Abstract: A method is provided for determining the presence or amount of an analyte in a sample and includes the steps of contacting a faradaic working electrode to a solution comprising the optionally pre-processed sample and an electrolyte, contacting a capacitive counter electrode to the solution, supplying electrical energy between the faradaic working electrode and the capacitive counter electrode sufficient to provide for faradaic charge transfer at the faradaic working electrode, and measuring at least one of (i) light, (ii) current, (iii) voltage, and (iv) charge to determine the presence or amount of the analyte in the sample.

Abstract: A system for executing a cyber investigation by a non-expert user, including a computer having a processor, a memory, and a display; a computer-readable medium having stored thereon instructions for execution of a wizard application, the processor adapted to execute the instructions when the computer-readable medium is inserted into the computer, the processor programmed to: receive case information; receive a type of activity being investigated in response to user inputs to select the activity type from a list of possible activity types; guide the user through capturing data related to the selected activity type through steps presented to the user through one or more screens shown in the display, the steps presented such that a non-expert user can follow them; receive user inputs through a screens to obtain information needed to continue capturing the data related to the selected activity; and store the captured data in a removable data storage device or medium for analysis and use in the cyber investigation

Abstract: A charged particle orbit control device (100) is used in a ring-shaped charged particle accelerator or a charged particle storage ring. The charged particle orbit control device (100) is configured to enable the orbit of a charged particle to return to the original orbit in multiple cycles. The charged particle orbit control device (100) includes multiple bending magnets (1) that bend the charged particle (3). In the charged particle orbit control device (100), the bending angle and relative position of each bending magnet (1) are prescribed such that every time the charged particle (3) passes through, the orbit of the charged particle (3) in each bending magnet (1) alternately switches between two orbits.

Abstract: The present invention provides methods of identifying the presence of or quantifying the amount of one or more of T helper (Th) cells and iTreg cells present in a sample by identifying the presence of an ADAM or the amount of an ADAM, such as ADAM12, present in a sample. The present invention also provides methods for increasing or decreasing signaling of a TGF such as TGF? by increasing or decreasing the biological activity or expression of an ADAM. Further, the present invention provides methods for inhibiting or stimulating, downregulating or upregulating, an immune response, and for treating diseases associated with an immune response such as cancer, viral, bacterial and fungal infections, autoimmune diseases and graft versus host diseases. Still further, the invention provides screening methods effective for identifying therapeutic agents, pharmaceutical compositions containing therapeutic agents, and vaccines.

Abstract: A lithographically structured device has an actuation layer and a control layer operatively connected to the actuation layer. The actuation layer includes a stress layer and a neutral layer that is constructed of materials and with a structure such that it stores torsional energy upon being constructed. The control layer is constructed to maintain the actuation layer substantially in a first configuration in a local environmental condition and is responsive to a change in the local environmental condition such that it permits a release of stored torsional energy to cause a change in a structural configuration of the lithographically structured device to a second configuration, the control layer thereby providing a trigger mechanism. The lithographically structured device has a maximum dimension that is less than about 10 mm when it is in the second configuration.

Abstract: An automated calibration device that comprises a tube for trapping a multiphase sample between three ultrasound (US) transducer pairs, wherein each of the three transducer pairs is positioned to measure a different fraction of the multiphase sample.

Abstract: A method of co-expressing a portion of the VSV G protein gene or a truncated “stem” portion with GP64 and a retrovirus increases the titer of retroviral vectors. A truncated VSV G protein, preferably comprised of a small segment from the C-terminal portion of the ectodomain plus the transmembrane (TM) and cytoplasmic tail (CTD) domains of VSV G, co-expressed with retroviral vectors, enhances the production titers of the retroviral vectors. A preferred embodiment uses a VSV G construct that includes an N-terminal c-Myc epitope plus 42 amino acids from the C-terminal portion of the ectodomain, 20 amino acids from the predicted TM domain, and 29 amino acids from the predicted CTD of the VSV G protein.

Abstract: Methods, compositions and articles of manufacture for contributing to the treatment of a solid cancerous tumor are disclosed. The methods, compositions and articles of manufacture can utilize an endothelin B agonist (ETB) to enhance the delivery of a chemotherapeutic agent to a solid tumor in mammals, including humans.

Abstract: The present invention provides thermal detectors having an optical cavity that is optimized to couple light into a sensor. Light that is on resonance is coupled with the sensor with as high as 100% efficiency, while light off resonance is substantially reflected away. Light that strikes the sensor from the sides (i.e. not on the optical cavity axis) only interacts minimally with sensor because of the reduced absorption characteristics of the sensor. Narrowband sensors in accordance with the present invention can gain as much as 100% of the signal from one direction and spectral band, while receiving only a fraction of the normal radiation noise, which originates from all spectral bands and directions.

Abstract: Provided herein is a pharmaceutical formulation of etravirine, said formulation comprising: etravirine; a dipolar aprotic solvent; a non-ionic water dispersible surfactant; and water. Further provided is a pharmaceutical formulation of etravirine, said formulation comprising: etravirine; a non-ionic water dispersible surfactant; and water.

