Patents Assigned to Yissum Research Development Company of the Hebrew University
  • SUSTAINED-RELEASE INJECTABLE ANTIBIOTICAL FORMULATION
    Publication number: 20210315803
    Abstract: Provided herein are compositions of injectable antibiotics for veterinary use. The compositions are characterized by forming a gel at animal physiological temperature, said gel being characterized by a stable and repeatable release profile of the antibiotic. The compositions comprise high loading of drug in poloxamer solutions with addition of a co-solvent, and preferably with an addition of a cellulose derivative at least partially soluble in organic solvents. Methods of treatment of veterinary infections are also provided.
    Type: Application
    Filed: September 5, 2019
    Publication date: October 14, 2021
    Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Michael FRIEDMAN, David KIRMAYER, Zakhar NUDELMAN, Amnon HOFFMAN, Eran LAVY, Ayala BAR-HAI, Irith GATI
  • CELLULOSE-BASED TOPICAL FORMULATIONS
    Publication number: 20210299157
    Abstract: The technology concerns topical formulations including nanocellulose materials for application on a skin or tissue of a subject.
    Type: Application
    Filed: August 6, 2019
    Publication date: September 30, 2021
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Oded SHOSEYOV, Tal BEN SHALOM
  • Device and method for determination of pupil size in a subject having closed eyelids
    Patent number: 11122972
    Abstract: Devices and method for determining a pupil size of a subject having closed eyelids.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: September 21, 2021
    Assignees: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD., YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Jose Cohen, Vladimir Goldman, Yousef Nadim Farraj, Amnon Buxboim, Yoav Mintz, Elchanan Fried, Gahl Levy, Tsevi Beatus, Yoav Kan-Tor
  • Method of needle localization via partial computerized tomographic scanning and system thereof
    Patent number: 11109822
    Abstract: There is provided a method of locating a tip of a metallic instrument inserted in a body, utilizing a baseline sinogram comprising projections in N exposure directions and derived from a prior computerized tomography (CT) scanning of the body, the method comprising: performing three-dimensional Radon space registration of a sparse repeat sinogram to the baseline sinogram, the repeat CT scanning having the metallic instrument inserted into the body, the metallic instrument having an attached marker located at a known distance from the instrument tip; subtracting the baseline sinogram from the repeat sinogram in accordance with the registration parameters to obtain projection difference images; and using the projection difference images and the known distance of the attached marker from the metallic instrument tip to determine a three-dimensional location of the metallic instrument tip.
    Type: Grant
    Filed: August 20, 2019
    Date of Patent: September 7, 2021
    Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD
    Inventors: Leo Joskowicz, Guy Medan
  • Methods for disrupting biofilms
    Patent number: 11103547
    Abstract: Provided are methods for disrupting biofilms and/or preventing the formation of biofilms. Further provided are random-sequence peptide mixtures for use in disrupting bacterial biofilms. The random-sequence peptides include hydrophobic and/or cationic amino acids, and the ratio of the total hydrophobic and cationic amino acids in the mixture is predefined.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: August 31, 2021
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventor: Zvi Hayouka
  • Toll-like receptor 9 antagonists
    Patent number: 11104677
    Abstract: A method of preventing or treating a disease characterized by an excessive immune response in a subject in need thereof is provided. The method includes administering to the subject a composition including an active component, wherein the active component is a first compound, a second compound, a third compound, a pharmaceutically acceptable salt thereof, a solvate thereof, or a combination thereof, wherein the first, second, and third compounds include: respectively.
    Type: Grant
    Filed: October 21, 2019
    Date of Patent: August 31, 2021
    Assignees: FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V., YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, LTD.
    Inventors: Anke Burger-Kentischer, Angela Mattes, Maria Zatsepin, Amriam Goldblum
  • COMPOUNDS AND USES FOR THE TREATMENT AND PREVENTION OF DISEASES AND CONDITIONS ASSOCIATE WITH OR AGGREVATED BY IMPARED MITOPHAGY
    Publication number: 20210253511
    Abstract: The present invention provides compounds and methods for the treatment and prevention of diseases and conditions associate with or aggravated by impaired mitophagy.
