Abstract: A method is disclosed for purifying non-homogeneous systems, known as liposomic suspensions, from non-entrapped drugs wherein said suspensions are treated with liquid or solid polymers of synthetic and organic nature having chemical functionality, which are used as ion-exchangers. The liquid or solid polymers are based on styrene, divinylbenzene, acrylic acid, methacrylic acid, and the like, normally known as ion-exchange resins, and may include carboxylic, phosphonic, or sulphonic functions of different matrices. The ion-exchange resins may also include salified quaternary ammonium, primary, secondary and tertiary amminic or phosphinic functions or other functions with different matrices, including phenolformaldehyde, styrene-divinylbenzene, acrylates, methacrylates, hydrocarbons and condensation-resins.
Type:
Grant
Filed:
January 14, 1980
Date of Patent:
July 17, 1984
Assignee:
Farmitalia Carlo Erba S.p.A.
Inventors:
Luigi Moro, Guido Neri, Alessandro Rigamonti
Abstract: A composition for repelling birds, the composition having as active ingredients finely divided dried pepper from pungent fruits of plants of the genus Capsicum and finely divided dried garlic and typically being diluted by inert, finely divided mineral material or water for application to the earth surface or to growing plants to repel birds given to eating seeds, plants, vegetables, and fruits.
Abstract: Salicylazobenzoic acid is more useful than salazosulfapyridine for the treatment of colitis ulcerosa, enteritis regionalis (Morbus Crohn), chronic nonspecific colitis and diverticulitis. Salicylazobenzoic acid is used in the form of tablets and dragees or enemae in which it may be used in the form of free acid, compatible salts or mixtures thereof.
Type:
Grant
Filed:
July 9, 1981
Date of Patent:
June 19, 1984
Assignee:
Henning Berlin GmbH Chemie- und Pharmawerk
Abstract: A composition and process for producing pigmentation in hair and skin is disclosed which employs non-mutagenic compounds to duplicate naturally occurring biosynthetic colors. The composition for imparting golden coloration comprises as active ingredients a solution of a tyrosine derivative having a side chain with a substituted amine group in admixture with certain compounds having a reactive nitrogen moiety, and is topically applied in the presence of an oxidant. The composition for imparting a dark coloration comprises as active ingredients a solution of tyrosine derivative having a side chain free for indole formation in admixture with certain compounds having a reactive nitrogen moiety, and is topically applied in the presence of an oxidant. Mixtures of the two compositions may be applied to impart proportionate intermediate colors.
Abstract: This invention provides an extract from the plant Cerastium viscusum L. (Coryophyllaceae) Mississippi and a method of obtaining same. The extract is obtained by subjecting the plant to a series of extraction steps with a plurality of solvents having different polarities. In each extraction step, the solvent used has a polarity higher than that used in the preceding extraction step. All extraction steps are conducted at room temperature. The extracts have been found to possess biological activity.
Abstract: This invention provides an extract from the plant Myrcia fallax (Myrtaceae) Peru and a method of obtaining same. The extract is obtained by subjecting the plant to a series of extraction steps with a plurality of solvents having different polarities. In each extraction step, the solvent used has a polarity higher than that used in the preceding extraction step. All extraction steps are conducted at room temperature. The extracts have been found to possess biological activity.
Abstract: A process for extracting raw and crude avocado oil from avocados with optimum yield and minimal chemical change in the oil. Raw avocado oil is extracted from ripe fruit following maceration, heating, addition of herbaceous silicious material, and pressure extraction. Crude avocado oil can be extracted from the remaining cake by refluxing with suitable solvents. The oil can further be refined by treatment in a diatomaceous earth filter.
Abstract: A nematocidal composition containing as an active ingredient(s) therein sesame plant extracts including roots, seeds or stalks, oils and acids extracted therefrom, but primarily sesamin, sesamolin and sesamol.
Abstract: Corn oil is produced by several process modifications in which maize is initially milled, the higher oil-content germ is separated from the lower oil-content germ, and then the lower oil content germ is pelletized. Thereafter, the processes vary with regard to mixing, heating and flaking the different oil-content germ fractions prior to a final step in which a mixed flaked product is extracted to remove corn oil therefrom.
