Patents Assigned to Vanderbilt University
  • Optical overlay device
    Patent number: 11937897
    Abstract: Devices and methods for visibly highlighting areas of a region including an imager configured to image the region with a sensitivity to at least one of wavelength, light level, or contrast greater than the human eye, an overlay element configured to visibly highlight areas of the region and registered to the imager to produce alignment of imaged features with highlighted features at the same location on the region, and at least one of a controller executing a program or logic configured to process acquired images from the imager to identify areas of the region determined not visible to the human eye, and control the overlay element to visibly highlight those areas on the region.
    Type: Grant
    Filed: June 24, 2022
    Date of Patent: March 26, 2024
    Assignees: AI Biomed Corp, Vanderbilt University
    Inventors: Adnan Abbas, Melanie McWade, Anita Mahadevan-Jansen
  • Continuous automated perfusion culture analysis system (CAPCAS) and applications of same
    Patent number: 11939563
    Abstract: A continuous automated perfusion culture analysis system (CAPCAS) comprises one or more fluidic systems configured to operate large numbers of biodevices in parallel. Each fluidic system comprises an input reservoir plate for receiving media; a biodevice plate comprising an array of biodevices fluidically coupled to the input reservoir plate, configured such that each biodevice has independent media delivery, fluid removal, stirring, and gas control, and each biodevice is capable of continuously receiving the media from the input reservoir plate; and an output plate fluidically coupled to the biodevice plate for real-time analysis and sampling. The operations of the CAPCAS are automated and computer-controlled wirelessly. The CAPCAS can also be used for abiotic and biotic chemical synthesis processes.
    Type: Grant
    Filed: September 19, 2022
    Date of Patent: March 26, 2024
    Assignee: VANDERBILT UNIVERSITY
    Inventors: Ronald S. Reiserer, Gregory B. Gerken, David K. Schaffer, John P. Wikswo
  • Pan-ebola virus neutralizing human antibodies and methods of use therefor
    Patent number: 11939370
    Abstract: The present disclosure is directed to human antibodies binding to and neutralizing ebolavirus and methods for use thereof. A further embodiment involves a monoclonal antibody, wherein the antibody or antibody fragment is characterized by clone-paired heavy and light chain CDR sequences. In yet another embodiment, there is provided a hybridoma or engineered cell encoding an antibody or antibody fragment. An additional embodiment comprises a vaccine formulation comprising one or more antibodies or antibody fragments characterized by clone-paired heavy and light chain CDR sequences. In still a further embodiment, there is provided a method of protecting the health of a placenta and/or fetus of a pregnant a subject infected with or at risk of infection with ebolavirus comprising delivering to said subject the antibody or antibody fragment.
    Type: Grant
    Filed: July 11, 2019
    Date of Patent: March 26, 2024
    Assignees: VANDERBILT UNIVERSITY, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: James E. Crowe, Jr., Pavlo Gilchuk, Alexander Bukreyev
  • Carbon fiber reinforced thermoplastic sheets for efficient microwave heating with dispersed wavy carbon nanotubes
    Patent number: 11932736
    Abstract: A non-woven carbon fiber reinforced thermoplastic (CFRTP) composite object is formed by the variable frequency microwave (VFM) irradiation of a mixed fiber sheet of thermoplastic fibers, carbon fibers and wavy carbon nanotubes (CNTs). The mixed fiber sheets are prepared from a slurry of the thermoplastic fibers, carbon fibers, and wavy CNTs such that the wavy CNTs contact the carbon fibers and thermoplastic fibers. Upon irradiation with VFM radiation, the wavy CNTs generate heat and transfer the heat to the thermoplastic fibers, causing melting of the thermoplastic to form the matrix of the CFRTP composite object. The mixed fiber sheets can be combined alone or with other sheets to form laminar composites that are molded into objects and heated by VFM irradiation.
    Type: Grant
    Filed: May 4, 2021
    Date of Patent: March 19, 2024
    Assignees: Toyota Motor Engineering & Manufacturing North America, Inc., Vanderbilt University
    Inventors: Yuyang Song, Umesh N. Gandhi, Piran R. Kidambi
  • PCR DETECTION OF SMALL FRAGMENTS OF A KNOWN NUCLEIC ACID TARGET
    Publication number: 20240084372
    Abstract: The present disclosure is directed to methods of detecting small fragments of known nucleic acid biomarkers.
