Abstract: 4,5-Dihydro-4-R-6-(4-pyridinyl)-3(2H)-pyridazinone (IA) or pharmaceutically-acceptable acid-addition salt thereof, where R is hydrogen or methyl, is shown as the active component in cardiotonic composition and method for increasing cardiac contractility in a patient requiring such treatment. Also shown is the preparation of IA by reacting a lower-alkyl 2-R-4-(BN)-4-cyano-4-(4-pyridinyl)butanoate with hydrazine, where R is hydrogen or methyl, and BN is 4-morpholinyl, 1-piperidinyl or 1-pyrrolidinyl.

Abstract: From the roots of the plant Mandassi (Cyperus articulatus L.) a fraction is extracted which is therapeutically useful, more particularly as an anticonvulsant.

Abstract: Polymeric quaternary ammonium compounds having recurring vinylbenzyl ammonium units are disclosed. The quaternary ammonium units preferably have 2 alkyl substituents of 1 to 4 carbons and 1 alkyl substituent of 4 to 12 carbons. These materials have antimicrobial properties and are particularly useful for preserving ophthalmic solutions.

Abstract: Use is made in the oxidative dyeing of hair of a preliminary coloring stage of the general formula ##STR1## wherein R signifies COOR', CONH.sub.2, CONHR', CONR'.sub.2, CONH--NH.sub.2, CONH--OH, CN, CH.sub.2 OH, CHO, CH(OH)(OR'), CH(OR').sub.2 and R' represents an alkyl group with 1 to 5 carbon atoms. The preliminary coloring stages as per formula (I) may be contained in the hair dyeing agents singly or in a mixture with known preliminary coloring stages and/or direct-acting hair dyeing agents. The hair dyeing agents may, in particular, additionally contain amino acids present in nature, their esters and/or their amides. The hair dyeing agents as described, are well compatible physiologically and it will particularly be brown to reddish-brown colorings having a natural effect, that may be obtained by their use.

Abstract: The invention relates to a process for obtaining preparations of toxoplasmas, improved for the diagnosis of toxoplasmosis by direct agglutination, said process comprising, in a first step, the inoculation in mice of a mixture of toxoplasmas and of sarcomatous cells, in a second step the inoculation in other mice of a mixture of sarcomatous cells infected with toxoplasmas coming from the mice of the first step and of non-infected sarcomatous cells, and finally the collection of the ascitic exsudate of these latter mice from 48 to 72 hours after inoculation.

Abstract: The invention relates to an extremely thermophilic bacterium, Thermus T-351, and a thermophilic protease, Caldolysin, derived therefrom. The bacterium cells are Gram negative, non-sporulating rods. Its natural environment is a hot pool at 79.degree..+-.4.degree. C. The protease is stable at temperatures up to 75.degree. C. at a pH range of 4 to 12. It is most active at temperatures of 65.degree. C. to 85.degree. C. but retains at least some activity at lower temperatures.

Abstract: The invention relates to a method of detecting, analyzing, quantifying or locating a protein, antibody, antigen, hapten, hormone, metabolite, nucleic acid or steroid, in which the substance of interest is linked to a chemi-luminescent or bio-luminescent label. A luminescent reaction is then triggered by the addition of an oxidizing agent or a catalyst and the emitted light is observed in order to provide information about the substance. The invention employs a luminescent reagent which consists of antibodies labelled with a luminescent material such as luminol. The luminescent reagent can be used to quantify antigens in an immunological assay. The luminescent labelled antibodies selectively bind to the antigens and the amount of light emitted in a luminescent reaction gives an indication of the amount of antigens present. A luminescent labelled substance can also be reacted with an antibody or antigen labelled with a fluorescent material in order to carry out a homogeneous assay.

Abstract: m-Amino-.alpha.-methylphenethylamine, when administered internally, induces water diuresis in patients having edema.

Abstract: A method for controlling plant pathogens which grow on plant leaves, softening the leaves or accelerating the decomposition of the leaves comprises inoculating the leaves with Athelia bombacina. The method is effective in controlling apple scab.

Abstract: There is disclosed an orally administered composition useful in the treatment of constipation. The composition is a synergistic mixture of fruits, glycerine and compound senna which is efficacious at a dosage quantity far below that required of any of the ingredients when used alone.

