Abstract: Compounds that are selective binding agents specific for RNA secondary and tertiary structures and a fluorescence assay for detecting the binding of small molecules to T-box antiterminator model mRNAs. The compounds include novel tri-substituted oxazolidinones and amino alcohols. The assay provides fluorescently labeled model mRNAs that include conserved sequence information typical of antiterminator bulge regions found in the mRNA of T-box gene regulatory systems.
Type:
Grant
Filed:
October 24, 2005
Date of Patent:
June 23, 2009
Assignee:
Ahio University
Inventors:
Jennifer V. Hines, Stephen C. Bergmeier, Tina M. Henkin, Frank J. Grundy
Abstract: A scanning evanescent microwave microscope (SEMM) that uses near-field evanescent electromagnetic waves to probe sample properties is disclosed. The SEMM is capable of high resolution imaging and quantitative measurements of the electrical properties of the sample. The SEMM has the ability to map dielectric constant, loss tangent, conductivity, electrical impedance, and other electrical parameters of materials. Such properties are then used to provide distance control over a wide range, from to microns to nanometers, over dielectric and conductive samples for a scanned evanescent microwave probe, which enable quantitative non-contact and submicron spatial resolution topographic and electrical impedance profiling of dielectric, nonlinear dielectric and conductive materials. The invention also allows quantitative estimation of microwave impedance using signals obtained by the scanned evanescent microwave probe and quasistatic approximation modeling.
Type:
Grant
Filed:
June 30, 2000
Date of Patent:
June 23, 2009
Assignee:
The Regents of the University of California
Inventors:
Xiao-Dong Xiang, Chen Gao, Fred Duewer, Hai Tao Yang, Yalin Lu
Abstract: The present invention present invention relates to improved IRIS Fe oxide paint compositions, to the dried (or cured) residue of such paints, and to devices upon which such paint compositions have been applied (IRIS devices) used to assess reducing conditions in soils, especially wetland soils. The improved IRIS Fe oxide paints contain from about 30 to about 70 mole percent goethite, more preferably, from about 40 to about 60 mole percent goethite, and still more preferably, about 50 mole percent goethite.
Abstract: Systems and methods for measuring a pulse length (?0) of an ultra-short light pulse (P0) based on processing a number of substantially similar light pulses. The system includes an autocorrelation optical system adapted to receive the light pulses P0 and create from each light pulse two beams having an associated optical path length difference ?OPL. Providing a different ?OPL for each light pulse creates an autocorrelation interference pattern representative of an autocorrelation of the light pulse P0. An LED detector detects the autocorrelation interference pattern and generates therefrom an autocorrelation signal. A signal-processing unit forms from the autocorrelation signal a digital count signal representative of a number of counted peaks in the autocorrelation signal above the full-width half maximum. Control electronics unit causes the varying ?OPL and provides a difference signal (S?) representative of the ?OPL to the signal-processing unit.
Type:
Grant
Filed:
April 24, 2007
Date of Patent:
June 23, 2009
Assignee:
University of Central Florida Research Foundation, Inc.
Inventors:
Robert Bernath, Martin Richardson, Joshua Duncan, Michael Hemmer, Timothy McComb, Etienne Puyoo
Abstract: The present invention provides a new process for producing biodiesel from renewable oil under lipase catalysis in an organic medium reaction system. In this process, a short chain alcohol ROH is used as an acyl acceptor, a relatively hydrophilic organic solvent having no negative effect on the reactivity of lipase is used as the reaction medium, and a renewable oil raw material is catalyzed by a lipase to synthesize biodiesel through a transesterification reaction. In the process of the present invention, the renewable oil raw material can be almost completely converted into biodiesel and a byproduct glycerin, and the yield of the biodiesel is 94% or more. This new type organic medium reaction system promotes the solubility of the short chain alcohol in the renewable oil raw material, and dissolves part of the byproduct glycerin.
Abstract: An optical coupler includes a first optical port, a second optical port, a third optical port, and a fourth optical port. The optical coupler further includes a photonic-bandgap fiber having a cladding, a first core, and a second core. The cladding includes a material with a first refractive index and regions within the cladding. The regions have a second refractive index lower than the first refractive index. The first core is substantially surrounded by the cladding. The first core is optically coupled to the first optical port and to the second optical port. The second core is substantially surrounded by the cladding. The second core is optically coupled to the third optical port and to the fourth optical port. At least a portion of the first core is generally parallel to and spaced from at least a portion of the second core such that the first core is optically coupled to the second core. The first core, the second core, or both the first core and the second core is hollow.
