Patents Assigned to Yale University
  • Quinoline amides and methods of using same
    Patent number: 11135213
    Abstract: The present invention provides novel compounds that are quinoline foldamers. Such foldamers stabilize and bind to islet amyloid polypeptide (IAPP). In certain embodiments, the quinoline foldamers of the invention are soluble and cross biological membranes without cellular assistance. The present invention further provides novel method of preventing or treating diabetes in a subject in need thereof by administering to the subject an effective amount of at least one quinoline foldamer of the invention. The present invention further provides novel method of preventing or treating a neurodegenerative disease caused by a misfolded and/or unstructured protein in a subject in need thereof by administering to the subject an effective amount of at least one quinoline foldamer of the invention.
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: October 5, 2021
    Assignee: Yale University
    Inventors: Andrew Miranker, Sunil Kumar
  • Compositions and methods for inhibiting Dkk-1
    Patent number: 11135223
    Abstract: The present invention provides compositions and methods for inhibiting Dkk-1 for treating or preventing an inflammatory or inflammatory-related disease or disorder.
    Type: Grant
    Filed: January 20, 2017
    Date of Patent: October 5, 2021
    Assignee: Yale University
    Inventors: Wook-Jin Chae, Alfred Bothwell
  • Compositions for enhancing targeted gene editing and methods of use thereof
    Patent number: 11136597
    Abstract: Compositions and methods for enhancing targeted gene editing and methods of use thereof are disclosed. In the most preferred embodiments, gene editing is carried out utilizing a gene editing composition such as triplex-forming oligonucleotides, CRISPR, zinc finger nucleases, TALENS, or others, in combination with a gene modification potentiating agent such as stem cell factor (SCF), a CHK1 or ATR inhibitor, or a combination thereof. A particular preferred gene editing composition is triplex-forming peptide nucleic acids (PNAs) substituted at the ? position for increased DNA binding affinity. Nanoparticle compositions for intracellular delivery of the gene editing composition are also provided and particular advantageous for use with in vivo applications.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: October 5, 2021
    Assignees: Yale University, Carnegie Mellon University
    Inventors: W. Mark Saltzman, Peter Glazer, Raman Bahal, Nicole Ali McNeer, Danith H. Ly, Elias Quijano
  • TARGETED MEASURE OF TRANSCRIPTIONAL ACTIVITY RELATED TO HORMONE RECEPTORS
    Publication number: 20210292842
    Abstract: Provided herein are methods of determining tumoral sensitivity to hormonal (endocrine) therapy based upon an index of estrogen receptor (ER)- and progesterone receptor (PR)-related genes, referred to as the sensitivity to endocrine therapy index (SETER/PR index), and may have additional consideration for the proportion of ER gene (ESRI) RNA transcripts that contain a mutation relative to the value of the SETER/PR index. Further provided are methods of treating breast cancer patients determined to be sensitive to an endocrine therapy by the SETER/PR index.
    Type: Application
    Filed: April 28, 2017
    Publication date: September 23, 2021
    Applicants: Board of Regents, The University of Texas System, Yale University
    Inventors: William Fraser SYMMANS, Bruno SINN, Christos HATZIS, Chunxiao FU, Rosanna LAU
  • Compositions and methods for treating nonsteroidal anti-inflammatory drug (NSAID) associated coagulopathy, thrombocytopenia, glanzmann's thrombasthenia, and/or thrombosis
    Patent number: 11123408
    Abstract: The present invention relates to compositions and methods for modulating coagulation through modulating the level or activity of ENPP4.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: September 21, 2021
    Assignee: Yale University
    Inventors: Demetrios Braddock, Ronald Albright
  • Methods and kits for detecting misfolded proteins
    Patent number: 11125758
    Abstract: Methods, kits and compounds are provided that relate to the diagnosis, treatment, and/or prevention of preeclampsia.
