Abstract: Provided is a novel class of solid water-dispersible powders, including a plurality of water-insoluble photoinitiators in nanoparticle forms for use in water-based ink formulations.
Type:
Grant
Filed:
November 23, 2016
Date of Patent:
September 1, 2020
Assignee:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: Provided are tomato plants having fruit with red and yellow segments that appear across the fruit from the internal seed area to the most external layer of the epidermis. The present invention discloses that this phenotype, designated Arlecchino, is linked to insertion mutation within the Phytoene synthase 1 (Psy1) gene.
Type:
Grant
Filed:
July 5, 2016
Date of Patent:
August 25, 2020
Assignee:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: Provided relates to a crop Lisianthus (Eustoma grandiflorum) plants that do not require cold treatment (vernalization) for the inductions of bolting and flowering, and to means and methods for producing same.
Type:
Grant
Filed:
November 24, 2015
Date of Patent:
August 25, 2020
Assignee:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: The invention is a process of treating plastic waste, comprising converting one or more plastic polymers into a liquid form either by dissolving in an organic solvent or by melting, and degrading said polymer(s) with the aid of alkali hydroxide and hydrogen peroxide, optionally in the presence of a phase transfer catalyst.
Type:
Application
Filed:
January 3, 2017
Publication date:
August 20, 2020
Applicant:
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
Abstract: Provided are oligonucleotides capable of binding to and modulating the splicing of the pre-mRNA of the CFTR gene, compositions including said oligonucleotides, kits including the compositions, and uses thereof. In particular, the subject matter provides compositions of oligonucleotides useful in methods for suppressing exon skipping optionally in combination with additional CFTR therapeutics.
Type:
Grant
Filed:
January 12, 2018
Date of Patent:
August 4, 2020
Assignee:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Inventors:
Batsheva Kerem, Michal Tur Sinai, Loren Price, Stephen Donald Wilton, Sue Fletcher
Abstract: Provided are modified lipid compounds and their use in the formation of lipid assemblies. Also provided are lipid assemblies including (a) an amphoteric lipid including in covalent association with (i) one or more acyl chains; (ii) one or more weak base moiety; (iii) one or more weak acid moiety; the lipid assembly also including (b) one or more additional lipids, at least one of which being a zwitterionic lipid. In some embodiments, the amphoteric lipid is a compound including (a) a tri-functional moiety; (b) two non-phosphate lipid chains associated with two of the functional moieties of said tri-functional moiety; (c) optionally a spacer moiety associated with the third of the functional moieties of said tri-functional moiety; and (d) a polyalkylamine optionally including a short peptide with one to several carboxylic acid residues. Further provided are the uses of the lipid assembly, inter alia, for transfection or cancer treatment.
Type:
Grant
Filed:
February 4, 2016
Date of Patent:
July 28, 2020
Assignee:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: Disclosed are methods for treating, preventing and alleviating obesity, fatty liver syndrome, diabetes, one or more metabolic syndrome conditions or complications and/or cancer comprising administering an effective amount of ostreolysin, its functionally related variant, or an extract or mushroom extract comprising the same to subjects in need thereof.
Type:
Grant
Filed:
November 1, 2019
Date of Patent:
July 21, 2020
Assignee:
Yissum Research Development Company of the Hebrew University of Jerusalem
Abstract: An affinity binding moiety comprising an antigen recognition region which comprises complementarity determining region (CDR) amino acid sequences as set forth in heavy chain ordered N to C terminus: SEQ ID NOs: 4, 6 and 8, and light chain ordered N to C terminus: SEQ ID NOs: 12, 14 and 16 is disclosed. A pharmaceutical compositions comprising as an active ingredient the affinity binding moiety is also disclosed. Methods of diagnosing, preventing or treating an autoimmune disease or a cancer associated with an expression of NKp46 are also disclosed.
Type:
Grant
Filed:
March 14, 2018
Date of Patent:
July 21, 2020
Assignees:
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD., UNIVERSITY OF RIJEKA FACULTY OF MEDICINE
Abstract: The invention provides a process for the preparation of bismuth oxyhalide, comprising a precipitation of bismuth oxyhalide in an acidic aqueous medium in the presence of a reducing agent. Also provided are bismuth oxyhalide compounds doped with elemental bismuth Bi(0). The use of Bi(0) doped bismuth oxyhalide as photocatalysts in water purification is also described.
Type:
Grant
Filed:
August 4, 2014
Date of Patent:
July 21, 2020
Assignee:
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
Abstract: Provided is a novel class of solid water-dispersible powders, including a plurality of water-insoluble photoinitiators in nanoparticle forms for use in water-based ink formulations.
