Patents Assigned to Zhejiang University
  • Patent number: 11952436
    Abstract: The present disclosure discloses a method for extracting pectin rich in RG-I, in particular to an ultrasound and pressure assisted method for extracting pectin rich in RG-I. The main process includes: dispersing sieved citrus peel powers in alkaline solution containing sodium borohydride (20 to 50 mM); performing an ultrasound and pressure combined treatment on the above solution at 25 to 40° C., the treatment conditions include: static pressure of 0.2 to 0.4 MPa, ultrasonic intensity of 0.5 to 3.5 W/mL, and treatment time of 20 to 40 min; centrifuging the ultrasonically processed solution to remove residues, and sequentially carrying out precipitation with ethanol (50% to 80% v/v), precipitant dialysis (3000 to 3500 Da), and vacuum freeze drying on the extracted solution to obtain pectic polysaccharide.
    Type: Grant
    Filed: December 3, 2019
    Date of Patent: April 9, 2024
    Assignee: ZHEJIANG UNIVERSITY
    Inventors: Shiguo Chen, Weiwei Hu, Xingqian Ye, Huan Cheng, Donghong Liu, Chantapakul Thunthacha
  • Patent number: 11951228
    Abstract: Provided is a hemostatic composition comprising trypsin and zeolite, wherein pore channels of the zeolite are micropores, the zeolite contains divalent metal cations, and the mass ratio of the trypsin to the zeolite is 1:200-4:10. In the present invention, the trypsin specifically binds to the zeolite, allowing the trypsin to maintain a certain conformation on the surface of the zeolite and to obtain a higher procoagulant activity, thereby obtaining a hemostatic composition with an excellent blood coagulation effect. The hemostatic composition of the present invention has the advantages of a simple preparation method, low cost and convenient use, and can be widely used in hemostasis during trauma and operations, especially in emergent hemostasis in hemophilia patients.
    Type: Grant
    Filed: January 28, 2020
    Date of Patent: April 9, 2024
    Assignee: Zhejiang University
    Inventors: Jie Fan, Lisha Yu, Liping Xiao, Hao Chen, Xiaoqiang Shang
  • Patent number: 11956109
    Abstract: A low-computation underwater acoustic wake-up method based on a multi-carrier signal is provided. A multi-carrier signal corresponding to communication nodes is constructed, absolute values of the multi-carrier signal in a window at a receiver are summed for signal arrival detection, and then frequency points of the multi-carrier signal are detected many times by using the real fast Fourier transform to realize wake-up detection. The method is suitable for accurate wake-up at any distance within a maximum communication distance of two underwater acoustic nodes, has a small amount of calculation, and is suitable for low-power single-chip microcomputers. The modem can be in a low-power sleep state for a long time.
    Type: Grant
    Filed: March 31, 2022
    Date of Patent: April 9, 2024
    Assignee: ZHEJIANG UNIVERSITY
    Inventors: Fengzhong Qu, Zhe Lin, Yan Wei, Yezhou Wu
  • Patent number: 11952404
    Abstract: The present disclosure relates to the field of biotechnology, and particularly to use of a tomato gene mSlBZR1L in changing the morphology of tomato fruits. The present disclosure discloses a tomato gene mSlBZR1L comprising a nucleotide sequence as set forth in SEQ ID No: 3, and the gene can extend the length of the tomato fruits.
    Type: Grant
    Filed: August 13, 2021
    Date of Patent: April 9, 2024
    Assignee: ZHEJIANG UNIVERSITY
    Inventors: Qiaomei Wang, Haoran Liu, Lihong Liu, Zhiyong Shao, Fanliang Meng, Dongyi Liang
  • Patent number: 11951765
    Abstract: A blackboard eraser cleaning device is provided and includes an outer shell (1). A cover (2) is arranged at the upper part of the outer shell (1), an inner shell (3) is arranged inside the outer shell (1). A clamping mechanism (19) is arranged at the upper end of the inner shell (3). A leaning station (8) is defined inside the clamping mechanism (19). A cylinder (9) is arranged around the clamping mechanism (19). A height adjustment mechanism (10) is arranged inside the outer shell (1). The height adjustment mechanism (10) includes a servo (101) arranged inside the outer shell (1) and located on a side of the inner shell (3). According to the present application, a variety of cleaning modes may be achieved to meet the actual usage of the blackboard eraser.
