Patents Examined by Ba K. Trinh
  • Catalyst for use in production of epoxide, method for producing the catalyst, and method for producing epoxide
    Patent number: 6500967
    Abstract: To provide an epoxide-production-use catalyst that is suitably used for producing an epoxide by partial oxidation of an unsaturated hydrocarbon, a catalyst in accordance with the present invention is obtained by fixing gold fine particles to a carrier containing an oxide containing at least one of titanium and zirconium, and has an acid quantity of not more than 0.1 mmol/g determined by the NH3-TPD method. Such a catalyst for epoxide producing use can be produced by, for instance, fixing gold fine particles to a carrier having an acid quantity of not more than 0.15 mmol/g. The catalyst for epoxide producing use arranged as above is preferably used as a catalyst in partial oxidation of an unsaturated hydrocarbon to produce a corresponding epoxide.
    Type: Grant
    Filed: February 21, 2001
    Date of Patent: December 31, 2002
    Assignee: Nippon Shokubai Co., Ltd.
    Inventors: Toshio Hayashi, Masahiro Wada, Takahiro Inagaki
  • Ester compounds having alicyclic and oxirane structures and method for preparing the same
    Patent number: 6500971
    Abstract: An ester compound of formula (1) is provided. R1 is H or methyl, R2 is tertiary C4-20 alkyl, and k=0 or 1. A resist composition comprising as the base resin a polymer resulting from the ester compound is sensitive to high-energy radiation, has excellent sensitivity, resolution, etching resistance and substrate adhesion, and is suited for micropatterning using electron beams or deep-UV.
    Type: Grant
    Filed: June 5, 2001
    Date of Patent: December 31, 2002
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Takeru Watanabe, Takeshi Kinsho, Koji Hasegawa, Tsunehiro Nishi, Mutsuo Nakashima, Seiichiro Tachibana, Jun Hatakeyama
  • Integrated hydrogen peroxide production and organic chemical oxidation
    Patent number: 6500969
    Abstract: A process for producing oxidized organic chemical products from various organic chemical feedstocks utilizing as oxidant hydrogen peroxide (H2O2) produced by noble metal nanocatalysis with high selectivity at low hydrogen concentration. The organic chemical oxidation process step can optionally be carried out in situ concurrent with the production of hydrogen peroxide or in a two stage process. In the two stage process, the hydrogen peroxide intermediate is directly produced by noble metal nanocatalysis from hydrogen and oxygen feeds plus a suitable solvent in a first catalytic reaction step. An organic chemical feedstock and the hydrogen peroxide intermediate and solvent solution are fed into a second catalytic reactor to produce an oxidized organic chemical product.
    Type: Grant
    Filed: December 11, 2001
    Date of Patent: December 31, 2002
    Assignee: Hydrocarbon Technologies, Inc.
    Inventors: Bing Zhou, Michael Rueter
  • Recovery and purification of 3,4-epoxy-1-butene using high-boiling solvents
    Patent number: 6500970
    Abstract: Disclosed is a process of recovering 3,4-epoxy-1-butene (epoxybutene) from an epoxybutene-laden reaction product gas by absorption into a high-boiling solvent. Also disclosed is a process for the purification of the epoxybutene by separating epoxybutene from the solvent and other reaction by-products by a novel combination of distillation and decantation steps.
    Type: Grant
    Filed: July 20, 2001
    Date of Patent: December 31, 2002
    Assignee: Eastman Chemical Company
    Inventors: Scott Donald Barnicki, Jerome Leonard Stavinoha, Jr., Robert Sterling Kline, Jackie Lee Hamilton
  • Taxoid anti-tumor agents and pharmaceutical compositions thereof
    Patent number: 6500858
    Abstract: Pharmaceutical compositions, methods of administration, and methods of treatment of cancer with new generation taxoids, of formulas (I) and (II), and derivatives thereof, are described:
    Type: Grant
    Filed: April 2, 2001
    Date of Patent: December 31, 2002
    Assignee: The Research Foundation of the state University of New York
    Inventor: Iwao Ojima
  • Direct epoxidation process using a mixed catalyst system
    Patent number: 6498259
    Abstract: The liquid-phase epoxidation reaction of an olefin with hydrogen and oxygen in the presence of a catalyst mixture containing a titanium zeolite and a supported catalyst surprisingly produces less ring-opened products such as glycols when performed in the presence of a buffer. This is particularly surprising because a typical palladium on titanium zeolite catalyst is little effected by the presence of a buffer. Surprisingly, the use of a buffer also typically improves the activity of the process.
    Type: Grant
    Filed: October 19, 2001
    Date of Patent: December 24, 2002
    Assignee: Arco Chemical Technology L.P.
    Inventors: Roger A. Grey, C. Andrew Jones
  • Thermally degradable epoxy underfills for flip-chip applications
    Patent number: 6498260
    Abstract: A reworkable epoxy underfill is provided for use in an electronic packaged system which incorporates an integrated circuit, an organic printed wire board, and at least one eutectic solder joint formed therebetween. An exemplary embodiment of the encapsulant includes: a cycloaliphatic epoxide; an organic hardener; and a curing accelerator; wherein said cycloaliphatic epoxide includes a carbonate or carbamate group. The encapsulant can also include a filler, such as a silica filler. A method is also provided for forming the aforementioned reworkable epoxy underfills.
