Patents Assigned to Yale University
  • Methods and compositions for detecting misfolded proteins
    Patent number: 11079392
    Abstract: Various aspects and embodiments of the present disclosure are directed to methods and compositions (e.g., kits) for the identification of subjects with misfolded proteins in their urine. For example, methods and compositions for determining that a urine sample from a pregnant woman contains or does not contain misfolded are provided. In some embodiments, the presence of misfolded proteins in a urine sample from a pregnant woman is an indication of preeclampsia.
    Type: Grant
    Filed: May 8, 2019
    Date of Patent: August 3, 2021
    Assignee: Yale University
    Inventors: Irina Buhimschi, Catalin S. Buhimschi, Michael Choma, Hemant Tagare, Stephan Michael Jonas
  • METHODS AND SYSTEMS FOR TREATING A SUBJECT USING NIRS FEEDBACK
    Publication number: 20210225194
    Abstract: One aspect of the invention provides a method of treating a subject diagnosed with one or more mental disorders selected from the group consisting of: anxiety disorders, mood disorders, trauma-associated disorders, psychotic disorders, and obsessive-compulsive disorder and related disorders. The method includes: performing near-infrared spectroscopy (NIRS) imaging of one or more regions of interest in the subject's brain; presenting a representation of the NIRS imaging to the subject; and while continuing to perform the performing and presenting steps: presenting a stimulus of anxiety or other symptomatology to the subject; instructing the subject to increase activity in the one or more regions of interest; and instructing the subject to decrease activity in the one or more regions of interest.
    Type: Application
    Filed: June 8, 2017
    Publication date: July 22, 2021
    Applicant: Yale University
    Inventors: Christopher Pittenger, Michelle Hampson
  • TARGETING GENE AMPLIFICATION IN CANCER USING TRIPLEX FORMATION AS A THERAPEUTIC STRATEGY
    Publication number: 20210222175
    Abstract: Disclosed herein are methods and agents for the treatment of cancer using p53-independent apoptosis to reduce the number of cancer cells that have an amplified HER2 gene, such as p53-depleted or p53-mutated cancer cells that have an amplified HER2 gene. Also disclosed herein are methods and agents for the treatment of HER2-positive cancer in individuals with Li-Fraumeni Syndrome.
    Type: Application
    Filed: January 27, 2021
    Publication date: July 22, 2021
    Applicant: Yale University
    Inventor: Faye A. Rogers
  • Fluorescence amplification method for forward genetic discovery of factors in human mRNA degradation
    Patent number: 11060153
    Abstract: The present invention provides systems and methods for performing forward genetic screens in cells and methods of treating disease through inhibiting targets identified in a forward genetic screen as involved in a pathway associated with the disease. The invention involves the use of multiple tandem fluorescent reporter molecules separated by cleavage sites under the control of a single promoter to enhance the fluorescent readout from a cell screen.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: July 13, 2021
    Assignee: Yale University
    Inventors: Andrei Alexandrov, Joan Steitz
  • Tubular prostheses
    Patent number: 11058534
    Abstract: Tubular prostheses are provided for use in airways, upper digestive, and urinary tracts. Each of these uses has its own specific sets of biological specifications, based on what it must contain and exclude and the physical and chemical pressures and stresses to which it is subjected. The prostheses may be made from allogeneic cells. Thus they can be manufactured and stored prior to an individual's personal need arising.
    Type: Grant
    Filed: November 7, 2018
    Date of Patent: July 13, 2021
    Assignees: Humacyte, Inc, Yale University
    Inventors: Laura Niklason, Angela Huang, Liping Zhao, Shannon Dahl
  • TARGETING GENE AMPLIFICATION IN CANCER USING TRIPLEX FORMATION AS A THERAPEUTIC STRATEGY
    Publication number: 20210206874
    Abstract: Disclosed herein are methods and agents for the treatment of cancer using p53-independent apoptosis to reduce the number of p53-depleted or p53-mutated cancer cells that have amplified HER2 gene. Also disclosed herein are methods and agents for the treatment of HER2-positive cancer in individuals with Li-Fraumeni Syndrome.
