Patents Assigned to Yissum Research Development Company of the Hebrew University
  • Publication number: 20190185516
    Abstract: Provided are backbone cyclized peptides that interfere with signaling of the intracellular adaptor protein MyD88. Pharmaceutical compositions including these backbone cyclized peptides as well as their use in treatment of multiple sclerosis (MS) and other diseases associated with MyD88 signaling are also disclosed.
    Type: Application
    Filed: June 4, 2017
    Publication date: June 20, 2019
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Gabriel NUSSBAUM, Amnon HOFFMAN, Chaim GILON
  • Patent number: 10315953
    Abstract: Bismuth oxyhalide-added building materials are disclosed. The building material is a binder-containing building material, which sets and harden when mixed with water, such as gypsum and cement-based building material. Methods for applying bismuth oxyhalide—comprising coatings onto surfaces of building materials, to protect them against pollutants, are described.
    Type: Grant
    Filed: February 7, 2016
    Date of Patent: June 11, 2019
    Assignee: Yissum Research Development Company of The Hebrew University of Jerusalem Ltd
    Inventors: Yoel Sasson, Hani Gnayem
  • Publication number: 20190169256
    Abstract: Peptide-based neurokinin antagonists of fish reproduction are disclosed. Compositions comprising antagonists of fish neurokinin and methods of inhibiting or delaying puberty, fish maturation or reproduction processes using these compounds are also provided.
    Type: Application
    Filed: October 30, 2018
    Publication date: June 6, 2019
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Berta LEVAVI-SIVAN, Chaim GILON
  • Publication number: 20190169686
    Abstract: The invention relates to a hybrid structure comprising perforated solid substrate having at least one nanopore perforating therethrough, and devices and uses thereof.
    Type: Application
    Filed: December 10, 2018
    Publication date: June 6, 2019
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Danny PORATH, Oded SHOSEYOV, Yuval NEVO, Ke LIU, Dvir MAROM ROTEM
  • Patent number: 10309958
    Abstract: A system for detecting target elements such as bacteria in a host analyte, comprising a substrate with an ordered array of wells having diameters to fit the size of the targets. The substrate may be a periodic macro-PSi array structure (MPSiAS) illuminated with a broadband source. The reflected light spectrum diffracted from the substrate is optically analyzed to provide the effective optical depth of the wells. Fast Fourier Transform analysis may be used for the optical analysis. Entry of target elements into wells is detected by the change in the effective optical depths of the wells. Micro-organisms as large as bacteria and viruses having dimensions comparable with the wavelength of the illumination can thus be detected. Wells with an inner section impenetrable by the target cells enables compensation for environmental changes. The detection may be performed in real time, such that production line bacterial monitoring may be achieved.
    Type: Grant
    Filed: March 25, 2014
    Date of Patent: June 4, 2019
    Assignees: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD., TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
    Inventors: Amir Sa'ar, Ester Segal
  • Publication number: 20190164302
    Abstract: A method and a system for generating adaptive fast forward of egocentric videos are provided here. The method may include the following steps: obtaining a video footage containing a sequence of image frames captured by a non-stationary capturing device; estimating a moving direction of the non-stationary capturing device for a plurality of frames in the sequence of image frames; and generating a shortened video footage having fewer frames than said video footage, by sampling the sequence of image frames, wherein the sampling is carried out by selecting specific image frames and that minimize an overall cost associated with a deviation from a specific direction related to the moving direction, calculated for each of said plurality of image frames.
    Type: Application
    Filed: January 8, 2019
    Publication date: May 30, 2019
    Applicant: Yissum Research Development Company of The Hebrew University of Jerusalem Ltd.
    Inventors: Shmuel PELEG, Yair POLEG, Tavi HALPERIN, Chetan ARORA
  • Patent number: 10294383
    Abstract: The invention provides articles and methods for making such articles including a substrate coated on at least one region thereof with a layer of nanocomposites nano-cellulose materials and nanoparticles.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: May 21, 2019
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Oded Shoseyov, Yossef Paltiel, Shira Yochelis, Sigal Baruch-Sharon, Yuval Nevo
  • Publication number: 20190144924
    Abstract: Provided are molecular entities capable of transforming, aggregating or assembling into a three dimensional biosensors.
    Type: Application
    Filed: November 10, 2016
    Publication date: May 16, 2019
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Meital RECHES, Priyadip DAS
  • Patent number: 10287271
    Abstract: In a first aspect, the present invention relates to new compounds as depicted in formula (I). In particular, compounds according to the present invention are bisindolylcyclobuten-dione-based structures having antiprotozoal activity. In a further aspect, pharmaceutical compositions containing the same are provided as well as the use of the compounds and pharmaceutical compositions for the prophylaxis and treatment of parasite based diseases including malaria. Finally, methods for the treatment of parasite diseases including malaria are provided.
    Type: Grant
    Filed: July 10, 2015
    Date of Patent: May 14, 2019
    Assignees: TECHNISCHE UNIVERSITAET BRAUNSCHWEIG, YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Conrad Kunick, Hoang Lande, Johann Gruenefeld, Ron Dzikowski, Abed Nasereddin
  • Patent number: 10290754
    Abstract: The invention disclosed concerns a simple ring-hub arrangement of interacting two-level systems using a theoretical quantum jump approach which mimics a biological light-harvesting antenna connected to a reaction center.
    Type: Grant
    Filed: November 14, 2013
    Date of Patent: May 14, 2019
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Yossef Paltiel, Shira Yochelis, Nir Keren, Ido Eisenberg
  • Patent number: 10287331
    Abstract: Disclosed are fusion protein constructs comprising a functional mitochondrial protein, that can enter mitochondria within intact cells. Further disclosed are methods of treating mitochondrial disorders by the disclosed fusion proteins and compositions therefor.
