Abstract: The present disclosure is directed to antibodies binding to and neutralizing the coronavirus designated SARS-CoV-2 and methods for use thereof.
Type:
Grant
Filed:
March 25, 2021
Date of Patent:
May 31, 2022
Assignee:
Vanderbilt University
Inventors:
James E. Crowe, Jr., Seth Zost, Robert Carnahan, Pavlo Gilchuk
Abstract: Disclosed herein are substituted 2-azaspiro[3.3]heptane compounds of formula (I?), which may be useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.
Type:
Grant
Filed:
December 20, 2018
Date of Patent:
May 10, 2022
Assignee:
Vanderbilt University
Inventors:
Craig W. Lindsley, P. Jeffrey Conn, Darren W. Engers, Aaron M. Bender, Logan A. Baker
Abstract: Pyridine quinoline compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease states associated with glutamate dysfunction.
Type:
Grant
Filed:
June 28, 2018
Date of Patent:
May 3, 2022
Assignee:
Vanderbilt University
Inventors:
P. Jeffrey Conn, Craig W. Lindsley, Andrew S. Felts, Colleen M. Niswender, Rory A. Capstick, Paul K. Spearing, Sean R. Bollinger
Abstract: The present invention relates to quinazoline compounds and compositions that modulate Ras signaling. Compounds and compositions of the present invention are useful in the treatment of cancers and other disease states associated with Ras dysfunction (e.g., Ras-associated autoimmune leukoproliferative disorder, or certain types of mitochondrial dysfunction) in a subject, for example a mammal or a human.
Type:
Grant
Filed:
May 17, 2017
Date of Patent:
May 3, 2022
Assignee:
Vanderbilt University
Inventors:
Alex G. Waterson, Jason R. Abbott, J. Phillip Kennedy, Stephen W. Fesik, Qi Sun, Jason Phan, Michael C. Burns, Pratiq Patel
Abstract: Systems and methods for a running controller for a lower limb device including at least a powered knee joint are provided. The method includes collecting real-time sensor information for the lower limb device and configuring the lower limb device to a first state in a finite state model for an activity mode including the running mode. The method further includes, based on the sensor information, transitioning the lower limb device from a current state to a subsequent state in the finite state model for the detected mode when a pre-defined criteria for transitioning to the subsequent state is met, and repeating the transitioning until the activity mode changes. In the system and method, the finite state model includes at least one stance state and at least one swing state, where the at least one stance state includes at least one absorption state and at least one propulsion state.
Type:
Grant
Filed:
April 12, 2019
Date of Patent:
May 3, 2022
Assignee:
Vanderbilt University
Inventors:
Michael Goldfarb, Amanda Shultz, Brian Lawson
Abstract: Disclosed herein are glycidol-based polymers, nanoparticles, and methods related thereto useful for drug delivery. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Type:
Grant
Filed:
February 25, 2020
Date of Patent:
April 19, 2022
Assignee:
Vanderbilt University
Inventors:
Eva M. Harth, Dain B. Beezer, GuangZhao Li, Benjamin R. Spears, David M. Stevens
Abstract: The present invention relates generally to shape memory polymer devices that are porous. The porosity of the device may generate advantageous neovascularization, decrease inflammation, and decrease fibrosis. The device may include a surface having a pore size of 500-750 microns and a pore spacing of 220-250 microns.
Abstract: Disclosed herein are substituted hexahydro-1H-cyclopenta[c]pyrrole compounds, which may be useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.
Type:
Grant
Filed:
October 20, 2018
Date of Patent:
April 12, 2022
Assignee:
Vanderbilt University
Inventors:
Craig W. Lindsley, P. Jeffrey Conn, Darren W. Engers, Julie L. Engers, Kayla J. Temple, Aaron M. Bender, Logan A. Baker
Abstract: Disclosed are catheter systems and methods of using the catheter system to acquire mucosal impedance data of a patient. Also disclosed are methods of classifying or otherwise identifying esophageal conditions in a subject based on mucosal impedance data acquired using a catheter system. Unlike conventions systems that require subjective input from a physician to render a diagnosis, the systems and methods described herein can utilize the mucosal impedance measurements to generate a probability that the subject's esophagus corresponds to an esophageal condition or a set of esophageal conditions. In one embodiment, a classification model is used to generate the probability. The classification model may generate the probability based at least in part on a change in the mucosal impedance measurements between a distal location and a proximal location on the subject's esophagus.
Type:
Grant
Filed:
June 3, 2019
Date of Patent:
April 5, 2022
Assignees:
Diversatek Healthcare, Inc., Vanderbilt University
Inventors:
Michael F. Vaezi, Charles Lindsay, James M. Prinster
Abstract: Provided are improved optical detection systems and methods for using same, which systems and methods comprise single channel interferometric detection systems and methods for determining a characteristic property of samples. Such interferometric detection systems and methods employ a light beam that impinges two or more discrete zones along a channel, thereby avoiding variations that can result in increases in detection limits and/or measurement errors.
Abstract: A device according to one example of principles described herein may include a backplane, electrochemical actuator, and an optical resonator, wherein the electrochemical actuator is located between the backplane and optical resonator. Applied energy may be used to modify the volume of the electrochemical actuator material modifying the resonant/interferometric absorption, transmission, and reflection at visible and/or infrared frequencies.