    Type: Application
    Filed: November 13, 2019
    Publication date: July 8, 2021
    Applicant: Yale University
    Inventor: Faye A. Rogers
  • Genetically modified mice and engraftment
    Patent number: 11051499
    Abstract: A mouse with a humanization of the mIL-3 gene and the mGM-CSF gene, a knockout of a mRAG gene, and a knockout of a mII2rg subunit gene; and optionally a humanization of the TPO gene is described. A RAG/II2rg KO/hTPO knock-in mouse is described. A mouse engrafted with human hematopoietic stem cells (HSCs) that maintains a human immune cell (HIC) population derived from the HSCs and that is infectable by a human pathogen, e.g., S. typhi or M. tuberculosis is described. A mouse that models a human pathogen infection that is poorly modeled in mice is described, e.g., a mouse that models a human mycobacterial infection, wherein the mouse develops one or more granulomas comprising human immune cells. A mouse that comprises a human hematopoietic malignancy that originates from an early human hematopoietic cells is described, e.g., a myeloid leukemia or a myeloproliferative neoplasia.
    Type: Grant
    Filed: March 13, 2019
    Date of Patent: July 6, 2021
    Assignees: Regeneron Pharmaceuticals, Inc., Yale University, Institute for Research in Biomedicine (IRB)
    Inventors: Sean Stevens, Andrew J. Murphy, Richard Flavell, Elizabeth Eynon, Jorge Galan, Tim Willinger, Markus Manz, Anthony Rongvaux, George D. Yancopoulos
  • Method for GaN vertical microcavity surface emitting laser (VCSEL)
    Patent number: 11043792
    Abstract: Structures and methods for forming highly uniform and high-porosity gallium-nitride layers with sub-100-nm pore sizes are described. Electrochemical etching of heavily-doped gallium nitride at low bias voltages in concentrated nitric acid is used to form the porous gallium nitride. The porous layers may be used in reflective structures for integrated optical devices such as VCSELs and LEDs.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: June 22, 2021
    Assignee: Yale University
    Inventors: Jung Han, Cheng Zhang
  • METHODS AND COMPOSITIONS FOR THE DETECTION OF FLAVIVIRUS INFECTIONS
    Publication number: 20210181199
    Abstract: Disclosed are compositions and methods for the detection of a flavivirus infection. In some embodiments, the method comprises detecting a recent flavivirus infection by measuring the amount of anti-NS1 IgG3. In other embodiments, the method comprises detecting a prior Dengue virus infection in a subject previously immunized with a Dengue virus vaccine comprising one or more non-Dengue flavivirus proteins.
    Type: Application
    Filed: May 8, 2018
    Publication date: June 17, 2021
    Applicants: University of Pittsburgh--of the Commonwealth System of Higher Education, Yale University
    Inventors: Ernesto Torres De Azeved MARQUES, Jr., Eduardo NASCIMENTO, Albert Icksang KO, Donald S. BURKE
  • MODULAR, EXTENSIBLE COMPUTER PROCESSING ARCHITECTURE
    Publication number: 20210182073
    Abstract: One aspect of the invention provides a computer processing architecture including: a plurality of processors, each processor configured to: receive a set of data from one or more input channels or from another processor; execute at least one of a plurality of individualized processes on the data; and output the processed data according to an independent clock domain of the processor; a plurality of switches, wherein each switch connects a processor to an input channel of the one or more input channels or to another processor; and a micro-controller configured to: receive the processed data; control the plurality of switches by activating or deactivating each switch; generate a pipeline of processors from activating and deactivating the plurality of switches; and select one or more individualized processes of the plurality of individualized processes that each processor within the pipeline executes.
