Patents Assigned to University
  • COMPOSITIONS AND METHODS FOR ALTERING WNT AUTOCRINE SIGNALING
    Publication number: 20090163407
    Abstract: The present invention relates to compounds and methods for treating cancers in which the autocrine Wnt canonical signaling pathway is activated. In particular, there is provided a method for inhibiting growth of a tumor cell or sensitizing a cancer cell to treatment by contacting such a tumor cell with a compound that alters Wnt signaling. The compound that alters Wnt signaling can be a Wnt antagonist, a Wnt receptor antagonist, or a combination thereof.
    Type: Application
    Filed: November 15, 2005
    Publication date: June 25, 2009
    Applicant: Mount Sinai School of Medicine of New York University
    Inventors: Anna Bafico, Stuart Aaronson
  • Histone Deacetylase Inhibitors and Methods of Use Thereof
    Publication number: 20090163543
    Abstract: One aspect of the invention relates to HDAC inhibitors. Methods of sensitizing a cancer cell to the cytotoxic effects of radiotherapy are also provided. The invention also provides methods for treating cancer and methods for treating neurological diseases. Additionally, the invention further provides pharmaceutical compositions comprising an HDAC inhibitor of the invention, and kits comprising a container containing an HDAC inhibitor of the invention.
    Type: Application
    Filed: December 19, 2008
    Publication date: June 25, 2009
    Applicant: Georgetown University
    Inventors: Alan P. Kozikowski, Bin Chen
  • Methods to Identify Protein Arginine Deiminase 4 Inhibitors
    Publication number: 20090162877
    Abstract: In accordance with one embodiment of the present disclosure, a method to identify a protein arginine deiminase 4 inhibitor is disclosed. The method includes performing a competitive assay in which a potential inhibitor compound competes with rhodamine-conjugated fluoroamidine to bind to protein arginine deiminase 4. Fluorescence is measured to determine an estimate of the amount of fluorescent protein arginine deiminase 4 that is present in the assay.
    Type: Application
    Filed: October 31, 2008
    Publication date: June 25, 2009
    Applicant: University of South Carolina
    Inventors: Paul Ryan Thompson, Bryan Knuckley
  • Method for making touch panel
    Publication number: 20090159188
    Abstract: A method for making a touch panel includes the steps of: (a) providing a flexible substrate; (b) applying at least one carbon nanotube layer on the flexible substrate; (c) heat-pressing the carbon nanotube layer on the flexible substrate; (d) locating two electrodes on opposite ends of the flexible substrate; (e) placing an insulative layer on edges of a first surface of the flexible substrate, the first surface having the carbon nanotube layer formed thereon; and (f) securing the first electrode plate to a second electrode plate, with the insulative layer located between the first electrode plate and the second electrode plate, and wherein the carbon nanotube layer of the first electrode plate is adjacent to a carbon nanotube layer of the second electrode plate.
    Type: Application
    Filed: September 29, 2008
    Publication date: June 25, 2009
    Applicants: Tsinghua University, HON HAI Precision Industry CO., LTD.
    Inventors: Kai-Li Jiang, Liang Liu, Shou-Shan Fan
  • Methods of using beta glucan as a radioprotective agent
    Publication number: 20090163439
    Abstract: The invention relates to methods for treating and preventing radiation and/or chemotherapy related injury and/or afflictions, such as myelosuppression and decreased macrophage activity, by administering a prophylactically or therapeutically effective amount of particulate, bioavailable ?(1,3; 1,6) glucan. The invention also relates to methods in which ?(1,3; 1,6) glucan is provided in the form of whole glucan particles, microparticulate ?-glucan particles or a combination thereof.
    Type: Application
    Filed: July 8, 2008
    Publication date: June 25, 2009
    Applicants: Biopolymer Engineering, University of Louisville Research Foundation, Inc.
    Inventors: Gary R. Ostroff, Gordon D. Ross, Trunetta Jo Dockter Ross
  • Phorboxazole Compounds and Methods of Their Preparation
    Publication number: 20090163563
    Abstract: Novel macrolactone compounds, their methods of preparation, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the macrolactone compounds may be useful, inter alia, for treating various cancers, inducing apoptosis in malignant cells, or inhibiting cancer cell division.
