Patents Assigned to Zhejiang University
  • Publication number: 20210009635
    Abstract: This invention relates to a hybrid ligand, a hybrid biomimetic chromedia and a preparing method and a use thereof, wherein the hybrid biomimetic chromedia takes hydrophilic porous microsphere as a substrate in chromatography, activated with allyl bromide and undergoing bromo-alcoholization with N-bromosuccinimide, then coupled with the hybrid ligands. The sequence of the hybrid ligand is phenylalanine-tyrosine-glutamine-5-aminobenzimidazole. The hybrid biomimetic chromedia has both of the two functional groups of phenylalanine-tyrosine-glutamine tripeptide and aminobenzimidazole, while maintaining the high antibody selectivity of polypeptide ligand, hydrophobic electric charge inductive ligand is introduced to achieve more moderate elution requirement, realizing effective antibody separation.
    Type: Application
    Filed: January 16, 2018
    Publication date: January 14, 2021
    Applicant: ZHEJIANG UNIVERSITY
    Inventors: Shanjing YAO, Dongqiang LIN, Qilei ZHANG, Xujun ZOU, Huili LU
  • Publication number: 20210009514
    Abstract: The present disclosure discloses a preparation method for 4-phenylthio-benzenethiol. The preparation method comprises the following steps: subjecting phenyl sulfide as a raw material to a halogenation reaction to obtain 4-halophenyl sulfide; subjecting the 4-halophenyl sulfide to a sulfhydrylation reaction to obtain a 4-phenylthio-phenylthiolate; and subjecting the 4-phenylthio-phenylthiolate to acidification. The preparation method of the present disclosure avoids the use of materials such as thiophenol which pollutes the environment, and realizes efficient recycling of the reaction materials, solvents, water and the like. The preparation method of the present disclosure is a green process for the synthesis of 4-phenylthio-phenylthiol without organic waste, waste acid and waste water discharge.
    Type: Application
    Filed: July 12, 2018
    Publication date: January 14, 2021
    Applicants: Zhejiang NHU Company Ltd, Zhejiang University, Zhejiang NHU Special Materials Co., Ltd.
    Inventors: Zhirong CHEN, Woyuan LI, Hong YIN, Guíyang ZHOU, Haoran LI, Shuaifeng PAN, Ming LIAN, Guangde QIN, Qichuan LI
  • Patent number: 10889760
    Abstract: A biomass gas-carbon co-production reactor includes: multiple downward bed pyrolysis zones, a gas-solid separation zone, an activated carbon activation zone, and a secondary pyrolysis reaction zone; wherein the activated carbon activation zone communicates with the gas-solid separation zone and the secondary pyrolysis reaction zone; tops of the downward bed pyrolysis zones penetrate through a top of the gas-solid separation zone, and a heat carrier inlet and a raw material inlet are symmetrically arranged on a left side and a right side of each of the downward bed pyrolysis zones; bottoms of the downward bed pyrolysis zones are located inside the secondary pyrolysis reaction zone for communicating; a fluidizing air inlet is provided at a bottom of the secondary pyrolysis reaction zone, and an activated gas inlet is provided at a top of the secondary pyrolysis reaction zone; an activated carbon outlet is provided on the gas-solid separation zone.
    Type: Grant
    Filed: June 24, 2020
    Date of Patent: January 12, 2021
    Assignee: Zhejiang University Of Science & Technoiogy
    Inventors: Xikun Gai, Wanpeng Liu, Yin Li, Jing Di, Lijuan Chen, Ruiqin Yang, Shengdao Shan
  • Patent number: 10889605
    Abstract: The present disclosure relates to a light emitting material for a tetradentate cyclometalated platinum complex and an application thereof in the field of OLED. The tetradentate cyclometalated platinum complex is selected from one of compounds as shown in formula I. The present disclosure adjusts the photophysical properties of the tetradentate cyclometalated platinum complex by changing the structure of a ligand surrounding a metal center or regulating and controlling the structure of a substituent on a ligand, which can emit light in a range of about 400 nm to about 700 nm and has the advantages of narrow emission spectrum, high stability and high efficiency and has a wide application prospect in the field of OLED display and illumination.
