Patents Assigned to Vanderbilt University
  • HUMAN MONOCLONAL ANTIBODIES TO HANTAVIRUS AND METHODS OF USE THEREFORE
    Publication number: 20220380442
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing hantavirus and methods for use thereof.
    Type: Application
    Filed: November 10, 2020
    Publication date: December 1, 2022
    Applicant: Vanderbilt University
    Inventor: James E. CROWE, Jr.
  • Mucosal impedance measuring apparatus for detecting and measuring the condition of mucosa
    Patent number: 11504053
    Abstract: A mucosal impedance measuring apparatus detects and measures a condition of mucosa. The mucosal impedance measuring apparatus includes a catheter comprising a tube, impedance sensing electrodes on an exterior surface of the catheter, a balloon mounted on the tube in which the balloon is capable of inflation and deflation, and an impedance measuring system. The impedance measuring system is adapted to measure a pressure-regulated impedance measurement of the mucosa that is indicative of the condition of the mucosa when the balloon is inflated and the impedance sensing electrodes direct an electric current through mucosa while the balloon is pressed against the mucosa.
    Type: Grant
    Filed: May 6, 2019
    Date of Patent: November 22, 2022
    Assignees: Diversatek Healthcare, Inc., Vanderbilt University
    Inventors: Jerry E. Mabary, Michael F. Vaezi, Thomas D. Stuebe
  • CARBON FIBER REINFORCED THERMOPLASTIC SHEETS FOR EFFICIENT MICROWAVE HEATING WITH DISPERSED WAVY CARBON NANOTUBES
    Publication number: 20220356312
    Abstract: A non-woven carbon fiber reinforced thermoplastic (CFRTP) composite object is formed by the variable frequency microwave (VFM) irradiation of a mixed fiber sheet of thermoplastic fibers, carbon fibers and wavy carbon nanotubes (CNTs). The mixed fiber sheets are prepared from a slurry of the thermoplastic fibers, carbon fibers, and wavy CNTs such that the wavy CNTs contact the carbon fibers and thermoplastic fibers. Upon irradiation with VFM radiation, the wavy CNTs generate heat and transfer the heat to the thermoplastic fibers, causing melting of the thermoplastic to form the matrix of the CFRTP composite object. The mixed fiber sheets can be combined alone or with other sheets to form laminar composites that are molded into objects and heated by VFM irradiation.
    Type: Application
    Filed: May 4, 2021
    Publication date: November 10, 2022
    Applicants: Toyota Motor Engineering & Manufacturing North America, Inc., Vanderbilt University
    Inventors: Yuyang Song, Umesh N. Gandhi, Piran R. Kidambi
  • Systems and methods for compact optical relay
    Patent number: 11493751
    Abstract: An optical relay comprises a first scan mirror configured to receive an input optical beam, and to reflect the input optical beam as a first intermediate optical beam; a telecentric mirror configured to receive the first intermediate optical beam, and to reflect the first intermediate optical beam as a second intermediate optical beam; a second scan mirror configured to receive the second intermediate optical beam, and to reflect the second intermediate optical beam as an output optical beam; and a lens system disposed between the telecentric mirror and the first and second scan mirrors, such that the first intermediate optical beam and the second intermediate optical beam pass through the lens system. The optical relay may be a component of an optical system which further includes an optical engine.
    Type: Grant
    Filed: January 23, 2020
    Date of Patent: November 8, 2022
    Assignee: Vanderbilt University
    Inventors: Yuankai Tao, Joseph D. Malone
  • Prosthetic knee with swing assist
    Patent number: 11471306
    Abstract: The present disclosure provides for a device and method of control for an artificial prosthetic knee. A prosthetic knee according to the present disclosure relies on strictly passive means of providing support during weight bearing and supplements a resistive swing-phase mechanism with a small powered actuator. This actuator adds power to the knee, exclusively during swing phase, to improve swing-phase behavior. In particular, the knee still relies on the resistive swing-phase mechanism to provide nominal swing-phase knee motion, but supplements that motion as needed with the small powered actuator.
    Type: Grant
    Filed: January 25, 2019
    Date of Patent: October 18, 2022
    Assignee: Vanderbilt University
    Inventors: Michael Goldfarb, Almaskhan Baimyshev, Harrison Bartlett, Jantzen Lee
  • Methods of inhibiting tumor metastasis
    Patent number: 11471444
    Abstract: Thromboxane A2 receptor antagonists, such as ifetroban, inhibit solid tumor metastasis. The formation of surface and microscopic lung metastases are inhibited. Thromboxane A2 receptor antagonists can inhibit the tumor metastasis process without affecting the growth or development of a primary tumor.
