Patents Assigned to Zeneca
  • Patent number: 5898082
    Abstract: A process for removing N-(phosphonomethylglycine) (glyphosate) or a salt or ionic form thereof from an aqueous mixture in which it is present, wherein the aqueous mixture is an effluent from a glyphosate manufacturing process, the process comprising adding to the mixture of ions capable of forming an insoluble or partially soluble complex glyphosate salt, and removing the complex salt from the mixture. An additional process permits recovery of glyphosate from the precipitate of complex salts by a process comprising forming an aqueous slurry of the precipitate having a pH greater than 8 and removing the resultant metal oxide from the slurry to give an aqueous solution containing glyphosate.
    Type: Grant
    Filed: January 8, 1998
    Date of Patent: April 27, 1999
    Assignee: Zeneca Limited
    Inventor: Ian Hodgkinson
  • Patent number: 5891230
    Abstract: A bisazo dye of Formula (1) and salts thereof: ##STR1## in which R is H;R.sub.1 and R.sub.2 each independently is H, optionally substituted C.sub.1-4 -alkyl or optionally substituted aryl;R.sub.3 and R.sub.4 are each independently --OC.sub.1-4 -alkyl;R.sub.5 is H;R.sub.6 is COOH; andn is 1, 2 or 3.The dyes are useful for ink jet printing.
    Type: Grant
    Filed: October 9, 1997
    Date of Patent: April 6, 1999
    Assignee: Zeneca Limited
    Inventors: Peter Gregory, Prahalad Manibhai Mistry, Roy Bradbury, Paul Wight
  • Patent number: 5889024
    Abstract: Compounds of formula I ##STR1## wherein Q.sup.1, Q.sup.2, Q.sup.3, Q.sup.4 and Q.sup.5 have any of the meanings given in the specification, their N-oxides, and their pharmacuetically acceptable salts are nonpeptide antagonists NKA, useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.
    Type: Grant
    Filed: April 23, 1996
    Date of Patent: March 30, 1999
    Assignee: Zeneca Limited
    Inventors: Scott C. Miller, Robert T. Jacobs, Ashokkumar B. Shenvi
  • Patent number: 5889110
    Abstract: This invention relates to novel salts composed of a cation derived from a peptide containing at least one basic group and an anion derived from a carboxy-terminated polyester, processes for the manufacture of such salts, and the use of such salts in the manufacture of extended release pharmaceutical compositions. The salts of the invention possess a variety of properties which are useful in the formulation of extended release pharmaceutical compositions, whether the salts are in pure form or are in admixture with either an excess of the peptide in its free, unbound form or an excess of the free polyester.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: March 30, 1999
    Assignee: Zeneca Limited
    Inventor: Francis Gowland Hutchinson
  • Patent number: 5888818
    Abstract: The invention provides a modified tubulin comprising a tubulin polypeptide which confers resistance to an anti-tubulin agent when expressed within a biological organism, said polypeptide having at least one amino acid substitution such that hydrophobicity is increased at one or more positions in the polypeptide. DNA sequences encoding such modified tubulins may be used to confer resistance on organisms which otherwise would be susceptible to one or more anti-tubulin agents. For example, a plant which is resistant to a herbicide that disrupts microtubule structure or function may be produced.
    Type: Grant
    Filed: November 25, 1994
    Date of Patent: March 30, 1999
    Assignee: Zeneca Limited
    Inventors: Kathryn Elizabeth Cronin, John Raymond Ellis, deceased, Patrick Joseph Hussey, John Anthony Ray, Teresa Ruth Waldin
  • Patent number: 5888934
    Abstract: A glyphosate composition comprises (I) N-phosphonomethylglycine or an agriculturally acceptable salt thereof, (ii) an alkyl polyglycoside surfactant, (iii) an ethoxylated alcohol, for example an ethoxylated alcohol obtained by ethoxylation of a linear or branched chain aliphatic mono alcohol having a chain length of from 8 to 20 carbon atoms and a mean degree of ethoxylation of from 2 to 50 moles of ethylene oxide per mole of alcohol, and optionally (iv) an additional surfactant, and optionally (v) a humectant.
    Type: Grant
    Filed: November 19, 1996
    Date of Patent: March 30, 1999
    Assignee: Zeneca Limited
    Inventors: Jane Karen Townson, Clifford Arthur Hart, Martin Keith Osborn, Michael John Bean
  • Patent number: 5888286
    Abstract: A bisazo dye of Formula (1) and salts thereof: ##STR1## wherein: R.sub.1 and R.sub.2 each independently is H, optionally substituted C.sub.1-4 -alkyl or optionally substituted aryl;R.sub.3 is --NH.sub.2 ;R.sub.4 is OC.sub.1-4 -alkyl;each R.sub.5 independently is --COOH or --SO.sub.3 H; andn is 1,2, or 3.Also claimed are inks containing the dye, a process of ink jet printing using the inks and substrates coloured by the inks.