    Type: Grant
    Filed: August 14, 2018
    Date of Patent: January 12, 2021
    Assignees: AAC MICROTECH(CHANGZHOU)CO., LTD., ZHEJIANG UNIVERSITY OF TECHNOLOGY
    Inventor: Guijie Li
  • Patent number: 10888977
    Abstract: The present disclosure relates to a suction device including a shell with a chamber, the chamber including an opening. A fan is disposed in the chamber, and a power component for driving the fan to rotate is disposed on the shell. An external fluid source holding an additional fluid is connected to the chamber. The additional fluid of the external fluid source flows into the chamber to occupy a volume in the chamber and at least partially forces a first fluid originally present in the chamber out of the chamber. The fan drives fluids in the chamber to rotate so that a stepped negative pressure is generated in the chamber, with a magnitude of the negative pressure decreasing as a distance to a periphery of the chamber decreases. Thereby, a pressure difference between an inside and an outside of the shell is decreased, decreasing vacuum leakage of the suction device.
    Type: Grant
    Filed: March 1, 2019
    Date of Patent: January 12, 2021
    Assignee: ZHEJIANG UNIVERSITY
    Inventors: Xin Li, Kaige Shi
  • Patent number: 10870620
    Abstract: The present disclosure provides a radioactive carbon-14 labeled XCLSBM in the structure of Formula 4 and its preparation method and applications. A 14C labeled raw material is used to synthesize a 14C-labeled XCLSBM, and a method for synthesizing a trace 14C-labeled marker of 14C-labeled XCLSBM is established, which avoids high-temperature, high-pressure reactions and the production process is safe with a low synthesis cost. The radioactive carbon-14 labeled XCLSBM can be used to trace the migration and transformation, metabolic degradation, absorption and enrichment of XCLSBM in environment and living bodies, for providing technical supports for comprehensive evaluation of the ecological safety of XCLSBM.
    Type: Grant
    Filed: July 22, 2020
    Date of Patent: December 22, 2020
    Assignee: Zhejiang University
    Inventors: Wang Haiyan, Lu Yuhui, Ye Qingfu
  • Patent number: 10865391
    Abstract: The present invention relates to glutamate dehydrogenase mutants and their application in preparation of L-phosphinothricin. The amino acid sequences of the glutamate dehydrogenase mutants are as shown in SEQ ID NO. 1-9, 11, 13, 15, 17-19 and 22. By means of molecular engineering, mutating the specific alanine in glutamate dehydrogenase substrate-binding pocket into glycine and/or mutating the specific valine in glutamate dehydrogenase substrate-binding pocket into alanine, the present invention has obtained NADPH-specific glutamate dehydrogenase mutants with high enzyme activity in catalyzing the substrate 2-oxo-4-[(hydroxy)(methyl)phosphinoyl]butyric acid or its salt for L-phosphinothricin preparation or NADH-specific glutamate dehydrogenase mutants with catalytic activity toward PPO; this has significantly improved substrate conversion, and increased the product concentration of the L-phosphinothricin preparation process.
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: December 15, 2020
    Assignee: ZHEJIANG UNIVERSITY
    Inventors: Lirong Yang, Xinjian Yin, Jianping Wu, Gang Xu
  • Publication number: 20200386661
    Abstract: The present invention relates to a corrosion-fatigue-coupled test method and device for a steel bridge deck. The method includes: 1) installing an orthotropic steel bridge deck (OSBD) and pasting filter paper; 2) installing a sodium chloride solution delivery pipe; 3) installing an infrared (IR) lamp; 4) preparing a corrosive solution; 5) coupling corrosion and fatigue; and 6) acquiring test data. A device constructed by using the method includes a to-be-tested OSBD, a support device, a pressure pump, a water tank, a monitoring device, an IR lamp, a plastic water pipe, a thermostat and a rotary sprayer. The present invention solves the problem of laboratory accelerated corrosion of the OSBD. The present invention fully considers a coupling effect of a corrosive medium and an alternating stress, so that the created simulation environment is close to a service environment of the OSBD, and the test data are effective and reliable.