    Type: Application
    Filed: August 3, 2023
    Publication date: March 14, 2024
    Applicant: Vanderbilt University
    Inventors: Frederick R. HASELTON, David T. EVANS, Megan E. PASK, Emily C. KIGHT
  • ALTERING PROTEIN FUNCTION BY PHARMACOLOGICAL TARGETING OF MEMBRANE DOMAINS
    Publication number: 20240085429
    Abstract: Disclosed are methods, including automated methods, for identifying a compound that impacts a characteristic of a lipid raft phase domain, a characteristic of a non-raft phase domain, and/or a characteristic of one or more membrane proteins.
    Type: Application
    Filed: January 24, 2022
    Publication date: March 14, 2024
    Applicants: University of Virginia Patent Foundation, Vanderbilt University
    Inventors: Anne Kathleen Kenworthy, Nico Fricke, Ajit Tiwari, Charles R. Sanders, Krishnan Raghunathan, Hui Huang, Ricardo F. Capone, Joshua A. Bauer, Katherine M. Stefanski
  • Substituted phenyl ethynyl pyridine carboxamides as potent inhibitors of SARS virus
    Patent number: 11905306
    Abstract: The present disclosure is concerned with substituted phenyl ethynyl pyridine carboxamide compounds, pharmaceutical compositions comprising the compounds, and methods of treating viral infections due to a Coronavirus such as, for example, Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome coronavirus (SARS-CoV), and severe acute respiratory syndrome coronavirus disease 2019 (SARS-CoV-2), using the compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: December 21, 2022
    Date of Patent: February 20, 2024
    Assignees: Southern Research Institute, Vanderbilt University, University of North Carolina at Chapel Hill
    Inventors: Syed Kaleem Ahmed, Shilpa Dutta, John Phillip Tillotson, Corinne E. Augelli-Szafran, Ashish Kumar Pathak, Omar Moukha-Chafiq, Timothy Patrick Sheahan, Ralph S. Baric, Amy Catherine Sims, Mark R. Denison
  • Continuum robots with multi-scale motion through equilibrium modulation
    Patent number: 11897129
    Abstract: A robotic system, such as a continuum robot, that includes at least one hollow tube backbone and an equilibrium modulation wire at least partially positioned within the backbone. The robotic system is configured to adjust a position of an end effector by bending the hollow tube and to further adjust the position of the robotic device by adjusting a linear insertion position of the equilibrium modulation wire inside the hollow tube, wherein adjusting the linear insertion position of the equilibrium modulation wire changes a flexural rigidity of the hollow tube resulting in a change in the resulting bending angle of the robotic device.
    Type: Grant
    Filed: February 26, 2021
    Date of Patent: February 13, 2024
    Assignee: Vanderbilt University
    Inventors: Nabil Simaan, Giuseppe Del Giudice, Long Wang, Karen M. Joos, Jin-Hui Shen
  • Small molecule inhibitors of lactate dehydrogenase and methods of use thereof
    Patent number: 11897845
    Abstract: Provided is a compound of formula (I) in which Ar1, R1, U, V, W, X, and p are as described herein. Also provided are methods of using a compound of formula (I), including a method of treating cancer, a method of treating a patient with cancer cells resistant to an anti-cancer agent, and a method of inhibiting lactate dehydrogenase A (LDHA) and/or lactate dehydrogenase B (LDHB) activity in a cell.
    Type: Grant
    Filed: January 10, 2022
    Date of Patent: February 13, 2024
    Assignees: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, VANDERBILT UNIVERSITY, THE UAB RESEARCH FOUNDATION, THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: David J. Maloney, Alex Gregory Waterson, Ganesh Rai Bantukallu, Kyle Ryan Brimacombe, Plamen Christov, Chi V. Dang, Victor Darley-Usmar, Xin Hu, Ajit Jadhav, Somnath Jana, Kwangho Kim, Jennifer L. Kouznetsova, William J. Moore, Bryan T. Mott, Leonard M. Neckers, Anton Simeonov, Gary Allen Sulikowski, Daniel Jason Urban, Shyh Ming Yang
  • Fluidic device for the detection, capture, or removal of a disease material
    Patent number: 11883821
    Abstract: The present disclosure relates to a fluidic device to detect, capture, and/or remove disease material in a biological fluid. The present invention also relates to methods for the treatment/prevention of sepsis through the use of the claimed device.
