Abstract: A process for producing propylene oxide comprising the following steps: oxidation step: a step of obtaining isopropylbenzene hydroperoxide by oxidizing isopropylbenzene; epoxidation step: a step of obtaining propylene oxide and cumyl alcohol by reacting propylene with isopropylbenzene hydroperoxide obtained in the oxidation step; hydrogenolysis step: a step of obtaining isopropylbenzene by hydrogenolyzing cumyl alcohol obtained in the epoxidation step, and recycling this isopropylbenzene to the oxidation step as a raw material of the oxidation step; and organic acid removal step: a step of removing an organic acid out of the system in at least one point in said steps or between said steps.

Abstract: A process for producing propylene oxide, which comprises steps described below, wherein the concentration of ethylbenzene in a solution containing isopropylbenzene to be recycled to the oxidation step is 10% by weight or less: oxidation step; a step in which isopropylbenzene is oxidized to obtain isopropylbenzene hydroperoxide, epoxidation step; a step in which isopropyl hydroperoxide obtained in the oxidation step is reacted with propylene to obtain propylene oxide and cumyl alcohol, and hydrogenolysis step; a step in which cumyl alcohol obtained in the epoxidation step is subjected to hydrogenolysis to obtain isopropylbenzene, and said isopropylbenzene is recycled to the oxidation step as a raw material for the oxidation step.

Abstract: A process and catalysts for the direct oxidation of an olefin having three or more carbon atoms, such as propylene, by oxygen to an olefin oxide, such as prbpylene oxide. The process involves contacting the olefin under reaction conditions with oxygen in the presence of hydrogen and a catalyst. The catalyst contains silver and titanium, optionally gold, and optionally, at least one promoter element selected from Group 1, Group 2, zinc, cadmium, the platinum group metals, the lanthanide rare earths, the actinide elements, and combinations thereof. In preferred embodiments, the catalyst is calcined prior to use, rather than reduced prior to use. Suitable titanium-containing supports include titanium dioxide, titanium dioxide on silica, titanosilicates, promoter metal titanates, titanium dispersed on silica and promoter metal silicates.

Abstract: 7-substituted fused ring tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted fused ring tetracycline compounds are described.

Abstract: A method for stereoselective chemical synthesis, includes the steps of: (A) reacting a nucleophile and chiral or prochiral cyclic subtrate, said substrate comprising a carbocycle or a heterocycle having a reactive center susceptible to nucleophilic attack by the nucleophile, in the presence of a chiral non-racemic catalyst to produce a product mixture comprising a stereomerically enriched product wherein the product mixture further comprises a catalyst residue, at least a portion of the catalyst residue is in a first oxidation state, and the catalyst residue in the first oxidation state is active in catalyzing degradation of the stereoisomerically enriched product, and (B) chemically or electochemically changing the oxidation state of the catalyst residue from the first oxidation state to a second oxidation state, wherein catalyst residue in the second oxidation state is less active in catalyzing degradation of the stereoisomerically enriched product than is catalyst residue in the first oxidation state.

Abstract: The present invention provides a process for preparing optically active &agr;-hydroxy acids and derivatives thereof by subjecting the alkylated 1,3-dioxolanones of formula (IV) wherein R1 and R2 are the same or different and are each independently H or C1-6 alkyl; R5 is H, C1-16 alkyl, or unsubstituted or substituted phenyl; and R6 is C1-8 alkyl, C2-7 alkenyl or unsubstituted or substituted benzyl, to either alcoholysis or hydrolysis, in which the alkylated 1,3-dioxolanones are obtained by using 10-camphorsulfonamide as a chiral auxiliary.

Abstract: A process is provided for use in the conversion of alkanes into alkylene oxides, having particular utility in the conversion of propane to form propylene oxide, using a lanthanide-promoted, supported, silver catalyst prepared via precipitation. A preferred embodiment uses silver nitrate and lanthanum nitrate to form the catalyst on a BaCO3 support.

Abstract: The present invention relates to a process for the catalytic epoxidation of olefins in which in one reaction stage the olefin is reacted with aqueous hydrogen peroxide in an organic, water-miscible solvent in the presence of a titanium silicalite catalyst, wherein an exit gas stream is obtained which contains olefin oxide, unreacted olefin and oxygen and this exit gas stream is brought into contact in an absorption unit with the same solvent as used in the reaction stage and a solvent stream loaded with olefin and olefin oxide is drawn off from the absorption unit and an exit gas stream containing oxygen is discharged.

Abstract: The present invention refers to a new procedure for obtaining and purifying 2-bromo-5-(2-bromo-2-nitrovinyl)-furan in one reaction step starting with 2-nitrovinylfuran, and maintains high indexes of purity and an appropriate yield. The process involves the direct bromination of 2-nitrovinylfuran using charcoal from the beginning of the reaction, followed by the neutralization and dehydrobromination using pyridine, and finally crystallizing and purifying the product obtained with ethanol and charcoal. With the new procedure it is possible to reduce the time of obtaining the final product, the reaction becomes endothermic instead of exothermic, which facilitates the work of the operators and allows for the scaling up of the reaction to superior levels. The process significantly decreases the amount of chemicals in the reaction, some of them with toxic properties.