    Type: Application
    Filed: December 8, 2020
    Publication date: June 17, 2021
    Applicant: Yale University
    Inventors: Ioannis Karageorgos, Karthik Sriram, Jan Vesely, Rajit Manohar, Abhishek Bhattacharjee
  • ENHANCED CHEMILUMINESCENT ENZYME-LINKED IMMUNOSORBENT ASSAY FOR DETECTION OF ANTIBODIES AGAINST BABESIA MICROTI
    Publication number: 20210181190
    Abstract: Identification of immunodominant Babesia microti antigens using genome-wide immunoscreening is described. Candidate antigens were screened against sera from patients with clinical babesiosis. Also described are diagnostic assays with high sensitivity and specificity for detecting B. microti-specific antibodies in patient samples using the identified immunodominant antigens.
    Type: Application
    Filed: November 1, 2018
    Publication date: June 17, 2021
    Applicants: The U.S.A., as represented by the Secretary, Department of Health and Human Services, Yale University
    Inventors: Sanjai Kumar, Nitin Verma, Ankit Puri, Peter J. Krause
  • Techniques for quantum error correction using bosonic modes and related systems and methods
    Patent number: 11037068
    Abstract: Some aspects are directed to a method of operating a circuit quantum electrodynamics system that includes a physical qubit dispersively coupled to a quantum mechanical oscillator, the method comprising measuring a parity of a first state of the quantum mechanical oscillator, subsequent to measuring the parity of the first state, measuring a parity of a second state of the quantum mechanical oscillator, the second state being different from the first state, applying a first drive waveform to the quantum mechanical oscillator, and applying a second drive waveform to the physical qubit concurrent with the application of the first drive waveform, wherein the first drive waveform and the second drive waveform are selected based at least in part on a result of comparing the measured parity of the second state to the measured parity of the first state.
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: June 15, 2021
    Assignee: Yale University
    Inventors: Steven M. Girvin, Liang Jiang, Marios H. Michael, Matti Silveri, Richard T. Brierley, Victor V. Albert, Juha Salmilehto
  • INTERPRETABLE DEEP MACHINE LEARNING FOR CLINICAL RADIO;OGY
    Publication number: 20210174154
    Abstract: One aspect of the invention provides a computer-implemented method of identifying one or more clinical factors associated with an artificial intelligence prediction. The computer implemented method includes: applying a previously trained deep neural network to one or more images for a subject to produce a prediction, the previously trained deep neural network comprising a plurality of nodes; comparing outputs of the nodes to previously identified patterns of node outputs for a plurality of individual clinical factors; and identifying which of the plurality of individual clinical factors are most correlated with the outputs of the nodes.
    Type: Application
    Filed: August 7, 2019
    Publication date: June 10, 2021
    Applicant: Yale University
    Inventors: James S. Duncan, Brian Letzen, Julius Chapiro, Clinton Wang
  • Genetically modified non-human animals and methods of use thereof
    Patent number: 11026408
    Abstract: The invention relates generally to genetically modified non-human animals expressing human polypeptides and their methods of use.
    Type: Grant
    Filed: September 27, 2019
    Date of Patent: June 8, 2021
    Assignees: Regeneron Pharmaceuticals, Inc., Yale University, Institute for Research in Biomedicine (IRB)
    Inventors: Richard Flavell, Markus Manz, Anthony Rongvaux, Till Strowig, Tim Willinger, Andrew J. Murphy, Sean Stevens, George Yancopoulos
  • Modulators of BTK proteolysis and methods of use
    Patent number: 11028088
    Abstract: The present disclosure relates to bifunctional compounds, which find utility as modulators of Burton's Tyrosine Kinase (BTK). In particular, the present disclosure is directed to bifunctional compounds. One end of a bifunctional compound includes a Von Hippel-Lindau, Cereblon, Inhibitors of Apotosis Proteins, or Mouse Double-Minute Homolog 2 ligand that binds to the respective E3 ubiquitin ligase. The other end of a bifunctional compound includes a moiety that binds a target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. Diseases or disorders that result from aggregation, accumulation, and/or overactivation of the target protein can be treated or prevented with compounds and compositions of the present disclosure.
