Abstract: Embodiments profile cannabinoids using a nanopore detector. Embodiments use an applied potential to electrophoretically draw a nanopore blockade reporter molecule into a nanopore channel to establish an electrophoretic molecular channel-capture for the reporter molecule. The reporter molecule includes one of an aptamer or a monoclonal antibody and has a specific binding to at least one of: a specific cannabinoid, a particular cannabinoid isoform; or a specific cannabinoid family. Embodiments receive a blockade channel current signal in response to a nanoscale membrane channel of the nanopore detector being partially blockaded by a presence of the reporter molecule non-covalently bonded to the membrane channel. Embodiments receive a blockade signal for the reporter molecule that is toggling between more than one level.

Abstract: The present disclosure relates to a semiconductor device and a cell potential measuring apparatus capable of amplifying and reading a potential of solution with high accuracy. A reading electrode reads the potential of the solution. A differential amplifier includes a current mirror circuit. The reading electrode is connected to a first input terminal of the differential amplifier which is connected to a gate of a first input transistor connected to a diode-connected pMOS transistor of the current mirror circuit. An output terminal of the differential amplifier is connected to a second input terminal of the differential amplifier, which is connected to a gate of a second input transistor connected to a pMOS transistor of the current mirror circuit which is not diode-connected, via a capacitor. For example, the present disclosure is applied to the cell potential measuring apparatus and the like.

Abstract: A mixed-potential type gas sensor includes: a first sensing electrode containing a Pt—Au alloy and a second sensing electrode containing Pt, both sensing electrodes being provided on the surface of a sensor element made of an oxygen-ion conductive solid electrolyte; a reference electrode provided inside the sensor element to be made contact with air; a first protective layer group covering the first sensing electrode; a second protective layer group covering the second sensing electrode; and concentration identification element configured to identify the concentration of a sensing target gas component based on potential differences between both of the first sensing electrode and the second sensing electrode and the reference electrode. The response times of the first and second sensing electrodes are both equal to or shorter than 10 seconds, and the response time difference therebetween is 2 seconds or shorter.

Abstract: An electrochemical sensor may include a common reference electrode, at least one counter electrode, and a work electrode platform including a plurality of respective work electrodes. Each respective work electrode of the plurality of respective work electrodes may be electrically coupled to the common reference electrode and include a respective reagent substrate configured to react with a respective analyte to produce a signal indicative of a concentration of the respective analyte.

Abstract: Electrochemical sensors for the detection of select analytes are provided. The electrochemical sensors include a barrier layer having a substantially uniformed thickness disposed between a sensing layer and an ion exchange membrane. The barrier layer includes a two-dimensional nanomaterial. The barrier layer has a thickness of less than or equal to about 1 nm. The sensing layer has a thickness of less than or equal to about 10 nm. The sensing layer generates ions in response to select analytes. The barrier layer allows the generation ions to pass therethrough and travel into the ion exchange membrane. The barrier layer acts as a physical barrier to contaminants and larger molecules.

Abstract: An electronic component includes a field effect transistor that functions as a working electrode of an ion sensor and a driving circuit that causes a potential difference between a source electrode and a drain electrode of the field effect transistor. A reference electrode potential of the field effect transistor is fixed.

Abstract: A method for diagnosing COVID-19 infection of a person. The method includes acquiring a sputum sample of a person, measuring a level of ROS in the sputum sample, and detecting a COVID-19 infection status of the person based on the measured level of ROS. Measuring the level of ROS in the sputum sample includes recording a cyclic voltammetry (CV) pattern from the sputum sample and measuring a current peak of the recorded CV pattern. Detecting the COVID-19 infection status of the person includes detecting COVID-19 infection of the person responsive to the measured current peak being in a first range of more than 230 ?A and detecting COVID-19 non-infection of the person responsive to the measured current peak being in a second range of less than 190 ?A.

Abstract: A cell extraction method includes providing a mixed-cell sample having both target cells and non-target cells slurried in a trailing-electrolyte solution. A leading electrolyte solution is provided to contact the trailing electrolyte solution via a capillary and a pressure control device. Focusing of the target cells at an interface between the leading- and trailing-electrolyte solutions occurs by applying pressure to the capillary and concurrently applying an electric potential via electrodes. The target cells are extracted into the capillary by applying a negative pressure and transferred to a receptacle. A cell extraction system for use with a gradient elution isotachophoresis method includes a trailing electrolyte solution adapted to migrate slower than the target cells and a leading electrolyte solution adapted to migrate faster than the target cells. A mixed-cell sample containing the target and non-target cells is slurried in the trailing electrolyte solution prior to cell extraction.

Abstract: A sensor technology comprising a single nano-material (gold nanoparticles and/or carbon nanotube) based sensor or a plurality of sensors in conjunction with a pattern recognition algorithm for non-invasive and accurate diagnosis of tuberculosis caused by M. tuberculosis bacteria in a subject. The sensor technology is suitable for population screening of tuberculosis, particularly in resource-poor and developing countries.