Type:
Application
Filed:
March 20, 2020
Publication date:
July 16, 2020
Applicant:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: Systems and method for classifying EEG signals of a human subject generated responsive to a series of images containing target images and non-target images. The EEG signals are in a spatio-temporal representation. The time points are classified independently, using a linear discriminant classifier, to compute spatio-temporal discriminating weights that are used to amplify the spatio-temporal representation, to create a spatially-weighted representation. Principal Component Analysis is used on a temporal domain for dimensionality reduction, separately for each spatial channel of the signals, to create a projection, which is applied to the spatially-weighted representation onto a first plurality of principal components, to create a temporally approximated spatially weighted representation.
Type:
Grant
Filed:
April 13, 2014
Date of Patent:
June 30, 2020
Assignees:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., B.G. Negev Technologies & Applications Ltd., at Ben-Gurion University
Inventors:
Leon Y. Deouell, Amir B. Geva, Galit Fuhrmann Alpert, Ran El Manor, Shani Shalgi
Abstract: The invention disclosed herein generally provides implantable medical devices and implants that may be removed on-demand from a subject's body at any time after their implanting in the body, without necessitating invasive procedures.
Type:
Grant
Filed:
October 7, 2015
Date of Patent:
June 30, 2020
Assignee:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: Isolated polypeptides of CD44 are provided. Accordingly, there is provided an isolated polypeptide consisting of an amino acid sequence selected from the group consisting of SEQ ID NOs: 1-3. Also provided is an isolated end-capping modified polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 1-3, wherein the modified polypeptide comprises an anti-inflammatory activity. Also provided are compositions of matter, fusion proteins and pharmaceutical compositions and their use in the treatment of inflammatory disease.
Type:
Application
Filed:
February 18, 2020
Publication date:
June 11, 2020
Applicant:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Inventors:
David NAOR, Lora ESHKAR-SEBBAN, Keren-Or AMAR, Shmuel COHEN
Abstract: An air treatment unit may include an air inlet to receive a flow of input air for treatment and a reaction reservoir configured to hold an aqueous air treatment solution. The air treatment unit may also include an air dispersing element flow connected with the air inlet, wherein the air dispersing element is configured to convert at least a portion of the flow of input air into a plurality of microbubbles for introduction into the aqueous air treatment solution, such that an amount of one or more target gas species contained within the plurality of microbubbles is reduced through reaction with the aqueous air treatment solution. The unit may include an air outlet configured to output treated air from the reaction reservoir.
Type:
Application
Filed:
June 28, 2017
Publication date:
June 4, 2020
Applicants:
SALAMANDRA ZONE LTD., YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERSUALEM LTD.
Inventors:
Marat MAAYAN, Uri STOIN, Yoel SASSON, Doron Weinfeld
Abstract: The present invention provides an optically active structure and the use thereof in a backlight unit. The optically active structure comprises a plurality of optically active particles configured to emit light of one or more predetermined wavelength range in response to pumping energy, and a plurality of light scattering elements. The plurality of light scattering elements comprises optically transparent void regions, such as void regions surrounding filler particles.
Type:
Grant
Filed:
June 25, 2015
Date of Patent:
June 2, 2020
Assignee:
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
Inventors:
Uri Banin, Ehud Shaviv, Denis Glozman, Hagai Arbell
Abstract: Provided is a unique class of foam materials characterized by regions of material unidirectionality. The foam materials are configured for a great variety of end-use applications as core materials or as materials in construction of multilayered structures. The novel and ingenious process for making the composite materials of the invention, permits modifying the foam materials to suite any specific end use.
Type:
Grant
Filed:
January 29, 2015
Date of Patent:
June 2, 2020
Assignees:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Melodea Ltd.
Abstract: A method of determining the methylation status of at least one methylation site of a double-stranded DNA molecule is disclosed. The method comprises analyzing the methylation status of both the forward strand and the reverse strand of the DNA molecule.
Type:
Application
Filed:
July 13, 2018
Publication date:
May 28, 2020
Applicants:
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD., HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.
Inventors:
Yuval DOR, Ruth SHEMER, Benjamin GLASER, Judith MAGENHEIM
Abstract: Provided are backbone cyclized peptides that interfere with signaling of the intracellular adaptor protein MyD88. Pharmaceutical compositions including these backbone cyclized peptides as well as their use in treatment of multiple sclerosis (MS) and other diseases associated with MyD88 signaling are also disclosed.
Type:
Grant
Filed:
June 4, 2017
Date of Patent:
May 26, 2020
Assignee:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Inventors:
Gabriel Nussbaum, Amnon Hoffman, Chaim Gilon