Patents Assigned to Vanderbilt University
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Publication number: 20230295262Abstract: The disclosure describes engineered cells for the treatment of joint and bone disease. The cells are engineered to sense signals only found in diseased compartments and in turn produce therapeutic molecules that are secreted into the local environment.Type: ApplicationFiled: March 10, 2023Publication date: September 21, 2023Applicants: Vanderbilt University, University of Tennessee Research FoundationInventors: Jonathan M. Brunger, Karen A. Hasty, Bonnie L. Walton, Craig L. Duvall
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Patent number: 11666636Abstract: The present disclosure relates to glucagon-like peptide-1 receptor (GLP-1R) agonists and methods of treating or preventing allergic inflammation and/or methods of treating or preventing respiratory syncytial virus (RSV) infection.Type: GrantFiled: February 14, 2018Date of Patent: June 6, 2023Assignee: Vanderbilt UniversityInventors: Kevin Niswender, Stokes Peebles
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Patent number: 11666221Abstract: A method for identification of biochemical markers associated with cervical remodeling over the course of pregnancy of humans includes obtaining Raman signals from the cervix of each of a group of humans with pregnancy at each phase of pregnancy; finding Raman signatures corresponding to each type of cervical tissue from the obtained Raman signals; and identifying biochemical markers associated with cervical remodeling at each phase of pregnancy corresponding to the Raman signatures.Type: GrantFiled: May 18, 2018Date of Patent: June 6, 2023Assignee: VANDERBILT UNIVERSITYInventors: Christine O'Brien, Katherine Cochran, Anita Mahadevan-Jansen, Kristen Rose Findley, William Stokes, Lowell Hays, Mohsin Tejani, Anne-Marie Crowe
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Patent number: 11666463Abstract: Systems and methods of operating a lower limb device having at least a powered joint are provided. A method includes configuring the device to a first state in a finite state model for a current activity mode including a stair ascent mode or a stair descent mode. The method also includes, based on real-time sensor information, transitioning the device between different states in the finite state model when pre-defined criteria for transitioning among the different states are met. In the method, the finite state model for stair ascent includes lifting and swing phases, where the lifting phase includes a powered knee extension and a powered ankle push-off. The finite state model for stair descent includes yielding and swing states, where the swing states include providing a powered plantarflexion of the powered ankle joint and the yielding states include providing a resistive and passive plantarflexion of the powered ankle joint.Type: GrantFiled: October 12, 2021Date of Patent: June 6, 2023Assignee: Vanderbilt UniversityInventors: Michael Goldfarb, Brian Lawson, Atakan Huseyin Varol
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Patent number: 11667697Abstract: The present disclosure is directed to antibodies binding to and neutralizing Poxvirus and methods for use thereof.Type: GrantFiled: October 18, 2017Date of Patent: June 6, 2023Assignee: VANDERBILT UNIVERSITYInventors: James E. Crowe, Jr., Iuliia Gilchuk
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Patent number: 11660332Abstract: The present invention relates to compositions and methods for inducing an adaptive immune response against Hepatitis C virus (HCV) in a subject. In some embodiments, the present invention provides a composition comprising a nucleoside-modified nucleic acid molecule encoding a HCV antigen, adjuvant, or a combination thereof. For example, in some embodiments, the composition comprises a vaccine comprising a nucleoside-modified nucleic acid molecule encoding a HCV antigen, adjuvant, or a combination thereof.Type: GrantFiled: April 27, 2018Date of Patent: May 30, 2023Assignees: The Trustees of the University of Pennsylvania, The Johns Hopkins University, Vanderbilt UniveisilyInventors: Drew Weissman, George M. Shaw, Justin R. Bailey, Stuart C. Ray, James Crowe, Jr., Andrew Flyak
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Publication number: 20230150943Abstract: The present disclosure is directed to a cleavable agent for enhanced magnetic resonance generally corresponding to the formula Y-L-R, wherein Y represents a catalyst-binding moiety having at least one isotopically labeled heteroatom, L represents a cleavable bond, and R represents a hyperpolarized payload having at least one isotopically labeled carbon. Also disclosed herein is a method of cleaving the cleavable agent for enhanced magnetic resonance.Type: ApplicationFiled: January 4, 2023Publication date: May 18, 2023Applicants: Board of Trustees of Southern Illinois University, Vanderbilt UniversityInventors: Boyd M. Goodson, Eduard Y. Chekmenev, Bryce E. Kidd, Jamil A. Mashni, Miranda Limbach, Yuqing Hou, Fan Shi