    Type: Grant
    Filed: October 9, 1997
    Date of Patent: March 30, 1999
    Assignee: Zeneca Limited
    Inventors: Peter Gregory, Prahalad Manibhai Mistry, Roy Bradbury, Paul Wight
  • Patent number: 5886164
    Abstract: A method of modifying ethylene biosynthesis in a plant comprises inserting into the genome of the said plant a DNA sequence such as SEQ-ID-NO-1 (encoding 1-aminocyclopropane-1-carboxylic acid synthase (ACS)) and/or sequence SEQ-ID-NO-2 (encoding an ethylene-forming enzyme (EFE)) which modifies the activity of at least one of ACS or EFE. The method may be used to modify fruit ripening characteristics, especially in bananas.
    Type: Grant
    Filed: April 15, 1996
    Date of Patent: March 23, 1999
    Assignee: Zeneca Limited
    Inventors: Colin Roger Bird, Jonathon David Fletcher
  • Patent number: 5886231
    Abstract: A process for preparing a compound of formula (I): ##STR1## by rearrangement of a compound of formula (II): ##STR2## in a non-polar solvent in the presence of a cyanide source, an alkali or alkaline earth metal carbonate, a phase transfer catalyst and 1-6 moles of water with respect to the compound of formula (II).
    Type: Grant
    Filed: June 24, 1997
    Date of Patent: March 23, 1999
    Assignee: Zeneca Limited
    Inventors: Stephen Martin Brown, Howard Rawlinson
  • Patent number: 5886193
    Abstract: A support carrying a homocyclic or heterocyclic ring containing a first and second carbon atom wherein: (i) the first carbon atom is substituted by a nucleophilic group or a group convertible to a nucleophilic group on treatment with base; (ii) the second carbon atom is substituted by a hydroxy group, a hydroxy group protected by an acid labile protecting group, or a phosphate group substituted by an oligonucleotide; and (iii) the first and second carbon atoms are directly connected by a covalent bond; which is suitable for use in oligonucleotide synthesis. Methods for its preparation and use, and novel compounds for attachment to the support are described.
    Type: Grant
    Filed: May 9, 1997
    Date of Patent: March 23, 1999
    Assignee: Zeneca Limited
    Inventors: Michael Joseph McLean, Andrew John Garman
  • Patent number: 5885569
    Abstract: A recombinant baculovirus for use as an insect control agent having a genome which comprises a polyhedrin gene and a heterologous gene, which expresses an insecticidal protein, wherein the polyhedrin gene and the heterologous gene are not under the control of the same promoter, and are located on the genome such that viral progeny produced by a recombination event with wild-type baculovirus which are viable do not retain expression of both the polyhedrin gene and the heterologous gene.
    Type: Grant
    Filed: September 24, 1996
    Date of Patent: March 23, 1999
    Assignee: Zeneca Limited
    Inventor: John David Windass
  • Patent number: 5882391
    Abstract: A bisazo dye of Formula (1) and salts thereof: ##STR1## in which R is H or ##STR2## R.sub.1 and R.sub.2 each independently is H, optionally substituted C.sub.1-4 -alkyl or optionally substituted aryl;R.sub.3 and R.sub.5 together with the carbon atoms to which they are attached form a 5- or 6-membered carbocyclic ring which is optionally substituted by SO.sub.3 H;R.sub.4 is H;R.sub.6 is COOH;n is 1, 2 or 3; andp is 1, 2, 3 or 4.The dyes are useful for ink jet printing.
    Type: Grant
    Filed: October 9, 1997
    Date of Patent: March 16, 1999
    Assignee: Zeneca Limited
    Inventors: Peter Gregory, Prahalad Manibhai Mistry, Roy Bradbury, Paul Wight
  • Patent number: 5882338
    Abstract: A medical syringe comprises a cylindrical barrel 1 having therein a plunger 4 which can be axially driven by a plunger rod 3. The plunger rod 3 passes through an aperture in the centre of a finger grip 2 having two finger grip projections 2b at opposite sides thereof. A data carrier means in the form of an electrically or magnetically operable device 2c is mounted near the end of one of the two finger grip projections 2b, with preferably a device 2c mounted near the end of each finger grip projection 2b. The device 2c carries data relating to the medicament contained or to be contained within the syringe, and can be read by a suitably adapted syringe pump when the syringe is mounted thereon to be driven by the syringe pump.
    Type: Grant
    Filed: November 3, 1995
    Date of Patent: March 16, 1999
    Assignee: Zeneca Limited
    Inventor: John Martyn Gray
  • Patent number: 5882833
    Abstract: A toner resin composition comprising a toner resin and an aromatic sulphonic acid salt of a guanidine such as the bis-diphenylguanidine salt of naphthalene-1,5-disulphonic acid. The diphenyl guanidine salts are novel.