Abstract: An improvement in the method or technique of conditioning a gas sensor is provided through the application of Pulse Discharge Technique (PDT) in order to condition mixed-potential gas sensors. A modified planar sensor design to minimize sodium atom diffusion and platinum electrode poisoning under conditions of PDT are provided. Modification of the PDT hardware is provided without modification of the sensor design. The improvement method comprises: a) Replace a single polarity power supply with a power supply with floating positive and negative output; b) Connect one of the heater leads with the reference electrode lead and connect it to the ground.

Abstract: The application relates to an electrode for use in the electrochemical detection of a target species, wherein the electrode has a planar surface disposed on which are probe molecules that are capable of binding selectively to the target species, wherein the electrode, prior to binding of the probe molecules with the target species, has an electron transfer resistance per area of the electrode of from 10 megaohms cm?2 to 95 megaohms cm?2.

Abstract: Isotachophoresis (ITP) is exploited to control various aspects of chemical reactions. In a first aspect, at least one of the reactants of a chemical reaction is confined to an ITP zone, but the resulting product of the chemical reaction is separated from this ITP zone by the ITP process. In a second aspect, one or more reactants of a chemical reaction are confined to an ITP zone, and one or more other reactants of the chemical reaction are not confined to this ITP zone. In a third aspect, ITP is employed to confine at least one reactant of a chemical reaction to an ITP zone, and at least one reactant of the chemical reaction is delivered to the ITP zone in two or more discrete doses. These aspects are especially relevant to performing polymerase chain reactions using chemical denaturants as opposed to thermal cycling.

Abstract: Devices, systems, methods and products for measuring concentrations of analytes in-situ, including concentrations of ions, proteins, DNA, and, RNA in a variety of mediums including solutions, suspensions, soils, slurries, biological fluids and living organic material such as agricultural crops. Embodiments of the disclosed inventions measure analyte concentration in-situ without clogging reference electrodes, leaking reference solution or having to dilute a medium prior to taking the analyte measurements. In-situ analyte measurements are made without clogging reference electrodes using a combination of solid-state sensors connected to a transducer, a reference electrode enclosed by a non-porous enclosure and a metallic plug extending from the interior cavity of the non-porous enclosure outwardly exterior to the non-porous enclosure, contacting the medium being measured.

Abstract: An electrophoretic device for detecting biomarkers in collected bodily fluid and methods of using the same.

Abstract: The present disclosure relates to fluidic systems and devices for processing, extracting, or purifying one or more analytes. These systems and devices can be used for processing samples and extracting nucleic acids, for example by isotachophoresis. In particular, the systems and related methods can allow for extraction of nucleic acids, including non-crosslinked nucleic acids, from samples such as tissue or cells. The systems and devices can also be used for multiplex parallel sample processing.

Abstract: An electrochemical test device for determining the concentration of an analyte in a fluid sample, wherein the electrochemical test device has a substrate is provided. The device comprises a micro-voided synthetic polymer.

Abstract: An electrochemical acrylonitrile sensor comprises a housing, an electrolyte disposed within the housing, and a plurality of electrodes in contact with the electrolyte within the housing. The plurality of electrodes comprises a working electrode and a counter electrode. The electrodes comprise a catalytic material, which may comprise gold. A potential is applied between the counter electrode and the working electrode.

Abstract: An electrochemical microarray chip to detect specific sequences of single-stranded DNA (ssDNA) or single-stranded RNA (ssRNA) target molecules in solution using a microarray of microspots of probe molecules immobilized on an electrode. The chip pertains to both regulating the immunospecific binding to the array of probes on the electrode and their subsequent detection on the microarray spots on the monolith electrode by electrochemical methods. The device can quantitatively measure the concentration of target molecules of specific sequence at high specificity and high sensitivity.

Abstract: An electrochemical hydrogen cyanide sensor (1) comprises a housing (10) comprising an opening (2) allowing gas to enter the sensor (1); an electrolyte disposed within the housing (10); a plurality of electrodes in contact with the electrolyte within the housing (10), wherein the plurality of electrodes comprise a working electrode (5) and a counter electrode (7), and wherein the electrodes comprise a metal catalytic material; and a filter (3) operable to cover the opening (2) of the housing (10), and prevent hydrogen sulfide from reaching the electrodes, wherein the filter (3) comprises silver sulfate layered onto a polytetrafluoroethylene support material.

Abstract: The present disclosure relates to a sensor for determining measured values of a measured variable representing an analyte content in a measuring fluid, comprising a measuring probe with a probe housing that comprises an immersion region provided for immersion into the measuring fluid, and a single-layer or multi-layer membrane arranged in the immersion region, wherein the membrane comprises at least a first layer that is formed from a polymer and comprises a superhydrophobic surface that is in contact with the measuring fluid when the immersion region is immersed in the measuring fluid.