the specific fracture energy of the epoxy resin.
    Type: Grant
    Filed: June 27, 2003
    Date of Patent: June 23, 2009
    Assignee: The University of Newcastle Research Associates Limited
    Inventors: Ho Sung Kim, Nam Ho Kim
  • Patent number: 7551939
    Abstract: A radio link management system for a home or office substantially (i) an ad hoc network of agents wirelessly communicating among themselves, while (iii) clients wirelessly communicate with proximate agents. Control of the network may be centralized as network controller integrated with an agent, or may be distributed upon the network of agents. Some agent or agents, which may include an agent that is also the network controller, typically serves as a gateway device which connects to a worldwide communications network external to the home or office, normally by fiber or by wire. Each agent is most commonly a small radio transceiver plus logic and power supply that mounts upon a wall and plugs directly into an AC power socket. Agents wirelessly communicate among themselves and with the controller—which may be centralized or distributed—in a bandwidth-efficient mode since prime power is not an issue.
    Type: Grant
    Filed: March 26, 2007
    Date of Patent: June 23, 2009
    Assignee: The Regents of the University of California
    Inventor: Anthony Acampora
  • Patent number: 7550201
    Abstract: A photonic material comprising a core and an envelope is provided for use in telecommunications, diagnostics, imaging and other applications. In its simplest form, the core comprises at least one nanoparticle. The nanoparticle comprises an inorganic material and at least one luminescent ion, wherein the inorganic material is suitably selected to bind the luminescent ion. The envelope comprises a suitably selected organic stabilizing layer that overlays the core. The core and envelope may have a shell located between them.
    Type: Grant
    Filed: March 24, 2004
    Date of Patent: June 23, 2009
    Assignee: University of Victoria Innovation and Development Corporation
    Inventors: Franciscus Cornelis Jacobus Maria van Veggel, Jan Willem Stouwdam
  • Patent number: 7550154
    Abstract: Polymeric microparticles have been developed which encapsulate therapeutic compounds such as drugs, cellular materials or components, and antigens, and can have targeting ligands directly bound to the microparticle surface. Preferred applications include use in tissue engineering matrices, wound dressings, hone repair or regeneration materials, and other applications where the microparticles are retained at the site of application or implantation. Another preferred application is in the use of microparticles to deliver anti-proliferative agents to the lining of blood vessels following angioplasty, transplantation or bypass surgery to prevent or decrease restenosis, and in cancer therapy. In still another application, the microparticles are used to treat or prevent macular degeneration when administered to the eye, where agents such as complement inhibitors are administered.
    Type: Grant
    Filed: July 30, 2007
    Date of Patent: June 23, 2009
    Assignee: Yale University
    Inventors: William Mark Saltzman, Tarek Fahmy, Peter Fong
  • Patent number: D594855
    Type: Grant
    Filed: September 29, 2008
    Date of Patent: June 23, 2009
    Assignee: Baltic Latvian Universal Electronics, LLC
    Inventors: Todd Metlen, Bjern Simundson, Eli Probst