    Type: Grant
    Filed: August 17, 2017
    Date of Patent: September 21, 2021
    Assignees: Yale University, The Regents of the University of California
    Inventors: Catalin S. Buhimschi, Irina Buhimschi, Charles G. Glabe
  • System, apparatus, and method for monitoring organic compounds in a gas environment
    Patent number: 11125732
    Abstract: The invention relates to a system and micro monitor apparatus, a space-, time-, and cost-efficient device to concentrate, identify, and quantify organic compounds in gas environments. The invention further relates to a method centered on gas chromatography for identifying and quantifying organic compounds in gas environments, using air as the carrier gas, without the need for a compressed pre-bottled purified carrier gas.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: September 21, 2021
    Assignee: Yale University
    Inventor: Drew Gentner
  • Compositions and methods for treating and preventing pancreatitis, renal injury and cancer
    Patent number: 11124779
    Abstract: The present invention includes compositions and methods for detecting, treating and preventing renal and pancreatic diseases and disorders.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: September 21, 2021
    Assignee: Yale University
    Inventor: Gary Desir
  • DNA BRICK-ASSISTED LIPOSOME SORTING
    Publication number: 20210267894
    Abstract: A method for producing uniform-size liposomes is provided. The liposomes are coated with a sorting agent to yield a plurality of density-modified liposomes of different sizes. These liposomes are then separated using a densitometric method. The sorting agent includes both a density-modifying moiety and a targeting moiety.
    Type: Application
    Filed: January 29, 2021
    Publication date: September 2, 2021
    Applicant: Yale University
    Inventors: Chenxiang LIN, Yang YANG
  • Electrochemical separation and recovery of metals
    Patent number: 11103878
    Abstract: The invention provides a novel filtration apparatus for the selective separation of metals from a mixture thereof. The invention also provides a method for the separation and isolation of metals from a sample using electrochemical precipitation.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: August 31, 2021
    Assignee: Yale University
    Inventors: Megan O'Connor, Desiree Plata
  • Techniques for universal quantum control of quantum coherent states and related systems and methods
    Patent number: 11106991
    Abstract: Some aspects are directed to a method of operating an apparatus, the apparatus comprising a first quantum system having a plurality of coherent quantum states, the first quantum system being coupled to a second quantum system, the method comprising providing an input energy signal to the second quantum system that stimulates energy transfer between the first quantum system and the second quantum system and that causes net dissipation of energy to be output from the second quantum system, wherein the input energy signal includes at least two components having different frequencies and each having an amplitude and a phase, and adiabatically varying the amplitude and the phase of the at least two components of the input energy signal to cause a change in one or more of the plurality of coherent quantum states of the first quantum system.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: August 31, 2021
    Assignee: Yale University
    Inventors: Liang Jiang, Robert J. Schoelkopf, III, Michel Devoret, Victor V. Albert, Stefan Krastanov, Chao Shen
  • MYC G-QUADRUPLEX STABILIZING SMALL MOLECULES AND THEIR USE
    Publication number: 20210261516
    Abstract: Methods for treating a tumor, such as a benign or malignant tumor, are disclosed herein. The methods include administering a therapeutically effective amount of a small molecule that selectively binds to and stabilizes G-quadruplex DNA in the promoter of the c-MYC gene to the subject. The methods are also of use to decrease the size and/or number of metastases. Compounds for use in the disclosed methods are also provided.
    Type: Application
    Filed: May 3, 2021
    Publication date: August 26, 2021
    Applicants: The United States of America, as represented by the Secretary, Department of Health and Human Servic, Yale University
    Inventors: John Schneekloth, JR., John Simmons, Kenneth Felsenstein, Beverly Mock, Lindsey Saunders, Peter Gareiss, David Calabrese, Elena Leon
  • Methods of identifying patients responsive to immunotherapeutic strategies
    Patent number: 11098367
    Abstract: The invention includes a method of determining whether a mammal's cancerous tumor is associated with a hypermutator phenotype (i.e., harboring a large number of mutations) for the DNA Polymerase epsilon (POLE) gene as compared to normal cells. The invention further includes a method of selecting patients harboring an immunogenic tumor that is responsive to immunotherapy.
    Type: Grant
    Filed: January 26, 2015
    Date of Patent: August 24, 2021
    Assignee: Yale University
    Inventor: Alessandro Santin
  • Brillouin laser
    Patent number: 11101616
    Abstract: Techniques for producing a Brillouin laser are provided. According to some aspects, techniques are based on forward Brillouin scattering and a multimode acousto-optic waveguide in which light is scattered between optical modes of the waveguide via the Brillouin scattering. This process may transfer energy from a waveguide mode of pump light to a waveguide mode of Stokes light. This process may be referred to herein as Stimulated Inter-Modal Brillouin Scattering (SIMS). Since SIMS is based on forward Brillouin scattering, laser (Stokes) light may be output in a different direction than back toward the input pump light, and as such there is no need for a circulator or other non-reciprocal device to protect the pump light as in conventional devices.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: August 24, 2021
    Assignee: Yale University
    Inventors: Peter Rakich, Nils Thomas Otterstrom, Eric Andrew Kittlaus, Ryan Orson Behunin, Zheng Barton Wang
  • Time lapse sequencing: a convertible-nucleoside approach to enrichment-free analysis of RNA dynamics
    Patent number: 11098342
    Abstract: The invention provides methods and compositions for generating mutations in new nucleic acid molecules through incorporation of a transformable nucleoside into the nucleic acid and subsequent transformation of the nucleoside through oxidative-nucleophilic-aromatic-substitution chemistry, referred to as TimeLapse chemistry. The invention further provides methods for detecting the mutations, referred to as TimeLapse-seq.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: August 24, 2021
    Assignee: Yale University
    Inventors: Matthew Simon, Jeremy Schofield
  • METHODS AND KITS FOR DETECTING MISFOLDED PROTEINS
    Publication number: 20210255192
    Abstract: Methods, kits and compounds are provided that relate to the diagnosis, treatment, and/or prevention of preeclampsia.