Abstract: Phosphorus-containing benzoxazine-based bisphenols and derivatives thereof are disclosed. The phosphorus-containing benzoxazine-based bisphenols are prepared by reacting DOPO with benzoxazine to form the phosphorus-containing benzoxazine-based bisphenols. The phosphorus-containing benzoxazine-based bisphenols can further to form advanced epoxy resins. The advanced epoxy resins can further be cured to form flame retardant epoxy thermosets.

Abstract: A wearable robot for assisting muscular strength of the lower extremity of a user: The wearable robot can be worn on user's legs and includes a central securing part, a hip joint part hingably coupled to either side of a lower end of the central securing part, a femur part fastened to the hip joint part and having rigidity, a knee part including an outer frame and a knee assistant, and a drive unit fastened to one of the hip joint part and the knee joint part to allow operation of the joint part. The outer frame includes an upper side outer frame fastened to a lower end of the femur part and a lower side outer frame fastened to the upper side outer frame by a rotatable knee joint part Both the upper side outer frame and the lower side outer frame are fastened to the knee assistant worn by the user.

Abstract: The present approach is based on the use of an integrated capacitance bridge circuit to measure the capacitance of a device under test. A significant feature of this approach is that the operating point is not the null point of the bridge circuit. Instead, the operating point of the bridge circuit is tuned to be away from the null point. By moving away from the null point, the output signal from the bridge circuit is increased. Preferably, this output signal is substantially larger than the input noise floor of an amplifier connected to the bridge circuit output, while being substantially less than G?DUT, where G is the gain provided by the bridge circuit transistor and ?DUT is the AC signal applied to the device under test. Experiments on graphene devices and on carbon nanotube FETs demonstrate about 10 aF resolution (graphene) and about 13 aF resolution (carbon nanotube FET) at room temperature.

Abstract: A system that incorporates teachings of the present disclosure may include, for example, a solid-state selector having a vessel for carrying a liquid medium with one or more molecules surrounded by ions, a solid state conductive structure doped with impurities having one or more through-holes extending between two surfaces of the solid state conductive structure positioned within the liquid medium of the vessel, a voltage source coupled to the solid state conductive structure to selectively stimulate the ions surrounding the one or more molecules to pass through the one or more through-holes. Additional embodiments are disclosed.

Abstract: The elliptic curve-based message authentication code is a computational method for improving the security of existing message authentication code (MAC) generating methods through the use of elliptic curve cryptography. Particularly, the message authentication codes and elliptic curve cryptography are based on an elliptic curve discrete logarithm problem, which is well known in mathematics to be a computationally hard problem.

Abstract: The invention relates to an inductor element, an integrated circuit device and a three-dimensional circuit device where a wire passes through the opening of a coil so that the efficiency in the use of wires is high. Coil elements are provided in the main direction of wires in at least two adjacent layer levels having different main directions of wires, and the coil elements are connected to coil elements formed in different layer levels so that a single coil is formed.

Abstract: Drug affinity responsive target stability (DARTS) is a method of drug target ID with several significant advantages over current techniques. In certain embodiments the method involves contacting a sample comprising one or more protein target(s) with a test agent to form a sample/test agent mixture; contacting the mixture with a protease; and identifying a protein or protein fragment that is protected from proteolysis, wherein the protection from proteolysis is an indicator that the protein or protein fragment binds to or interacts with the test agent.

Abstract: A sustaining manipulator arm capable of being set on a ground includes a first linkage set. The first linkage set includes a first link, a second link, a first ball joint, a second ball joint, a third link, and a first elastic element. A first end of the first link is connected to a first revolution element, and the first revolution element has a first revolution direction. A first end of the second link is connected to a second revolution element. The second revolution element has a second revolution direction. The first revolution direction and the second revolution direction are the same direction, and the first revolution element and the second revolution element are on a first plane. The first ball joint is set in the first link. The second ball joint is set in the second link. A first end of the third link is connected to the first ball joint. A second end of the third link is connected to the second ball joint, and the third link is parallel to the first plane.

Abstract: The method for mitigating interference in Orthogonal Frequency Division Multiplexing (OFDM) communications systems uses comb-type pilot signals in a doubly selective channel where the pilot signals are calculated to have zero correlation sequences in order to maintain orthogonality where there is a high Doppler effect to mitigate intercarrier interference. The pilot signals may be precomputed, stored in a look-up table, and selected based upon total power constraints of the pilot signals. The steps of the method may be performed by a Finite Impulse Response (FIR) equalizer.

Abstract: Provided is an isolated polypeptide having triterpene methyltransferase activity. Also provided is an isolated nucleic acid molecule that encodes the triterpene methyltransferase polypeptides; a vector comprising the nucleic acid molecules that encode the triterpene methyltransferase polypeptides; and a host cell(s) transfected with the aforementioned nucleic acid molecule or vector. In another aspect, a method of producing a methylated triterpene is provided. The method comprises providing a metabolizable carbon source to a host cell transfected with a nucleic acid molecule that encodes a triterpene methyltransferase under conditions sufficient for production of a methylated triterpene. The method optionally further comprises isolating the methylated triterpene produced by the host cell.