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Patent number: 11650031Abstract: Shaped charge devices, systems, and related methods of use. A housing sheet is configurable to form at least part of a shaped charge enclosure enclosing a shaped charge and biasing an explosion in a desired direction. The housing sheet can include one or more incisions in at least one surface thereof. The housing sheet can have at least one connection mechanism integrally formed therein, and the housing sheet can be configurable to form a plurality of sizes of shaped charge housing portions. The housing sheet can also provide for forming a plurality of dimensions of the shaped charge enclosure.Type: GrantFiled: August 7, 2020Date of Patent: May 16, 2023Assignees: Vanderbilt University, The United States of America as Represented by the Secretary of the ArmyInventors: Kevin C. Galloway, Kelsay E. Neely, Aimee J. Valles, Robert J. Clark, Jesse L. Frederick
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Patent number: 11633370Abstract: Methods and compounds for use in promoting survival of at least one eukaryotic cell, wherein the compounds are effective as gamma-ketoaldehyde scavengers.Type: GrantFiled: July 6, 2017Date of Patent: April 25, 2023Assignee: Vanderbilt UniversityInventors: L. Jackson Roberts, II, Thuy T. Nguyen
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Publication number: 20230077983Abstract: Described herein are methods and compositions related to treating and preventing an engraftment arrhythmia with an effective amount of amiodarone and ivabradine. Also described herein is a method of cardiomyocyte transplant, the method comprises: dministering in vitro-differentiated cardiomyocytes to cardiac tissue of a subject in need thereof; and administering to the subject an amount of amiodarone and an amount of ivabradine effective to reduce engraftment arrhythmia in the subject.Type: ApplicationFiled: February 9, 2021Publication date: March 16, 2023Applicants: UNIVERSITY OF WASHINGTON, VANDERBILT UNIVERSITYInventors: Robert Scott THIES, William Robb MACLELLAN, Kenta NAKAMURA, Charles E. MURRY, Bjorn KNOLLMANN
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Publication number: 20230085393Abstract: The present disclosure is directed to antibodies binding to and neutralizing Zika vims and methods for use thereof.Type: ApplicationFiled: November 9, 2020Publication date: March 16, 2023Applicant: Vanderbilt UniversityInventors: James E. Crowe, Jr., Robert H. Carnanhan, Pavlo Gilchuk
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Patent number: 11602743Abstract: A method of fabricating a carbon nanotube (“CNT”) array includes providing a substrate with a CNT catalyst disposed on a surface of the substrate, heating the CNT catalyst to an annealing temperature, exposing the CNT catalyst to a CNT precursor for an exposure period to pre-load the CNT catalyst, and exposing the pre-loaded CNT catalyst to a carbon source for a growth period to form the CNT array. The formed CNT array comprises a plurality of CNT bundles that are aligned with one another in an alignment direction. At least one of the plurality of bundles comprises an average structural factor of 1.5 or less along an entirety of the length thereof.Type: GrantFiled: March 31, 2021Date of Patent: March 14, 2023Assignees: Toyota Motor Engineering & Manufacturing North America, Inc., Vanderbilt UniversityInventors: Yuyang Song, Shailesh N. Joshi, Piran R. Kidambi, Peifu Cheng
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Publication number: 20230073075Abstract: The present disclosure is directed to antibodies binding to and neutralizing henipavirus and methods for use thereof. Thus, in accordance with the present disclosure, there is provided a method of detecting a henipavirus infection in a subject comprising (a) contacting a sample from said subject with an antibody or antibody fragment having clone-paired heavy and light chain CDR sequences from Tables 3 and 4, respectively; and (b) detecting henipavirus in said sample by binding of said antibody or antibody fragment to a henipavirus antigen in said sample.Type: ApplicationFiled: November 12, 2020Publication date: March 9, 2023Applicant: Vanderbilt UniversityInventor: James E. CROWE, Jr.
