Patents Assigned to Vanderbilt University
  • Patent number: 11026641
    Abstract: Systems and methods are provided for classifying a tissue mass as malignant or benign. The method includes identifying a region of interest in the tissue mass in computed tomography (CT) imaging data, segmenting the CT imaging data to delimit at least a portion of the tissue mass into image segments, extracting a set of radiomic parameters indicative of the tissue mass. The set of radiomic parameters may include tissue mass location, tissue mass shape, tissue mass surface characteristic, or tissue mass texture distribution indicative of the amount of image segments identified. The method also includes generating a report classifying the indeterminate lung nodule as being malignant or benign based on the set of radiomic parameters of the indeterminate lung nodule.
    Type: Grant
    Filed: October 16, 2018
    Date of Patent: June 8, 2021
    Assignees: Mayo Foundation for Medical Education and Research, Vanderbilt University
    Inventors: Tobias Peikert, Ronald A. Karwoski, Fabien Maldonado, Srinivasan Rajagopalan, Brian J. Bartholmai
  • Patent number: 11027129
    Abstract: A method for designing a patient-customized EA or selecting an existing EA that fits the patient best includes segmenting shapes of SOIs of the cochlea in a pre-operative CT image using a shape model; defining a 3D curve of interest within the shape model of the SOIs as a sequence of points-; automatically transforming the defined 3D curve to the pre-operative CT image so as to obtain a structure curve in the cochlea; determining a length and curvatures of the structure curve at the sequence of points; and designing a patient-customized EA or selecting an existing EA based on the determined length and curvatures of the structure curve such that after the EA shape model, which estimates the resting state shape of the EA, is rigidly registered to the structure curve in the cochlea, the EA shape model has a registration error smaller than a preset value.
    Type: Grant
    Filed: April 24, 2018
    Date of Patent: June 8, 2021
    Assignee: VANDERBILT UNIVERSITY
    Inventors: Jack H. Noble, Robert F. Labadie, Benoit M. Dawant
  • Patent number: 11030487
    Abstract: The exemplified methods and systems facilitate the training of a noise-robust deep learning network that is sufficiently robust in the recognition of objects in images having extremely noisy elements such that the noise-robust network can match, or exceed, the performance of human counterparts. The extremely noisy elements may correspond to extremely noisy viewing conditions, e.g., that often manifests themselves in the real-world as poor weather or environment conditions, sub-optimal lighting conditions, sub-optimal image acquisition or capture, etc. The noise-robust deep learning network is trained both (i) with noisy training images with low signal-to-combined-signal-and-noise ratio (SSNR) and (ii) either with noiseless, or generally noiseless, training images or a second set of noisy training images having a SSNR value greater than that of the low-SSNR noisy training images.
    Type: Grant
    Filed: September 5, 2019
    Date of Patent: June 8, 2021
    Assignee: Vanderbilt University
    Inventors: Frank Tong, Hojin Jang
  • Patent number: 11027027
    Abstract: Embodiments of the invention include a novel synthesis of the translocator protein (TSPO) ligands, and methods of imaging a molecular events. Also disclosed are compounds for treatment of diseases, including cancer.
    Type: Grant
    Filed: February 1, 2016
    Date of Patent: June 8, 2021
    Assignee: Vanderbilt University
    Inventors: H. Charles Manning, Yiu-Yin Cheung, Jason R. Buck, Jun Li
  • Patent number: 11026992
    Abstract: The present invention relates to compositions and methods for preventing and reducing inflammation and preventing and treating diseases and disorders associated with inflammation. It has been shown that CRADD plays a pivotal role in maintaining the integrity of endothelial monolayers. The recombinant cell-penetrating CRADD protein (CP-CRADD)-based compositions and methods described herein provide for the development of a novel treatment for inflammatory vascular disorders including cardiovascular, cerebrovascular, respiratory, gastrointestinal, and renal systems.
    Type: Grant
    Filed: June 21, 2019
    Date of Patent: June 8, 2021
    Assignee: Vanderbilt University
    Inventors: Jack J. Hawiger, Ruth Ann Veach, Yan Liu, Huan Qiao, Lukasz S. Wylezinski
  • Patent number: 11021533
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing Zika virus and methods for use thereof.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: June 1, 2021
    Assignee: VANDERBILT UNIVERSITY
    Inventor: James E. Crowe, Jr.