    Type: Grant
    Filed: April 10, 2014
    Date of Patent: May 14, 2019
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Haya Lorberboum-Galski, Hagar Greif
  • Publication number: 20190135622
    Abstract: The invention provides a process for the production of hydrogen, comprising catalytically decomposing a concentrated aqueous solution of potassium formate in a reaction vessel to form bicarbonate slurry and hydrogen, discharging the hydrogen from said reaction vessel, and treating a mixture comprising the bicarbonate slurry and the catalyst with an oxidizer, thereby regenerating the catalyst. Pd/C catalysts useful in the process are also described.
    Type: Application
    Filed: December 28, 2018
    Publication date: May 9, 2019
    Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Yoel SASSON, Harold WIENER, Ariel GIVANT
  • Patent number: 10280209
    Abstract: The present disclosure relates to a method for the treatment of a non-pathogen associated inflammatory disorders in a subject in need thereof, comprising administering to said subject an isolated peptide which specifically binds to an amino acid sequence within the dimer interface of a T cell costimulatory pathway member, particularly the T cell costimulatory pathway members CD28 and CTLA4. The present disclosure also relates to pharmaceutical compositions comprising the isolated peptide and to use of the peptide in treating of a non-pathogen associated inflammatory disorders.
    Type: Grant
    Filed: March 27, 2018
    Date of Patent: May 7, 2019
    Assignees: ATOX BIO LTD., YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD
    Inventors: Raymond Kaempfer, Anat Shirvan, Gila Arad
  • Patent number: 10268077
    Abstract: A polarized light source configured for use in display device and backlight unit is described. The polarized light source comprising: at least one optically active structure comprising a plurality of nanorods configured to emit light of one or more wavelengths in response to exciting pumping field, said plurality of nanorods comprising nanorods aligned with a predetermined alignment axis so as to produce a desired polarization direction of the emitted light; and a light directing assembly comprising one or more optical elements in optical path of light emitted from the light emitting structure, said light directing assembly being configured to enhance output of the emitted light from the emitting structure while substantially maintaining the polarization of the emitted light passing therethrough. Preferably, layers associated with the polarized light source are aligned with parallel principal axes.
    Type: Grant
    Filed: June 25, 2018
    Date of Patent: April 23, 2019
    Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Qlight Nanotech Ltd.
    Inventors: Uri Banin, Ehud Shaviv, Hagai Arbell
  • Publication number: 20190106418
    Abstract: The present invention relates to a compound or a pharmaceutically acceptable salt thereof or a solvate thereof or a pharmaceutical composition comprising said compound, a process for obtaining or screening for a toll-like receptor 9 (TLR9) antagonist and a toll-like receptor 9 (TLR9) antagonist or a pharmaceutically acceptable salt thereof or a solvate thereof, preferably being obtainable thereby.
    Type: Application
    Filed: March 24, 2016
    Publication date: April 11, 2019
    Applicants: FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWAND TEN FORSCHUNG E.V., YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, LTD.
    Inventors: Anke BURGER-KENTISCHER, Angela MATTES, Maria ZATSEPIN, Amriam GOLDBLUM
  • Publication number: 20190106453
    Abstract: Provided is a conductive nucleic acid-metal complex including a polyG and PolyC consisting nucleic acids associated with a plurality of metal atoms, and methods for its preparation.
    Type: Application
    Filed: February 28, 2017
    Publication date: April 11, 2019
    Applicants: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Ramot at Tel-Aviv University Ltd.
    Inventors: Danny PORATH, Dvir MAROM ROTEM, Alexander KOTLYAR, Genady EIDELSHTEIN
  • Publication number: 20190100732
    Abstract: An isolated polynucleotide encoding a fusion protein which comprises a catalytically inactive CRISPR associated 9 (dCas9) protein linked to a TET protein is disclosed. Use thereof and of the fusion protein itself is also disclosed.
    Type: Application
    Filed: June 2, 2017
    Publication date: April 4, 2019
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Asaf HELLMAN, Nurit MERON
  • Patent number: 10239903
    Abstract: Provided are Pt (IV) lipophilic derivatives for improved drug performance in cancer therapy, as well as nanocarriers including the same.
    Type: Grant
    Filed: April 30, 2015
    Date of Patent: March 26, 2019
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Simon Benita, Taher Nassar, Dan Gibson, Aiman Abu Ammar
  • Patent number: 10239848
    Abstract: Compositions that include certain phenyl substituted cyclohexenyl compounds are administered to a subject in a method for treating obesity or an associated disease or disorder or in a method of reducing food consumption or body weight.
    Type: Grant
    Filed: November 22, 2017
    Date of Patent: March 26, 2019
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Ruth Gallily, Raphael Mechoulam, Aviva Breuer
  • Patent number: 10234726
    Abstract: A polarized light source configured for use in display device and backlight unit is described. The polarized light source comprising: at least one optically active structure comprising a plurality of nanorods configured to emit light of one or more wavelengths in response to exciting pumping field, said plurality of nanorods comprising nanorods aligned with a predetermined alignment axis so as to produce a desired polarization direction of the emitted light; and a light directing assembly comprising one or more optical elements in optical path of light emitted from the light emitting structure, said light directing assembly being configured to enhance output of the emitted light from the emitting structure while substantially maintaining the polarization of the emitted light passing therethrough. Preferably, layers associated with the polarized light source are aligned with parallel principal axes.
    Type: Grant
    Filed: June 25, 2018
    Date of Patent: March 19, 2019
    Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Qlight Nanotech Ltd.
    Inventors: Uri Banin, Ehud Shaviv, Hagai Arbell