Type:
Grant
Filed:
March 1, 2007
Date of Patent:
June 23, 2009
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Vinayak Dangui, Michel J. F. Digonnet, Gordon S. Kino
Abstract: A method and device are disclosed for an associative and approximate, analog or digital scanning of databases that allows for the asynchronous accessing of data from a mass storage medium. The invention includes providing dedicated analog and digital circuitry and decision logic at the mass storage medium level for determining a key identifying the data of interest, continuously comparing the key to a signal generated from a reading of the data from the mass storage medium with an approximate or exact matching circuit to determine a pattern match, determining a correlation value between the key and the data as it is read in a continuous fashion, and determining a match based upon a preselected threshold value for the correlation value. The pattern matching technique eliminates any need to compare data based on its intrinsic structure or value, and instead is based on an analog or digital pattern. The key and data may be either analog or digital.
Type:
Grant
Filed:
January 8, 2007
Date of Patent:
June 23, 2009
Assignee:
Washington University
Inventors:
Ronald S. Indeck, Ron Kaplan Cytron, Mark Allen Franklin
Abstract: Thrombin-conjugated nanoparticles, wherein said nanoparticles comprise one or more organic and/or inorganic compounds and process for preparing the same are provided. The thrombin-conjugated nanoparticles are suitable for use in the preparation of fibrin-based biological sealant.
Abstract: The invention relates to a novel bacteriophage which is lytic for species of the genus Methylobacterium, Human Blood Bacterium (HBB) or both, and derivatives, progeny and recombinant and mutated forms thereof. The invention further relates to compositions, methods and kits for using the bacteriophage of the invention in agricultural and therapeutic settings.
Abstract: The present invention provides processes for the production of docetaxel. Docetaxel is produced by protecting the C(7) and the C(10) hydroxy groups of 10-DAB with a bridging silicon-based protecting group. The resulting 7,10-protected 10-DAB derivative is then derivatized and deprotected to form docetaxel.
Type:
Grant
Filed:
June 8, 2006
Date of Patent:
June 23, 2009
Assignee:
Florida State University Research Foundation, Inc.
Abstract: A composition for treating cancer cells and a preparation method therefor are provided. The novel flavonoid compounds are obtained from natural plants, and more particularly the compounds have a cytotoxicity on cancer cells.
Abstract: Novel growth peptides derived from protein factors having molecular weights of about 22 and 45 kDa stimulate mitogenic activity of epithelial, but not fibroblastic cells, in particular, kidney epithelial cells. A source of the factors is scrape-wounded kidney epithelial cells in culture. Synthetic peptides having sixteen amino acids or less, in particular a hexapeptide, YPQGNH (SEQ ID NO: 2) maintain the mitogenic activity. The peptide AQPYPQGNHEASYG (14-Ser) (SEQ ID NO: 15) is effective in reversing acute renal failure in animals. The growth-promoting characteristics of the 22 and 45 kDa proteins and the peptides are useful in treating and diagnosing patients with kidney disease. Nucleotide sequences that encode the factor are useful to develop probes to locate similar factors, to identify genetic disorders involving the factor, and to produce the factor by genetic recombinant methods. The nucleotide sequences and fragments thereof, are also useful for diagnosis and treatment of kidney disorders.
Type:
Grant
Filed:
November 6, 2006
Date of Patent:
June 23, 2009
Assignee:
The University of Chicago
Inventors:
F. Gary Toback, Margaret M. Walsh-Reitz
Abstract: Stress-related nucleic acid molecules and polypeptides and fragments and variants thereof are disclosed in the current invention. In addition, stress-related fusion proteins, antigenic peptides, and anti-stress-related antibodies are encompassed. The invention also provides recombinant expression vectors containing a nucleic acid molecule of the invention and cells into which the expression vectors have been introduced. Methods for producing the polypeptides and methods of use for the polypeptides of the invention are further disclosed.
