Abstract: Isoquinolinone compounds and derivatives inhibit WDR5 and associated protein-protein interactions, and the compounds and their pharmaceutical compositions are useful for treating disorders and conditions in a subject, such as cancer cell proliferation.
Type:
Grant
Filed:
October 24, 2019
Date of Patent:
June 4, 2024
Assignee:
Vanderbilt University
Inventors:
Taekyu Lee, Joseph R. Alvarado, Jianhua Tian, Kenneth M. Meyers, Changho Han, Jonathan J. Mills, Kevin B. Teuscher, Shaun R. Stauffer, Stephen W. Fesik, Rocco D. Gogliotti
Abstract: The disclosure provides adenosine deaminases that are capable of deaminating adenosine in DNA to treat Hutchin-son-Gilford progeria syndrome (HOPS). The disclosure also provides fusion proteins, guide RNAs and compositions comprising a Cas9 (e.g., a Cas9 nickase) domain and adenosine deaminases that deaminate adenosine in DNA, for example in a LNA gene. In some embodiments, adenosine deaminases provided herein are used to correct a C1824T mutation in LMNA. In some embodiments, the methods and compositions provided herein are used to treat Hutchinson-Gilford progeria syndrome (HGPS).
Type:
Application
Filed:
September 5, 2019
Publication date:
May 30, 2024
Applicants:
The Broad Institute, Inc., Baylor College of Medicine, Vanderbilt University, President and Fellows of Harvard College
Inventors:
David R. Liu, Luke W. Koblan, Jonathan D. Brown, Charles Yang Lin
Abstract: Wearable assistance devices and methods of operating the same are provided. A wearable assistance device includes an upper-body interface with a front side and a rear side and a lower-body interface with a front side and a rear side. The assistance device also includes one or more elastic members, each of the elastic members mechanically coupling the upper-body interface to the lower-body interface and extending from the rear side of the upper-body interface to the rear side of the lower-body interface and along a back of the user so as to provide an assistive force parallel to the back of the user. Further, the assistance device also includes a clutch mechanism associated with each one of the elastic members, the clutch mechanism configured for selectively adjusting the assistive force provided by the one of the elastic members.
Type:
Grant
Filed:
January 19, 2018
Date of Patent:
May 14, 2024
Assignee:
Vanderbilt University
Inventors:
Karl Zelik, Matthew Yandell, Dustin Howser, Erik Lamers
Abstract: Provided arm biocompatible polymer compositions, and methods of printing such polymer compositions using a fused deposition modelling printer to form a solid scaffold. In particular, the disclosed compositions may include a thermoresponsive polymer, and the printed scaffold may be used as a sacrificial template providing a three-dimensional vascular structure upon temperature-dependent disintegration. The present compositions and methods may be particularly useful for engineering thick tissues.
Abstract: The present disclosure is directed to human monoclonal IgE antibodies, and IgG antibodies engineered therefrom. Such engineered antibodies can be used to blunt pathologic IgE responses in subjects, such as in the treatment or prevention of allergies.
Abstract: A system for transcranial magnetic resonance (MR)-guided focused ultrasound and method of using transcranial MR-guided focused ultrasound are disclosed. The system includes a transcranial ultrasound transducer configured to apply ultrasound radiation to a patient's head. The system also includes an antenna that reflects radio frequency (RF) waves. The antenna is configured to be positioned between the transducer and the patient's head. The antenna and at least a portion of the patient's head are surrounded by a fluid. Embodiments foster improved MR image quality scans of the patient's head when the transducer is filled with the fluid.
Abstract: Hemofilters for in vivo filtration of blood are disclosed. The hemofilters disclosed herein provide an optimal flow of blood through the filtration channels while maintaining a pressure gradient across the filtration channel walls to enhance filtration and minimize turbulence and stagnation of blood in the hemofilter.