    Type: Grant
    Filed: May 5, 1997
    Date of Patent: March 16, 1999
    Assignee: Zeneca Limited
    Inventor: James Stanley Campbell
  • Patent number: 5882392
    Abstract: A dye of Formula (1) and salts thereof: ##STR1## in which R is H, --NHC.sub.1-4 -alkylN(C.sub.1-4 -alkyl).sub.2 or ##STR2## R.sub.1 and R.sub.2 each independently is H, optionally substituted C.sub.1-4 -alkyl or optionally substituted aryl;R.sub.3 is C.sub.1-4 -alkyl;R.sub.4 is C.sub.1-4 -alkyl or OC.sub.1-4 -alkyl;R.sub.5 is H;R.sub.6 is COOH; andn is 1, 2 or 3.The dyes are useful for preparing ink jet printer inks.
    Type: Grant
    Filed: October 9, 1997
    Date of Patent: March 16, 1999
    Assignee: Zeneca Limited
    Inventors: Peter Gregory, Prahalad Manibhai Mistry, Roy Bradbury, Paul Wight
  • Patent number: 5880130
    Abstract: The invention concerns pyrimidine derivatives of formula wherein m is 1, 2 or 3; each R.sup.1 is independently hydrogen, hydroxy, (un)substituted amino, nitro, halogeno, cyano, carboxy, (un)substituted carbamoyl, ureido, (1-4C) alkoxycarbonyl, (un)substituted (1-4C)alkyl, (un)substituted (1-4C)alkoxy, (1-3C)alkylenedioxy, (1-4C)alkylthio, (1-4C)alkylsulphinyl, (1-4C)alkyl-sulphonyl, (2-4C)alkanoyloxy; n is 1, 2 or 3; and each R.sup.2 is independently hydrogen, hydroxy, halogeno, trifluoromethyl, trifluoromethoxy, amino, nitro, cyano, (1-4C)alkyl, (1-4C)alkoxy, (1-4C)alkylamino, di-?(1-4C)alkyl!amino, (1-4C)alkylthio, (1-4C)alkylsulphinyl, (1-4C)alkylsulphonyl, (2-4C)alkanoylamino, (2-4C)alkanoyl or (1-3C)alkylenedioxy; or a pharmaceutically-acceptable salt thereof; processes for their preparation; pharmaceutical compositions containing them; and the use of the receptor tyrosine kinase inhibitory properties of the compounds in the treatment of cell-proliferation diseases.
    Type: Grant
    Filed: June 7, 1996
    Date of Patent: March 9, 1999
    Assignee: Zeneca Limited
    Inventor: Andrew Peter Thomas
  • Patent number: 5879810
    Abstract: There is provided a composite article which comprises a first substrate comprising a body of metal containing aluminium or galvanised steel, a second substrate and, interposed between said first and second substrates whereby to provide adhesive bonding between said substrates, an adhesive and 2.sup.1,3,4.sup.1,5,7-pentahydroxyflavone with the proviso that when either substrate is etched or anodised aluminium, the pentahydroxyflavone is not present thereon as a primer coat.
    Type: Grant
    Filed: July 11, 1996
    Date of Patent: March 9, 1999
    Assignee: Zeneca Limited
    Inventors: Michael Ellwood, Stephen William Leeming
  • Patent number: 5880188
    Abstract: A method for the protection of a medium by susceptible to microbial attack by the treatment of the medium with an oxaborale or a salt of an oxaborale.
    Type: Grant
    Filed: December 9, 1996
    Date of Patent: March 9, 1999
    Assignee: Zeneca Limited
    Inventors: Peter William Austin, Christopher Juan Kneale, Patrick Jelf Crowley, John Martin Clough
  • Patent number: 5877026
    Abstract: The present invention provides novel methods of treating pain comprising administering to a mammal in need of such treatment an effective analgesic amount of a peptide having the amino acid sequence of SEQ ID. NO.: 1 or SEQ ID NO: 2. The invention further provides a purified peptide having the amino acid sequence of SEQ ID NO: 1. The peptides of SEQ ID NO.: 1 and SEQ ID NO.: 2 can also be used in methods for identifying compounds having analgesia-inducing activity.
    Type: Grant
    Filed: June 19, 1998
    Date of Patent: March 2, 1999
    Assignee: Zeneca Limited
    Inventor: Richard Alexander Lampe
  • Patent number: RE36118
    Abstract: A method for the recovery of a metal from an organic complex thereof, said method comprising treating the complex with a weakly acid aqueous solution of an alkali metal or alkaline earth metal chloride having a chloride content of at least 4 molar whereby said complex is decomposed and metal ions are transferred to the aqueous solution.
    Type: Grant
    Filed: July 26, 1996
    Date of Patent: March 2, 1999
    Assignee: Zeneca Limited
    Inventors: Domenico C. Cupertino, Peter A. Tasker