Patents Assigned to Vanderbilt University
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Patent number: 12144816Abstract: The present disclosure provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present disclosure also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of Mcl-1 protein.Type: GrantFiled: December 9, 2022Date of Patent: November 19, 2024Assignee: Vanderbilt UniversityInventors: Taekyu Lee, James C. Tarr, KyuOk Jeon, James M. Salovich, Subrata Shaw, Nagarathanam Veerasamy, Kwangho Kim, Plamen P. Christov, Edward T. Olejniczak, Bin Zhao, Stephen W. Fesik, Zhiguo Bian
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Patent number: 12138785Abstract: A moment arm extension system and method for improving the mechanical advantage of a wearable assistance device by increasing the moment arm of a force-bearing member relative to an underlying body segment of a user are disclosed. The moment arm extension system achieves this by shifting the force-bearing member to lie farther away from the body segment of the user.Type: GrantFiled: May 28, 2020Date of Patent: November 12, 2024Assignee: Vanderbilt UniversityInventors: Karl Zelik, Erik Lamers, Keaton Scherpereel
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Patent number: 12139498Abstract: 6,7-Dihydrothiazolo[5,4-c]pyridines substituted in the 5-position with heterocyclic rings are positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4) and may have use in treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction.Type: GrantFiled: April 18, 2024Date of Patent: November 12, 2024Assignee: Vanderbilt UniversityInventors: Craig W. Lindsley, Darren W. Engers, Kayla J. Temple, Alison R. Gregro, Madeline F. Long, Anna E. Ringuette, Julie L. Engers
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Patent number: 12115371Abstract: A system and method for determining the location of an implant such as a cochlear implant relative to a structure of interest such as a tissue wall. The implant has an electrode array including a first electrode and a second electrode. The electrode array is insertable into an electrically-conductive volume relative to the inner wall of the scala tympani of the cochlea. A pulse generator generates a biphasic, constant-current pulse on the first and second electrodes. A controller measures the differential voltage across the pair of electrodes during the current pulse. The controller determines the proximity between the inner wall and the segment of the electrode array between the first and second electrodes based on the differential voltage between the first and second electrodes.Type: GrantFiled: April 17, 2020Date of Patent: October 15, 2024Assignee: Vanderbilt UniversityInventors: Trevor L. Bruns, Robert J. Webster
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Publication number: 20240325089Abstract: Systems and methods for navigation and identification for endoscopic kidney surgery may include generating a map of an internal space of a patient's collecting system, including segmentation preoperative CT scans, using localization and three-dimensional reconstruction techniques on endoscopic video to create a point cloud, and registering the point cloud to the segmented CT scans. The systems and methods may include tracking a tip of the endoscope during the endoscopic kidney surgery using localization and three-dimensional reconstruction techniques. The systems and methods may include identifying and tracking kidney stones during the endoscopic kidney surgery using computational models.Type: ApplicationFiled: March 29, 2024Publication date: October 3, 2024Applicant: Vanderbilt UniversityInventors: Nicholas L. Kavoussi, Ipek Oguz, Zachary Stoebner, Ayberk Acar, Jie Ying Wu, Daiwei Lu
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Publication number: 20240318229Abstract: Variation in a single nucleotide of a target or template nucleic acid may be significant in many ways. For infectious disease, many drug resistance mutations are known and a simple means to confirm their absence would more quickly match a patient with an infection with the most effective treatment. This disclosure provides for a simple, low resource strategy allowing the detection of single nucleotide variation using only low-cost diagnostic methods already available in many locations. A key to this approach is the use of left-handed DNA (L-DNA) as a comparator molecule for D-DNA targets. L-DNA provides numerous additional advantages such as low cost and stability.Type: ApplicationFiled: February 23, 2024Publication date: September 26, 2024Applicant: Vanderbilt UniversityInventor: Frederick R. HASELTON
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Patent number: 12082916Abstract: An implantable bioresorbable radio frequency (RF) coil for high-resolution and high-specificity post-surgical evaluating or monitoring with magnetic resonance imaging (MRI) is disclosed. The coil includes a bioresorbable conductor configured to be resorbed within a patient while the coil is implanted in the patient. In one embodiment, the target application of this coil is the evaluation or monitoring (via MRI) of peripheral nerve regeneration following surgical repair.Type: GrantFiled: March 1, 2021Date of Patent: September 10, 2024Assignees: Vanderbilt University, Northwestern UniversityInventors: Mark D. Does, John A. Rogers
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Publication number: 20240288426Abstract: The present disclosure is directed to antibodies binding to and neutralizing Crimean Congo Hemorrhagic Fever Virus and methods for use thereof.Type: ApplicationFiled: January 11, 2021Publication date: August 29, 2024Applicant: Vanderbilt UniversityInventor: James E. CROWE, Jr.