    Type: Application
    Filed: May 22, 2020
    Publication date: December 10, 2020
    Applicant: Zhejiang University
    Inventors: Xiaowei YE, Zhiwen CHEN, Xin QIAN, Yuliang HE
  • Publication number: 20200388044
    Abstract: The present invention discloses a plant point cloud acquisition, registration, and optimization method based on a time of flight (TOF) camera, which includes the following steps: (1) placing a to-be-tested plant on a turntable, adjusting a view angle of the TOF camera, and aligning the TOF camera with the to-be-tested plant; (2) turning on the turntable so that it rotates automatically, and enabling the TOF camera to acquire point cloud data of the to-be-tested plant at intervals; (3) performing real-time preprocessing on each frame of point cloud data acquired by the TOF camera; (4) performing registration and optimization on every two adjacent frames of point cloud data, and then integrating the data to obtain complete plant point cloud data; and (5) using statistical filtering to remove the discrete noise in the plant point cloud data obtained in the registration and optimization process to obtain final point cloud data.
    Type: Application
    Filed: May 28, 2020
    Publication date: December 10, 2020
    Applicant: Zhejiang University
    Inventors: Haiyan CEN, Yong HE, Zhihong MA, Hui FANG
  • Publication number: 20200368168
    Abstract: This invention provides a method for preparing electrospraying particles to improve stability of polyphenol including the following steps: preparing a pectin-silica composite; adding polyphenolic compounds into the pectin-silica composite to prepare a core solution; and coaxial electrospraying the core solution and a shell solution to prepare electrospraying particles loaded polyphenol. This method utilizes a pectin-silica composite as a polyphenol loading carrier, improves the encapsulating efficiency of polyphenols, reduces the contact probability of polyphenols with oxygen and water, and improves the stability of polyphenols; and an acidic aqueous solution is used as a shell solution to synergize with the pectin-silica composite to further improve the stability of polyphenols.
    Type: Application
    Filed: May 22, 2019
    Publication date: November 26, 2020
    Applicant: Zhejiang University of Technology
    Inventors: Ping Shao, Ben Niu, Ligang Jiang
  • Publication number: 20200368728
    Abstract: The present invention is related to a method of coupling methane dry-reforming and composite catalyst regeneration. A composite catalyst is filled into a reactor, and methane or a methane mixture gas is introduced therein. CaCO3 in the composite catalyst is decomposed under 600-850° C. CO2 obtained by the decomposition reacts with methane to perform methane dry-reforming reaction and produce synthesis gas containing CO and hydrogen. The composite catalyst contains CaCO3 , active nickel and alumina support. This method couples the CaCO3 decomposition reaction in calcium looping and methane dry-reforming reaction to solve the technical problem of limiting CaCO3 decomposition by high-temperature equilibrium. The decomposition of CaCO3 is enhanced, and the CO2 produced by decomposing CaCO3 is dry-reformed to produce synthesis gas to be utilized.