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: October 18, 2022
    Assignee: Vanderbilt University
    Inventors: Jill M. Pulley, Robert R. Lavieri
  • METHODS FOR FABRICATING CARBON NANOTUBE ARRAYS WITH A HIGH STRUCTURAL FACTOR
    Publication number: 20220314211
    Abstract: A method of fabricating a carbon nanotube (“CNT”) array includes providing a substrate with a CNT catalyst disposed on a surface of the substrate, heating the CNT catalyst to an annealing temperature, exposing the CNT catalyst to a CNT precursor for an exposure period to pre-load the CNT catalyst, and exposing the pre-loaded CNT catalyst to a carbon source for a growth period to form the CNT array. The formed CNT array comprises a plurality of CNT bundles that are aligned with one another in an alignment direction. At least one of the plurality of bundles comprises an average structural factor of 1.5 or less along an entirety of the length thereof.
    Type: Application
    Filed: March 31, 2021
    Publication date: October 6, 2022
    Applicants: Toyota Motor Engineering & Manufacturing North America, Inc., Vanderbilt University
    Inventors: Yuyang Song, Shailesh N. Joshi, Piran R. Kidambi, Peifu Cheng
  • GENERATION OF HUMAN ALLERGEN- AND HELMINTH-SPECIFIC IGE MONOCLONAL ANTIBODIES FOR DIAGNOSTIC AND THERAPEUTIC USE
    Publication number: 20220308065
    Abstract: The present disclosure is directed to human monoclonal IgE antibodies, and IgG antibodies engineered therefrom. Such engineered antibodies can be used to blunt pathologic IgE responses in subjects, such as in the treatment or prevention of allergies.
    Type: Application
    Filed: May 26, 2022
    Publication date: September 29, 2022
    Applicant: Vanderbilt University
    Inventor: Scott A. SMITH
  • System and method of testing for leaks after anastomosis
    Patent number: 11452481
    Abstract: Devices, kits, and methods for testing the integrity of a cavity within an anatomical organ. For example, the devices, kits, and methods described herein are useful for detecting leaks in an anastomosis or for testing the integrity or repair of a defect in anatomy.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: September 27, 2022
    Assignee: Vanderbilt University
    Inventor: Timothy M. Geiger
  • HUMAN MONOCLONAL ANTIBODIES TO SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-CoV-2)
    Publication number: 20220281958
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing the coronavirus designated SARS-CoV-2 and methods for use thereof.
    Type: Application
    Filed: March 18, 2022
    Publication date: September 8, 2022
    Applicant: Vanderbilt University
    Inventors: James E. CROWE, JR., Seth ZOST, Robert CARNAHAN, Pavlo GILCHUK
  • Efficient laser-induced single-event latchup and methods of operation
    Patent number: 11435399
    Abstract: Systems and methods are provided for testing a threshold energy required to cause a latchup on an electronic component. An exemplary method includes applying a series of laser pulses to a testing object with a pulsed laser unit. The testing object is connected to a testing circuit which can measure the energy of each of the series of laser pulses, and detect whether a pulse of the series of laser pulses resulted in a latchup on the testing object. Upon detecting the pulse, the method provides for logging the energy of the pulse using a recording unit and logging the latchup status of the test device. If a latchup is detected, the testing circuit automatically mitigates the latchup event.
    Type: Grant
    Filed: February 8, 2018
    Date of Patent: September 6, 2022
    Assignee: Vanderbilt University
    Inventors: Andrew L. Sternberg, Ronald D. Schrimpf, Robert A. Reed
  • Indazole compounds as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
    Patent number: 11427573
    Abstract: Indazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease states associated with glutamate dysfunction.
    Type: Grant
    Filed: August 16, 2018
    Date of Patent: August 30, 2022
    Assignee: Vanderbilt University
    Inventors: P. Jeffrey Conn, Craig W. Lindsley, Andrew S. Felts, Colleen M. Niswender, Rory A. Capstick, Paul K. Spearing, Sean R. Bollinger
  • Antagonists of the muscarinic acetylcholine receptor M
    Patent number: 11414406
    Abstract: Disclosed herein are 3-azabicyclo[3.1.0]hexan-6-amine compounds, which may be useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.
