Abstract: Disclosed herein are compounds of formula (III) useful as antagonists of the muscarinic acetylcholine receptor MC4 (mAChR M4).

Abstract: Described are 6-aryl quinazolin-4(3H)-ones as negative allosteric modulators of metabotropic glutamate receptor 2 (mGlu2), pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for treating depression, anxiety, obsessive-compulsive disorder, cognitive disorders, Alzheimer's disease, or autism spectrum disorders in a subject.

Abstract: In one embodiment, the orthotic device can include a powered hand portion, a switching element, and a controller. The wearer can interact with the switching element to generate input signals for adjusting an operation of the powered hand portion. The controller can receive the input signals and generate control signals to accordingly adjust the operation of the powered hand portion. In some embodiments, a powered hand portion can be comprised of a plurality of linkages and at least one powered actuator to assist with an opening and closing of the hand portion. The plurality of linkages can be operated by at least one electric motor with quick-connect elements to link onto fingers of a user. In some embodiments, an electrically-actuated clutch mechanism can be affixed to an upper arm section and a lower arm section of an orthotic device. The clutch mechanism can be configured into different positions.

Abstract: The present disclosure is directed to antibodies binding to and neutralizing Rift Valley Fever Virus and methods for use thereof.

Abstract: The present disclosure is directed to human IgE antibodies and fragments thereof binding to galactose-?-1, 3-galactose, a known red meat allergen, and methods for use thereof.

Abstract: Disclosed herein are engineered cell-based peptide delivery platforms based on T cells lacking Perforin function. Perforin-null T cells lack cytotoxic effector function and thus are not capable of killing target cells by conventional Perforin dependent pathways. However, they efficiently home to target tissues where they can invade, persist, and proliferate. The homing ability of perforin lacking T cells can therefore be used to deliver anti-cancer or pre-immune peptides to tumors, or therapeutic peptides to other target tissues based on antigen recognition. Because the cells lack cytotoxic effector function due to loss, knockdown, or inhibition of Perforin, they can be targeted to tissues based on antigen recognition without destroying the target tissue directly.

Abstract: The present disclosure is directed to antibodies binding to and neutralizing Crimean Congo Hemorrhagic Fever Virus and methods for use thereof.

Abstract: Isoquinolmone compounds and derivatives inhibit WDR5 and associated protein-protein interactions, and the compounds and their pharmaceutical compositions are useful for treating disorders and conditions in a subject, such as cancer cell proliferation.

Abstract: A composition, transgenic organism, and method of protecting against desiccation or heat are provided. The composition includes a DtpA protein and a heterologous biologic. The transgenic organism includes the nucleic acid sequence encoding the amino acid sequence of SEQ ID NO: 1. The method includes contacting a heterologous biologic or organism with a DtpA protein.

Abstract: A vehicle control device includes a computer memory, an environmental sensor and a processor. The computer memory is configured to store vehicle trajectories in association with road segments of a map. The environmental sensor is configured to detect traveling environment of a host vehicle. The processor is configured to determine one of the vehicle trajectories along which the host vehicle is traveling, determine whether switching from the one of the vehicle trajectories to the other one of the vehicle trajectories is needed, and control a turn signal of the host vehicle according to a detection result of the environment sensor in response to determining that the switching from the one of the vehicle trajectories to the other one of the vehicle trajectories is needed.

Abstract: A clutch mechanism includes a spool that is configured to receive a cable, a disk with elasticity, a mechanism configured for locking and unlocking the movement of the disk, and at least one sensor. The at least one sensor being configured to measure the movement of at least one of the disk and the spool in the unlocked mode and to measure the movement of the spool relative to the disk when in a locked mode.