    Type: Grant
    Filed: March 8, 2019
    Date of Patent: June 8, 2021
    Assignee: Yale University
    Inventors: Craig M. Crews, Saul Jaime-Figueroa, Momar Toure
  • Method to make buried, highly conductive p-type III-nitride layers
    Patent number: 11018231
    Abstract: A conductive, porous gallium-nitride layer can be formed as an active layer in a multilayer structure adjacent to one or more p-type III-nitride layers, which may be buried in a multilayer stack of an integrated device. During an annealing process, dopant-bound atomic species in the p-type layers that might otherwise neutralize the dopants may dissociate and out-diffuse from the device through the porous layer. The release and removal of the neutralizing species may reduce layer resistance and improve device performance.
    Type: Grant
    Filed: November 30, 2015
    Date of Patent: May 25, 2021
    Assignee: Yale University
    Inventors: Jung Han, Yufeng Li, Cheng Zhang, Sung Hyun Park
  • Techniques for coupling qubits to acoustic resonators and related systems and methods
    Patent number: 11017310
    Abstract: Techniques for operating a mechanical oscillator as a quantum memory are described. According to some aspects, a qubit may be coupled to a piezoelectric material such that the electric field of the qubit causes stress within the piezoelectric material. The piezoelectric material may be in contact with a crystalline substrate forming an acoustic resonator such that the qubit couples to bulk acoustic waves in the crystalline substrate via its interaction with the piezoelectric material. According to some aspects, application of a suitable electromagnetic pulse to the qubit may cause an exchange of energy from the qubit to the acoustic phonon system and thereby transfer quantum information from the qubit to the phonon system.
    Type: Grant
    Filed: February 28, 2018
    Date of Patent: May 25, 2021
    Assignee: Yale University
    Inventors: Yiwen Chu, Prashanta Kharel, William Renninger, Luke Burkhart, Luigi Frunzio, Peter Rakich, Robert J. Schoelkopf, III
  • Systems and methods for particulate removal using polymeric microstructures
    Patent number: 11001785
    Abstract: Systems and methods for removing particles from a surface of a substrate without damage to the substrate are provided. The disclosed systems/methods use polymeric microstructures, e.g., microfibrils, to remove micrometric and sub-micrometric particles from a substrate surface by establishing interfacial interactions with the particles that effectively debond the particles from the surface of the substrate. The disclosed systems/methods have wide ranging applications, including particle removal in art conservation processes, microelectronic applications, optical applications and any other field that stands to benefit from precise removal of particles/dust from a surface without damage to the surface.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: May 11, 2021
    Assignee: Yale University
    Inventors: Hadi Izadi, T Kyle Vanderlick
  • QUANTUM INFORMATION PROCESSING WITH AN ASYMMETRIC ERROR CHANNEL
    Publication number: 20210125096
    Abstract: Techniques for performing quantum information processing using an asymmetric error channel are provided. According to some aspects, a quantum information processing includes a data qubit and an ancilla qubit, the ancilla qubit having an asymmetric error channel. The data qubit is coupled to the ancilla qubit. The ancilla qubit may be driven with a stabilizing microwave field to create the asymmetric error channel.
    Type: Application
    Filed: June 28, 2019
    Publication date: April 29, 2021
    Applicant: Yale University
    Inventors: Shruti Puri, Alexander Grimm, Philippe Campagne-lbarcq, Steven M. Girvin, Michel Devoret
  • System, device and method for high-throughput multi-plexed detection
    Patent number: 10983116
    Abstract: The present invention relates to a system, device, and method for the high throughput multiplexed detection of a wide number of compounds. The invention comprises of a microwell array coupled to a capture agent array to form a plurality of interfaces between a microwell and a set of immobilized capture agents. The set of capture agents comprises a plurality of distinguishable features, with each feature corresponding to the detection of a particular compound of interest. In certain embodiments, each microwell is configured to contain a single cell. The invention is therefore capable of performing a high throughput analysis of single cell profiles, including profiles of secreted compounds.
    Type: Grant
    Filed: March 6, 2019
    Date of Patent: April 20, 2021
    Assignee: Yale University
    Inventors: Rong Fan, Yao Lu, Jonathan Chen