Patents Assigned to Zeneca
  • Ink jet printing ink
    Patent number: 5876491
    Abstract: Ink compositions comprising an aqueous medium containing:(1) at least one water-soluble dye;(2) at least one cyclic ester or amide of the formula: ##STR1## wherein m is a whole number from 3 to 5 and X represents --O-- or --N(R)-- in which R represents hydrogen, alkyl or substituted alkyl;(3) at least one hydroxy compound selected from polyhydroxy compounds having at least four hydroxy groups, optionally substituted cycloalkanols, cyclohexane dimethanol, benzyl alcohol, benzene dimethanol, phenol and polyhydroxybenzenes, and(4) at least one water-soluble organic solvent selected from alkanediols, alkanetriols, ether glycols and thioether glycols and suitable for use in inkjet printing processes for coloration of substrates such as paper or overhead projector slides.
    Type: Grant
    Filed: October 29, 1997
    Date of Patent: March 2, 1999
    Assignee: Zeneca Limited
    Inventors: Janet Gunn, Mark Holbrook, Aidan Joseph Lavery
  • M6P/IGF-II receptor tumor suppressor gene
    Patent number: 5874222
    Abstract: The present invention relates, in general, to a tumor suppressor and, in particular, to the mannose 6-phosphate/insulin-like growth factor-II (M6P/IGF-II) receptor and to diagnostic and therapeutic approaches based on same.
    Type: Grant
    Filed: November 15, 1996
    Date of Patent: February 23, 1999
    Assignees: Duke University, Zeneca Limited
    Inventors: Randy L. Jirtle, Angus T. DeSouza, Gerald R. Hankins
  • Process for preparing 4,4,4-trichlorobutan-1-ol
    Patent number: 5874650
    Abstract: A process for the preparation of 4,4,4-trichlorobutan-1-ol which comprises reacting allyl alcohol with chloroform in the presence of a radical initiator. Preferably the allyl alcohol is added incrementally to the chloroform over the period of the reaction.
    Type: Grant
    Filed: July 8, 1997
    Date of Patent: February 23, 1999
    Assignee: Zeneca Limited
    Inventor: Martin Charles Bowden
  • Herbicide intermediates
    Patent number: 5869740
    Abstract: Compounds of the formula: ##STR1## wherein R is CH.sub.2 X or CHX.sub.2 and X is chloro or bromo and R.sup.1 is chloro, bromo or nitro which are useful as intermediates for preparing herbicidal 2-(2'-substituted)-4'-(alkylsulfonyl)benzoyl-1,3-cyclohexanedione compounds.
    Type: Grant
    Filed: March 20, 1997
    Date of Patent: February 9, 1999
    Assignee: Zeneca Limited
    Inventors: Richard D. Gless, Jr., Nancy Kerlinger
  • Stabilised dye composition
    Patent number: 5869627
    Abstract: A composition of a water-soluble bis-azo dye of the Formula (1) and an oxidising agent. ##STR1## wherein A is optionally substituted phenyl or optionally substituted naphthyl;B is optionally substituted phenylene or optionally substituted naphthylene;R.sup.1 is H or sulpho;R.sup.2 is H, optionally substituted alkyl, optionally substituted aryl or optionally substituted acyl;R.sup.3 is H, optionally substituted aryl, optionally substituted alkyl or a group, -D-E,D is optionally substituted C.sub.2-6 -alkylene; andE is a group of the Formula (1a): ##STR2## R.sup.4 & R.sup.5 each independently is H or optionally substituted alkyl; andR.sup.6 is H, optionally substituted alkyl, optionally substituted aryl or optionally substituted acyl.
    Type: Grant
    Filed: January 8, 1998
    Date of Patent: February 9, 1999
    Assignee: Zeneca Limited
    Inventors: Peter Gregory, Ronald Wynford Kenyon, Paul Wight
  • Heterocyclic compounds
    Patent number: 5866568
    Abstract: The invention concerns pharmaceutically useful compounds of the formula I, in which A.sup.1, A.sup.2, A.sup.3, A.sup.4, B.sup.1, m, Ar, W, X, Y, Z and R.sup.1 have any of the meanings defined herein, and their pharmaceutically acceptable salts, and pharmaceutical compositions containing them. The novel compounds possess endothelin receptor antagonist activity and are useful, for example, in the treatment of diseases or medical conditions in which elevated or abnormal levels of endothelin play a significant causative role. The invention further concerns processes for the manufacture of the novel compounds and the use of the compounds in medical treatment.
    Type: Grant
    Filed: June 4, 1996
    Date of Patent: February 2, 1999
    Assignee: Zeneca Limited
    Inventors: Robert Hugh Bradbury, Roger John Butlin, Roger James
  • Plant-derived enzyme and DNA sequences and uses thereof
    Patent number: 5866792
    Abstract: The chemically-inducible 27 kD subunit of the enzyme glutathione-S-transferase, isoform II (GST-II-27) and sequences encoding it are provided. In particular, a genomic DNA sequence encoding the gene promoter for the GST-II-27 subunit is provided. Then linked to an exogenous gene and introduced into a plant by transformation, and GST-II-27 promoter provides a means for the external regulation of expression of that exogenous gene. Transformation with DNA encoding glutathione-S-transferase polypeptides produces herbicide resistance transgenic plants.
