Abstract: A method for using dual indices to support query expansion, relevance/non-relevance models, blind/relevance feedback and an intelligent search interface, the method comprising: accessing an inverted index to obtain an initial retrieval of results in response to a query, and to generate a rank list of the results, the results referring to information units (IUs) where the query occurs; and determining a number of “N” IUs in the results that are assumed to be relevant by accessing a forward index; wherein the forward index and inverted index have pointers to locations in the IUs where terms of the query occur, and the forward index retrieves a term frequency vector of the IU or a set of contexts of the IU.

Abstract: Image projection utilizing light-emitting diodes on a silicon (LEDoS) substrate is described herein. LEDoS devices selectively activate LED pixels to produce light. Light can excite color conversion materials of the LEDoS devices to form color images. Images can be projected onto a projection surface.

Abstract: Devices, methods, and systems for an articulated ankle-foot orthosis with a selectively retractable stop are presented. The orthosis includes at least one of a foot mold, a shank mold, a forefoot sensor, a heel sensor, a stop, and a connecting mechanism. The stop is positioned between the foot mold and the shank mold, and the stop is selectively retractable between a closed position and a generally opposing open position that allows plantar flexion of the foot mold during the stance phase of a typical human gait cycle. The connecting mechanism is configured to move the stop from the closed position to the open position in response to a signal from the heel sensor indicating a heel-strike event. The connecting mechanism is also configured to move the stop from the open position back to the closed position in response to a signal from the forefoot sensor indicating a toe-off event.

Abstract: A method for generating a lattice cell shape for a stent comprising generating a unit cell model representing a stent cell to be made of a given material, the unit cell model comprising elements each comprising points defining a G2-continuous curve, setting a weighting factor to a same value for each one of the points, the weighting factor representing a contribution of a corresponding one of the points to a curvature of an optimal curve, determining a curvature of the G2-continuous curve as a function of the weighting factors having the same value, and structurally optimizing the unit cell model by iteratively determining a variable value for the weighting factor value using stress-strain characteristics for the given material, determining a new curvature of the G2-continuous curve as a function of the variable value, and minimizing the new curvature, thereby obtaining an optimized curve corresponding to an optimized lattice cell shape.

Abstract: Compounds, methods, uses, compositions, kits and packages for the prevention and/or treatment of neural injury or a neurodegenerative disease, based on the use of a retinoic acid derivative, such as fenretinide, and/or analogs, derivatives, prodrugs, precursors thereof, and/or salts thereof, are described.

Abstract: This disclosure relates to cyclodextrin-based drug delivery agents that comprise a cyclodextrin moiety covalently linked to a moiety of a gemini surfactant. Pharmaceutical compositions comprising the drug delivery agent and a therapeutic agent are also disclosed.

Abstract: Methods to synthesize self-assembling peptides embedded with complex organic electronic subunits are provided.

Abstract: Data measured by PS-OCT is corrected in a non-linear manner to enhance the quantitative analysis capability of PS-OCT and permit accurate quantitative diagnosis, including diagnosis of disease stage of lesions, as a useful means for computer diagnosis. Even when retardation per PS-OCT 1 contains error and becomes noise and its distribution is not normal or symmetrical around the true value, measured data is converted using a distribution conversion function obtained by analyzing the characteristics of noise via Monte Carlo simulation to remove the systematic error and estimate the true value otherwise buried in noise and thereby correct the PS-OCT 1 image more clearly.

Abstract: In an embodiment, a computer-implemented intellectual property exchange module manages a price rules database along with many items of digital content (e.g. documents). The intellectual property exchange module maintains information (e.g., a unique identifiers) about where the digital documents reside anywhere on the World Wide Web and delivers the documents to a consumer by means of a hyperlink. In an embodiment of the present invention, a document identifier database maintains information about where a document may reside. An embodiment of the present invention implements license filtering so as to dynamically filter for pre-existing applicable licenses. For example, license filtering is used to translate the many details of a legal license into concepts that can be implemented in a digital computer.

Abstract: Methods for use of a composition comprising agents that increase pancreatic interleukin-22 production in the treatment of pancreatic inflammatory disorders including pancreatitis-associated acute lung injury.

Abstract: An electrode material for a secondary battery includes crystal primary particles of an electrode active material which releases or absorbs cations of a monovalent or divalent metal when subjected to electrochemical oxidation or reduction and which has a crystal lattice in which the cations can move only in a one-dimensional movable direction during the process of oxidation or reduction. The electrode material also includes an ion-conductive substance and conductive carbon which coexist on the surface of the primary particles, in which the ion-conductive substance has a property which allows two or three-dimensional movement of the cations, and the cations are movable via a layer in which the ion-conductive substance and the conductive carbon coexist.

