Patents Assigned to Yale University
  • MicroRNAs as biomarkers for endometriosis
    Patent number: 10982282
    Abstract: Disclosed herein are compositions and methods useful for the diagnosis, assessment, and characterization of endometriosis in a subject in need thereof, based upon the expression level of at least one miRNA that is associated with endometriosis.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: April 20, 2021
    Assignee: Yale University
    Inventor: Hugh Taylor
  • Biaryltriazole inhibitors of macrophage migration inhibitory factor
    Patent number: 10968198
    Abstract: The present disclosure describes biaryl triazole compounds, as well as their compositions and methods of use. The compounds inhibit the activity of macrophage migration inhibitory factor and are useful for the treatment of diseases, e.g., inflammatory diseases and cancer.
    Type: Grant
    Filed: May 22, 2019
    Date of Patent: April 6, 2021
    Assignee: Yale University
    Inventors: William L. Jorgensen, Pawel Dziedzic, Jose Cisneros
  • DETERMINISTIC BARCODING FOR SPATIAL OMICS SEQUENCING
    Publication number: 20210095331
    Abstract: Provided herein, in some embodiments, are compositions and methods for producing a molecular expression map of a biological sample using Deterministic Barcoding in Tissue for spatial omics sequencing (DBiT-seq).
    Type: Application
    Filed: September 29, 2020
    Publication date: April 1, 2021
    Applicant: Yale University
    Inventors: Rong Fan, Yang Liu, Yanxiang Deng
  • Compositions for treating pathological calcification conditions, methods, and host cells using the same
    Patent number: 10960049
    Abstract: The present invention includes compositions and methods for treating diseases or disorders associated with pathological calcification or pathological ossification. In certain embodiments, the diseases or disorders are selected from the group consisting of Generalized Arterial Calcification of Infancy (GACI), Idiopathic Infantile Arterial Calcification (IIAC), Ossification of the Posterior Longitudinal Ligament (OPLL), hypophosphatemic rickets, osteoarthritis, calcification of atherosclerotic plaques, PXE, hereditary and non-hereditary forms of osteoarthritis, ankylosing spondylitis, hardening of the arteries occurring with aging, calciphylaxis resulting from end stage renal disease and progeria.
    Type: Grant
    Filed: November 14, 2017
    Date of Patent: March 30, 2021
    Assignee: Yale University
    Inventors: Demetrios Braddock, Ronald Albright
  • Methods for treating pseudoxanthoma elasticum (PXE)
    Patent number: 10960050
    Abstract: The present invention includes compositions and methods for treating diseases or disorders associated with pathological calcification or pathological ossification. In certain embodiments, the diseases or disorders are selected from the group consisting of Generalized Arterial Calcification of Infancy (GACI), Idiopathic Infantile Arterial Calcification (IIAC), Ossification of the Posterior Longitudinal Ligament (OPLL), hypophosphatemic rickets, osteoarthritis, calcification of atherosclerotic plaques, PXE, hereditary and non-hereditary forms of osteoarthritis, ankylosing spondylitis, hardening of the arteries occurring with aging, calciphylaxis resulting from end stage renal disease and progeria.
    Type: Grant
    Filed: March 25, 2020
    Date of Patent: March 30, 2021
    Assignee: Yale University
    Inventors: Demetrios Braddock, Ronald Albright
  • Cell-penetrating anti-DNA antibodies and uses thereof inhibit DNA repair
    Patent number: 10961301
    Abstract: Antibodies that penetrate cell nuclei and inhibit DNA repair or interfere with DNA metabolism are provided for treatment of cancer (both directly and by sensitizing cancer cells to DNA-damaging treatments) or inhibiting or preventing viral infection, proliferation or metabolism. The method involves treating cells with a composition containing cell-penetrating anti-DNA antibodies or derivatives thereof, alone or in combination with treatment that induces DNA damage such as DNA-damaging chemotherapy or radiation. The impact of the cell-penetrating anti-DNA antibodies or derivatives thereof is potentiated in cancer cells that are deficient in DNA repair, and the cell-penetrating anti-DNA antibodies or derivatives thereof are synthetically lethal to cancer cells with DNA repair deficiencies.
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: March 30, 2021
    Assignees: Yale University, The Regents of the University of California, The United States Government Represented by the Department of Veterans Affairs
    Inventors: James E. Hansen, Peter M. Glazer, Richard H. Weisbart, Robert N. Nishimura, Grace Chan
  • SINGLE-CELL FREEZE-THAW LYSIS
    Publication number: 20210087549
    Abstract: Provided herein, in some embodiments, are high-throughput single-cell mRNA profiling methods that include freeze-thaw cycling as the means to release mRNA from cells.
