Patents Assigned to Zeneca
  • Nucleic acid detection with energy transfer
    Patent number: 5827653
    Abstract: A method for the detection of a nucleic acid analyte by complementary probe hybridisation and formation of a chelated lanthanide complex which, upon irradiation by light, results in a characteristic delayed luminescence emission.
    Type: Grant
    Filed: May 20, 1996
    Date of Patent: October 27, 1998
    Assignee: Zeneca Limited
    Inventors: Peter George Sammes, Andrew John Garman
  • Modification of starch synthesis in plants
    Patent number: 5824790
    Abstract: A method of producing a plant with novel starch-synthesising ability comprises stably incorporating into the genome of a recipient plant at least one target gene encoding an enzyme involved in a starch or glycogen biosynthetic pathway. A plant with novel starch-synthesising ability may have novel starch quality (eg altered fine structure). Starch or glycogen biosynthetic enzymes include soluble starch synthase, branching enzyme, glycogen synthase, ADP-glucose pyrophosphorylase, self-glucosylating protein, glycogenin and amylogenin. Mutants involving said enzymes for use in this method are described, including specific gene-dosage combinations which provide novel starch fine structures and starch properties. DNA constructs for use in this method are described, as well as plants transformed with said DNA constructs, the seeds and progeny of such plants, and hybrids whose pedigree includes such plants.
    Type: Grant
    Filed: December 15, 1995
    Date of Patent: October 20, 1998
    Assignee: Zeneca Limited
    Inventors: Peter Lewis Keeling, Mary E. Knight, Hanping Guan
  • Biocidal proteins
    Patent number: 5824869
    Abstract: Biocidal proteins isolated from seeds have been characterised, in particular proteins isolated from members of the Brassicaceae, Compositae and Leguminosae families including Raphanus, Brassica, Sinapis, Arabidopsis, Dahlia, Cnicus, Lathyrus and Clitoria. The proteins show a wide range of antifungal activity and some are active against Gram-positive bacteria. All share a common amino acid sequence. DNA encoding the proteins has been isolated and incorporated into vectors. Plants transformed with this DNA may be produced. The proteins find commercial application as antifungal or antibacterial agents; transformed plants will show increased disease-resistance.
    Type: Grant
    Filed: December 27, 1996
    Date of Patent: October 20, 1998
    Assignee: Zeneca Limited
    Inventors: Willem F. Broekaert, Bruno P.A. Cammue, Rupert W. Osborn, Sarah B. Rees, Franky R.G. Terras, Jozef Vanderleyden
  • Tomato ripening TOM41 compositions and methods of use
    Patent number: 5824873
    Abstract: The present invention provides a method for modifying fruit ripening characteristics in plants and is particularly suitable for modification of tomato plants. The DNA expressing an enzyme involved in fruit ripening has been identified and characterized. The DNA is useful in genetically modifying plants to improve shelf life, flavor, resistance to post-harvest pathogens and improved processing characteristics.
    Type: Grant
    Filed: April 10, 1996
    Date of Patent: October 20, 1998
    Assignees: University of Florida, Zeneca Limited
    Inventors: Donald Grierson, Susan Dale Lawrence, Gloria Andrews Moore, Wolfgang Walter Schuch
  • Ink compositions containing disazo dyes
    Patent number: 5820661
    Abstract: An ink composition comprising:(i) a dye of Formula (1) or a salt thereof: ##STR1## wherein: A is optionally substituted phenylene;B and E each independently is optionally substituted phenylene or optionally substituted naphthylene;D is a coupling component;each R.sup.1 independently is H or optionally substituted alkyl;X is a labile or non-labile atom or group;each Z independently is --OR.sup.3, --SR.sup.3, --NR.sup.4 R.sup.5 or --Y--SO.sub.3 H in which Y is O or S; andR.sup.3, R.sup.4 and R.sup.5 each independently is H, optionally substituted alkyl, optionally substituted alkenyl, cycloalkyl, optionally substituted aralkyl, optionally substituted aryl or R.sup.4 or R.sup.5 together with the nitrogen atom to which they are attached form a 5 or 6 membered ring; and(ii) a medium comprising a low melting point solid, an organic solvent, or a mixture of water and one or more water-soluble organic solvent(s).