    Type: Application
    Filed: March 13, 2019
    Publication date: August 19, 2021
    Applicant: Yissum Research Development Company of The Hebrew University of Jerusalem Ltd.
    Inventors: Shmuel BEN-SASSON, Einav GROSS
  • PYRAZOLE PYRIMIDINE DERIVATIVE AND USES THEREOF
    Publication number: 20210251992
    Abstract: The present invention provides pyrazole pyrimidine derivatives which inhibit Casein kinase I (CKI) and/or Interleukin-1 receptor-associated kinase 1 (IRAKI) and methods of their manufacture, compositions comprising them and uses thereof in methods of treating malignant disease and disorders and methods for treating inflammatory diseases and disorders.
    Type: Application
    Filed: March 29, 2021
    Publication date: August 19, 2021
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Yinon Ben-Neriah, Guy Brachya, Ido Burstain, Waleed Minzel, Irit Snir-Alkalay, Joseph P. Vacca, Dansu Li
  • Processes for the preparation of heterocyclic scaffolds from alpha enaminones
    Patent number: 11091438
    Abstract: The present invention provides processes for the preparation of diverse heterocyclic scaffolds from alpha-enaminone building bloc of formula (I).
    Type: Grant
    Filed: March 21, 2018
    Date of Patent: August 17, 2021
    Assignee: Yissum Research Development Company of The Hebrew University of Jerusalem Ltd.
    Inventor: Dmitry Tsvelikhovsky
  • Out-of-band authentication in group communications
    Patent number: 11095452
    Abstract: System, method, and computer program product for authenticating a message among a groups of computing devices communicating over an unsecured channel, based on an out-of-band (OOB) authenticated channel which may be used to send a short message to all receivers.
    Type: Grant
    Filed: April 15, 2019
    Date of Patent: August 17, 2021
    Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Gil Segev, Lior Rotem
  • High performance method and system for performing fault tolerant matrix multiplication
    Patent number: 11080131
    Abstract: A computer implemented method for performing fault tolerant numerical linear algebra computation task consisting of calculation steps that include at least classic or fast matrix multiplication, according to which, a controller splits the task among P processors, which operate in parallel. Additional processors are assigned according to execution and resources parameters, which are also used to select a slice-coded recovery algorithm or a posterior-recovery algorithm for executing the task. Pipelined-reduce operations are used to generate error correcting codes to protect the input blocks and outer products from faults. Upon detecting faults in one or more processors, if the slice-coded recovery algorithm has been selected, a slice-coded recovery algorithm is executed to recover lost input blocks and outer products that.
    Type: Grant
    Filed: June 18, 2018
    Date of Patent: August 3, 2021
    Assignee: Yissum Research Development Company of The Hebrew University of Jerusalem Ltd.
    Inventors: Oded Schwartz, Noam Birnbaum
  • Self-processing synthesis of hybrid nanostructures
    Patent number: 11078073
    Abstract: Provided is a self-processing synthesis of hybrid nanostructures, novel nanostructures and uses thereof in the construction of electronic and optoelectronic devices.
    Type: Grant
    Filed: April 21, 2016
    Date of Patent: August 3, 2021
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Roie Yerushalmi, Yossef Paltiel, Ori Pinchas-Hazut, Sharon Waichman, Amir Ziv, Shira Yochelis
  • HAPLOID HUMAN EMBRYONIC STEM CELL LINES AND SOMATIC CELL LINES AND METHODS OF MAKING THE SAME
    Publication number: 20210230539
    Abstract: Haploid human embryonic stem cells and cell lines, haploid multipotent human cells, and haploid differentiated human cells are provided. In addition, methods of making and using the haploid human cells are provided.
    Type: Application
    Filed: December 15, 2020
    Publication date: July 29, 2021
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Dietrich M. EGLI, Nissim BENVENISTY, Ido SAGI
  • ANTIBODIES SPECIFIC TO HUMAN T-CELL IMMUNOGLOBULIN AND ITIM DOMAIN (TIGIT)
    Publication number: 20210220472
    Abstract: Natural killer (NK) cell killing of various tumors is inhibited in the presence of ligands of TIGIT, an inhibitory receptor present on all human NK cells and on various T cells. Monoclonal antibodies that recognize TIGIT and inhibit its suppressive activity on T-cells are provided as well as pharmaceutical compositions comprising them and methods for their use in cancer immunotherapy and in diagnosis and treatment of immune disorders.