    Type: Application
    Filed: May 15, 2018
    Publication date: November 26, 2020
    Applicant: ZHEJIANG UNIVERSITY
    Inventors: Sufang WU, Jiayan XU, Hao LIU, Qirui LIN, Hui XIAO
  • Patent number: 10843904
    Abstract: Provided is an offshore crane heave compensation control system and method using video rangefinding to achieve heave compensation in a directly driven pump-controlled electro-hydraulic heave compensator. The heave compensation and the heave compensator are applicable for special operation and control requirements on a fixed offshore platform and allow the crane to achieve steady lifting of a load away from or lowering of a load on to a supply vessel without being influenced by the motion of the supply vessel caused by ocean currents, ocean winds, or ocean waves. Also provided is a test platform for the offshore crane heave compensation control system using video rangefinding. The test platform provides a realistic simulation for all lifting and lowering processes of an offshore platform crane in offshore environments to study the motion control of the provided system.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: November 24, 2020
    Assignee: Zhejiang University
    Inventors: Guofang Gong, Yakun Zhang, Weiqiang Wu, Xiangping Liao, Huayong Yang
  • Patent number: 10844171
    Abstract: The present disclosure provides a production method of a semi-aromatic polyamide, and a semi-aromatic polyamide. Said production method of a semi-aromatic polyamide includes: step 1 of subjecting an initial charge of a diamine and a binary acid in an amine/acid molar ratio of less than 1.0 to form a slurry together with water and a catalyst, and subjecting the slurry to heating and dissolution to form a saline solution; step 2 of dehydrating said saline solution after detecting the composition thereof, detecting the content of diamine in a steam condensate from a dehydration unit, adjusting the amine/acid molar ratio to be larger than 1.0 by a molten diamine and a monoacid as a molecular weight regulator, and performing pre-polymerization; and step 3 of subjecting a pre-polymerization solution to post-polycondensation after vacuum flashing. The semi-aromatic polyamide of the present disclosure has a low gel content, excellent performance and extensive scope of application.
    Type: Grant
    Filed: June 29, 2017
    Date of Patent: November 24, 2020
    Assignees: Zhejiang Nhu Special Materials Co., Ltd., Zhejiang University, Zhejiang Nhu Company Ltd.
    Inventors: Zhirong Chen, Hong Yin, Qin Zhang, Xiaoxiao Wu, Wengang Hong, Hangjun Deng, Guiyang Zhou, Changze Wang
  • Publication number: 20200362317
    Abstract: The invention discloses a glutamate dehydrogenase mutant and an application thereof. The mutant is one of the following: a mutation of the 402th lysine of the amino acid sequence shown in SEQ ID NO. 1 to phenylalanine or aspartic acid; a mutation of the 406th isoleucine to phenylalanine or threonine; a combined mutation of the 121th threonine and the 123th leucine; a combined mutation of the 379th alanine and the 383th leucine. In the invention, the catalytic activity of glutamate dehydrogenase derived from Pseudomonas putida to 2-carbonyl-4-(hydroxymethylphosphonoyl)butanoic acid (PPO) is significantly improved by a molecular transformation method combining directed evolution and a semi-rational design; and the issue of low glutamate dehydrogenase activity in the process of preparing L-glufosinate by reductive amination is solved.
    Type: Application
    Filed: November 14, 2019
    Publication date: November 19, 2020
    Applicant: ZHEJIANG UNIVERSITY
    Inventors: Lirong YANG, Xinjian YIN, Jianping WU, Gang XU
  • Patent number: 10827937
    Abstract: The present invention discloses a method for noninvasive imaging of cardiac electrophysiological based on low rank and sparse constraints. This method decomposes the spatio-temporal distribution of endocardial and epicardial potentials into a low-rank matrix representing smooth potential components and a sparse matrix representing the details of potential salience according to the prior condition of spatio-temporal correlation of the endocardial and epicardial potential distribution of the heart. By introducing low rank and sparse constraints, the solution of the ill-conditioned inverse problem of ECG is constrained to the unique optimal solution. The invention combines the individualized three-dimensional heart model of the subject to obtain a three-dimensional dynamic distribution image of the cardiac endocardial and epicardial potential of the subject, which has important practical application value.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: November 10, 2020
    Assignee: ZHEJIANG UNIVERSITY
    Inventors: Huafeng Liu, Lin Fang
  • Patent number: 10829170
    Abstract: The present invention relates to a multifunctional robot system and method. The multifunctional robot system comprises an independently movable supply station and a plurality of robot units. The supply station comprises a power supply system and a supply station moving device; each robot unit is provided with a robot driving device, an operation execution device and a robot moving device; the supply station is connected with each robot unit respectively through a connecting cable. The multifunctional robot system is provided with the independent supply station, and the execution device of the robot is separated from the driving device thereof and a supply device; the supply station continuously provides raw materials and energy for the robot, the weight and size of the robot side are reduced, and working efficiency is improved.