    Type: Grant
    Filed: June 17, 1996
    Date of Patent: February 2, 1999
    Assignee: Zeneca Limited
    Inventors: Ian George Bridges, Simon William Jonathan Bright, Andrew James Greenland, David Charles Holt, Ian Jepson, Wolfgang Walter Schuch
  • Modification of lignin synthesis in plants
    Patent number: 5866791
    Abstract: The synthesis of lignin by plants, particularly cereal and forage crops, is modified by genetic transformation with a construct which includes a DNA sequence which modifies the activity of the enzyme cinnamyl coenzyme A reductase (CCR). Sequence-ID-1 is the CCR sequence from Zea mays.
    Type: Grant
    Filed: March 13, 1996
    Date of Patent: February 2, 1999
    Assignee: Zeneca Limited
    Inventor: Karen Anne Holt
  • Blue to green disperse dyes for synthetic fiber material
    Patent number: 5865857
    Abstract: A dye of Formula (1): ##STR1## wherein: D is a group of Formula (2): ##STR2## or a group of Formula (3): ##STR3## or a group of Formula (4): ##STR4## The variables are defined in the disclosures. The dyes and dye mixtures produce blue to green shades on synthetic textile materials such as polyester which have good build up and good light- and wet-fastness.
    Type: Grant
    Filed: June 19, 1997
    Date of Patent: February 2, 1999
    Assignee: Zeneca Limited
    Inventors: Denise Cavanagh, Mark Robert James, Barry Huston Meyrick, Paul Wight
  • Therapeutic amines
    Patent number: 5866611
    Abstract: Compounds of formula I, and their pharmaceutically acceptable salts, ##STR1## in which R.sup.1 and R.sup.2 are hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, phenylalkyl or alkenyl; or NR.sup.1 R.sup.2 is a heterocyclic group; A is trimethylene optionally substituted by alkyl and the phenyl ring is optionally substituted by substituents such as halogeno, alkenyl, amino, cyano, ureido, alkyl, carbamoylalkyl, alkanoylamino, alkoxycarbonyl, N-alkyl-alkanoylamino, alkanoyl and amines thereof; are inhibitors of squalene synthese and hence useful in treating diseases in which a lowering of cholesterol is desirable. As well as the use of these compounds in medicine, novel compounds, processes for their preparation and pharmaceutical compositions are also referred to.
    Type: Grant
    Filed: May 19, 1994
    Date of Patent: February 2, 1999
    Assignee: Zeneca Limited
    Inventors: George Robert Brown, Murdoch Allan Eakin, Peter John Harrison, deceased, Keith Blakeney Mallion
  • Newly characterized oxalate and uses therefor
    Patent number: 5866778
    Abstract: This invention pertains to methods for using oxalate oxidase in plant pathology. A substantially pure gene encoding the oxalate oxidase enzyme is elucidated. The expression product of the gene which can be stably incorporated into a foreign plant host has a unique profile including a pH optimum of 3.5, a positive heat stability, a single sub-unit of approximately 25 kilodaltons and protease stability. The methodology of this invention exploiting oxalate oxidase for protection against oxalic acid encompasses providing to a plant in need of oxalic acid protection an oxalic acid degrading enzyme in an amount sufficient to protect the plant from the oxalic acid.
    Type: Grant
    Filed: July 11, 1994
    Date of Patent: February 2, 1999
    Assignee: Zeneca Limited
    Inventors: Christina L. Hartman, Sarjit S. Johal, Mark R. Schmitt
  • Quinazoline derivatives
    Patent number: 5866572
    Abstract: The invention concerns quinazoline derivatives of the formula I ##STR1## wherein X.sup.1 is a direct link or a group such as CO, C(R.sup.2).sub.2 and CH(OR.sup.2);wherein Q.sup.1 is phenyl, naphthyl or a 5- or 6-membered heteroaryl moiety and Q.sup.1 optionally bears up to 3 substituents;wherein m is 1 or 2 and each R.sup.1 may be a group such as hydrogen, halogeno and trifluoromethyl; andwherein Q.sup.2 may be phenyl or a 9- or 10-membered bicyclic heterocyclic moiety and Q.sup.2 optionally bears up to 3 substituents;or a pharmaceutically-acceptable salt thereof;processes for their preparation, pharmaceutical compositions containing them and the use of their receptor tyrosine kinase inhibitory properties in the treatment of proliferative disease such as cancer.
    Type: Grant
    Filed: February 13, 1997
    Date of Patent: February 2, 1999
    Assignee: Zeneca Limited
    Inventors: Andrew John Barker, Craig Johnstone
  • Herbicidal 4-benzoylisoxazoles derivatives
    Patent number: 5863865
    Abstract: This invention relates to 4-benzoylisoxazoles of formula (I) ##STR1## as well as herbicide compositions containing them and their use as herbicides.