    Type: Grant
    Filed: April 2, 1997
    Date of Patent: October 13, 1998
    Assignee: Zeneca Limited
    Inventors: Peter Gregory, Mark Kenworthy, Andrew Hunter Morris Renfrew
  • Aniline derivatives
    Patent number: 5821246
    Abstract: The invention concerns aniline derivatives of formula I ##STR1## wherein m is 1, 2 or 3, n is 0, 1, 2 or 3, Q is phenyl or naphthyl or a 5- or 6-membered heteroaryl moiety containing 1, 2 or 3 heteroatoms selected from oxygen, nitrogen and sulfur, and X, R.sup.1 and R.sup.2 are defined in the claims; or pharmaceutical compositions containing them, and the methods of using the compounds as tyrosine kinase inhibitors and for the treatment of proliferative diseases such as cancer.
    Type: Grant
    Filed: May 21, 1997
    Date of Patent: October 13, 1998
    Assignee: Zeneca Limited
    Inventors: Dearg Sutherland Brown, Jeffrey James Morris, Andrew Peter Thomas
  • Process for treating stained fabrics with manganese phthalocyanines
    Patent number: 5817154
    Abstract: A substituted phthalocyanine in which at least one of the peripheral carbon atoms in the 1-16 positions of the phthalocyanine nucleus (MnPc) as shown in Formula (1) ##STR1## is linked via an oxygen atom or a sulphur atom to an organic radical, the remaining peripheral carbon atoms being unsubstituted or substituted by any combination of atoms or groups and sulphonated derivatives thereof.
    Type: Grant
    Filed: August 29, 1995
    Date of Patent: October 6, 1998
    Assignee: Zeneca Limited
    Inventors: Peter Gregory, Stephen James Reynolds, Raymond Lesley White
  • Quinazoline compounds
    Patent number: 5814630
    Abstract: The invention concerns quinazoline compounds of the formula I ##STR1## wherein Q.sup.1 is a 5- or 6-membered heteroaryl moiety and Q.sup.1 optionally bears up to 3 substituents;wherein m is 1 or 2 and each R.sup.1 may be a group such as hydrogen, halogeno and trifluoromethyl;and wherein Q.sup.2 is phenyl which optionally bears up to 3 substituents; or a pharmaceutically-acceptable salt thereof;processes for their preparation, pharmaceutical compositions containing them and the use of their receptor tyrosine kinase inhibitory properties in the treatment of proliferative disease such as cancer.
    Type: Grant
    Filed: February 13, 1997
    Date of Patent: September 29, 1998
    Assignee: Zeneca Limited
    Inventors: Andrew John Barker, Craig Johnstone
  • Ortho substituted aromatic compounds useful as antagonists of the pain enhancing effects of E-type prostaglandins
    Patent number: 5811459
    Abstract: The invention relates to compounds of the formula (I): ##STR1## wherein A, B and D are various ring systems such as phenyl, R.sup.1 includes carboxy, R.sup.3 is hydrogen or C.sub.1-4 alkyl and Z is a linking group such as --(CH(R.sup.5)).sub.m -- wherein m is 2, 3 or 4, and R.sub.5 includes hydrogen and methyl; and pharmaceutically acceptable salts and in vivo hydrolysable esters or amides thereof, processes for preparing these compounds, pharmaceutical compositions comprising them, and their use in the treatment of pain.
    Type: Grant
    Filed: June 4, 1996
    Date of Patent: September 22, 1998
    Assignee: Zeneca Limited
    Inventors: Gloria Ann Breault, John Oldfield, Howard Tucker, Peter Warner
  • Production of optically active 1,2-dihydroxyindance derivatives by asymetric assimilation
    Patent number: 5811294
    Abstract: A process for resolution of a mixture of cis-dihydroxydihydroindene enantiomers comprising treating the mixture of enantiomers with a Pseudomonas putida species microorganism.Resolved dihydroxydihydroindenes are valuable intermediates for the synthesis of biologically active compounds such as pharmaceuticals and agrochemicals.