    Type: Grant
    Filed: March 29, 2001
    Date of Patent: December 24, 2002
    Assignee: Georgia Tech Research Corp.
    Inventors: Lejun Wang, Haiying Li, Ching-Ping Wong
  • 9-desoxotaxanes and process for the preparation of 9-desoxotaxanes
    Patent number: 6495704
    Abstract: Process for the preparation of a derivative or analog of baccatin III or 10-desacetyl baccatin III having a C9 substituent other than keto in which the C9 keto substituent of taxol, a taxol analog, baccatin III or 10-desacetyl baccatin III is selectively reduced to the corresponding hydroxy group.
    Type: Grant
    Filed: May 9, 2000
    Date of Patent: December 17, 2002
    Assignee: Florida State University
    Inventors: Robert A. Holton, Carmen Somoza, Yukio Suzuki, Mitsuru Shindo
  • Efficient process for the production of 10-DAB III by selective hydrazinolysis of various taxanes
    Patent number: 6495705
    Abstract: The present invention describes a process for producing 10-deacetyl baccatin III from a solution containing a solvent reactive with hydrazine hydrate and a spectrum of taxanes. The solution is contacted with hydrazine hydrate thereby converting some taxanes therein into 10-deacetyl baccatin III. The process can target taxanes having an ester functionality on at least one of the C-10 and C-13 positions. The hydrazine hydrate cleaves the ester functionality of the taxane solute, The process may be used to produce 10-deacetyl baccatin III from a biomass extract by contacting the biomass extract with a mixture of a solvent and a hydrazine hydrate. The solvent may have a functional group that is cleaved by hydrazine. Acetate solvents are contemplated.
    Type: Grant
    Filed: July 5, 2001
    Date of Patent: December 17, 2002
    Assignee: NaPro BioTherapeutics, Inc.
    Inventors: Madhavi C. Chander, James D. McChesney
  • Acyclic chiral derivatives of hibiscus acid and the process of preparing the same
    Patent number: 6489493
    Abstract: The present invention relates to a novel acyclic chiral derivatives of Hibiscus acid of formula I, wherein: R1=R5=lower aryl or alkyl ester or substituted aryl or alkyl alcohol R3=substituted aryl or alkyl ester or substituted aryl alcohol R2=R4=hydroxyl or and a process for preparing the same.
    Type: Grant
    Filed: September 5, 2001
    Date of Patent: December 3, 2002
    Assignee: Department of Science and Technology, Technology Bhavan
    Inventors: Ibrahim Ibnu Saud, Rani Rajasekharan Nair
  • Thermodynamically stable crystal form of 4?-deoxy-4?-epi-methylamino avermectin B1a/B1b benzoic acid salt and processes for its preparation
    Patent number: 6486195
    Abstract: The most thermodynamically stable crystalline form of the benzoic acid salt of 4″-deoxy-4″-epi-methylamino avermectin B1a/B1b as the hemihydrate is obtained by crystallization from organic solvents containing a controlled amount of water.
    Type: Grant
    Filed: January 20, 1995
    Date of Patent: November 26, 2002
    Assignee: Merck & Co., Inc.
    Inventors: Raymond Cvetovich, James A. McCauley, Richard Demchak, Richard J. Varsolona
  • Spiro and dispiro 1,2,4-trioxolane antimalarials
    Patent number: 6486199
    Abstract: A means and method for treating malaria using a spiro or dispiro 1,2,4-trioxolane is described. The preferred 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl or spiropiperidyl ring on the other side of the trioxolane group, whereby the spirocyclohexyl ring is preferably functionalized or substituted at the 4-position or a spiropiperidyl ring that is functionalized or substituted at the nitrogen atom. In comparison to artemisinin semisynthetic derivatives, the compounds of this invention are structurally simple, easy to synthesize, non-toxic, and potent against malarial parasites.
    Type: Grant
    Filed: June 21, 2001
    Date of Patent: November 26, 2002
    Assignee: Medicines for Malaria Venture MMV International Centre Cointrin
    Inventors: Jonathan L. Vennerstrom, Yuxiang Dong, Jacques Chollet, Hugues Matile
  • Process for the preparation of &bgr;-isophorone epoxide
    Patent number: 6482964
    Abstract: Process for the selective preparation of &bgr;-isophorone epoxide by epoxidation of &bgr;-isophorone with organic percarboxylic acids at a water content of less than 5 wt. %.
