Patents Assigned to Yissum Research Development Company of the Hebrew University
  • COMPLEXES OF NUCLEIC ACID MOLECULES AND METALS
    Publication number: 20190106453
    Abstract: Provided is a conductive nucleic acid-metal complex including a polyG and PolyC consisting nucleic acids associated with a plurality of metal atoms, and methods for its preparation.
    Type: Application
    Filed: February 28, 2017
    Publication date: April 11, 2019
    Applicants: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Ramot at Tel-Aviv University Ltd.
    Inventors: Danny PORATH, Dvir MAROM ROTEM, Alexander KOTLYAR, Genady EIDELSHTEIN
  • ASSAY FOR THE REMOVAL OF METHYL-CYTOSINE RESIDUES FROM DNA
    Publication number: 20190100732
    Abstract: An isolated polynucleotide encoding a fusion protein which comprises a catalytically inactive CRISPR associated 9 (dCas9) protein linked to a TET protein is disclosed. Use thereof and of the fusion protein itself is also disclosed.
    Type: Application
    Filed: June 2, 2017
    Publication date: April 4, 2019
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Asaf HELLMAN, Nurit MERON
  • Pt (IV) derivatives and nanocarriers comprising them
    Patent number: 10239903
    Abstract: Provided are Pt (IV) lipophilic derivatives for improved drug performance in cancer therapy, as well as nanocarriers including the same.
    Type: Grant
    Filed: April 30, 2015
    Date of Patent: March 26, 2019
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Simon Benita, Taher Nassar, Dan Gibson, Aiman Abu Ammar
  • Cyclohexenyl compounds, compositions comprising them and uses thereof
    Patent number: 10239848
    Abstract: Compositions that include certain phenyl substituted cyclohexenyl compounds are administered to a subject in a method for treating obesity or an associated disease or disorder or in a method of reducing food consumption or body weight.
    Type: Grant
    Filed: November 22, 2017
    Date of Patent: March 26, 2019
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Ruth Gallily, Raphael Mechoulam, Aviva Breuer
  • Polarized light source device
    Patent number: 10234726
    Abstract: A polarized light source configured for use in display device and backlight unit is described. The polarized light source comprising: at least one optically active structure comprising a plurality of nanorods configured to emit light of one or more wavelengths in response to exciting pumping field, said plurality of nanorods comprising nanorods aligned with a predetermined alignment axis so as to produce a desired polarization direction of the emitted light; and a light directing assembly comprising one or more optical elements in optical path of light emitted from the light emitting structure, said light directing assembly being configured to enhance output of the emitted light from the emitting structure while substantially maintaining the polarization of the emitted light passing therethrough. Preferably, layers associated with the polarized light source are aligned with parallel principal axes.
    Type: Grant
    Filed: June 25, 2018
    Date of Patent: March 19, 2019
    Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Qlight Nanotech Ltd.
    Inventors: Uri Banin, Ehud Shaviv, Hagai Arbell
  • DOWNREGULATING MIR-132 FOR THE TREATMENT OF LIPID RELATED DISORDERS
    Publication number: 20190078090
    Abstract: A method of treating a lipid-related disorder in a subject in need thereof is disclosed. The method comprises administering to the subject a therapeutically effective amount of a polynucleotide agent which is substantially complementary to a nucleotide sequence of human miR-132, thereby treating the lipid related disorder in the subject.
    Type: Application
    Filed: November 19, 2018
    Publication date: March 14, 2019
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Hermona SOREQ, Geula HANIN, David S. GREENBERG
  • Semiconducting particles in electronic elements
    Patent number: 10229957
    Abstract: The present invention relates inter alia to a color display comprising nanoparticles and color filters.
    Type: Grant
    Filed: February 1, 2016
    Date of Patent: March 12, 2019
    Assignees: MERCK PATENT GMBH, YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, LTD.
    Inventors: Bernhard Rieger, Edgar Boehm, Volker Hilarius, Christof Pflumm, Uri Banin
  • POMEGRANATE OIL FOR PREVENTING AND TREATING NEURODEGENERATIVE DISEASES
    Publication number: 20190070111
    Abstract: The present invention relates to the use of pomegranate oil and fractions thereof for preventing and treating neurodegenerative diseases. Particularly, the present invention relates to emulsions of the pomegranate oil or fractions thereof for the prevention and treatment of brain diseases, including Creutzfeldt-Jacob disease (CJD) and multiple sclerosis (MS).