    Type: Grant
    Filed: July 24, 2023
    Date of Patent: April 9, 2024
    Assignee: ZHEJIANG UNIVERSITY
    Inventors: Qinmin Yang, Qi Qiu, Hao Chen, Mingbin Gong
  • Patent number: 11948068
    Abstract: The present invention discloses a brain machine interface decoding method based on spiking neural network, comprising: (1) constructing a liquid state machine model based on a spiking neural network, the liquid state machine model consists of an input layer, an middle layer and an output layer, wherein, a connection weight from the input layer to the middle layer is Whh, a loop connection weight inside the middle layer is Whh, a readout weight from the middle layer to the output layer is Wyh; (2) Inputting a neuron spike train signal, and training each weight with the following strategy: (2-1) Using STDP without supervision to train the connection weight Whh from the input layer to the middle layer; (2-2) Setting the loop connection weight Whh inside the middle layer by means of distance model and random connection, and obtaining a middle layer liquid information R(t); (2-3) Using ridge regression with supervision to train the readout weight Wyh from the middle layer to the output layer, and establishing a ma
    Type: Grant
    Filed: October 27, 2021
    Date of Patent: April 2, 2024
    Assignee: ZHEJIANG UNIVERSITY
    Inventors: Yu Qi, Tao Fang, Gang Pan, Yueming Wang
  • Patent number: 11947930
    Abstract: A method and a device for remote acquisition of correlated pseudo-random numbers based on semi-trusted hardware. When applied to semi-trusted hardware, the method comprises: acquiring a random seed of a sender and a selected number of a receiver; generating a plurality of first correlated pseudo-random numbers and first commitment seeds according to the random seed and a predetermined category of the correlated pseudo-random number; generating a first commitment value and a first open value by a commitment mechanism according to the first correlated pseudo-random numbers and the first commitment seeds; generating a Merkle proof according to the first commitment value and the selected number; sending the first correlated pseudo-random numbers, the first commitment value, the first open value and the Merkle proof corresponding to the selected number to the receiver.
    Type: Grant
    Filed: December 12, 2023
    Date of Patent: April 2, 2024
    Assignees: ZHEJIANG UNIVERSITY, ZJU-HANGZHOU GLOBAL SCIENTIFIC AND TECHNOLOGICAL INNOVATION CENTER
    Inventors: Bingsheng Zhang, Yibiao Lu, Weiran Liu, Kui Ren
  • Patent number: 11947002
    Abstract: A method for recognizing an identity and a gesture based on radar signals includes: reading a radar echo signal reflected by various gestures of a tester and received by a radar sensor; frequency-mixing the radar echo signal with a radar transmission signal; after filtering and centralizing a frequency-mixed signal, training and obtaining a neural network capable of identity verification and a neural network capable of gesture recognition; in a real-time detection process, verifying an identity of a user; and if the identity is verified, determining that a gesture of the user is valid; verifying the gesture of the user and executing a corresponding operation according to correspondence between the gesture of the user and an operation. It can be determined by the method whether the gesture belongs to the corresponding user and whether the operation corresponding to the gesture is performed according to the determined result.
    Type: Grant
    Filed: March 31, 2021
    Date of Patent: April 2, 2024
    Assignee: ZHEJIANG UNIVERSITY
    Inventors: Yong Wang, Junyi Chen, Jiahe Cao
  • Patent number: 11944986
    Abstract: A device and a method for reducing wind resistance power of a large geotechnical centrifuge are provided. A semicircular tube cylindrical cooling device is provided between an internal side of a high-speed rotor system and a cylindrical shell. A serpentine top semicircular tube cooling plate is provided right above a hanging basket, and return helium gas inlet holes are provided at a center of the top semicircular tube cooling plate. A helium gas in a helium gas storage tank passes through helium gas outlets on the helium gas inlet pipes, and enters a centrifuge chamber from a bottom sealing plate. The helium gas is used to replace air in the centrifuge chamber to reduce the wind resistance power and corresponding energy consumption. No vacuuming is required, so sealing requirements are lower. Heat dissipation equipment is placed inside the centrifuge chamber, and a helium gas circulation wind duct is added.
    Type: Grant
    Filed: November 5, 2019
    Date of Patent: April 2, 2024
    Assignee: ZHEJIANG UNIVERSITY
    Inventors: Chuanxiang Zheng, Shuang Wei, Haifeng Zhou
  • Patent number: 11944106
    Abstract: A continuous quantitative spraying structure for sterilization of harvested fruits is provided. The continuous quantitative spraying structure includes a track provided thereon with equally spaced trays for conveying fruits, where the trays each include a circular tray body; a central part of the tray body is provided with a central hole allowing the fruit to fall off; a bottom part of the central hole is provided with two parallel rollers; an inner bottom surface of the tray body is provided with a flap; an inner end of a central shaft of the roller passes through the flap, and is fixed to a rolling wheel; a bearing is provided between the roller and the flap; the track is provided with a spraying sterilization section; the spraying sterilization section is sequentially provided with 3 to 4 sets of sterilization nozzles above a tray conveying route.
