Abstract: A vehicle control device includes a computer memory, an environmental sensor and a processor. The computer memory is configured to store vehicle trajectories in association with road segments of a map. The environmental sensor is configured to detect traveling environment of a host vehicle. The processor is configured to determine one of the vehicle trajectories along which the host vehicle is traveling, determine whether switching from the one of the vehicle trajectories to the other one of the vehicle trajectories is needed, and control a turn signal of the host vehicle according to a detection result of the environment sensor in response to determining that the switching from the one of the vehicle trajectories to the other one of the vehicle trajectories is needed.

Abstract: A clutch mechanism includes a spool that is configured to receive a cable, a disk with elasticity, a mechanism configured for locking and unlocking the movement of the disk, and at least one sensor. The at least one sensor being configured to measure the movement of at least one of the disk and the spool in the unlocked mode and to measure the movement of the spool relative to the disk when in a locked mode.

Abstract: A method of screening for amyloid-binding compounds, amyloid-binding compounds, and a method of detecting amyloid-? (Abeta) plaques in a subject are disclosed. The method of screening for amyloid-binding compounds includes combining amyloid, a dye, and at least one test compound to form a sample solution; equilibrating the sample solution; measuring a fluorescence signal of the sample solution; and comparing the measured fluorescence signal of the sample to a control; wherein attenuation of the fluorescence signal, as compared to the control, indicates that one or more of the test compounds bind amyloid. The amyloid-binding compound includes a compound detected by the screening method. The method of detecting amyloid-? (Abeta) plaques in a subject includes administering one or more of the amyloid-binding compounds to the subject, and detecting the compound within the subject.

Abstract: The invention relates to the use of CTLA4 agonist for treating or preventing adverse events in patient treated with an immune checkpoint inhibitor.

Abstract: An electric vehicle charging control device includes a charging station and an electronic dynamic charging schedule generator. The charging station has at least a first charging port and a second charging port. The electronic dynamic charging schedule generator has an electronic controller is configured to determine when a first electric vehicle user accesses the first charging port. The electronic controller is further configured to determine when a second electric vehicle user accesses the second charging port. The second electric user accesses the second charging port after the first user accesses the first charging port. The electronic controller is programmed to generate a first charging schedule for the first electric vehicle. The electronic controller is programmed to generate a second charging schedule for the second electric vehicle. The electronic controller is programmed to update the first charging schedule based on the second charging schedule.

Abstract: A system for identifying objects in images is provided. The system may include an optical front end and a digital back end. The optical front end includes a metalens that duplicates a received image into multiple images, and a metasurface that receives the duplicate images and outputs a feature map based on the received images. The feature map may be equivalent to the computationally expensive convolution operations previously performed by a neural network. The feature map is provided to the digital back end, which uses a neural network to classify the object. Because the feature map included the convolution operations, the digital back end can classify the object more quickly and using fewer computing resources than previous systems.

Abstract: The present disclosure is directed to methods for treating a neuropsychiatric disorder associated with expression of autoantibodies to ionotropic glutamate receptor, NMD A 2A (GiuN2A), expression of anti-double-stranded (ds) DNA antibodies that cross react with one or more subunits of the NMD A receptor, or a mutation in the ionotropic glutamate receptor NMD A type subunit 2A (GRIN2A) gene. The methods involve administering a memantine, or a pharmaceutically acceptable salt thereof, to a subject suffering from a neuropsychiatric disorder associated with expression of GluN2A or a mutation in the GRIN2A gene.

Abstract: A polymeric nanocarrier and method of treating a bone disease are provided. The polymeric nanocarrier includes an amphiphilic copolymer including a hydrophobic block and a hydrophilic block, where the hydrophilic block comprises a random copolymer. The method of treating a bone disease includes administering the polymeric nanocarrier to a subject in need thereof.

Abstract: In an embodiment, a neuroimager alignment and coupling evaluation (NACE) system, includes a neuroimaging device; a fiducial affixed to the neuroimaging device; an imaging device; and an augmented reality (AR) module coupled to the imaging device and configured to provide alignment data for the neuroimaging device by tracking facial or cranial landmarks and the fiducial.

Abstract: The present disclosure is directed to antibodies binding to and neutralizing Venezuelan Equine Encephalitis Vims (VEEV) and methods for use thereof.

Abstract: A system for RF based frequency encoding utilizing a Bloch-Siegert shift, includes a controller, an RF encoding system, and an injection transformer simultaneous transmit and receive filter. The controller generates RF excitation pulses, RF based frequency encoding pulses, and a cancellation signal. The RF encoding system includes one or more RF coils configured to transmit the RF excitation pulses and RF based frequency encoding pulses, and to receive an MR signal from the subject where the MR signal includes a leakage signal induced by the RF based frequency encoding pulses. The injection transformer simultaneous transmit and receive filter is in signal communication with the controller and the RF encoding system. The injection transformer simultaneous transmit receive filter is configured to receive the cancellation signal, the MR signal including the leakage signal, and to cancel the leakage signal from the received MR signal to generate a filtered MR signal.