Abstract: The present invention relates to a process for the reaction of at least one organic compound with one oxygen-delivering substance, for example a hydroperoxide, in the presence of at least one catalyst containing a metal-organic framework material comprising pores and a metal ion and an at least bidentate organic compound, said bidentate organic compound being coordinately bound to the metal ion. Further, the present invention is directed to the products being obtainable by the process according to the invention.

Abstract: A process for producing an oxirane compound from an organic peroxide other than ethylbenzene hydroperoxide and an olefin in the presence of an immobilized catalyst bed, wherein the process satisfies the following conditions (1) to (4): (1) the catalyst bed is divided into n catalyst beds and the catalyst beds are used in series, wherein n is an integer of 2 or more, (2) a fresh organic peroxide is divided into portions, which are supplied to respective inlets of the catalyst beds, (3) a fresh olefin is supplied to the inlet of the first catalyst bed, and (4) the reaction mixture discharged from each outlet of respective catalyst beds excluding the final catalyst bed is supplied to the inlet of the subsequent catalyst bed.

Abstract: A process for the catalytic epoxidation of olefins with hydrogen peroxide in a continuous flow reaction system, wherein the reaction mixture includes at least one liquid phase which is passed through a fixed catalyst bed positioned between parallel heat exchange plates and the reaction heat is at least partially removed during the course of the reaction by passing a cooling medium through the heat exchange plates.

Abstract: Taxanes having an ester substituent at C(7), a hydroxy substituent at C(10), and a range of C(2), C(9), C(14), and side chain substituents.

Abstract: A process for the catalytic epoxidation of olefins with hydrogen peroxide in a multiphase reaction mixture comprising a liquid aqueous hydrogen peroxide rich phase containing an organic solvent having a solubility in water of at least 10% by weight at 25° C. and a liquid organic olefin rich phase.

Abstract: The invention relates to a method for oxidizing hydrocarbons with a hydrogen/oxygen mixture in the presence of a catalyst. The catalyst contains a) a support material which contains titanium and b) silver particles having an average particle size ranging from 0.3 to 100 nm.

Abstract: It provide a catalyst for the production of epoxides by a vapor-phase oxidation of an unsaturated hydrocarbon having a chain length of 4-20 carbon atoms and containing no allylic hydrogen atom, characterized by having a catalytic component containing silver and at least one element selected from the group consisting of alkali metals and thallium deposited onto a carrier obtained by mixing &agr;-alumina having a sodium content in the range of 1-70 mmol (as reduced to Na) per kg of &agr;-alumina with an aluminium compound, a silicon compound, and a sodium compound and calcining the resultant mixture, the carrier having a silicon content (as reduced to SiO2) in the range of 0.3 -11.5 mass % based on the mass of the carrier and a sodium content (as reduced to Na2O) in the range of 0.11-2.5 mass % based on the mass of the carrier.

Abstract: A process for the catalytic epoxidation of olefins with hydrogen peroxide in a continuous flow reaction system, wherein the reaction mixture is passed through a fixed catalyst bed within a reactor equipped with cooling means while maintaining a temperature profile within the reactor such that the cooling medium temperature of the cooling means is at least 40° C. and the maximum temperature within the catalyst bed is 60° C. at most.

Abstract: The present invention provides a method for enantioselectively producing a nonracemic 6,7-dihydroxy geranyloxy compound from a geranyloxy compound. In particular, methods of the present invention involve enantioselectively epoxidizing the geranyloxy compound and hydrolyzing the epoxide moiety under conditions sufficient to produce the nonracemic 6,7-dihydroxy geranyloxy compound.

Abstract: A process for producing propylene oxide, which comprises steps described below, wherein isopropylbenzene hydroperoxide supplied to an epoxidation step has not undergone a heat history including heating at a temperature not lower than the temperature (t° C.) represented by the following equation (1), t(° C.)=150−0.8×W  (1) W: content (% by weight) of isopropylbenzene hydroperoxide in a solution containing isopropylbenzene hydroperoxide: oxidation step; a step in which isopropylbenzene is oxidized to obtain isopropylbenzene hydroperoxide, epoxidation step; a step in which isopropylbenzene hydroperoxide obtained in the oxidation step is reacted with propylene to obtain propylene oxide and cumyl alcohol, and hydrogenolysis step; a step in which cumyl alcohol obtained in the epoxidation step is subjected to hydrogenolysis to obtain isopropylbenzene, and said isopropylbenzene is recycled to the oxidation step as a raw material for the oxidation step.

Abstract: A process for the catalytic epoxidation of olefins with hydrogen peroxide in a continuous flow reaction system, wherein the reaction mixture is passed through a fixed catalyst bed in down-flow operation mode and the reaction heat is at least partially removed during the course of the reaction.