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Patent number: 12070407Abstract: In one embodiment, the orthotic device can include a powered hand portion, a switching element, and a controller. The wearer can interact with the switching element to generate input signals for adjusting an operation of the powered hand portion. The controller can receive the input signals and generate control signals to accordingly adjust the operation of the powered hand portion. In some embodiments, a powered hand portion can be comprised of a plurality of linkages and at least one powered actuator to assist with an opening and closing of the hand portion. The plurality of linkages can be operated by at least one electric motor with quick-connect elements to link onto fingers of a user. In some embodiments, an electrically-actuated clutch mechanism can be affixed to an upper arm section and a lower arm section of an orthotic device. The clutch mechanism can be configured into different positions.Type: GrantFiled: November 30, 2022Date of Patent: August 27, 2024Assignee: Vanderbilt UniversityInventors: Michael Goldfarb, Benjamin William Gasser, Daniel Alvin Bennett
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Patent number: 12070486Abstract: The present invention relates to compositions and methods for treating autoimmune, microbial, metabolic, neoplastic, and posttraumatic diseases mediated by inflammation in a subject. Compositions and methods including at least one importin beta-selective nuclear transport modifier (NTM) and/or at least one importin alpha-selective NTM, and/or at least one importin alpha-specific NTM, and/or at least one inhibitor of importin alpha and importin beta complex formation may be administered to a subject to modulate the transport of transcription factors, mediated by nuclear import adaptors, into the nucleus of a cell resulting in a decrease or abrogation of inflammation.Type: GrantFiled: June 21, 2022Date of Patent: August 27, 2024Assignee: Vanderbilt UniversityInventors: Jack J. Hawiger, Jozef Zienkiewicz
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Patent number: 12065433Abstract: Described are positive allosteric modulators of muscarinic acetylcholine receptor M1 (mAChR M1), pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for treating neurological disorders, psychiatric disorders, or a combination thereof.Type: GrantFiled: October 24, 2019Date of Patent: August 20, 2024Assignee: Vanderbilt UniversityInventors: Craig W. Lindsley, P. Jeffery Conn, Darren W. Engers, Aaron M. Bender
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Patent number: 12065649Abstract: Provided herein are a selective pattern recognition receptor (PRR) agonist and a method of selectively activating a PRR. The selective PRR agonist includes a nucleic acid agonist and a macromolecule conjugated to the nucleic acid agonist. The method includes administering the selective PRR agonist to a subject, and cleaving at least a portion of the macromolecule conjugated to the nucleic acid agonist, the cleaving of at least a portion of the macromolecule permitting the agonist to bind a PRR.Type: GrantFiled: January 9, 2019Date of Patent: August 20, 2024Assignee: Vanderbilt UniversityInventors: John T. Wilson, Christian Palmer
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Patent number: 12060396Abstract: Disclosed herein are compositions and methods for inhibiting collagen production mediated by the Fused in Sarcoma (FUS) ribonucleoprotein. As disclosed herein, the C terminal domain of FUS contains an uncommon nuclear localization sequence (NLS) motif called PY-NLS that binds the nuclear import receptor transportin. Phosphorylation of FUS leads to its association with transportin and nuclear translocation with consequent increased in collagen production. Therefore, disclosed herein is an isolated peptide having a transportin-binding moiety, which inhibits FUS from binding transportin, linked to a membrane translocating motif. These compositions and methods can be used to inhibit FUS-mediated collagen production, and treat fibrotic disease involving FUS-mediated collagen accumulation in kidneys and other organs displaying fibrotic diseases.Type: GrantFiled: January 29, 2018Date of Patent: August 13, 2024Assignees: Vanderbilt University, The United States as Represented by the Department of Veterans AffairsInventors: Ambra A. Pozzi, Manuel Chiusa, Jack J. Hawiger, Jozef Zienkiewicz
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Patent number: 12053268Abstract: A system and method of magnetic particle imaging (MPI) are disclosed. The system and method use ultrasound to drive magnetic particles (such as nanoparticles) through a magnetic field gradient to generate a signal and map the magnetic particles' distribution or concentration.Type: GrantFiled: October 23, 2023Date of Patent: August 6, 2024Assignee: Vanderbilt UniversityInventors: William A. Grissom, Charles F. Caskey