Type:
Grant
Filed:
November 14, 2022
Date of Patent:
April 16, 2024
Assignees:
The Regents of the University of California, Vanderbilt University
Inventors:
Shuvo Roy, William Fissell, Nathan Wright, Mark Goodin, Steven G. Goebel, Amanda Buck, Joey Groszek
Abstract: The present invention relates to compositions and methods for preventing and reducing inflammation and preventing and treating diseases and disorders associated with inflammation. It has been shown that CRADD plays a pivotal role in maintaining the integrity of endothelial monolayers. The recombinant cell-penetrating CRADD protein (CP-CRADD)-based compositions and methods described herein provide for the development of a novel treatment for inflammatory vascular disorders including cardiovascular, cerebrovascular, respiratory, gastrointestinal, and renal systems.
Type:
Grant
Filed:
June 7, 2021
Date of Patent:
April 9, 2024
Assignee:
Vanderbilt University
Inventors:
Jack J. Hawiger, Ruth Ann Veach, Yan Liu, Huan Qiao, Lukasz S. Wylezinski
Abstract: A nucleic acid molecule is uniquely designed and encodes an entire CRISPRi or CRISPRa system, while being sized for packaging within a single adeno-associated virus (AAV) vector. Examples of the nucleic acid molecule include about 4600 to 4700 base pairs. Examples of the nucleic acid molecule can include a nucleotide encoding a Cas polypeptide; a nucleotide encoding a repressor or an activator domain attached to the nucleotide encoding the Cas polypeptide via a linker; a first promoter operably connected to the nucleotide encoding the repressor or activator domain or the nucleotide encoding the Cas polypeptide; a nucleotide encoding an alpha-helical connecting the nucleotide encoding the Cas polypeptide to a nuclear localization signal (NLS); and a second promoter operably connected to a guide RNA (gRNA).
Abstract: The present invention encompasses compounds of formula (I) wherein R1a, R1b, R2a, R2b, Z, R3 to R5, A, p, U, V, W, L and E have the meanings given in the claims and specification, their use as inhibitors of mutant Ras family proteins, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.
Type:
Grant
Filed:
June 1, 2021
Date of Patent:
April 2, 2024
Assignees:
Boehringer Ingelheim International GmbH, Vanderbilt University
Inventors:
Jason Abbott, Joachim Broeker, Jianwen Cui, Steve W. Fesik, Andreas Gollner, Tim Hodges, Jale Karolyi-Oezguer, Andrew Little, Andreas Mantoulidis, Jason Phan, Dhruba Sarkar, Christian Alan Paul Smethurst, Qi Sun, Matthias Treu, Alex Waterson
Abstract: Devices and methods for visibly highlighting areas of a region including an imager configured to image the region with a sensitivity to at least one of wavelength, light level, or contrast greater than the human eye, an overlay element configured to visibly highlight areas of the region and registered to the imager to produce alignment of imaged features with highlighted features at the same location on the region, and at least one of a controller executing a program or logic configured to process acquired images from the imager to identify areas of the region determined not visible to the human eye, and control the overlay element to visibly highlight those areas on the region.
Abstract: A non-woven carbon fiber reinforced thermoplastic (CFRTP) composite object is formed by the variable frequency microwave (VFM) irradiation of a mixed fiber sheet of thermoplastic fibers, carbon fibers and wavy carbon nanotubes (CNTs). The mixed fiber sheets are prepared from a slurry of the thermoplastic fibers, carbon fibers, and wavy CNTs such that the wavy CNTs contact the carbon fibers and thermoplastic fibers. Upon irradiation with VFM radiation, the wavy CNTs generate heat and transfer the heat to the thermoplastic fibers, causing melting of the thermoplastic to form the matrix of the CFRTP composite object. The mixed fiber sheets can be combined alone or with other sheets to form laminar composites that are molded into objects and heated by VFM irradiation.
Type:
Grant
Filed:
May 4, 2021
Date of Patent:
March 19, 2024
Assignees:
Toyota Motor Engineering & Manufacturing North America, Inc., Vanderbilt University
Inventors:
Yuyang Song, Umesh N. Gandhi, Piran R. Kidambi
Abstract: Disclosed are methods, including automated methods, for identifying a compound that impacts a characteristic of a lipid raft phase domain, a characteristic of a non-raft phase domain, and/or a characteristic of one or more membrane proteins.