    Type: Application
    Filed: March 2, 2021
    Publication date: August 19, 2021
    Applicant: Yale University
    Inventors: Catalin S. Buhimschi, Irina Buhimschi
  • INDUCTIVELY-SHUNTED TRANSMON QUBIT FOR SUPERCONDUCTING CIRCUITS
    Publication number: 20210258010
    Abstract: Techniques for modifying the Josephson potential of a transmon qubit by shunting the transmon with an inductance are described. The inclusion of this inductance may increase the confined potential of the qubit system compared with the conventional transmon, which may lead to a transmon qubit that is stable at much higher drive energies. The inductive shunt may serve the purpose of blocking some or all phase-slips between the electrodes of the qubit. As a result, the inductively shunted transmon may offer an advantage over conventional devices when used for applications involving high energy drives, whilst offering few to no drawbacks in comparison to conventional devices when used at lower drive energies.
    Type: Application
    Filed: December 11, 2019
    Publication date: August 19, 2021
    Applicant: Yale University
    Inventors: W. Clarke Smith, Jayameenakshi Venkatraman, Xu Xiao, Lucas Verney, Luigi Frunzio, Shyam Shankar, Mazyar Mirrahimi, Michel Devoret
  • Compositions for treating pathological calcification conditions, and methods using same
    Patent number: 11090359
    Abstract: The present invention includes compositions and methods for treating diseases or disorders associated with pathological calcification or pathological ossification. In certain embodiments, the diseases or disorders are selected from the group consisting of Generalized Arterial Calcification of Infancy (GACI), Idiopathic Infantile Arterial Calcification (IIAC), Ossification of the Posterior Longitudinal Ligament (OPLL), hypophosphatemic rickets, osteoarthritis, calcification of atherosclerotic plaques, PXE, hereditary and non-hereditary forms of osteoarthritis, ankylosing spondylitis, hardening of the arteries occurring with aging, calciphylaxis resulting from end stage renal disease and progeria.
    Type: Grant
    Filed: December 27, 2019
    Date of Patent: August 17, 2021
    Assignee: Yale University
    Inventors: Demetrios Braddock, Ronald Albright
  • Method for a GaN vertical microcavity surface emitting laser (VCSEL)
    Patent number: 11095096
    Abstract: Methods and structures for forming vertical-cavity light-emitting devices are described. An n-side or bottom-side layer may be laterally etched to form a porous semiconductor region and converted to a porous oxide. The porous oxide can provide a current-blocking and guiding layer that aids in directing bias current through an active area of the light-emitting device. Distributed Bragg reflectors may be fabricated on both sides of the active region to form a vertical-cavity surface-emitting laser. The light-emitting devices may be formed from III-nitride materials.
    Type: Grant
    Filed: April 15, 2015
    Date of Patent: August 17, 2021
    Assignee: Yale University
    Inventors: Jung Han, Chia-Feng Lin, Danti Chen
  • Tubular Prostheses
    Publication number: 20210236273
    Abstract: Tubular prostheses are provided for use in airways, upper digestive, and urinary tracts. Each of these uses has its own specific sets of biological specifications, based on what it must contain and exclude and the physical and chemical pressures and stresses to which it is subjected. The prostheses may be made from allogeneic cells. Thus they can be manufactured and stored prior to an individual's personal need arising.
    Type: Application
    Filed: April 21, 2021
    Publication date: August 5, 2021
    Applicants: Humacyte, Inc., Yale University
    Inventors: Laura Niklason, Angela Huang, Liping Zhao, Shannon Dahl