Patents Examined by Ba K. Trinh
  • Methods of reducing chloride content in epoxy compounds
    Patent number: 6677468
    Abstract: In accordance with the present invention, methods have been developed for the reduction of the chloride content of epoxy compound starting materials. Invention methods comprise fractionating an epoxy compound starting material into portions (e.g., fractions or cuts) having different chloride content relative to the epoxy compound starting material. Certain of these collected portions (i.e., the portions fractionated and collected after collection of the forecut and before discontinuation of the fractionation) contain substantially reduced chloride levels relative to the epoxy compound starting material.
    Type: Grant
    Filed: July 24, 2001
    Date of Patent: January 13, 2004
    Assignee: Loctite Corporation
    Inventors: Mark T. Dimke, Richard E. Miller
  • Oxirane production using peroxidized compound
    Patent number: 6677467
    Abstract: Process for manufacturing oxirane by reaction of an olefin with a peroxide compound in the presence of a catalyst and a solvent in at least two reactors arranged in series, each of which contains a portion of catalyst, according to which the peroxide compound is introduced only into the first reactor, the subsequent reactor(s) not being fed with fresh peroxide compound, but only with the peroxide compound which is present in the medium obtained from the preceding reactor and which was not consumed in this preceding reactor.
    Type: Grant
    Filed: December 27, 2002
    Date of Patent: January 13, 2004
    Assignee: Solvay (Societe Anonyme)
    Inventor: Dominique Balthasart
  • Pentacyclic taxan compound
    Patent number: 6677456
    Abstract: This invention is to provide a novel taxol derivative useful as an antitumor compound having respective substituent groups, represented by the following formula (I) which can be orally administered
    Type: Grant
    Filed: March 6, 2002
    Date of Patent: January 13, 2004
    Assignee: Daiichi Pharmaceutical Co., Ltd.
    Inventors: Tsunehiko Soga, Kouichi Uoto, Yasuyuki Takeda
  • C7 heterosubstituted acetate taxanes
    Patent number: 6673833
    Abstract: Taxanes having a heterosubstituted acetate substituent at C(7), a hydroxy substituent at C(10), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Grant
    Filed: February 2, 2001
    Date of Patent: January 6, 2004
    Assignee: FSU Research Foundation, Inc.
    Inventor: Robert A. Holton
  • Hydroperylene derivatives
    Patent number: 6673834
    Abstract: Compounds of the formula I are suitable for producing pharmaceuticals for the prophylaxis and therapy of diseases in which high blood platelet aggregations occur.
    Type: Grant
    Filed: November 21, 2002
    Date of Patent: January 6, 2004
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Michael Kurz, Matthias Herrmann, Luigi Toti, Laszlo Vertesy
  • Fluorinated oxetane derivatives and production process thereof
    Patent number: 6673948
    Abstract: A process for preparing compounds of formula (I) comprising radical addition of RfI to 3-(allyloxy)methyl-3-alkyloxetane (1) wherein R is C1-3 alkyl and Rf is C1-18 linear or branched fluoroalkyl. The compounds of formula (I) are useful as intermediates for preparing various fluorine-containing functional materials.
    Type: Grant
    Filed: September 23, 2002
    Date of Patent: January 6, 2004
    Assignee: Daikin Industries, Ltd.
    Inventors: Tetsuya Masutani, Akinori Yamamoto
  • Method for reacting an organic compound with a hydroperoxide
    Patent number: 6673950
    Abstract: In a process for reacting an organic compound with a hydroperoxide using at least one heterogeneous catalyst, both the pH and the temperate of the reaction medium are changed during the reaction
    Type: Grant
    Filed: February 1, 2002
    Date of Patent: January 6, 2004
    Assignee: BASF Aktiengesellschaft
    Inventors: Joaquim Henrique Teles, Alwin Rehfinger, Peter Bassler, Norbert Rieber, Anne Wenzel, Andreas Walch, Wolfgang Harder
  • Process for the expoxidation of olefins
    Patent number: 6670492
    Abstract: The invention described herein relates to a process for the catalytic epoxidation of olefins with hydrogen peroxide in a continuous flow reaction system, wherein a gaseous phase containing an olefin and a liquid phase containing the hydrogen peroxide is present in the reaction system and the gaseous phase flows in countercurrent to the liquid phase.