    Type: Application
    Filed: November 8, 2018
    Publication date: March 7, 2019
    Applicants: Hadasit Medical Research Services and Development Ltd., Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Ruth GABIZON, Haim OVADIA, Oded ABRAMSKY, Shlomo MAGDASSI, Liraz LARUSH
  • MULTI DRUG COMPOSITE, METHODS AND USES THEREOF
    Publication number: 20190060247
    Abstract: The invention provides mesoporous nanoparticles loaded within its pores with at least one loaded pharmaceutically active agent and at least one capping pharmaceutically active agent chemically coordinated with at least one ligand being boronic acid or derivative thereof on the surface of said pores; compositions comprising such mesoporous nanoparticles and uses thereof.
    Type: Application
    Filed: March 2, 2017
    Publication date: February 28, 2019
    Applicant: Yissum Research Development Company, of The Hebrew University of Jerusalem Ltd.
    Inventors: Itamar WILLNER, Vered HELEG-SHABTAI, Ruth AIZEN, Sharon ETERY, Natalie ENKIN
  • ACTIVITY BASED PROBE AND USES THEREOF FOR IMAGING
    Publication number: 20190054193
    Abstract: Provided is a compound including at least one carrier moiety associated with a plurality of CT imaging moieties, and with at least one enzyme interacting moiety as well as uses thereof in diagnosis.
    Type: Application
    Filed: February 16, 2017
    Publication date: February 21, 2019
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Galia BLUM, Darya TSIVRKUN, Hanmant GAIKWAD
  • SELF-ASSEMBLED PEPTIDE NANOFIBERS AND USE THEREOF FOR TARGETED DRUG DELIVERY
    Publication number: 20190054035
    Abstract: Provided are peptide-based nanostructures, as well as diagnostic and therapeutic methods using same.
    Type: Application
    Filed: April 10, 2018
    Publication date: February 21, 2019
    Applicants: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Ramot at Tel-Aviv University Ltd.
    Inventors: Galia BLUM, Yael BEN-NUN, Ehud GAZIT, Lihi ADLER-ABRAMOVICH, Galit FICHMAN
  • COMPOSITIONS OF THERAPEUTIC SUBSTANCES, METHODS AND USES THEREOF
    Publication number: 20190054176
    Abstract: Provided is a composition for oral administration which includes a lipophilic active substance and a phospholipid, providing a prolonged therapeutic effect.
    Type: Application
    Filed: December 6, 2016
    Publication date: February 21, 2019
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventor: Elka TOUITOU
  • Method for storage and release of hydrogen
    Patent number: 10207921
    Abstract: The invention provides a process for the production of hydrogen, comprising catalytically decomposing a concentrated aqueous solution of potassium formate in a reaction vessel to form bicarbonate slurry and hydrogen, discharging the hydrogen from said reaction vessel, and treating a mixture comprising the bicarbonate slurry and the catalyst with an oxidizer, thereby regenerating the catalyst. Pd/C catalysts useful in the process are also described.
    Type: Grant
    Filed: November 5, 2014
    Date of Patent: February 19, 2019
    Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Yoel Sasson, Harold Wiener, Ariel Givant
  • Method and system for generating adaptive fast forward of egocentric videos
    Patent number: 10210620
    Abstract: A method and a system for generating adaptive fast forward of egocentric videos are provided here. The method may include the following steps: obtaining a video footage containing a sequence of image frames captured by a non-stationary capturing device; estimating a moving direction of the non-stationary capturing device for a plurality of frames in the sequence of image frames; and generating a shortened video footage having fewer frames than said video footage, by sampling the sequence of image frames, wherein the sampling is carried out by selecting specific image frames and that minimize an overall cost associated with a deviation from a specific direction related to the moving direction, calculated for each of said plurality of image frames.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: February 19, 2019
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Shmuel Peleg, Yair Poleg, Tavi Halperin, Chetan Arora
  • METHODS FOR DISRUPTING BIOFILMS
    Publication number: 20190038701
    Abstract: Provided are methods for disrupting biofilms and/or preventing the formation of biofilms. Further provided are random-sequence peptide mixtures for use in disrupting bacterial biofilms. The random-sequence peptides include hydrophobic and/or cationic amino acids, and the ratio of the total hydrophobic and cationic amino acids in the mixture is predefined.