Type:
Grant
Filed:
September 19, 2018
Date of Patent:
March 29, 2022
Assignee:
Vanderbilt University
Inventors:
Jason G. Valentine, Cary L. Pint, Zachary J. Coppens, Adam P. Cohn
Abstract: An ion manipulation device and systems and methods for controlling the ion manipulation device. The ion manipulation device includes a pair of counter-facing surfaces and a plurality of electrodes arranged in one or more linear array on each of the counter-facing surfaces. At least one RF power source is coupled to the electrodes and configured to apply an RF potential to the electrodes to create an electric field that inhibits charged particles from approaching the counter-facing surfaces. At least one DC power source is coupled to the electrodes and configured to apply a DC potential to affect the movement of ions between the counter-facing surfaces in a direction parallel to the counter-facing surfaces. The DC potential and the RF potential are applied to the electrodes simultaneously.
Type:
Grant
Filed:
January 3, 2019
Date of Patent:
March 1, 2022
Assignee:
Vanderbilt University
Inventors:
Katrina L. Leaptrot, Jody C. May, John A. Mclean
Abstract: Methods of treating bladder or urethra dysfunction or disease in a subject and methods of increasing bladder smooth muscle contractility or increasing bladder wall volume in a subject are disclosed. In some examples, a purine nucleoside phosphorylase (PNPase) inhibitor or purine nucleoside substrate is administered, such as 8-aminoguanine or forodesine.
Type:
Application
Filed:
March 13, 2020
Publication date:
February 24, 2022
Applicants:
University of Pittsburgh - Of the Commonwealth System of Higher Education, Vanderbilt University, The Trustees of The University of Pennsylvania
Inventors:
Edwin Kerry Jackson, Lori Ann Birder, Amanda Sue Wolf-Johnston, Roger Dmochowski, Alan J. Wein
Abstract: In one aspect, the invention relates to polymers, crosslinked polymers, functionalized polymers, nanoparticles, and functionalized nanoparticles and methods of making and using same. In one aspect, the invention relates to degradable polymers and degradable nanoparticles. In one aspect, the invention relates to methods of preparing degradable nanoparticles and, more specifically, methods of controlling particle size during the preparation of degradable nanoparticles. In one aspect, the degradable nanoparticles are useful for complexing, delivering, and releasing payloads, including pharmaceutically active payloads. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Type:
Grant
Filed:
August 21, 2019
Date of Patent:
February 22, 2022
Assignee:
Vanderbilt University
Inventors:
Eva M. Harth, David J. Calkins, Alice E. Van Der Ende
Abstract: Isoquinoline amine compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
Type:
Grant
Filed:
November 8, 2017
Date of Patent:
February 8, 2022
Assignee:
Vanderbilt University
Inventors:
P. Jeffrey Conn, Craig W. Lindsley, Andrew Felts
Abstract: A self-decoupled RF coil and method for adjusting the same is disclosed. The RF coil is an array of elements including at least one loop. Electromagnetic coupling between elements in the array causes an induced current in the at least one loop. The induced current has two modes. A reactance inserted in the at least one loop balances the two modes. The balanced current modes cancel. This cancelation results in self-decoupling of at the least one loop from the other elements in the RF coil array.
Type:
Grant
Filed:
March 21, 2018
Date of Patent:
February 1, 2022
Assignee:
Vanderbilt University
Inventors:
Xinqiang Yan, John C. Gore, William A. Grissom
Abstract: Disclosed herein are octahydropyrrolo[3,4-b]pyrrole compounds of formula (I), which may be useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.
Type:
Grant
Filed:
August 8, 2018
Date of Patent:
January 18, 2022
Assignee:
Vanderbilt University
Inventors:
Craig W. Lindsley, P. Jeffrey Conn, Darren W. Engers, Kayla J. Temple
Abstract: System and methods are provided for characterizing an internal surface of a lens using interferometry measurements. Sphere-fitting a distorted radius determines distorted pathlengths. Ray-tracing simulates refraction at all upstream surfaces to determine a cumulative path length. A residual pathlength is scaled by the group-index and rays are propagated based on the phase-index. After aspheric surface fitting, a corrected radius is determined. To estimate a glass type for the lens, a thickness between focal planes of the lens surfaces is determined using RCM measurements. Then, for both surfaces, the surface is positioned into focus, interferometer path length matching is performed, a reference arm is translated to stationary phase point positions for three wavelengths to determine three per-color optical thicknesses, and ray-tracing is performed. A glass type is identified by minimizing an error function based on optical parameters of the lens and parameters determined from known glass types from a database.
Abstract: An asymmetric linear actuator is provided which integrates a hydraulic dissipater and an electric motor and power screw which generates small forces. The actuator is configured so that an electric motor drives a power screw which drives a rod through a cylinder to provide linear actuation. The cylinder is fluid-filled and incorporates a piston that separates the cylinder into a first and second fluid chamber which are filled with a first and second volume of working fluid. Movement of the piston and rod assembly results in fluid movement between the first and second volumes of working fluid and through the fluidic restriction. The fluidic restriction can be proportionally controllable via an electric motor which enables controllable power dissipation via control of the fluidic restriction motor and controllable power generation via control of the power screw motor.
Type:
Grant
Filed:
January 8, 2021
Date of Patent:
January 4, 2022
Assignee:
Vanderbilt University
Inventors:
Michael Goldfarb, Harrison Bartlett, Brian Lawson