    Type: Application
    Filed: February 5, 2021
    Publication date: July 22, 2021
    Applicants: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD., UNIVERSITY OF RIJEKA FACULTY OF MEDICINE
    Inventors: Ofer MANDELBOIM, Noa S. KAYNAN, Pinchas TSUKERMAN, Stipan JONJIC
  • Methods for treatment of Prader-Willi syndrome
    Patent number: 11058652
    Abstract: The present disclosure provides pharmaceutical compositions comprising a fatty acid amide of an amino acid as defined herein, such as oleoyl-?-methyl-serine, or a stereoisomer or salt thereof, for improving, as in increasing or preventing loss of, bone mineral density and/or treating osteoporosis in patients suffering from Prader-Willi syndrome; and their methods of use.
    Type: Grant
    Filed: April 13, 2017
    Date of Patent: July 13, 2021
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Raphael Mechoulam, Joseph Tam, Reem Smoum, Saja Baraghithy
  • Sustained-release injectable formulation
    Patent number: 11052043
    Abstract: A composition which comprises a biologically active agent and a polymer that exhibits a reverse thermal gelation at a physiological temperature, in a carrier, and in which the active agent is in an undissolved form is disclosed herein. Further disclosed herein are methods utilizing the compositions for treating subjects, including non-human subjects, as well as kits for preparing and using a composition. The composition is preferably a sustained release formulation, and is particularly useful for treating animals, where single-dose treatment is desired.
    Type: Grant
    Filed: March 28, 2012
    Date of Patent: July 6, 2021
    Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Michael Friedman, Amnon Hoffman, Eran Lavy
  • TWO DIMENSIONAL ORGANO-METAL HALIDE PEROVSKITE NANORODS
    Publication number: 20210188884
    Abstract: Organometal halide perovskites are provided as nanoparticles for the construction of efficient light harvesters in photovoltaic solar cells. Further provided are methods of manufacturing the nanoparticles and uses thereof.
    Type: Application
    Filed: March 8, 2017
    Publication date: June 24, 2021
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Lioz ETGAR, Sigalit AHARON
  • Regeneration and repair of mesenchymal tissue using amelogenin
    Patent number: 11034753
    Abstract: A method of treating an injury to hyaline cartilage in a subject in need thereof. The method comprises administering to the subject a therapeutically effective amount of amelogenin.
    Type: Grant
    Filed: February 20, 2018
    Date of Patent: June 15, 2021
    Assignees: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD., HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.
    Inventors: Dan Deutsch, Amir Haze, Anat Blumenfeld
  • INDOLINE DERIVATIVES, COMPOSITIONS COMPRISING THEM AND USES THEREOF
    Publication number: 20210169850
    Abstract: The present invention is directed to indoline derivatives and salts thereof, compositions comprising them and uses thereof for the treatment of diseases and disorders associated with at least one of oxidative stress, an immune response, release of NO and release of pro-inflammatory cytokine.
    Type: Application
    Filed: January 19, 2017
    Publication date: June 10, 2021
    Applicants: Yissum Research Development Company of The Hebrew University of Jerusalem Ltd., BAR ILAN UNIVERSITY
    Inventors: Marta WEINSTOCK-ROSIN, Abraham NUDELMAN, Shani ZEELI
  • Air treatment systems and methods
    Patent number: 11027236
    Abstract: An air treatment unit may include an air inlet to receive a flow of input air for treatment and a reaction reservoir configured to hold an aqueous air treatment solution. The air treatment unit may also include an air dispersing element flow connected with the air inlet, wherein the air dispersing element is configured to convert at least a portion of the flow of input air into a plurality of microbubbles for introduction into the aqueous air treatment solution, such that an amount of one or more target gas species contained within the plurality of microbubbles is reduced through reaction with the aqueous air treatment solution. The unit may include an air outlet configured to output treated air from the reaction reservoir.
    Type: Grant
    Filed: June 28, 2017
    Date of Patent: June 8, 2021
    Assignees: Airovation Technologies Ltd., Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Marat Maayan, Uri Stoin, Yoel Sasson, Doron Weinfeld