    Type: Application
    Filed: February 22, 2019
    Publication date: March 25, 2021
    Applicant: Yale University
    Inventors: Rong Fan, Burak Dura
  • Methods for inducing tumor regression, inhibiting tumor growth, and inducing apoptosis in breast tumors with geranylgeranyltransferase I inhibitors
    Patent number: 10946012
    Abstract: Methods of inducing tumor regression, inhibiting tumor growth, and inducing apoptosis with selective peptidomimetic inhibitors of geranylgeranyltransferase I (GGTase I), are provided. In one aspect, GGTI-2418 and its methylester GGTI-2417, increase levels of the cyclin-dependent kinase (Cdk) inhibitor p27Kip1 and induce breast tumor regression in vivo. In another aspect, GGTI-2417 inhibits the Cdk2-mediated phosphorylation of p27Kip1 at Thr187 and accumulates p27Kip1 in the nucleus.
    Type: Grant
    Filed: July 29, 2011
    Date of Patent: March 16, 2021
    Assignees: H. Lee Moffitt Cancer Center and Research Institute, Inc., Yale University
    Inventors: Said M. Sebti, Andrew D. Hamilton
  • Methods and tools for detecting, diagnosing, predicting, prognosticating, or treating a neurobehavioral phenotype in a subject
    Patent number: 10950327
    Abstract: The present tools and methods for detecting, diagnosing, predicting, prognosticating, or treating a neurobehavioral phenotype in a subject. These tools and methods relates to a genotype and neurophenotype topography-based approach for analyzing brain neuroimaging and gene expression maps to identify drug targets associated with neurobehavioral phenotypes and, conversely, neurobehavioral phenotypes associated with potential drug targets, to develop rational design and application of pharmacological therapeutics for brain disorders, and to provide methods and tools for treatment of subjects in need of neurological therapy.
    Type: Grant
    Filed: March 7, 2019
    Date of Patent: March 16, 2021
    Assignees: BlackThorn Therapeutics, Inc., Yale University
    Inventors: John D. Murray, Alan Anticevic, William J. Martin
  • Interferon production using short RNA duplexes
    Patent number: 10947543
    Abstract: The present invention provides a small hairpin nucleic acid molecule that is capable of stimulating interferon production. The nucleic acid molecule of the present invention has a double-stranded section of less than 19 base pairs and at least one blunt end. In certain embodiments, the molecule comprises a 5? triphosphate or a 5? diphosphate.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: March 16, 2021
    Assignee: Yale University
    Inventors: Anna Marie Pyle, Andrew Kohlway, Dahai Luo, David Rawling, Akiko Iwasaki
  • Magnetic resonance imaging with spatial encoding by fast moving or vibrating magnetic field generator components
    Patent number: 10935615
    Abstract: A magnet assembly for magnetic resonance imaging is used to generate the basic magnetic field with a strength needed to produce the steady state or equilibrium position of nuclei or nuclear spins in magnetic resonance imaging. This magnet, or a part thereof, is vibrated or tilted or otherwise periodically moved so as to change its position and thereby generate a time-varying gradient field, which is used to enter the acquired magnetic resonance signals as raw data into k-space.
    Type: Grant
    Filed: March 27, 2019
    Date of Patent: March 2, 2021
    Assignees: Yale University, Siemens Healthcare GmbH
    Inventors: Markus Vester, Peter Speier, Stefan Popescu, Edgar Mueller, Robert Todd Constable, Gigi Galiana
  • Methods for inducing the differentiation of blood monocytes into functional dendritic cells
    Patent number: 10934526
    Abstract: Methods are provided for treating blood monocytes to produce functional antigen presenting dendritic cells. An extracorporeal quantity of a subject's blood is treated to separate the blood and produce a leukocyte concentrate comprising monocytes and plasma containing proteins. The leukocyte concentrate comprising monocytes and plasma containing proteins is pumped through a plastic treatment device, such as a photopheresis device. The resulting treated cells may be incubated for a sufficient period of time to allow the monocytes to form dendritic cells, or the treated cells may be reinfused directly to the subject.
    Type: Grant
    Filed: September 19, 2018
    Date of Patent: March 2, 2021
    Assignee: Yale University
    Inventor: Richard Leslie Edelson
  • Compositions and methods for treating an inflammatory disease or disorder
    Patent number: 10925953
    Abstract: The invention relates to compositions and methods for treating inflammatory diseases and disorders in a subject in need thereof. In certain aspects, the invention relates to immunogenic compositions (e.g., vaccines) to diminish the number or pathogenic effects of one or more bacteria associated with the development or progression of an inflammatory disease or disorder.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: February 23, 2021
    Assignee: Yale University
    Inventors: Richard Flavell, Noah Palm, Marcel De Zoete
  • USES OF PARASITE MACROPHAGE MIGRATION INHIBITORY FACTORS
    Publication number: 20210030859
    Abstract: This invention relates to compositions (e.g. vaccine compositions) which can be used to provide a subject with protective immunity against a parasite infection. The compositions comprise: (i) an immunologically effective amount of a nucleic acid (e.g. a nucleic acid-based vaccine) comprising a sequence which encodes a parasite macrophage migration inhibitory factor (MIF) antigen; (ii) a parasite MIF antigen; or (iii) an antibody which specifically binds to a parasite MIF antigen. The compositions may be used to treat infections and diseases caused by parasitic protozoans, such as a Plasmodium parasite, or parasitic helminths.