    Type: Grant
    Filed: February 1, 2019
    Date of Patent: August 16, 2022
    Assignee: Vanderbilt University
    Inventors: Craig W. Lindsley, P. Jeffrey Conn, Darren W. Engers, Julie L. Engers, Aaron M. Bender
  • Actively reconfigurable, hyperbolic metasurfaces
    Patent number: 11409142
    Abstract: Metallic and dielectric domains in phase change materials (PCM) provide spatially localized changes in the local dielectric environment, enabling launching, reflection, and transmission of hyperbolic polaritons (HPs) at the PCM domain boundaries, and tuning the wavelength of HPs propagating in hyperbolic materials over these domains, providing a methodology for realizing planar, sub-diffractive refractive optics. This approach offers reconfigurable control of in-plane HP propagation to provide design optical functionality because the phase change material can be manipulated by changing the local structure, for example, to manipulate polaritons in the adjacent hyperbolic material, thus tuning the wave propagation properties of the polaritons in the hyperbolic material.
    Type: Grant
    Filed: March 7, 2019
    Date of Patent: August 9, 2022
    Assignees: Vanderbilt University, University of Georgia Research Foundation, Inc.
    Inventors: Joshua D. Caldwell, Thomas G. Folland, Richard F. Haglund, Yohannes Abate
  • Methods of preventing platelet activation
    Patent number: 11400103
    Abstract: A method of preventing or reducing the occurrence of malondiadehyde and/or levuglandin protein modification in a subject in need thereof, comprising administering to said subject an effective amount of at least one reactive dicarbonyl scavenger compound, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: April 17, 2020
    Date of Patent: August 2, 2022
    Assignee: Vanderbilt University
    Inventors: John A. Oates, Olivier Boutaud, Irene Zagol-Ikapitte
  • Phosphorylated hexaacyl disaccharides (PHADs) for treating or preventing infections
    Patent number: 11389465
    Abstract: The present disclosure relates to phosphorylated hexaacyl disaccharide (PHAD) compounds, compositions, and methods for treating or preventing infections.
    Type: Grant
    Filed: May 1, 2018
    Date of Patent: July 19, 2022
    Assignee: Vanderbilt University
    Inventors: Edward Sherwood, Antonio Hernandez, Julia Bohannon
  • Methods for treating atherosclerosis with gamma-ketoaldehyde scavengers
    Patent number: 11389414
    Abstract: A method of treating atherosclerosis, comprising administering to a patient in need there of an effective gamma-ketoaldehyde scavenging amount of a gamma-ketoaldehyde scavenging compound.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: July 19, 2022
    Assignee: Vanderbilt University
    Inventors: Macrae F. Linton, John A. Oates, Sean S. Davies, L. Jackson Roberts, II, Venkataraman Amarnath, Patricia G. Yancey, Huan Tao
  • Positive allosteric modulators of the muscarinic acetylcholine receptor M4
    Patent number: 11376254
    Abstract: Disclosed herein are tricyclic compounds, including 3-(difluoromethyl)-4-methylpyrimido[4?,5?:4,5]thieno[2,3-c]pyridazin-8-amine compounds, which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.
    Type: Grant
    Filed: December 5, 2018
    Date of Patent: July 5, 2022
    Assignee: Vanderbilt University
    Inventors: Craig W. Lindsley, P. Jeffrey Conn, Darren W. Engers, Julie L. Engers
  • Systems, compositions and methods for treating diabetes
    Patent number: 11357829
    Abstract: This disclosure provides methods for treatment comprising co-administering insulin and glucagon to a subject, and co-formulations comprising insulin and glucagon.
    Type: Grant
    Filed: February 2, 2018
    Date of Patent: June 14, 2022
    Assignee: Vanderbilt University
    Inventors: Alan Cherrington, David Maggs, Soumitra Ghosh, Christopher A. Rhodes, Jui-Chen Lin
  • Antagonists of the muscarinic acetylcholine receptor M
    Patent number: 11352344
    Abstract: Disclosed herein are substituted hexahydro-1H-cyclopenta[c]pyrrole compounds of formula (Ia), which may be useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.
    Type: Grant
    Filed: October 31, 2018
    Date of Patent: June 7, 2022
    Assignee: Vanderbilt University
    Inventors: Craig W. Lindsley, P. Jeffrey Conn, Darren W. Engers, Kayla J. Temple