    Type: Application
    Filed: December 1, 2008
    Publication date: June 25, 2009
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Thomas M. Razler, Amos B. Smith, III, Jeffrey P. Ciavarri, Tomoyasu Hirose, Tomoyasu Ishikawa
  • METHODS, COMPOSITIONS, AND KITS RELATING TO CHITINASES AND CHITINASE-LIKE MOLECULES AND INFLAMMATORY DISEASE
    Publication number: 20090162347
    Abstract: The present invention includes compositions and methods for the treatment of inflammatory disease (e.g., asthma, COPD, inflammatory bowel disease, atopic dermatitis, atopy, allergy, allergic rhinitis, scleroderma, and the like), relating to inhibiting a chitinase-like molecule. The invention further includes methods to identify new compounds for the treatment of inflammatory disease, including, but not limited to, asthma, COPD and the like. This is because the present invention demonstrates, for the first time, that expression of IL-13, and of a chitinase-like molecule, mediates and/or is associated with inflammatory disease and that inhibiting the chitinase-like molecule treats and even prevents, the disease. Thus, the invention relates to the novel discovery that inhibiting a chitinase-like molecule treats and prevents an inflammatory disease.
    Type: Application
    Filed: November 21, 2008
    Publication date: June 25, 2009
    Applicant: Yale University
    Inventors: Jack A. Elias, Zhou Zhu
  • Biodegradable thermoplasticized starch-polyester reactive blends for thermoforming applications
    Publication number: 20090160095
    Abstract: The disclosure relates to a starch-polyester graft copolymer, for example formed by the reactive blending of a thermoplastic starch (TpS) and/or a modified thermoplastic starch (MTpS) with a biodegradable polyester. The thermoplastic starch includes starch (e.g., a high-amylose starch) and a plasticizer, and can further include a chemical modifier and an optional initiator. The graft copolymer preferably is completely (or substantially completely) biodegradable, for example based on the biodegradability of each of its components. The graft copolymer can be formed into sheets of material that can be subsequently thermoformed, for example into single-use, disposable articles.
    Type: Application
    Filed: December 4, 2008
    Publication date: June 25, 2009
    Applicant: Board of Trustees of Michigan State University
    Inventors: Ramani Narayan, Jacqueline Stagner, Vanessa Dias Alves
  • Method for making light metal-based nano-composite material
    Publication number: 20090162574
    Abstract: A method for fabricating a light metal-based nano-composite material, the method includes the steps of: (a) providing melted metal and nanoscale reinforcements; (b) ultrasonically dispersing the nanoscale reinforcements in the melted metal by means of ultrasonically mixing to achieve a mixture with the nanoscale reinforcements uniformly dispersed therein; and (c) cooling the mixture.
    Type: Application
    Filed: November 24, 2008
    Publication date: June 25, 2009
    Applicants: Tsinghua University, HON HAI Precision Industry CO., LTD.
    Inventors: Nai-Yi Li, Tadayoshi Tsukeda, Kuo-Jung Chung, Kam-Shau Chan, Cheng-Shi Chen, Qing-Chun Du, Wen-Zhen Li
  • Wave soldering apparatus
    Publication number: 20090159640
    Abstract: A wave soldering apparatus includes: two parallel tracks; a soldering bath defining a wave soldering region between the tracks for soldering circuit boards passing therethrough; a conveying unit including two belts that are movably and respectively mounted on the tracks, and a plurality of clamping members mounted on the belts; and two adjusting mechanisms, each of which is mounted on a respective one of the tracks and each of which includes a pressing plate that is disposed at a top side of the wave soldering region and that is adjustable in height relative to the tracks so as to press downwardly against the clamping members that are under the pressing plate.
    Type: Application
    Filed: May 22, 2008
    Publication date: June 25, 2009
    Applicant: Universal Scientific Industrial Co., Ltd.