  • Patent number: 11020939
    Abstract: Nanofiber electrodes for electrochemical devices and fabricating methods of the same are disclosed. In one embodiment, the method includes forming a liquid mixture containing a catalyst, a first polymer of perfluoro sulfonic acid and a second polymer of polyethylene oxide, the first polymer of perfluoro sulfonic acid being pre-treated to remove protons in the first polymer by exchange with a cation species like Na+; and electro spinning the liquid mixture to generate electro spun fibers and deposit the generated fibers on a collector substrate to form a fiber electrode mat comprising a network of fibers, where each fiber has a plurality of particles of the catalyst distributed thereon.
    Type: Grant
    Filed: November 16, 2018
    Date of Patent: June 1, 2021
    Assignee: VANDERBILT UNIVERSITY
    Inventor: Peter N. Pintauro
  • Patent number: 11016152
    Abstract: Provided are methods for nuclear spin polarization enhancement via signal amplification by reversible exchange at very low magnetic fields. The spin polarization is hyperpolarization of isotopically enriched heteronuclei by using a catalyst and parahydrogen to create a complex using iridium and applying magnetic fields in the microtesia range to transfer the spin order from parahydrogen to the complex.
    Type: Grant
    Filed: May 12, 2018
    Date of Patent: May 25, 2021
    Assignees: Vanderbilt University, Duke University, The Board of Trustees of Southern Illinois University
    Inventors: Eduard Y. Chekmenev, Danila A. Barskiy, Roman V. Shchepin, Warren S. Warren, Thomas Theis, Boyd Goodson
  • Patent number: 11008335
    Abstract: Disclosed herein are pyrido[3?,2?:4,5]thieno[2,3-d]pyridazin-8-amine and thieno[2,3-c:4,5-d?]dipyridazin-8-amine compounds, which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.
    Type: Grant
    Filed: November 7, 2017
    Date of Patent: May 18, 2021
    Assignee: Vanderbilt University
    Inventors: Craig W. Lindsley, Darren W. Engers, P. Jeffrey Conn, Sean R. Bollinger, Julie L. Engers
  • Patent number: 11011756
    Abstract: A bipolar membrane comprising a cation exchange mat of one or more cation exchange polymers, an anion exchange mat of one or more anion exchange polymers, and an internal 3D bipolar interface, disposed between the cation and anion exchange layers, including a mixture of at least one cation exchange polymer and at least one anion exchange polymer, such that an interface of the at least one cation exchange polymer and the at least one anion exchange polymer is the internal 3D bipolar interface that has a large area, and the at least one cation exchange polymer in the 3D bipolar interface is connected to the one or more cation exchange polymers of the cation exchange layer, and the at least one anion exchange polymer in the 3D bipolar interface is connected to the one or more anion exchange polymers of the anion exchange layer.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: May 18, 2021
    Assignee: VANDERBILT UNIVERSITY
    Inventors: Peter N. Pintauro, Eduardo Pereira, Ryszard Wycisk
  • Patent number: 10995000
    Abstract: Disclosed herein are methods of making a plurality of carbon nanotubes, the methods comprising applying a current across a catalytically passive anode and a catalytic cathode; wherein the catalytic cathode comprises a catalyst and the catalyst comprises Fe, Co, Mo, Cr, Cu, or a combination thereof; wherein the catalytically passive anode and the catalytic cathode are in electrochemical contact with a molten carbonate electrolyte and a source of CO2; thereby forming a plurality of carbon nanotubes on the catalytic cathode.
    Type: Grant
    Filed: August 1, 2017
    Date of Patent: May 4, 2021
    Assignee: Vanderbilt University
    Inventors: Anna Douglas, Cary Pint
  • Patent number: 10996227
    Abstract: Pre-coated analysis substrates, and methods of making the substrates and using them to analyze animal tissue, are described. The pre-coated analysis substrates can be made by forming a matrix surface on an analysis substrate; adding a protease to the matrix surface to form a pre-coated analysis substrate; and placing an animal tissue specimen on the matrix surface. The animal tissue can then be analyzed by allowing the protease to partially digest the animal tissue specimen; and analyzing the partially digested animal tissue specimen by mass spectrometry.