Abstract: A method of screening for amyloid-binding compounds, amyloid-binding compounds, and a method of detecting amyloid-? (Abeta) plaques in a subject are disclosed. The method of screening for amyloid-binding compounds includes combining amyloid, a dye, and at least one test compound to form a sample solution; equilibrating the sample solution; measuring a fluorescence signal of the sample solution; and comparing the measured fluorescence signal of the sample to a control; wherein attenuation of the fluorescence signal, as compared to the control, indicates that one or more of the test compounds bind amyloid. The amyloid-binding compound includes a compound detected by the screening method. The method of detecting amyloid-? (Abeta) plaques in a subject includes administering one or more of the amyloid-binding compounds to the subject, and detecting the compound within the subject.

Abstract: The invention relates to the use of CTLA4 agonist for treating or preventing adverse events in patient treated with an immune checkpoint inhibitor.

Abstract: An electric vehicle charging control device includes a charging station and an electronic dynamic charging schedule generator. The charging station has at least a first charging port and a second charging port. The electronic dynamic charging schedule generator has an electronic controller is configured to determine when a first electric vehicle user accesses the first charging port. The electronic controller is further configured to determine when a second electric vehicle user accesses the second charging port. The second electric user accesses the second charging port after the first user accesses the first charging port. The electronic controller is programmed to generate a first charging schedule for the first electric vehicle. The electronic controller is programmed to generate a second charging schedule for the second electric vehicle. The electronic controller is programmed to update the first charging schedule based on the second charging schedule.

Abstract: A system for identifying objects in images is provided. The system may include an optical front end and a digital back end. The optical front end includes a metalens that duplicates a received image into multiple images, and a metasurface that receives the duplicate images and outputs a feature map based on the received images. The feature map may be equivalent to the computationally expensive convolution operations previously performed by a neural network. The feature map is provided to the digital back end, which uses a neural network to classify the object. Because the feature map included the convolution operations, the digital back end can classify the object more quickly and using fewer computing resources than previous systems.

Abstract: The present disclosure is directed to methods for treating a neuropsychiatric disorder associated with expression of autoantibodies to ionotropic glutamate receptor, NMD A 2A (GiuN2A), expression of anti-double-stranded (ds) DNA antibodies that cross react with one or more subunits of the NMD A receptor, or a mutation in the ionotropic glutamate receptor NMD A type subunit 2A (GRIN2A) gene. The methods involve administering a memantine, or a pharmaceutically acceptable salt thereof, to a subject suffering from a neuropsychiatric disorder associated with expression of GluN2A or a mutation in the GRIN2A gene.

Abstract: A polymeric nanocarrier and method of treating a bone disease are provided. The polymeric nanocarrier includes an amphiphilic copolymer including a hydrophobic block and a hydrophilic block, where the hydrophilic block comprises a random copolymer. The method of treating a bone disease includes administering the polymeric nanocarrier to a subject in need thereof.

Abstract: In an embodiment, a neuroimager alignment and coupling evaluation (NACE) system, includes a neuroimaging device; a fiducial affixed to the neuroimaging device; an imaging device; and an augmented reality (AR) module coupled to the imaging device and configured to provide alignment data for the neuroimaging device by tracking facial or cranial landmarks and the fiducial.

Abstract: The present disclosure is directed to antibodies binding to and neutralizing Venezuelan Equine Encephalitis Vims (VEEV) and methods for use thereof.

Abstract: A system for RF based frequency encoding utilizing a Bloch-Siegert shift, includes a controller, an RF encoding system, and an injection transformer simultaneous transmit and receive filter. The controller generates RF excitation pulses, RF based frequency encoding pulses, and a cancellation signal. The RF encoding system includes one or more RF coils configured to transmit the RF excitation pulses and RF based frequency encoding pulses, and to receive an MR signal from the subject where the MR signal includes a leakage signal induced by the RF based frequency encoding pulses. The injection transformer simultaneous transmit and receive filter is in signal communication with the controller and the RF encoding system. The injection transformer simultaneous transmit receive filter is configured to receive the cancellation signal, the MR signal including the leakage signal, and to cancel the leakage signal from the received MR signal to generate a filtered MR signal.