    Type: Application
    Filed: February 2, 2017
    Publication date: February 7, 2019
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventor: Zvi HAYOUKA
  • IGF-1R signaling pathway inhibitors useful in the treatment of neurodegenerative diseases
    Patent number: 10188659
    Abstract: The present invention provides compounds acting as Insulin/IGF signaling modulators useful in the treatment of neurodegenerative diseases and disorders. The invention provides pharmaceutical compositions including such compounds, and methods of using these compounds and compositions for the treatment of neurodegenerative diseases, in particular neurodegenerative diseases caused by proteotoxicity such as Alzheimer's disease.
    Type: Grant
    Filed: August 24, 2017
    Date of Patent: January 29, 2019
    Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, LTD.
    Inventors: Hadas Reuveni, Ehud Cohen, Alexander Levitzki, Shmuel Ben-Sasson
  • Self-assembly of perovskite for fabrication of transparent devices
    Patent number: 10192689
    Abstract: Provided is a continuous material pattern, the pattern is selected to have a plurality of material-free voids, the material including at least one perovskite material.
    Type: Grant
    Filed: January 7, 2016
    Date of Patent: January 29, 2019
    Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Lioz Etgar, Shlomo Magdassi, Sigalit Aharon, Michael Layani
  • TOMATO PLANTS HAVING FRUIT WITH YELLOW AND RED SEGMENTS
    Publication number: 20190021251
    Abstract: Provided are tomato plants having fruit with red and yellow segments that appear across the fruit from the internal seed area to the most external layer of the epidermis. The present invention discloses that this phenotype, designated Arlecchino, is linked to insertion mutation within the Phytoene synthase 1 (Psy1) gene.
    Type: Application
    Filed: July 5, 2016
    Publication date: January 24, 2019
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Joseph HIRSCHBERG, Dani ZAMIR, Yaacov Micha BROG, Itay ZEMACH, Orly DERY
  • SEARCHABLE SYMMETRIC ENCRYPTION WITH ENHANCED LOCALITY VIA BALANCED ALLOCATIONS
    Publication number: 20190026502
    Abstract: A method for searchable symmetric encryption. The method includes: accessing a computerized database that comprises keyword lists, each of the keyword lists comprising memory addresses of electronic documents that all contain a respective keyword; binning the memory addresses by performing balanced allocation of the memory addresses into ordered bins, such that at least some of the ordered bins each contains memory addresses of electronic documents that contain different keywords; encrypting each of the memory addresses with an encryption key that is derived from the keyword of the respective memory address; and storing the ordered bins at consecutive locations in a non-transient computer-readable memory, wherein the consecutive locations preserve the order of the ordered bins.
    Type: Application
    Filed: January 19, 2017
    Publication date: January 24, 2019
    Applicants: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Yeda Research and Development Co. Ltd.
    Inventors: Gil SEGEV, Ido SHAHAF, Gilad ASHAROV, Moni NAOR
  • Liposomes comprising polymer-conjugated lipids and related uses
    Patent number: 10179106
    Abstract: The present invention provides liposomes comprising a lipid bilayer and a polymer-conjugated lipid, wherein said polymer-conjugated lipid is incorporated into said lipid bilayer. The present invention also provides methods of producing the liposomes as well as a method of delivering a nucleic acid to a subject comprising the step of administering said nucleic acid encapsulated in a mixed liposome, a method for performing diagnostic imaging in a subject, comprising the step of administering a diagnostic agent encapsulated in a mixed liposome, and methods for treating, inhibiting, or suppressing a pathological condition in a subject comprising administering to said subject a mixed liposome.
    Type: Grant
    Filed: May 10, 2012
    Date of Patent: January 15, 2019
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventor: Saul Yedgar