    Type: Grant
    Filed: October 8, 2022
    Date of Patent: April 2, 2024
    Assignee: ZHEJIANG UNIVERSITY ZHONGYUAN INSTITUTE
    Inventors: Di Wu, Weinan Huang, Dandan Zheng, Feng Jiang, Chongde Sun, Kunsong Chen
  • Publication number: 20240102922
    Abstract: A three-dimensional detection method for red tide algae based on holographic imaging is provided, including: constructing a coaxial optical path based on a structure of a Mach-Zehnder interferometer; determining reconstruction distances of the system under different object distances; constructing an original hologram database of the algae; selecting an original hologram, and two reconstructed holograms with different reconstruction distances as a three-dimensional spatial sample of the original hologram; labeling algae in sample, and recording species and bounding boxes of the algae; training a target detection network with the sample of the holograms and a label file; detecting, with the trained target detection neural network, the sample of the algae to obtain species and a quantity of plankton in imaged water. The disclosure further provides a three-dimensional detection device for red tide algae. The method can improve a detection speed and detection accuracy of the red tide algae.
    Type: Application
    Filed: May 16, 2023
    Publication date: March 28, 2024
    Applicant: ZHEJIANG UNIVERSITY
    Inventors: Xiaoping WANG, Kaiqi LANG, Jiaqing QIANG, Yuyi QIU
  • Patent number: 11940366
    Abstract: A centrifugal testing device for simulating ground subsidence induced by buried pipeline leakage and infiltration includes a model box provided with a transparent observation window at a front side, a chamber partitioning plate, a damaged pipeline model, permeable plates, and a water-soil separation device. A front part of the model box is divided into a test soil chamber for filling model soil and seepage chambers located at two sides of the test soil chamber. A rear part of the model box is divided into a soil filtration chamber and water circulation supply chambers located at two sides of the soil filtration chamber. The damaged pipeline model includes a front end provided with an electric push rod for controlling a crack of the damaged pipeline model to be opened and closed and a rear end provided with a ball valve device and connected to a water pump.
    Type: Grant
    Filed: November 10, 2023
    Date of Patent: March 26, 2024
    Assignee: ZHEJIANG UNIVERSITY
    Inventors: Yao Tang, Qingguo Yang, Bo Huang, Yunmin Chen
  • Patent number: 11941522
    Abstract: The present disclosure discloses an address information feature extraction method based on a deep neural network model. The present disclosure uses a deep neural network architecture, and transforms tasks, such as text feature extraction, address standardization construction and semantic-geospatial fusion, into quantifiable deep neural network model construction and training optimization problems. Taking a character in an address as a basic input unit, the address language model is designed to express it in vectors, then a key technology of standardization construction of Chinese addresses is realized through neural network target tasks.
    Type: Grant
    Filed: September 28, 2020
    Date of Patent: March 26, 2024
    Assignee: ZHEJIANG UNIVERSITY
    Inventors: Feng Zhang, Ruichen Mao, Zhenhong Du, Liuchang Xu, Huaxin Ye
  • Patent number: 11943133
    Abstract: The present invention discloses a hierarchical routing method oriented to a cross-boundary service network. The hierarchical routing method includes the following steps: (1): proposing reference services for services with same or similar functions in a service network, with differences in format and usage mode, and establishing a unified and standardized usage view for a user; and (2): establishing a method for mapping between the reference services and ordinary services to map the multiple ordinary services with similar functions into the unified reference services, and automatically selecting an optimal ordinary service when called by the user. The hierarchical routing method provided by the present invention can implement high-speed routing of service call in the service network, thereby providing a basis for aggregation and interoperation of cross-boundary services.
    Type: Grant
    Filed: January 14, 2022
    Date of Patent: March 26, 2024
    Assignee: ZHEJIANG UNIVERSITY
    Inventors: Jianwei Yin, Bangpeng Zheng, Shengye Pang, Maolin Zhang, Yucheng Guo
  • Patent number: 11939599
    Abstract: Disclosed are a gene mining method combining functional sequence and structure simulation, an NADH-preferring phosphinothricin dehydrogenase mutant and an application thereof. The gene mining method comprises the following steps: (1) analyzing a characteristic sequence which an NADH-type glutamate dehydrogenase should have; (2) searching a gene library based on the characteristic sequence; (3) performing clustering analysis and protein structure simulation on genes obtained by the searching; (4) selecting genes that feature high gene aggregation and a protein structure similar to that of the known phosphinothricin dehydrogenase as candidate genes. A wild-type phosphinothricin dehydrogenase with an amino acid sequence as set forth in SEQ ID No.