    Type: Grant
    Filed: October 28, 1997
    Date of Patent: January 26, 1999
    Assignee: Zeneca Limited
    Inventors: David L. Lee, Nigel Barnes
  • Therapeutic heterocyclic compounds
    Patent number: 5863935
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: January 26, 1999
    Assignee: Zeneca Limited
    Inventors: Alan D. Robertson, Alan P. Hill, Robert C. Glen, Graeme R. Martin
  • Therapeutic heterocycles
    Patent number: 5861392
    Abstract: Compounds of formula I ##STR1## wherein G, J, L, M, m and D have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of neurokinin A and useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.
    Type: Grant
    Filed: August 5, 1996
    Date of Patent: January 19, 1999
    Assignee: Zeneca Limited
    Inventor: Scott Carson Miller
  • N-heterocyclyl sulphonamide derivatives and their use as endothelin antagonists
    Patent number: 5861401
    Abstract: The invention concerns pharmaceutically useful N-heterocyclyl sulphonamide derivatives, their pharmaceutically acceptable salts, processes for their manufacture, their use for antagonising one or more actions of endothelin in a human or other warm-blooded animal, their use in methods of treatment of diseases or medical conditions in which elevated or abnormal levels of endothelin play a significant causative role.
    Type: Grant
    Filed: September 30, 1996
    Date of Patent: January 19, 1999
    Assignee: Zeneca Limited
    Inventor: Robert Hugh Bradbury
  • Antimicrobial proteins from aralia and impatiens
    Patent number: 5861480
    Abstract: Antimicrobial proteins capable of isolation from seeds of Aralia or Impatiens show a wide range of antifungal activity and some antibacterial activity. DNA encoding the proteins may be isolated and incorporated into vectors. Plants transformed with this DNA may be produced. The proteins find commerical application as antifungal or antibacterial agents; transformed plants will show increased disease-resistance. The invention further provides a method of expressing polyproteins in transgenic plants using DNA constructs based on the structure of the gene encoding the Impatiens antimicrobial proteins.
    Type: Grant
    Filed: August 19, 1996
    Date of Patent: January 19, 1999
    Assignee: Zeneca Limited
    Inventors: Shelia Attenborough, Willem Frans Broekaert, Rupert William Osborn, John Anthony Ray, Sarah Bronwen Rees, Ravindra Haribhai Tailor
  • Process for preparing an antifungal azole with hydrazino and amidrazone intermediates
    Patent number: 5861516
    Abstract: A process for preparing an antifungal azole compound of formula (I) by reacting an epoxide with hydrazine to from a hydrazino compound which is subsequently reacted with an iminoether. The amidrazone product is subsequently reacted with an orthoformate to provide the antifungal azole. The azole, known as ZD0870, shows good activity against human fungal infections including Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus.
    Type: Grant
    Filed: April 9, 1997
    Date of Patent: January 19, 1999
    Assignee: Zeneca Limited
    Inventors: Elwyn Peter Davies, John David Pittam, Keith Blakeney Mallion, Nigel Philip Taylor
  • Plants and processes for obtaining them
    Patent number: 5859333
    Abstract: Plants with an altered starch synthesizing ability are produced by incorporating into the genome of the plant at least one donor gene encoding a starch primer. The starch primer is an enzyme capable of initiating starch synthesis, such as an amylogenin and/or glycogenin. DNA constructs encoding a starch primer are provided, particularly constructs encoding amylogenin from maize.
    Type: Grant
    Filed: December 18, 1995
    Date of Patent: January 12, 1999
    Assignees: Zeneca Limited, The University of Miami
    Inventors: Peter Lewis Keeling, Joseph Lomako, Dave Gieowar-Singh, George William Singletary, William Joseph Whelan
  • Insecticidal, acaricidal or nematicidal 3-cyano-8-azabicyclo?3.2.1!octane derivatives
    Patent number: 5859024
    Abstract: The invention provides novel compounds of formula (I) and formula (II) ##STR1## wherein R.sup.1 represents a group of formula (A) ##STR2## where each of W, X, Y and Z and represents either a group CR or the nitrogen atom, provided that not more than two of W, X, Y and Z represent the nitrogen atom and where each R present is independently selected from hydrogen and halogen atoms and cyano, amino, hydrazino, acylamino, hydroxy, alkyl, hydroxyalkyl, alkoxy, haloalkyl, haloalkoxy, alkenyl, alkenyloxy, alkoxyalkenyl, alkynyl, carboxylic acyl, alkoxycarbonyl, aryl and heterocyclyl groups, said groups comprising up to 6 carbon atoms, and wherein R.sup.2 represents a group XR.sup.3 where X represents oxygen or a group NR.sup.4 where R.sup.3 and R.sup.
    Type: Grant
    Filed: May 31, 1997
    Date of Patent: January 12, 1999
    Assignee: Zeneca Limited
    Inventors: Matthew Brian Hotson, Roger Salmon