    Type: Grant
    Filed: September 1, 2021
    Date of Patent: January 30, 2024
    Assignee: Vanderbilt University
    Inventors: Sinead E. Miller, Charleson S. Bell, Todd D. Giorgio, Andrew L. Cook
  • Substituted pyrimido[1,2-b]pyridazines as positive allosteric modulators of the muscarinic acetylcholine receptor M
    Patent number: 11884676
    Abstract: Disclosed herein are analogues of 6-(4-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)oxy)piperidin-1 -yl)-[1,2,4]triazolo[4,3-b]pyridazine of formula (Ib), which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.
    Type: Grant
    Filed: March 22, 2023
    Date of Patent: January 30, 2024
    Assignee: Vanderbilt University
    Inventors: Craig W. Lindsley, P. Jeffrey Conn, Darren W. Engers, Alison R. Gregro, Kayla J. Temple, Madeline F. Long, Anna E. Ringuette, Logan A. Baker, Thomas Jensen
  • Prosthetic knee with swing assist
    Patent number: 11883304
    Abstract: The present disclosure provides for a device and method of control for an artificial prosthetic knee. A prosthetic knee according to the present disclosure relies on strictly passive means of providing support during weight bearing and supplements a resistive swing-phase mechanism with a small powered actuator. This actuator adds power to the knee, exclusively during swing phase, to improve swing-phase behavior. In particular, the knee still relies on the resistive swing-phase mechanism to provide nominal swing-phase knee motion, but supplements that motion as needed with the small powered actuator.
    Type: Grant
    Filed: October 13, 2022
    Date of Patent: January 30, 2024
    Assignee: Vanderbilt University
    Inventors: Michael Goldfarb, Almaskhan Baimyshev, Harrison Bartlett, Jantzen Lee
  • Patient-customized electrode arrays based on patient-specific cochlear information, and designing/selecting methods and applications of same
    Patent number: 11872398
    Abstract: A method for designing a patient-customized EA or selecting an existing EA that fits the patient best includes segmenting shapes of SOIs of the cochlea in a pre-operative CT image using a shape model; defining a 3D curve of interest within the shape model of the SOIs as a sequence of points-; automatically transforming the defined 3D curve to the pre-operative CT image so as to obtain a structure curve in the cochlea; determining a length and curvatures of the structure curve at the sequence of points; and designing a patient-customized EA or selecting an existing EA based on the determined length and curvatures of the structure curve such that after the EA shape model, which estimates the resting state shape of the EA, is rigidly registered to the structure curve in the cochlea, the EA shape model has a registration error smaller than a preset value.
    Type: Grant
    Filed: June 7, 2021
    Date of Patent: January 16, 2024
    Assignee: VANDERBILT UNIVERSITY
    Inventors: Jack H. Noble, Robert F. Labadie, Benoit M. Dawant
  • Control method for a robotic system
    Patent number: 11865723
    Abstract: An exemplary robotic system includes a plurality of controllable joints and a controller. An exemplary control method provides for controlling the controllable joints by the controller. The control method provides for determining a configuration space for the robotic system and determining a reference movement path within the configuration space. The control method then provides for assigning a plurality of streamlines in the configuration space to yield a flow field based on the reference movement path. The control method then provides for measuring actual velocity vectors of the robotic system in the configuration space. The control method then provides for determining an error velocity vector based on a difference between the actual velocity vector and the desired velocity vector given by the flow field corresponding to the current robot configuration.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: January 9, 2024
    Assignee: Vanderbilt University
    Inventors: Michael Goldfarb, Andres Martinez-Guerra, Brian Lawson
  • Binary compositions as disruptors of Orco-mediated odorant sensing
    Patent number: 11856955
    Abstract: In one aspect, the invention relates to binary compositions that disrupt ORco-mediated odorant sensing. In particular, compounds and compositions are provided that can inhibit sensory (e.g., host targeting) functions in organisms that express ORco receptors such as airborne insects, e.g., mosquitos, and ticks. Methods of employing such agents, and articles incorporating the same, are also provided. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: August 26, 2020
    Date of Patent: January 2, 2024
    Assignee: Vanderbilt University
    Inventors: Laurence J. Zwiebel, Ian M. Romaine, Sam Ochieng, Alex Gregory Waterson, Gary A. Sulikowski
  • Antibody-mediated neutralization of chikungunya virus
    Patent number: 11851478
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing Chikungunya virus (CHIKV) and methods for use thereof.