Abstract: The invention relates to an extremely thermophilic bacterium, THERMUS T-351, and a thermophilic protease, CALDOLYSIN, derived therefrom. The bacterium cells are Gram negative, non-sporulating rods. Its natural environment is a hot pool at 79.degree..+-.4.degree. C. The protease is stable at temperatures up to 75.degree. C. at a pH range of 4 to 12. It is most active at temperatures of 65.degree. C. to 85.degree. C. but retains at least some activity at lower temperatures.
Type:
Grant
Filed:
August 8, 1980
Date of Patent:
April 10, 1984
Assignee:
Development Finance Corporation of New Zealand
Abstract: A chemical composition for warding off racoons, dogs and the like from garbage comprising a combination of chemical agents including a member of the isothiocyanate family (commonly referred to as mustard oil), preferably allyl isothiocyanate.The combination of mustard oil with lemon grass oil together with masking agents is particularly preferred so that the composition as applied to household garbage and receptacles is not unpleasant to human smell while nevertheless repulsive to foraging animals.In addition to use about homes, restaurants and the like, the present composition may be used at camp sites for similar purposes.
Type:
Grant
Filed:
February 24, 1983
Date of Patent:
April 3, 1984
Assignees:
Bernard Weiss, Jonathan J. Stern, Burt B. Houseworth
Abstract: A method of reducing local hemorrhage and tissue necrosis resulting from the bite or sting of a venomous animal whereby an envenomated mammal is treated with a compound of the formula ##STR1## or a corresponding disulfide wherein n is 1, 2 or 3; Z is O, S or NH; R is H, a straight or branched chain lower alkyl group of from 1 to 4 carbon atoms, hydroxy, a straight or branched chain lower alkoxy group of from 1 to 4 carbon atoms, fluoro, chloro, bromo, iodo or trifluoromethyl; or a pharmaceutically acceptable salt thereof.
Abstract: A process for the preparation of .beta.-carotene micellar solutions, wherein a non-ionic emulsifier which is suitable for the preparation of micellar solutions is heated at from 160.degree. to 180.degree. C. and a total of from 20 to 30% by weight, based on the emulsifier, of .beta.-carotene is introduced in the presence of a conventional antioxidant, the hot homogeneous mixture is cooled rapidly to below 100.degree. C. by adding water, and the formulation is brought to the desired concentration of from 3 to 6% by weight by adding further water, and the .beta.-carotene micellar solutions obtained by this process. The non-ionic emulsifiers used in this process have an HLB value of from 12 to 16, and are in particular oxyethylated triglycerides of fatty acids of 12 to 18 carbon atoms containing 20-60 oxyethylene units. Parenteral admininstration of the stable .beta.-carotene micellar solutions according to the invention to cattle relieves the disturbed estrus cycle and impaired fertility caused by .beta.
Type:
Grant
Filed:
December 9, 1981
Date of Patent:
March 6, 1984
Assignee:
BASF Aktiengesellschaft
Inventors:
Peter P. Hoppe, Joachim U. Schneider, Bernhard Schulz, Hubert Tiefenbacher
Abstract: Plaque disclosing compositions containing the natural red dye from sugar beets as the disclosant, and the process of treating the oral cavity therewith.
Abstract: An L-arginine producing microorganism which is constructed by transforming into a recipient strain of the genus Escherichia of a vector having inserted therein an arg A gene derived from a chromosomal DNA of the genus Escherichia, is useful for the production of high levels of L-arginine by fermentation.
Abstract: An L-glutamic acid producing microorganism which is constructed by incorporation into a recipient strain of the genus Brevibacterium or Corynebacterium of a hybrid plasmid having inserted therein a DNA fragment with genetic information related to L-glutamic acid production which is derived from a donor strain of the genus Brevibacterium or Corynebacterium, is useful for the production of high levels of L-glutamic acid by fermentation.
Abstract: A stable preparation of a lyophilized .beta.-lactam antibacterial containing a 7.beta.-(.alpha.-carboxy-.alpha.-arylacetamido)-7.alpha.-methoxy-3-heteroc yclic thiomethyl-1-dethia-1-oxa-3-cephem-4-carboxylic acid (I) alkali metal salt as the antibacterial component and a sugar or sugar alcohol compound as the stabilizing agent.
Abstract: This invention is directed to a pharmaceutical preparation for transdermal application, which comprises a film comprising a skin-compatible polyacrylate, which swells in water and a pharmaceutically active substance in amorphous form.The invention is also directed to the preparation of said pharmaceutical preparation and its use in administering pharmaceutically active substances.