    Type: Grant
    Filed: April 4, 1997
    Date of Patent: September 22, 1998
    Assignee: Zeneca Limited
    Inventors: Christopher Curtis Royston Allen, Derek Raymond Boyd, Howard Dalton
  • Method of characterisation
    Patent number: 5811235
    Abstract: A method of characterizing a test sample of genomic DNA which method comprises amplifying a tandemly repeated region, comprising more than one type of repeat unit, as far as internal repeat units of a specific type so as to generate a set of amplification products which identify the relative positions of the internal repeat units within the tandemly repeated region, and separating the set of amplification products to provide a sample code. The sample codes are suitable for computerized storage on, and retrieval from, a database. The invention also provides a novel method for the detection of diagnostic base sequences in one or more nucleic acids contained in a sample.
    Type: Grant
    Filed: April 5, 1995
    Date of Patent: September 22, 1998
    Assignee: Zeneca Limited
    Inventor: Alec John Jeffreys
  • Catalytic antibodies for carbamate activation by a non-spontaneous reaction mechanism
    Patent number: 5807688
    Abstract: Catalytic antibodies capable of catalysing activation of a carbamate (--O--CO--NH--) containing prodrug suitable for Antibody Directed Abzyme Prodrug Therapy (ADAPT) by catalysing breakdown of the prodrug at the carbamate position by a non-spontaneous reaction mechanism. The non-spontaneous reaction preferably has a B.sub.Ac 2 mechanism and the prodrug is a preferably a nitrogen mustard aryl carbamate. The invention also includes relevant immunogens, screens for catalytic activity using short transition state analogues and ADAPT systems.
    Type: Grant
    Filed: May 24, 1996
    Date of Patent: September 15, 1998
    Assignee: Zeneca Limited
    Inventors: George Michael Blackburn, Paul Wentworth
  • Aminotetralin derivative and compositions and method of use thereof
    Patent number: 5807897
    Abstract: The invention relates to aminotetralin derivatives of the formula I: ##STR1## wherein: R.sup.1 is methyl or ethyl; R.sup.2 is hydrogen, halogen, lower-alkoxy or thiolower-alkyl; R.sup.3 is hydrogen, halogen, lower-alkoxy or lower-alkyl; and the chiral center * is in the (S)(-) form; or a pharmaceutically acceptable acid-addition salt thereof, with the proviso that when R.sup.2 and R.sup.3 are both hydrogen, R.sup.1 must be methyl; to pharmaceutical compositions containing them and to methods for the treatment or prevention of movement disorders utilizing them.
    Type: Grant
    Filed: February 21, 1997
    Date of Patent: September 15, 1998
    Assignee: Zeneca Limited
    Inventors: Edward John Warawa, Bernard Migler
  • Proline derivatives
    Patent number: 5808097
    Abstract: The present invention relates to particular forms of a novel 1-substituted-N-?2-methyl-1-(trifluoroacetyl)propyl!pyrrolidine-2-carboxam ide which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes pharmaceutical compositions containing such forms, processes for preparing the forms and intermediates useful in the synthesis of the forms.
    Type: Grant
    Filed: August 22, 1997
    Date of Patent: September 15, 1998
    Assignee: Zeneca Limited
    Inventors: Chris Allan Veale, Peter Robert Bernstein, Elwyn Peter Davies
  • Analgesic peptides from venom of grammostola spatulata and use thereof
    Patent number: 5807821
    Abstract: The present invention provides novel methods of treating pain comprising administering to a mammal in need of such treatment an effective analgesic amount of a peptide having the amino acid sequence of SEQ ID. NO.: 1 or SEQ ID NO: 2. The invention further provides a purified peptide having the amino acid sequence of SEQ ID NO: 1. The peptides of SEQ ID NO.:1 and SEQ ID NO.: 2 can also be used in methods for identifying compounds having analgesia-inducing activity.