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Patent number: 11596679Abstract: The present disclosure relates to compositions and methods for inducing an adaptive immune response against Hepatitis C virus (HCV) in a subject. In some embodiments, the present disclosure provides a composition comprising a nucleic acid molecule encoding a HCV antigen, an HCV antigen, an adjuvant, or a combination thereof. For example, in some embodiments, the composition comprises a vaccine comprising a nucleic acid molecule encoding a HCV antigen, an HCV antigen, an adjuvant, or a combination thereof.Type: GrantFiled: April 27, 2018Date of Patent: March 7, 2023Assignees: VANDERBILT UNIVERSITY, THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE JOHNS HOPKINS UNIVERSITYInventors: James E. Crowe, Jr., Andrew Flyak, Justin Bailey, Stuart Ray, George Shaw
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Patent number: 11596639Abstract: The present disclosure provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present disclosure also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of Mcl-1 protein.Type: GrantFiled: March 3, 2017Date of Patent: March 7, 2023Assignee: Vanderbilt UniversityInventors: Taekyu Lee, James C. Tarr, KyuOk Jeon, James M. Salovich, Subrata Shaw, Nagarathanam Veerasamy, Kwangho Kim, Plamen P. Christov, Edward T. Olejniczak, Bin Zhao, Stephen W. Fesik, Zhiguo Bian
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Patent number: 11596770Abstract: Systems and method for controlling the bending of a robotic catheter. A control backbone of the robotic catheter is coupled to a linear movement stage by a spring and linear movement of the control backbone causes a controllable bending of the robotic catheter. A sensor monitors a deflection of the spring and the bending of the catheter is controlled based on the spring deflection signal from the sensor. The spring allows passive bending of the robotic catheter without movement of the active linear movement stage and, conversely, allows external forces applied to the robotic catheter to limit a bending movement of the robotic catheter caused by—movement of the active linear movement stage. In some implementations, the robotic catheter includes a selectively deployable tip mechanism for deploying a steerable tip or for selectively exposing side windows on the catheter for increasing traction for clot removal.Type: GrantFiled: September 16, 2020Date of Patent: March 7, 2023Assignee: Vanderbilt UniversityInventors: Nabil Simaan, Giuseppe Del Giudice, Colette Abah, Rohan V. Chitale
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Publication number: 20230063625Abstract: The present disclosure is directed to antibodies binding to and neutralizing Rift Valley Fever Virus and methods for use thereof.Type: ApplicationFiled: January 8, 2021Publication date: March 2, 2023Applicant: Vanderbilt UniversityInventor: James E. CROWE, JR.
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Patent number: 11591443Abstract: Disclosed herein are crosslinked polycarbonates, composition thereof and methods thereof. The crosslinked polycarbonates can be prepared from allyl or epoxy polycarbonates. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: GrantFiled: March 17, 2021Date of Patent: February 28, 2023Assignee: Vanderbilt UniversityInventors: Eva M. Harth, David M. Stevens
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Patent number: 11589801Abstract: One aspect of the invention relates to a method for intraoperative assessment of parathyroid gland viability in a surgery. The method includes diffusing a beam of light onto a tissue surface of a parathyroid gland of a patient to illuminate the tissue surface; acquiring images of the illuminated tissue surface, where each of the acquired images includes a speckle pattern; and processing the acquired images to obtain speckle contrast images for the intraoperative assessment of parathyroid gland viability.Type: GrantFiled: December 29, 2017Date of Patent: February 28, 2023Assignee: VANDERBILT UNIVERSITYInventors: Emmanuel A. Mannoh, Anita Mahadevan-Jansen
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Patent number: 11592286Abstract: System and methods are provided for characterizing an internal surface of a lens using interferometry measurements. Sphere-fitting a distorted radius determines distorted pathlengths. Ray-tracing simulates refraction at all upstream surfaces to determine a cumulative path length. A residual pathlength is scaled by the group-index and rays are propagated based on the phase-index. After aspheric surface fitting, a corrected radius is determined. To estimate a glass type for the lens, a thickness between focal planes of the lens surfaces is determined using RCM measurements. Then, for both surfaces, the surface is positioned into focus, interferometer path length matching is performed, a reference arm is translated to stationary phase point positions for three wavelengths to determine three per-color optical thicknesses, and ray-tracing is performed. A glass type is identified by minimizing an error function based on optical parameters of the lens and parameters determined from known glass types from a database.Type: GrantFiled: December 3, 2021Date of Patent: February 28, 2023Assignee: Vanderbilt UniversityInventors: Yuankai Tao, Mohamed T. El-Haddad