    Type: Grant
    Filed: December 30, 2021
    Date of Patent: March 26, 2024
    Assignee: ZHEJIANG UNIVERSITY OF TECHNOLOGY
    Inventors: Yaping Xue, Feng Cheng, Jiamin Zhang, Shuping Zou, Jianmiao Xu, Yuguo Zheng
  • Publication number: 20240094197
    Abstract: The present invention relates to a method for removing protein corona on the surface of nanometer particle. Specifically, the invention provides a method for removing protein corona of protein corona modified nanometer particle, the method comprises the following steps: subjecting the protein corona modified nanometer particle to ultrasound stimulation to remove the protein corona of the protein corona modified nanometer particle; the nanometer particle comprises perfluoropentane. Ultrasound stimulation can remove protein corona on the surface of nanometer particle, overcome the masking effect of the protein corona on the ligand modified on the surface of nanometer particle, and prevent the protein corona from blocking the binding of the ligand modified on the surface of nanometer particle to cell receptor.
    Type: Application
    Filed: February 19, 2023
    Publication date: March 21, 2024
    Applicant: ZHEJIANG UNIVERSITY
    Inventors: Guowei Wang, Pintong Huang, Yifan Jiang, Chao ZHANG, Tao LIN
  • Patent number: 11936390
    Abstract: Disclosed is a low-power fractional-N phase-locked loop circuit, which comprises a phase detector, a voltage-to-current converter, a loop filter, a voltage-controlled oscillator, a frequency divider and a digital logic processor; the phase detector, the voltage-to-current converter, the loop filter, the voltage-controlled oscillator and the frequency divider are connected in sequence; a reference signal is input from the phase detector, the phase detector detects the phases of the reference signal and a feedback signal with a quantization error output by the frequency divider, compensates a quantization phase error generated by fractional frequency division, and outputs a compensated phase detection result to the voltage-to-current converter; the quantization error generated by fractional frequency division is converted into a voltage domain through a digital domain or directly coupled to a phase error signal in the phase detector to complete the compensation of the quantization error.
    Type: Grant
    Filed: October 25, 2022
    Date of Patent: March 19, 2024
    Assignee: ZHEJIANG UNIVERSITY
    Inventors: Xiang Gao, Gaofeng Jin, Fei Feng
  • Patent number: 11935191
    Abstract: A data processing method for an analogue modelling experiment of a hypergravity geological structure includes steps of: performing two-dimensional photographing and three-dimensional elevation scanning with an analogue modelling experiment device with a curved model surface for the hypergravity geological structure, so as to collect initial elevation data and initial velocity field data; and correcting the initial elevation data and the initial velocity field data to obtain corrected elevation data and corrected velocity field data. The data processing method can realize orthographic correction and three-dimensional projection transformation of initial elevation data, as well as orthographic correction and two-dimensional projection transformation of initial velocity field data, which can more realistically and objectively reflect the experimental phenomenon, which is conducive to truly expressing the experimental results and facilitates the analogy analysis with the actual geological prototype.
    Type: Grant
    Filed: April 2, 2019
    Date of Patent: March 19, 2024
    Assignee: ZHEJIANG UNIVERSITY
    Inventors: Liangtong Zhan, Chi Zhang, Jianxun Zhou
  • Publication number: 20240081359
    Abstract: A continuous quantitative spraying structure for sterilization of harvested fruits is provided. The continuous quantitative spraying structure includes a track provided thereon with equally spaced trays for conveying fruits, where the trays each include a circular tray body; a central part of the tray body is provided with a central hole allowing the fruit to fall off, a bottom part of the central hole is provided with two parallel rollers; an inner bottom surface of the tray body is provided with a flap; an inner end of a central shaft of the roller passes through the flap, and is fixed to a rolling wheel; a bearing is provided between the roller and the flap; the track is provided with a spraying sterilization section; the spraying sterilization section is sequentially provided with 3 to 4 sets of sterilization nozzles above a tray conveying route.
    Type: Application
    Filed: October 8, 2022
    Publication date: March 14, 2024
    Applicant: ZHEJIANG UNIVERSITY ZHONGYUAN INSTITUTE
    Inventors: Di WU, Weinan HUANG, Dandan ZHENG, Feng JIANG, Chongde SUN, Kunsong CHEN
  • Patent number: 11927659
    Abstract: Disclosed is a method and apparatus for frequency drift correction of magnetic resonance CEST imaging, and a medium and an imaging device. The method comprises the following steps: firstly, in the frequency drift correction module, exciting a target slice by using a small flip-angle radio-frequency pulse, and acquiring a single line of free induction decay signals or two lines of non-phase encoding gradient echo signals; secondly, respectively calculating a value of the main magnetic field frequency drift according to phase information and an acquisition time of the single line of free induction decay signals or the two lines of non-phase encoding gradient echo signals; then adjusting the center frequency of the magnetic resonance device in real time according to the calculated value of the main magnetic field frequency drift, and achieving the real-time correction of main magnetic field frequency drift; and finally, performing CEST imaging.
    Type: Grant
    Filed: August 1, 2022
    Date of Patent: March 12, 2024
    Assignee: ZHEJIANG UNIVERSITY
    Inventors: Yi Zhang, Ruibin Liu, Hongxi Zhang, Dan Wu