Abstract: A proactive networking system and method is disclosed. The network anticipates the user demands in advance and utilizes this predictive ability to reduce the peak to average ratio of the wireless traffic and yield significant savings in the required resources to guarantee certain Quality of Service (QoS) metrics. The system and method focuses on the existing cellular architecture and involves the design and analysis of learning algorithms, predictive resource allocation strategies, and incentive techniques to maximize the efficiency of proactive cellular networks. The system and method further involve proactive peer-to-peer (P2P) overlaying, which leverages the spatial and social structure of the network. Machine learning techniques are applied to find the optimal tradeoff between predictions that result in content being retrieved that the user ultimately never requests, and requests that are not anticipated in a timely manner.

Abstract: Imaging devices include an IR up-conversion device on a CMOS imaging sensor (CIS) where the up-conversion device comprises a transparent multilayer stack. The multilayer stack includes an IR sensitizing layer and a light emitting layer situated between a transparent anode and a transparent cathode. In embodiments of the invention, the multilayer stack is formed on a transparent support that is coupled to the CIS by a mechanical fastener or an adhesive or by lamination. In another embodiment of the invention, the CIS functions as a supporting substrate for formation of the multilayer stack.

Abstract: This invention relates to a self leveling walker to assist persons who have insufficient strength or movement in their legs when standing and walking on uneven surfaces, and for traversing ramps and stairs. The inventive self leveling walker includes a frame assembly with a leveling assembly for adapting the relative length of the four legs of the walker to accommodate a substantially constant level of the walker so that the user may maintain an erect standing posture at all times, without the need to lean forward or back to accommodate uneven surfaces. The invention employs a fluid or gas based circuit between the front and back walker legs on each respective side, so as to shorten or lengthen each front and back leg with respect to each other, thereby maintaining the overall level of the walker on the subject surface being traversed.

Abstract: A power generation system includes a plurality of energy conversion devices for generating a plurality of power signals based on one or more sensed environmental conditions. The system further includes a plurality of power conditioning circuits each coupled to one or more of the energy conversion devices for receiving the power signals and storing energy in an energy storage system. The system also includes a selection circuit coupled to at least one of the power conditioning circuits and receiving a first input power signal from one of the power conditioning circuits and a second input power signal. The selection circuit is configured to deliver an output power signal representing a selection from between the first and second input power signals based on a relative voltage level of the first and second input power signals. A method of power generation, and associated power module, are also disclosed.

Abstract: The invention relates to monoclonal antibodies directed to a particular part of tropomyosin-related kinase B receptor (TrkB) and hybridoma cell lines producing these. Fragments of these antibodies, in particular fragments representing complementarity determining regions (CDRs), and proteins comprising these, are useful in a method of treating cancer, pain, anorexia, anorexia nervosa and/or cachexia.

Abstract: An object of the present invention is to provide a method of efficiently constructing a library abundant in diversity and also usable for screening of a compound that binds to a target substance having protease activity. The present invention provides a method of constructing an azoline compound library containing two or more azoline compounds having an azoline backbone introduced into at least one of Cys, Ser, Thr, and 2,3-diamino acid, and analogs thereof of Xaa0 of a peptide represented by the following formula (I): A-(Xaa0)n-B??(I) [wherein, m numbers of Xaa0s respectively represent arbitrary amino acids, at least one of which is an amino acid selected from the group consisting of Cys, Ser, Thr, and 2,3-diamino acid, and analogs thereof, m represents an inter selected from 2 to 40, and A and B each independently represent a peptide composed of from 0 to 100 amino acids].

Abstract: The present invention provides herein the design of monodisperse, amphiphilic anticancer drugs—which are now termed “drug amphiphiles” (DAs)—that can spontaneously associate into discrete, stable supramolecular nanostructures with the potential for self-delivery (no additional carriers are needed). The quantitative drug loading in the resulting nanostructures is ensured by the very nature of the molecular design. The DA is a composition comprising: D-L-PEP; wherein D is 1 to 4 hydrophobic drug molecules which can be the same or different; L is 1 to 4 biodegradable linkers which can be the same or different; and PEP is a peptide that can spontaneously associate into discrete, stable supramolecular nanostructures. In an alternate embodiment, the DA composition also comprises a targeting ligand (T). Methods of making DA molecules, as well as their use in treatment of disease are also provided.

Abstract: Sterilizable separator tubes and methods of utilization of same are presented. Methods include providing a separator tube containing a separator substance that can be polymerized to a desired hardness following sterilization using radical generating radiation. The separator substance is formulated to have a density between that of the average densities of separable fractions derived from a sample fluid such as blood, and to be flowable. Upon centrifugation of a separator tube containing a fluid sample, the separator substance forms a barrier between the fractions. The barrier subsequently hardens to form a solid barrier when triggered by a suitable energy source.

Abstract: A pump light pulse is generating a strain pulse in a sample that includes quantum wells. A signal is measured using a probe light pulse. The probe light pulse is delayed in relation to the pump light pulse. The signal derives from a change in an optical property of the sample, which optical property responds to the generated strain pulse. One may deduce parameters of interest of the sample, including the quantum wells, from the characteristics of the signal. For discerning between various components of the stress in the quantum wells a lead pump pulse, preceding the pump light, pulse my also be used. A system for the application of such methods is also disclosed.