Abstract: Disclosed are compounds of formula (I) wherein G1 is as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4) for use in the treatment of e.g. a neurodegenerative disorder, a movement disorder, or a brain disorder, such as e.g. Parkinson's disease, drug-induced Parkinsonism, dystonia, Tourette's syndrome, dyskinesias, schizophrenia, cognitive deficits associated with schizophrenia, excessive daytime sleepiness, attention deficit hyperactivity disorder (ADHD), Huntington's disease, chorea, cerebral palsy, and progressive supranuclear palsy. An exemplary compound is e.g. (2,5-difluoro-4-(6-(((3aR,5s,6aS)-2-((tetrahydro-2H-pyran-4-yl)methyl)octahydrocyclopenta[c]pyrrol-5-yl)amino)pyridazin-3-yl)phenyl)(imino)(methyl)-?6-sulfanone (e.g. example 12; compound no. 7) Pharmacological data on the activity of the compounds in an mAChR M4 cell-based assay are provided (e.g. table 2). TABLE 2 Human M4 Cpd. No. IC50 (nM) Emin (%)* 1 13.4 4 2 39.6 2 3 18.

Abstract: The present disclosure relates to antibodies and uses thereof for treating an HIV infection, an HCV infection, or an HIV/HCV co-infection.

Abstract: In one aspect, the disclosure relates to a dorsal spanning plate assembly comprising a first plate member that can be fixed to a bone or bone fragment distal to a distal radius fracture and a second plate member that can be fixed to a bone or bone fragment proximal to the distal radius fracture. In an aspect, the dorsal spanning plate assembly includes a joint such as, for example, a hinge joint or a ball-and-socket joint, wherein the joint is not fixed during placement of the dorsal spanning plate assembly. In still another aspect, a subject in whom the dorsal spanning plate assembly is implanted retains some range of motion in the fractured joint, thereby reducing muscle atrophy and retaining joint flexion during recovery. Also disclosed are methods of setting bone fractures using the dorsal spanning plate assembly.

Abstract: Methods and systems for segmentation of structures of interest (SOI) in a CT image post-operatively acquired with an implant user in a region of interest in which an implant is implanted. The method includes inputting the post-operatively acquired CT (Post-CT) image to trained networks to generate a dense deformation field (DDF) from the input Post-CT image to an atlas image; and warping a segmentation mesh of the SOI in the atlas image to the input Post-CT image using the DDF so as to generate the segmentation mesh of the SOI in the input Post-CT image, wherein the segmentation mesh of the SOI in the atlas image is generated by applying an active shape model-based method to the atlas image.

Abstract: A delivery device configured to deliver a medical device into a patient is provided. The delivery device includes a distal ring and a transition tunnel. The transition tunnel is sized to receive a medical device. The transition tunnel is coupled to the distal ring. The delivery device also includes a proximal chute that has an inner perimeter and an outer perimeter. The inner perimeter of the proximal chute is coupled to the transition tunnel. The proximal chute is configured to transition between opened and closed conditions. The outer perimeter of the proximal chute in the opened condition is spread radially outward from the transition tunnel and defines an opening for receiving the medical device. The proximal chute in the closed condition is configured to at least partially prevent the medical device from egressing the delivery device.

Abstract: One aspect of the invention relates to method and system for increasing signal-to-noise ratio (SNR) and suppressing range lobe artifacts in ultrasound imaging or sensing, active sonar, LIDAR, and/or radar. The method includes forming a coded excitation waveform with a chip waveform and a binary sequence; transmitting the coded excitation waveform into a medium of interest, and receiving signals generated from the medium of interest responsive to excitation of the coded excitation waveform; and performing pulse compression on the received signals using a decoding filter to increase the SNR and suppress the range lobe artifacts.

Abstract: An apparatus for intraoperative nerve identification and/or visualization of a target of interest of a living subject comprises a light source; an imaging head configured to acquire a polarized diffuse reflectance spectral image from the illuminated target of interest; and a controller configured to control the imaging head and to process the acquired polarized diffuse reflectance spectral image.

Abstract: Disclosed herein are cyclopropylpiperidine compounds, which may be useful as antagonists of the muscarinic acetylcholine receptor M4 (niAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.

Abstract: The invention relates to the use of CTLA4 agonist for treating or preventing adverse events in patient treated with an immune checkpoint inhibitor.