    Type: Grant
    Filed: February 4, 1998
    Date of Patent: September 15, 1998
    Assignee: ZENECA Limited
    Inventor: Richard Alexander Lampe
  • Plant gene construct comprising male flower specific promoters
    Patent number: 5808034
    Abstract: Male sterility is imparted to a plant by a cascade of gene sequences which expresses a protein which disrupts the biosynthesis of viable pollen. Expression of the disrupter protein is restricted to male parts of the plant by an upstream promoter sequence which is specific to male flowers, the male specific promoter being under control of an operator sequence. The cascade also includes a gene encoding a repressor protein specific for that operator. Expression of the repressor protein is under control of a chemically inducible promoter which is inducible by the application to the plant by, spraying or like process, of an exogenous chemical. In the absence of the exogenous chemical inducer, no repressor protein is expressed, resulting in expression of the disrupter protein and, consequently, male sterility.
    Type: Grant
    Filed: August 22, 1994
    Date of Patent: September 15, 1998
    Assignee: Zeneca Limited
    Inventors: Ian George Bridges, Simon William Jonathan Bright, Andrew James Greenland, Wolfgang Walter Schuch
  • Production of polymer emulsions
    Patent number: 5804632
    Abstract: Process for the production of an aqueous polymer emulsion which process comprises:a) preparing a low molecular weight polymer containing acid-functional groups using a free-radical polymerisation process which employs a free-radical initiator and, for the purpose of controlling molecular weight, a transition metal chelate complex, wherein said low molecular weight polymer has a number average molecular weight within the range of from 500 to 50,000;b) conducting an aqueous emulsion polymerisation process to form an aqueous emulsion of a hydrophobic polymer from at least one olefinically unsaturated monomer, wherein the low molecular weight polymer of step a) is introduced to the aqueous medium of said emulsion polymerisation process before the start of and/or during said emulsion polymerisation process and becomes dissolved or dispersed in said aqueous medium.
    Type: Grant
    Filed: January 29, 1996
    Date of Patent: September 8, 1998
    Assignees: Zeneca Limited, Zeneca Resins BV
    Inventors: David Mark Haddleton, John Christopher Padget, Gerardus Cornelis Overbeek
  • Substituted nitrogen heterocycles
    Patent number: 5801168
    Abstract: Antagonists at the NMDA receptor complex which are benz?b!azepines having a hydroxy, alkoxy or amino substituent at the 3-position and a 4-position alkenyl, alkynyl, aryl or heteroaryl substituent for treatment of stroke and/or other neurodegenerative disorders.
    Type: Grant
    Filed: February 3, 1997
    Date of Patent: September 1, 1998
    Assignee: Zeneca Limited
    Inventors: Marc Jerome Chapdelaine, Timothy W. Davenport, Laura E. Garcia-Davenport, Paul Francis Jackson, Jeffrey A. McKinney, Charles D. McLaren
  • Oligonucleotide signalling conjugate
    Patent number: 5800985
    Abstract: Oligonucleotide signalling conjugates including a nucleic acid sequence, an amino-group containing linker group, a sulphur (thio) containing group and a non-isotopic label or marker and thiolated oligonucleotide derivative intermediates reactive with activated non-isotopic label or marker are described. The non-isotopic label is especially an enzyme such as alkaline phosphatase or horse radish peroxidase. The conjugates have application in the detection or characterisation of nucleic acid sequences and in particular in genetic characterisation.
    Type: Grant
    Filed: September 22, 1994
    Date of Patent: September 1, 1998
    Assignee: Zeneca Limited
    Inventor: Andrew John Garman
  • Increasing the particle size of polymers
    Patent number: 5798440
    Abstract: Polyester particles in suspension in a liquid can be agglomerated below their melting points and the agglomerated particles are more easily filtered.
    Type: Grant
    Filed: January 24, 1995
    Date of Patent: August 25, 1998
    Assignee: Zeneca Limited
    Inventors: John Macdonald Liddell, Neil George