Type:
Grant
Filed:
August 8, 2005
Date of Patent:
June 23, 2009
Assignee:
North Carolina State University
Inventors:
Todd R. Klaenhammer, William M. Russell, Eric Altermann, Andrea Azcarate-Peril
Abstract: Compounds of formula (XXIII), or pharmaceutically acceptable salts or esters thereof, are inhibitors of reverse transcriptase: R4 is a nucleoside with Q substituting a 3? hydroxyl group, and Q is a moiety of formulas (XXIV)-(XXXII):
Type:
Grant
Filed:
May 19, 2004
Date of Patent:
June 23, 2009
Assignee:
The Board of Trustees of the University of Illinois
Abstract: A radioisotope identification and localization device having at least one radiation detector with three dimensional event localization that utilizes a spatial correlation of projection vectors arising from Compton scattering of gamma ray emissions. Source identification and location is supplied by a reconstruction that searches for solutions with radioactive material of unknown type. Detection, identification and localization does not require full energy deposition. Identification and location of known or unknown radioactive material somewhere in a large active area of interrogation is achieved.
Abstract: A control system stabilizes a turret having a gimbal and base and pointing a weapon mounted within the turret. The control system includes computer executable modules to receive turret data and operator commands and to modify operator commands in accordance with a generated line of sight vector and ballistic data. The modules include a time optimal controller to generate modified operator commands. The modules further include a gimbal stabilization controller to generate motor commands to stabilize the turret and point the weapon.
Type:
Grant
Filed:
January 20, 2005
Date of Patent:
June 23, 2009
Assignee:
Utah State University Research Foundation
Abstract: Isolated omentin polypeptides that selectively express in omental fat tissue and methods for the use of the polypeptides. The polypeptides can be used in a method for modifying insulin action and/or glucose metabolism in an animal. The polypeptides can be used to promote glucose uptake by animal adipocytes and other cells, tissues, and/or organs. The polypeptides can also used to provide a therapeutic treatment for diseases of or related to glucose metabolism and adipose tissues. The polypeptides are also incorporated into diagnostic tests and testing kits for diagnosing or detecting a disease or condition involving animal tissue that contains, uses, or expresses the polypeptide in an animal suspected of having the disease or condition.
Type:
Grant
Filed:
October 12, 2007
Date of Patent:
June 23, 2009
Assignee:
University of Maryland, Baltimore
Inventors:
Da-Wei Gong, John McLenithan, Alan Shuldiner, Rongze Yang
Abstract: A multi-phase voltage-control oscillator including a first voltage-control oscillator circuit and a second voltage-control oscillator circuit is provided. The first voltage-control oscillator circuit includes a first LC tank and a first inductor assembly unit. The second voltage-control oscillator circuit includes a second LC tank and a second inductor assembly unit. A mutual inductance effect is generated between the inductors of the first voltage-control oscillator and the inductors of the second voltage-control oscillator.
Type:
Grant
Filed:
December 28, 2006
Date of Patent:
June 23, 2009
Assignee:
National Taiwan University of Science and Technology
Inventors:
Sheng-Lyang Jang, Yun-Hsueh Chuang, Ren-Hong Yen, Shao-Hua Lee
Abstract: A novel gene (EPM2A) that is deleted or mutated in people with Lafora's disease is described. The EPM2A gene encodes a protein having an active catalytic site of a protein tyrosine phosphatase. Many different sequence mutations as well as several microdeletions in EPM2A have been found that co-segregate with Lafora's disease.
Type:
Grant
Filed:
July 8, 2004
Date of Patent:
June 23, 2009
Assignees:
McGrill University, The Hospital for Sick Children, The Regents of the University of California
Inventors:
Stephen W. Scherer, Berge A. Minassian, Antonio Delgado-Escueta, Guy Rouleu
Abstract: A computer program product being embodied on a computer readable medium for extracting semantic information about a plurality of documents being accessible via a computer network, the computer program product including computer-executable instructions for: generating a plurality of tokens from at least one of the documents, each token being indicative of a displayed item and a corresponding position; and, constructing at least one parse tree indicative of a semantic structure of the at least one document from the tokens dependently upon a grammar being indicative of presentation conventions.
Type:
Grant
Filed:
August 6, 2004
Date of Patent:
June 23, 2009
Assignee:
The Board of Trustees of the University of Illinois
Inventors:
Kevin Chen-Chuan Chang, Zhen Zhang, Bin He