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Publication number: 20240230665Abstract: The present disclosure is directed to human monoclonal IgE antibodies, and IgG antibodies engineered therefrom. Such engineered antibodies can be used to blunt pathologic IgE responses in subjects, such as in the treatment or prevention of allergies.Type: ApplicationFiled: October 30, 2023Publication date: July 11, 2024Applicant: Vanderbilt UniversityInventor: Scott A. SMITH
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Patent number: 12029501Abstract: Systems and methods for image-based guidance using automated instrument tracking. An en face image frame, generated from en face image data captured by a first imaging system (e.g., an SER imaging system), is analyzed to determine a location of an instrument in the first imaging plane. A control signal is then generated for the movement stage to control the scanning movement of a depth-based imaging system (e.g., an OCT imaging system) based on the determined location of the instrument. In some implementations, a trained neural-network is used to determine the location of the instrument based on the en face image frame and, in some implementations, the control signal adjusts the speed of the scanning movement to capture image data at a higher density7 at areas corresponding to the determined location of the instrument.Type: GrantFiled: January 10, 2020Date of Patent: July 9, 2024Assignee: Vanderbilt UniversityInventors: Yuankai Tao, Mohamed T. El-Haddad
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Patent number: 12025414Abstract: Shaped charge devices, systems, and related methods of use. A housing sheet is configurable to form at least part of a shaped charge enclosure enclosing a shaped charge and biasing an explosion in a desired direction. The housing sheet can include one or more incisions in at least one surface thereof. The housing sheet can have at least one connection mechanism integrally formed therein, and the housing sheet can be configurable to form a plurality of sizes of shaped charge housing portions. The housing sheet can also provide for forming a plurality of dimensions of the shaped charge enclosure.Type: GrantFiled: May 12, 2023Date of Patent: July 2, 2024Assignees: Vanderbilt University, The United States of America as Represented by the Secretary of the ArmyInventors: Kevin C. Galloway, Kelsay E. Neely, Aimee J. Valles, Robert J. Clark, Jesse L. Frederick
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Patent number: 12023134Abstract: An example method includes (a) generating, via a sensor of a computing device, a signal representing vibrations originating from a blood vessel of a subject, where the vibrations are indicative of heart beats and/or respirations of the subject; (b) using the signal to determine first times elapsed between respective pairs of consecutive heartbeats indicated by the vibrations and/or second times elapsed between respective pairs of consecutive respirations indicated by the vibrations; and (c) using the determined first times elapsed to determine a heart rate variability of the subject and/or the determined second times elapsed to determine a respiration rate variability of the subject.Type: GrantFiled: September 5, 2019Date of Patent: July 2, 2024Assignee: Vanderbilt UniversityInventors: Kyle M. Hocking, Colleen M. Brophy, Susan S. Eagle
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Patent number: 12014835Abstract: The invention provides methods for evaluating the therapeutic benefit of a combination therapy useful for treating a medical disorder, such as cancer.Type: GrantFiled: February 19, 2021Date of Patent: June 18, 2024Assignees: Vanderbilt University, Duet BioSystems Inc.Inventors: Christian T. Meyer, Vito Quaranta, Leonard A. Harris, Buddhi Bishal Paudel, David J. Wooten, Laurent Audoly
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Patent number: 12011455Abstract: A method for reducing or substantially preventing soft tissue calcification is provided. The method includes administering at least one of a downregulator of at least one plasmin inhibitors and plasmin(ogen) to a subject in need thereof, wherein the at least one plasmin inhibitor includes alpha2-antiplasmin. Further disclosed is a method comprises administering the compound subsequent to muscle injury, and the method further comprising administering an antifibrinolytic.Type: GrantFiled: March 17, 2017Date of Patent: June 18, 2024Assignee: Vanderbilt UniversityInventors: Jonathan Schoenecker, Masato Yuasa