Type:
Application
Filed:
January 24, 2022
Publication date:
March 14, 2024
Applicants:
University of Virginia Patent Foundation, Vanderbilt University
Inventors:
Anne Kathleen Kenworthy, Nico Fricke, Ajit Tiwari, Charles R. Sanders, Krishnan Raghunathan, Hui Huang, Ricardo F. Capone, Joshua A. Bauer, Katherine M. Stefanski
Abstract: The present disclosure is concerned with substituted phenyl ethynyl pyridine carboxamide compounds, pharmaceutical compositions comprising the compounds, and methods of treating viral infections due to a Coronavirus such as, for example, Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome coronavirus (SARS-CoV), and severe acute respiratory syndrome coronavirus disease 2019 (SARS-CoV-2), using the compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Type:
Grant
Filed:
December 21, 2022
Date of Patent:
February 20, 2024
Assignees:
Southern Research Institute, Vanderbilt University, University of North Carolina at Chapel Hill
Inventors:
Syed Kaleem Ahmed, Shilpa Dutta, John Phillip Tillotson, Corinne E. Augelli-Szafran, Ashish Kumar Pathak, Omar Moukha-Chafiq, Timothy Patrick Sheahan, Ralph S. Baric, Amy Catherine Sims, Mark R. Denison
Abstract: A robotic system, such as a continuum robot, that includes at least one hollow tube backbone and an equilibrium modulation wire at least partially positioned within the backbone. The robotic system is configured to adjust a position of an end effector by bending the hollow tube and to further adjust the position of the robotic device by adjusting a linear insertion position of the equilibrium modulation wire inside the hollow tube, wherein adjusting the linear insertion position of the equilibrium modulation wire changes a flexural rigidity of the hollow tube resulting in a change in the resulting bending angle of the robotic device.
Type:
Grant
Filed:
February 26, 2021
Date of Patent:
February 13, 2024
Assignee:
Vanderbilt University
Inventors:
Nabil Simaan, Giuseppe Del Giudice, Long Wang, Karen M. Joos, Jin-Hui Shen
Abstract: The present disclosure relates to a fluidic device to detect, capture, and/or remove disease material in a biological fluid. The present invention also relates to methods for the treatment/prevention of sepsis through the use of the claimed device.
Type:
Grant
Filed:
September 1, 2021
Date of Patent:
January 30, 2024
Assignee:
Vanderbilt University
Inventors:
Sinead E. Miller, Charleson S. Bell, Todd D. Giorgio, Andrew L. Cook
Abstract: The present disclosure provides for a device and method of control for an artificial prosthetic knee. A prosthetic knee according to the present disclosure relies on strictly passive means of providing support during weight bearing and supplements a resistive swing-phase mechanism with a small powered actuator. This actuator adds power to the knee, exclusively during swing phase, to improve swing-phase behavior. In particular, the knee still relies on the resistive swing-phase mechanism to provide nominal swing-phase knee motion, but supplements that motion as needed with the small powered actuator.
Type:
Grant
Filed:
October 13, 2022
Date of Patent:
January 30, 2024
Assignee:
Vanderbilt University
Inventors:
Michael Goldfarb, Almaskhan Baimyshev, Harrison Bartlett, Jantzen Lee
Abstract: Disclosed herein are analogues of 6-(4-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)oxy)piperidin-1 -yl)-[1,2,4]triazolo[4,3-b]pyridazine of formula (Ib), which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.
Type:
Grant
Filed:
March 22, 2023
Date of Patent:
January 30, 2024
Assignee:
Vanderbilt University
Inventors:
Craig W. Lindsley, P. Jeffrey Conn, Darren W. Engers, Alison R. Gregro, Kayla J. Temple, Madeline F. Long, Anna E. Ringuette, Logan A. Baker, Thomas Jensen