    Type: Grant
    Filed: June 9, 2016
    Date of Patent: May 4, 2021
    Assignee: VANDERBILT UNIVERSITY
    Inventors: Richard Caprioli, Junhai Yang, Jeremy L. Norris, Faizan Zubair, Paul Edward Laibinis
  • Publication number: 20210115115
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing West Nile virus and methods for use thereof.
    Type: Application
    Filed: March 26, 2019
    Publication date: April 22, 2021
    Applicant: Vanderbilt University
    Inventor: James E. Crowe, Jr.
  • Patent number: 10982058
    Abstract: Disclosed herein are crosslinked polycarbonates, composition thereof and methods thereof. The crosslinked polycarbonates can be prepared from allyl or epoxy polycarbonates. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: May 24, 2019
    Date of Patent: April 20, 2021
    Assignee: VANDERBILT UNIVERSITY
    Inventors: Eva M. Harth, David M. Stevens
  • Patent number: 10981979
    Abstract: The present disclosure is directed to antibodies binding to prefusion and postfusion forms of both human S. aureus and human metapneumovirus F proteins, including neutralizing antibodies, and methods for use thereof.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: April 20, 2021
    Assignee: VANDERBILT UNIVERSITY
    Inventors: James E. Crowe, Jr., Gopal Sapparapu, Isaac Thomsen, Buddy Creech
  • Patent number: 10978396
    Abstract: A composite element and methods of fabrication thereof are provided. The composite element can include a binder material and one or more electrical traces supported by the binder material, where a composition of the binder material is a thermoresponsive material and where each of the one or more electrical traces comprises an interconnected network of nanoparticles.
    Type: Grant
    Filed: November 20, 2017
    Date of Patent: April 13, 2021
    Assignee: VANDERBILT UNIVERSITY
    Inventors: Leon Bellan, Xin Zhang
  • Patent number: 10975033
    Abstract: A method of treating at least one of inflammation, psoriasis, and/or hypertension comprising administering to a patient in need there of an effective gamma-ketoaldehyde scavenging amount of a gamma-ketoaldehyde scavenging compound.
    Type: Grant
    Filed: July 12, 2012
    Date of Patent: April 13, 2021
    Assignee: Vanderbilt University
    Inventors: L. Jackson Roberts, II, Venkataraman Amarnath, David G. Harrison, Annet Kirabo
  • Patent number: 10967504
    Abstract: A robotic system, such as a continuum robot, that includes at least one hollow tube backbone and an equilibrium modulation wire at least partially positioned within the backbone. The robotic system is configured to adjust a position of an end effector by bending the hollow tube and to further adjust the position of the robotic device by adjusting a linear insertion position of the equilibrium modulation wire inside the hollow tube, wherein adjusting the linear insertion position of the equilibrium modulation wire changes a flexural rigidity of the hollow tube resulting in a change in the resulting bending angle of the robotic device.
    Type: Grant
    Filed: September 13, 2018
    Date of Patent: April 6, 2021
    Assignee: Vanderbilt University
    Inventors: Nabil Simaan, Giuseppe Del Giudice, Long Wang, Karen M. Joos, Jin-Hui Shen
  • Patent number: 10969392
    Abstract: A method of detecting cell membrane expression of an MHC molecule in a subject, a method of treating cancer in a subject with an immunotherapeutic agent, and an MHC complex are provided. The method of detecting cell membrane expression of an MHC molecule includes obtaining a tumor cell sample from a subject, and detecting cell membrane expression of the MHC molecule by contacting the tumor cell sample with an antibody targeting the MHC molecule and detecting binding between the MHC molecule and the antibody. The method of treating cancer in a subject with an immunotherapeutic agent includes detecting cell membrane expression of an MHC molecule in the subject and administering a therapeutically effective amount of the immunotherapeutic agent if the level of cell membrane expression of the MHC molecule exceeds a predetermined standard. The complex includes a tumor cell in complex with an antibody or an antigen-binding portion thereof.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: April 6, 2021
    Assignee: Vanderbilt University
    Inventors: Justin M. Balko, Douglas B. Johnson, Violeta Sanchez de Delgado, Melinda Sanders
  • Patent number: 10968227
    Abstract: Isoquinoline ether compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: April 6, 2021
    Assignee: Vanderbilt University
    Inventors: P. Jeffrey Conn, Craig W. Lindsley, Andrew Felts, Anna L. Blobaum