Abstract: An effective method to control aflatoxin produced by toxic strains of Aspergillus parasiticus fungi is disclosed. An effective amount of Beta-ionone is applied to said fungi to inhibit the growth and sporulation of the fungi and thereby control production of aflatoxin from the fungi without killing the fungi.

Abstract: A biocidal composition suitable for use as a stabilizer in polymer systems using 2-mercaptopyridene-1-oxide or a derivative combined with an organophosphorous compound and a benzotriazole wherein the organophosphorous compound and the benzotriazole act together to stabilize the mercaptopyridene against degradation and discoloration of the polymer system.

Abstract: A composition and method for the oxidative coloring of hair are disclosed, on the basis of a developer substance-coupler substance combination, whereby as coupler substance at least one 3,5-diaminopyridine derivative of the general Formula ##STR1## in which R.sup.1 and R.sup.2 independent of each other are CH.sub.3, C.sub.2 H.sub.5 or C.sub.2 H.sub.4 OH and R.sup.3 is hydrogen, C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.4 -hydroxyalkyl, also in the form of the physiologically compatible salt, is used. The coupler substance, 3,5-diamino-2,6-dimethoxypyridine being preferred, should be present in the hair coloring composition in a concentration from 0.01 to 3.0% by weight, preferably 0.1 to 2.0% by weight. The coupler substances according to Formual I are storage-stable, well soluble in water, and have toxicologically as well as dermatologically favorable characteristics.

Abstract: A cosmetic composition for application to the hair contains either (a) at least one compound having the formula ##STR1## wherein R is hydrogen, alkyl or halogen; andR' is hydrogen, alkyl, hydroxyalkyl, carbamylalkyl, mesylaminoalkyl, aminoalkyl, acylaminoalkyl, monoalkylaminoalkyl, dialkylaminoalkyl, piperidinoalkyl, morpholinoalkyl, carbamoyl, acyl or carbalkoxy; or (b) at least one of said compounds having formula I above and at least one benzene or heterocyclic oxidation base. The invention also relates to new couplers of formula I as well as to new indo compounds which result from the coupling of said compounds with an oxidation base. These cosmetic compositions for application to the hair are useful in direct dyeing, oxidation dyeing or simultaneous oxidation and direct dyeing or said hair.

Abstract: There is described a method of separating an asparaginase rich fraction from a thermophilic microoganism and then to divide this fraction into its D- and L-asparaginases. Substantially pure crystals of the D-asparaginase were obtained.

Abstract: A process for recovering flavoring substances from the vanilla capsule with carbon dioxide under fluid conditions is described, which consists in performing the extraction at temperatures between 10.degree. and 30.degree. C. and pressures of 80 to 350 bar, and producing the separation of the extract at temperatures of 0.degree. to 30.degree. C. and pressures of 30 to 60 bar. In this manner it is possible by a one-step process to extract all of the flavoring substances of the vanilla capsule with the recovery of a highly concentrated vanilla flavoring, and to obtain a material which is considerably superior to the products obtained by conventional extraction with organic solvents.

Abstract: An emulsifiable concentrate of Imidan, an acrylic resin, a surfactant and a common organic solvent functions as a controlled release insecticide when applied to plant foliage.

Abstract: The invention relates to pharmaceutical compositions containing an active antimicrobial compound of Formula (I). Also included in the invention are methods for combatting mycoses utilizing the above-identified pharmaceutical composition.

Abstract: The invention provides compositions which comprise, in an aqueous, alcoholic or aqueous-alcoholic vehicle, at least one compound of the general formula: ##STR1## in which R denotes a monohydroxyalkyl radical containing from 2 to 6 carbon atoms or a polyhydroxyalkyl radical containing from 3 to 6 carbon atoms. These dyeing compositions make it possible to obtain, on the hair, yellow shades with a very high chromaticity and possessing very good fastness to light and to washing.

Abstract: There are provided a crystalline and single rod products derivable from the Pili of Type 1 and Type 2 Neisseria gonorrhoeae organisms. There are provided methods of growing said organisms to produce the maximum yield of Pili and procedures for purifying said Pili to produce said crystalline material. There are further provided methods of utilizing said Pili to determine the presence, in a system infectable by N. gonorrhoeae organisms, of antibodies to the Pili of said organisms, and methods of serotyping said Pili. There is also provided a mode of utilizing said crystalline material to provide a substantial degree of immunization to infection by N. gonorrhoeae in mammalian systems susceptible to such infection.