    Inventor: Weiming Liu
  • Field Emission display device
    Publication number: 20090160312
    Abstract: A field emission device includes an insulating substrate, one or more grids located on the insulating substrate. Each grid includes a first, second, third and fourth electrode down-leads and an electron emitting unit. The first, second, third and fourth electrode down-leads are located on the periphery of the grid. The first and the second electrode down-leads are parallel to each other. The third and the fourth electrode down-leads are parallel to each other. The electron emitting unit includes a first electrode, a second electrode and at least one electron emitter. The first electrode is electrically connected to the first electrode down-lead, and the second electrode is electrically connected to the third electrode down-lead. One end of the electron emitter is connected to the second electrode and an opposite end of the electron emitter is spaced from the first electrode by a predetermined distance.
    Type: Application
    Filed: December 19, 2008
    Publication date: June 25, 2009
    Applicants: Tsinghua University, HON HAI Precision Industry CO., LTD.
    Inventors: Peng Liu, Liang Liu, Kai-Li Jiang, Shou-Shan Fan
  • POSITIVE ELECTRODE ACTIVE MATERIAL FOR NONAQUEOUS ELECTROLYTE SECONDARY BATTERY
    Publication number: 20090159838
    Abstract: Disclosed is a positive electrode active material for nonaqueous electrolyte secondary batteries which contains a complex oxide mainly containing sodium, nickel and a tetravalent metal while having a hexagonal structure. This positive electrode active material enables to obtain a nonaqueous electrolyte secondary battery with high operating voltage. The complex oxide is preferably expressed as Na[Na(1/3-2x/3)Ni(x-y)M(2/3-x/3-y)A2y]O2 (wherein M represents one or more tetravalent metals, A represents one or more trivalent metals, 0<x?0.5, 0?y<1/6, and x>y).
    Type: Application
    Filed: November 24, 2005
    Publication date: June 25, 2009
    Applicants: SUMITOMO CHEMICAL COMPANY, LIMITED, Kyushu University, National University Corp.
    Inventors: Shigeto Okada, Jun-ichi Yamaki, Yusuke Takahashi, Kenji Nakane
  • ENCAPSULATION OF CARBON MATERIAL WITHIN ALUMINUM
    Publication number: 20090162654
    Abstract: Disclosed is a method of encapsulating a carbon material within aluminum, the method including the steps of: (i) functionalizing a carbon material by introducing a defect therein; (ii) mixing the functionalized carbon material with aluminum; and (iii) ball milling the mixture under an inert gas atmosphere. In addition, the present invention discloses a method of fabricating an aluminum-carbon material composite, the method comprising the steps of: (i) functionalizing the carbon material by introducing a defect therein; (ii) mixing the functionalized carbon material with aluminum; and (iii) ball milling the mixture under an inert gas atmosphere, thereby encapsulating a carbon material within aluminum. Furthermore, the present invention discloses an aluminum-carbon material composite fabricated according to the method.
    Type: Application
    Filed: July 24, 2008
    Publication date: June 25, 2009
    Applicants: Sungkyunkwan University Foundation for Corporate Collaboration, Dayou Smart Aluminium Co., Ltd.
    Inventors: Kang Pyo So, Young Hee Lee
  • Modified Acrylic Block Copolymers For Hydrogels and Pressure Sensitive Wet Adhesives
    Publication number: 20090163661
    Abstract: A method of producing an acrylic block copolymer comprising hydrophobic poly (lower alkyl methoacrylate), hydrophilic poly (lower alkyl methacrylic acid), and hydrophobic poly (lower alkyl methacrylate).
    Type: Application
    Filed: February 27, 2009
    Publication date: June 25, 2009
    Applicant: Northwestern University
    Inventors: Kenneth R. Shull, Murat Guvendiren, Phillip B. Messersmith, Bruce P. Lee
  • METHODS AND COMPOSITIONS FOR INHIBITING UNDESIRABLE CELLULAR PROLIFERATION BY TARGETED LIPOSOME DELIVERY OF ACTIVE AGENTS
    Publication number: 20090162425
    Abstract: Provided are methods for inhibiting undesirable proliferation of a tumor cell or a tumor in a subject including administering to the subject a composition that includes an effective amount of an active agent, wherein the active agent is entrapped by one or more liposomes, the active agent has activity in inhibiting undesirable proliferation of the tumor cell or the tumor, and the one or more liposomes include one or more targeting agents that preferentially or specifically bind to a binding molecule expressed by the tumor cell or the tumor, present on the tumor cell or the tumor, present in the tumor cell or the tumor, or combinations thereof. Also provided are compositions for treating tumors, particularly gliomas, in a subject in need thereof.