    Type: Grant
    Filed: May 16, 2001
    Date of Patent: November 19, 2002
    Assignee: Degussa AG
    Inventors: Steffen Krill, Klaus Huthmacher, Alexander Möller
  • Hydrolysis-promoting hydrophobic taxane derivatives
    Patent number: 6482850
    Abstract: Provided herein is a taxane having a hydrocarbon attached at the 2′ and/or 7 positions, the hydrocarbon's alpha position being occupied by a “hydrolysis-promoting group” (“HPG”). In one embodiment, the hydrolysis promoting group is stereospecifically attached to the &agr;-carbon of the hydrophobic taxane. The Substitution of an HPG for the methylene unit ordinarily occupying the alpha position allows for enhanced in vivo hydrolysis of the hydrocarbon-taxane bond, and hence, for enhanced taxane therapeutic activity. Also provided herein are taxane-containing compositions, and methods of administering taxanes to animals, including those afflicted with cancers or inflammatory diseases.
    Type: Grant
    Filed: August 29, 2001
    Date of Patent: November 19, 2002
    Assignee: The Liposome Company
    Inventors: Shaukat Ali, J. Craig Franklin, Imran Ahmad, Eric Mayhew, Soumendu Bhattacharya, Gil Koehane, Andrew S. Janoff
  • C9 hydrido, hydroxy and acyloxy taxane derivatives and pharmaceutical compositions containing them
    Patent number: 6482963
    Abstract: Taxane derivatives having alternative C9 substituents.
    Type: Grant
    Filed: November 24, 1999
    Date of Patent: November 19, 2002
    Assignee: Florida State University
    Inventors: Robert A. Holton, Ki-byung Chai, Yukio Suzuki
  • Processes for the preparation of 2-methylfuran and 2-methyltetrahydrofuran
    Patent number: 6479677
    Abstract: Processes are disclosed for the preparation of 2-methylfuran and 2-methyltetrahydrofuran. The continuous vapor-phase processes are commercially viable and efficient because they permit the preparation of 2-methylfuran and 2-methyltetrahydrofuran using commercially-available catalysts, namely, a reduced copper-based catalyst consisting essentially of cupric oxide, chromium (III) oxide, manganese oxide and barium chromate and a reduced nickel-based catalyst consisting essentially of nickel, nickel (II) oxide, aluminum oxide and silica. An apparatus comprising two inline hydrogenators is used for preparing the 2-methylfuran or 2-methyltetrahydrofuran.
    Type: Grant
    Filed: October 26, 2000
    Date of Patent: November 12, 2002
    Assignee: Pure Energy Corporation
    Inventor: Irshad Ahmed
  • Metal alkoxide taxane and &bgr;-lactam compounds
    Patent number: 6479678
    Abstract: A process for preparing N-acyl, N-sulfonyl and N-phosphoryl substituted isoserine esters in which a metal alkoxide is reacted with a &bgr;-lactam.
    Type: Grant
    Filed: March 2, 2000
    Date of Patent: November 12, 2002
    Assignee: Florida State University
    Inventor: Robert A. Holton
  • Method for reacting an organic compound with a hydroperoxide
    Patent number: 6479680
    Abstract: A process for the reaction of an organic compound with a hydroperoxide comprises at least the steps (i) to (iii) below: (i) reaction of the hydroperoxide with the organic compound to give a mixture comprising the reacted organic compound and unreacted hydroperoxide, (ii) separation of the unreacted hydroperoxide from the mixture resulting from step (i), (iii) reaction of the hydroperoxide separated off in step (ii) with the organic compound.
    Type: Grant
    Filed: February 7, 2001
    Date of Patent: November 12, 2002
    Assignee: BASF Aktiengesellschaft
    Inventors: Peter Bassler, Wolfgang Harder, Peter Resch, Norbert Rieber, Wilhelm Ruppel, Joaquim Henrique Teles, Andreas Walch, Anne Wenzel, Peter Zehner
  • 2-aroyl-4-acyl paclitaxel (Taxol) analogs
    Patent number: 6476242
    Abstract: 2-debenzoyl-4-deacetyl paclitaxel, antineoplastic analogs thereof and intermediates are taught, as well as the formation of the compound, analogs and intermediates. The compound, analogs and intermediates may be used to form pharmaceutical compositions having anti-neoplastic activity. Further, the compound, analogs and intermediates may be used to treat cancer when applied in an effective amount by means such as a pharmaceutical composition.
    Type: Grant
    Filed: December 30, 1998
    Date of Patent: November 5, 2002
    Assignees: Bristol-Myers Squibb Company, Virginia Tech Intellectual Properties, Inc.
    Inventors: David George Ian Kingston, Mahendra Devichand Chordia, Prakash G. Jagtap, John Kadow
  • Process for mass production of GMP paclitaxel and related taxanes
    Patent number: 6469186
    Abstract: A process for the purification of paclitaxel and/or cephalomannine and/or 10-DAB III and/or 9-DHAB III is described. A series of extractions, separations, and purifications provides these products in commercial quantities with high purity. The source for these natural products is from readily available renewable biomaterials, such as leaves and stems from the yew, T. canadensis.
    Type: Grant
    Filed: November 7, 2001
    Date of Patent: October 22, 2002
    Assignee: Actipharm, Inc.
    Inventors: Gertrude C. Kasitu, Japheth Noah, Qasim Khan