    Type: Application
    Filed: October 16, 2020
    Publication date: February 4, 2021
    Applicants: Yale University, GlaxoSmithKline Biologicals SA
    Inventors: Richard BUCALA, Andrew GEALL
  • Applicators suitable for brachytherapy and methods using same
    Patent number: 10905899
    Abstract: The invention provides a two-step tapered applicator, which can be used to deliver high-dose-rate vaginal brachytherapy to a female patient's vagina post-hysterectomy. In certain embodiments, once inserted through the female patient's vaginal opening (or introitus), the applicator of the invention causes less physical discomfort to the female patient than currently available applicators. In other embodiments, the applicator is used in a female patient whose vaginal apex is larger in diameter than her vaginal introitus.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: February 2, 2021
    Assignee: Yale University
    Inventors: Amandeep Mahal, James Yu, Shari Damast, Rajwant Mahal
  • Systems and Methods for Chip-Scale Lasers with Low Spatial Coherence and Directional Emission
    Publication number: 20210028602
    Abstract: Exemplary embodiments of the present disclosure include chip-scale laser sources, such as semiconductor laser sources, that produce directional beams with low spatial coherence. The lasing modes are based on the axial orbit in a stable cavity and have good directionality. To reduce the spatial coherence of emission, the number of transverse lasing modes can be increased by fine-tuning the cavity geometry. Decoherence is reached in as little as several nanoseconds. Such rapid decoherence facilitates applications in ultrafast speckle-free full-field imaging.
    Type: Application
    Filed: July 24, 2020
    Publication date: January 28, 2021
    Applicant: Yale University
    Inventors: Hui Cao, Stefan Wolfgang Bittner, Kyungduk Kim
  • Genotype-guided dosing of opioid receptor agonists
    Patent number: 10900082
    Abstract: Provided herein, in some aspects, are methods of dosing opioid receptor agonists for treatment of opioid dependence and pain management.
    Type: Grant
    Filed: January 24, 2018
    Date of Patent: January 26, 2021
    Assignees: Yale University, The Trustees of the University of Pennsylvania
    Inventors: Joel Gelernter, Andrew Smith, Henry R. Kranzler
  • Macrophage migration inhibitory factor inhibitors, and methods of making and using same
    Patent number: 10899739
    Abstract: The present invention provides novel inhibitors of MIF tautomerase activity. In certain embodiments, the compounds of the invention are useful in treating or preventing inflammatory and/or auto-immune diseases. In other embodiments, the compounds of the invention are useful in reversing, ameliorating, and/or preventing tumor growth. In yet other embodiments, the compounds of the invention are useful in reversing, ameliorating, and/or preventing angiogenesis.
    Type: Grant
    Filed: November 12, 2018
    Date of Patent: January 26, 2021
    Assignee: Yale University
    Inventor: William L. Jorgensen
  • SUPERCONDUCTING NONLINEAR ASYMMETRIC INDUCTIVE ELEMENT AND RELATED SYSTEMS AND METHODS
    Publication number: 20210021245
    Abstract: A superconducting device includes two nodes and a Josephson junction coupled between the two nodes, wherein the Josephson junction is characterized by a superconducting phase difference, ?, wherein the superconducting device has a potential that varies as a function of the superconducting phase difference, ?, and has a single potential well. The potential has a non-zero cubic term and quartic term is zero. The Josephson junction may be a single small Josephson junction. The superconducting device may include a superconducting ring connected between the two nodes. The superconducting ring may include a first ring portion with a plurality of large Josephson junctions connected in series. The superconducting ring may also include a second ring portion that includes the single small Josephson junction in parallel with the plurality of large Josephson junctions between the two nodes.
    Type: Application
    Filed: December 11, 2018
    Publication date: January 21, 2021
    Applicant: Yale University
    Inventors: Nicholas Frattini, Uri Vool, Shyam Shankar, Anirudh Narla, Katrina Sliwa, Michel Devoret, Volodymyr Sivak
  • Stacking fault-free semipolar and nonpolar GaN grown on foreign substrates by eliminating the nitrogen polar facets during the growth
    Patent number: 10896818
    Abstract: Methods and structures for forming epitaxial layers of Ill-nitride materials on patterned foreign substrates with low stacking fault densities are described. Semipolar and nonpolar orientations of GaN that are essentially free from stacking faults may be grown from crystal-growth facets of a patterned substrate. Etching can be used to remove stacking faults if present. Crystal growth with an impurity can eliminate crystal growth from a facet that is responsible for stacking fault formation and permit substantially stacking-fault-free growth of the Ill-nitride material.
    Type: Grant
    Filed: August 11, 2017
    Date of Patent: January 19, 2021
    Assignee: Yale University
    Inventors: Jung Han, Jie Song