    Type: Grant
    Filed: January 4, 2019
    Date of Patent: December 26, 2023
    Assignee: VANDERBILT UNIVERSITY
    Inventor: James E Crowe, Jr.
  • Positive allosteric modulators of the muscarinic acetylcholine receptor M
    Patent number: 11851406
    Abstract: Described are positive allosteric modulators of muscarinic acetylcholine receptor M1 (mAChR M1), pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for treating neurological disorders, psychiatric disorders, or a combination thereof.
    Type: Grant
    Filed: June 13, 2019
    Date of Patent: December 26, 2023
    Assignee: Vanderbilt University
    Inventors: Craig W. Lindsley, P. Jeffrey Conn, Darren W. Engers, Julie L. Engers, Aaron M. Bender, Madeline Long
  • Activator of TREK (TWIK RElated Kchannels) channels
    Patent number: 11851428
    Abstract: Disclosed is a compound of formula (I): wherein all symbols are defined in the description. Also disclosed are pharmaceutical compositions comprising the compounds, methods of making the compounds, kits comprising the compounds, and methods of using the compounds, compositions and kits for treatment of disorders associated with TREK-1, TREK-2 or both TREK-1 and TREK-2 dysfunction in a mammal.
    Type: Grant
    Filed: May 24, 2021
    Date of Patent: December 26, 2023
    Assignees: ONO PHARMACEUTICAL CO., LTD., VANDERBILT UNIVERSITY
    Inventors: Craig W. Lindsley, Joshua M. Wieting, Kevin M. Mcgowan, Jerod S. Denton, Kentaro Yashiro, Haruto Kurata, Yoko Sekioka, Takahiro Mori, Yuzo Iwaki
  • System and method for B1-selective spatial encoding using magnetic resonance
    Patent number: 11841413
    Abstract: The present application provides a system and method for using a nuclear magnetic resonance (NMR) system. The method includes performing a pulse sequence using the NMR system that spatially encodes NMR signal evolutions to be acquired from a subject using an aggregated radio-frequency (B1) field incoherence and resolving the NMR signal evolutions acquired from the subject using at least one of a dictionary of known magnetic resonance fingerprinting (MRF) signal evolutions to determine matches in the NMR signal evolutions to the known MRF signal evolutions or an optimization process. The method also includes generating at least two spatially-resolved measurements indicating quantitative tissue parameters of the subject in at least two locations.
    Type: Grant
    Filed: December 30, 2020
    Date of Patent: December 12, 2023
    Assignees: Case Western Reserve University, Vanderbilt University
    Inventors: Mark A. Griswold, William A. Grissom
  • L-DNA ENCRYPTED TRACERS
    Publication number: 20230392205
    Abstract: The present disclosure is directed to the use of left-handed DNA (L-DNA) tracer to identify the source, track the distribution, and validate the integrity of products or resources that are highly regulated, valuable, or hazardous (e.g., pharmaceuticals, treated water, chemicals, designer products, and ammunitions). L-DNA tracers can encrypt unique identifying information, as well as more general information about the type of product, such as the manufacturing location, source, and date, directly into the nucleotide sequence. The L-DNA tracers can embed directly into the product so that it could neither be disassociated from the product nor be re-associated with another product. Because there are no technologies available to sequence L-DNA, the L-DNA tracers cannot be reverse engineered, copied, or falsified. The L-DNA tracers are only deciphered using a unique detection key.
    Type: Application
    Filed: May 26, 2023
    Publication date: December 7, 2023
    Applicant: Vanderbilt University
    Inventors: Nicholas M. ADAMS, Frederick R. HASELTON