    Type: Grant
    Filed: April 19, 2018
    Date of Patent: November 10, 2020
    Assignee: ZHEJIANG UNIVERSITY
    Inventor: Xin Li
  • Patent number: 10828608
    Abstract: Disclosed is a semipermeable membrane and its preparation method. The semipermeable membrane obtained has a Turing structure. The Turing structure is an ordered pattern composed of microstructures. The existence of the structure enables the semipermeable membrane of this invention to have both high water permeation flux and excellent salt retention performance, which breaks the flux limit value of the semipermeable membrane while ensuring high selective permeability of the membrane. It also has good anti-pollution properties. The preparation method of the invention can be easily integrated into the existing semipermeable membrane production line without further cost input which has far-reaching practical significance and commercial value.
    Type: Grant
    Filed: February 7, 2019
    Date of Patent: November 10, 2020
    Assignee: Zhejiang University
    Inventors: Lin Zhang, Zhe Tan, Shengfu Chen, Lida Meng
  • Patent number: 10821397
    Abstract: The present invention is related a square packed tower for collection of flue gas CO2. The square packed tower comprises an initial absorbent distributor on the lower end of the flue gas outlet, a vertical plate packer on the lower end of the initial absorbent distributor and a radial diversion gas distributor at the bottom of the square packed tower for delivery of carbon dioxide contained in the flue gas. The radial diversion gas distributor comprises a gas inlet pipe, a butterfly base plate, a butterfly seal plate and numerous radial deflectors. The butterfly base plate is connected with outlet of the gas inlet pipe. The radial deflectors are in radial arrangement between the butterfly base plate and butterfly seal plate along the outlet of gas inlet pipe.
    Type: Grant
    Filed: November 27, 2017
    Date of Patent: November 3, 2020
    Assignee: ZHEJIANG UNIVERSITY
    Inventors: Tao Wang, Mengxiang Fang, Wenfeng Dong, Qinhui Wang, Jianmeng Cen, Leming Cheng, Gang Xiao, Chenghang Zheng, Jinsong Zhou, Shurong Wang, Xiang Gao, Zhongyang Luo, Mingjiang Ni, Kefa Cen
  • Patent number: 10822327
    Abstract: A 2-substituted aromatic ring-pyrimidine derivative as shown in a general formula I, and an optical isomer or a pharmaceutically acceptable salt or a solvate thereof are provided. The present invention designs and synthesizes a series of novel small molecular Chk1 inhibitors by using N-substituted pyridin-2-aminopyrimidine obtained through structure-based virtual screening as a lead compound, and carries out Chk1 kinase inhibitory activity test. The experiment confirmed that said compounds possess strong anti-cancer effect, Chk1 kinase inhibitory activity and are promising Chk1 inhibitors. The compounds can be used as new cancer therapeutic drugs, which can be applied to treat solid tumors or hematologic tumors related to proliferative disease of human or animal.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: November 3, 2020
    Assignees: ZHEJIANG UNIVERSITY, SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
    Inventors: Tao Liu, Jia Li, Yongzhou Hu, Yubo Zhou, Xiaowu Dong, Anhui Gao, Pinrao Song, Peipei Wang, Lexian Tong, Xiaobei Hu, Mingbo Su
  • Patent number: 10818032
    Abstract: The present invention discloses a method which comprises the following steps: inputting the image waiting for test and the template; log-polar transforming the image waiting for test; performing feature extraction on transformed image object; capturing an image feature; achieving a response map of scale and rotation of the image object corresponding to a template through a phase correlation by using features extracted from the image features; calculating a relative displacement by using a response value and coordinates of the response value in a surround area of a maximum value of the response pattern; calculating the scale and the rotation of an object in the image waiting for test corresponding to the template through the relative displacement. The present invention adopts the log-polar space as the image operating space to estimate the change in size and rotation of the object and provide a fast and robust select for upper applications.
    Type: Grant
    Filed: December 27, 2017
    Date of Patent: October 27, 2020
    Assignee: ZHEJIANG UNIVERSITY
    Inventors: Jianke Zhu, Yang Li