    Type: Application
    Filed: September 19, 2008
    Publication date: June 25, 2009
    Applicant: University of Tennessee Research Foundation
    Inventors: Murali Krishna Divi, George C. Wood, M. Waleed Gaber, Laura Thoma
  • ULTRASONIC DIAGNOSTIC APPARATUS
    Publication number: 20090163805
    Abstract: An object of the invention is to provide an ultrasonic diagnostic apparatus that can conduct elastic modulus measurement with high accuracy without enlarging the circuit scale. A calculator 3 uses a signal from a receiver-transmitter 2 to calculate the motion velocity or the move displacement of body tissue and the strain variation of the body tissue. A frequency analyzer 4 conducts frequency analysis of the motion velocity and the move displacement of the body tissue found in the calculator 3. A strain induced by stress and elastic wave separator 5 separates a frequency component with strain of an arterial wall caused by blood pressure change caused by pulsation of the heart, a frequency component of vibration caused by flow of blood into the lumen of artery, and a frequency component of noise based on the determination result of the frequency analyzer 4.
    Type: Application
    Filed: June 15, 2006
    Publication date: June 25, 2009
    Applicants: Matsushita Electric Industrial Co., Ltd., Tohoku University
    Inventors: Kazuhiro Sunagawa, Hiroshi Kanai
  • Metal hydroxide derivatives containing chemically bound organophosphorus or polyphosphate species as flame retardants
    Patent number: 7550099
    Abstract: Novel metal hydroxide derivatives which chemically combine positively charged metal hydroxide layers with negatively charged phosphorus-containing species, which can be either anionic organophosphorus materials or phosphorus-containing polymeric anions, are described. The metal hydroxide derivatives are useful flame retardants through their ability to be completely dispersed and their formation of a crust or char to prevent flame propagation.
    Type: Grant
    Filed: March 29, 2006
    Date of Patent: June 23, 2009
    Assignee: University of North Texas
    Inventors: Paul S. Braterman, Nandika D'Souza, Amit Dharia
  • Photo-reactive polymers and devices for use in hair treatments
    Patent number: 7550136
    Abstract: The invention provides new methods to treat hair to achieve a permanent wave, curl, or straightness.
    Type: Grant
    Filed: December 19, 2003
    Date of Patent: June 23, 2009
    Assignee: University of Massachusetts
    Inventors: John C. Warner, Amy S. Cannon, Jennifer Raudys, Arundhati Undurti
  • Tissue graft scaffold made from cholecyst-derived extracellular matrix
    Patent number: 7550152
    Abstract: Bioengineered tissue graft scaffolds and method for producing such scaffolds are provided. The scaffolds are useful to replace or repair damaged mammalian tissues and organs.
    Type: Grant
    Filed: September 14, 2005
    Date of Patent: June 23, 2009
    Assignee: National University of Ireland, Galway
    Inventors: Abhay Pandit, Thapasimuthu Vijayamma Anilkumar
  • Pan-antagonists for the androgen receptor and androgen receptor mutants associated with anti-androgen withdrawal
    Patent number: 7550505
    Abstract: Disclosed herein are novel antagonists of the androgen receptor and androgen receptor mutations associated with clinical failure of currently prescribed anti-androgens and use of said antagonists in the treatment of conditions associated with inappropriate activation of the androgen receptor.
    Type: Grant
    Filed: July 24, 2007
    Date of Patent: June 23, 2009
    Assignee: University of Delaware
    Inventors: John Tze-tzun Koh, Paula Lynn McGinley, Hongmu Pan