    Type: Grant
    Filed: October 4, 2002
    Date of Patent: December 30, 2003
    Assignees: Degussa AG, UHDE GmbH
    Inventors: Willi Hofen, Georg Thiele
  • Process and apparatus for integrating an alkene derivative process with an ethylene process
    Patent number: 6667409
    Abstract: An integrated process and apparatus for integrating an alkene derivative process, such as ethylene oxide process, with an ethylene process so that any ethylene entrapped in the purge stream of the alkene derivative process can be effectively recovered through the ethylene process portion of the integrated process.
    Type: Grant
    Filed: September 27, 2001
    Date of Patent: December 23, 2003
    Assignee: Praxair Technology, Inc.
    Inventors: Minish Mahendra Shah, M. Mushtaq Ahmed, Raymond Francis Drnevich
  • C10 heterosubstituted acetate taxanes
    Patent number: 6664275
    Abstract: Taxanes having a heterosubstituted acetate substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Grant
    Filed: February 2, 2001
    Date of Patent: December 16, 2003
    Assignee: FSU Research Foundation, Inc.
    Inventor: Robert A. Holton
  • C10 carbonate substituted taxanes
    Patent number: 6660866
    Abstract: Taxanes having a carbonate substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Grant
    Filed: February 2, 2001
    Date of Patent: December 9, 2003
    Assignee: PSU Research Foundation, Inc.
    Inventor: Robert A. Holton
  • Nitrosated and nitrosylated taxanes, compositions and methods of use
    Patent number: 6656966
    Abstract: The present invention describes novel nitrosated and/or nitrosylated taxanes, and novel compositions comprising at least one nitrosated and/or nitrosylated taxane, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The present invention also provides novel compositions comprising at least one taxane and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The compounds and compositions of the present invention can also be bound to a matrix.
    Type: Grant
    Filed: June 22, 2001
    Date of Patent: December 2, 2003
    Assignee: NitroMed, Inc.
    Inventors: David S. Garvey, L. Gordon Letts, Chia-En Lin, Stewart K. Richardson, Tiansheng Wang
  • Process for the preparation of ammonium alkoxides
    Patent number: 6653490
    Abstract: A process for preparing N-acyl, N-sulfonyl and N-phosphoryl substituted isoserine esters in which a metal or an ammonium alkoxide is reacted with a &bgr;-lactam.
    Type: Grant
    Filed: July 12, 2002
    Date of Patent: November 25, 2003
    Assignee: Florida State University
    Inventor: Robert A. Holton
  • Method for production of polyether alcohols
    Patent number: 6653441
    Abstract: In a process for preparing polyether alcohols by catalytic addition of at least two alkylene oxides onto H-functional initiator substances, at least one multimetal cyanide compound is used as catalyst and the addition of the alkylene oxides onto the initiator substance includes incorporation of at least one oxyalkylene block during whose formation at least two alkylene oxides are metered in together and the ratio of the alkylene oxides to one another in the mixture is changed during the joint introduction.
    Type: Grant
    Filed: May 21, 2002
    Date of Patent: November 25, 2003
    Assignee: BASF Aktiengesellschaft
    Inventors: Kathrin Harre, Gerd Höppner, Georg Heinrich Grosch, Stephan Bauer, Jürgen Winkler, Els Paredis, Reinhard Lorenz, Inge Rotermund
  • C10 ester substituted taxanes
    Patent number: 6649632
    Abstract: Taxanes having an ester substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Grant
    Filed: February 2, 2001
    Date of Patent: November 18, 2003
    Assignee: FSU Research Foundation, Inc.
    Inventor: Robert A. Holton
  • Methods of preparing amino acid taxane derivatives and polymer conjugates containing the same
    Patent number: 6649778
    Abstract: Methods of preparing amino acid-substituted taxanes such as: using selected blocked amino acids are disclosed. After coupling of the blocked amino acid to the taxane, deprotection is carried out with about an equimolar amount of a secondary amine thus substantially avoiding base-catalyzed hydrolysis of amino acid from the taxane. The preferred amino acid-taxanes are useful as intermediates in the production of polymer conjugated therapeutic compositions or as part of pharmaceutically acceptable formulations.
    Type: Grant
    Filed: September 20, 2002
    Date of Patent: November 18, 2003
    Assignee: Enzon, Inc.
    Inventors: Hong Zhao, Richard B. Greenwald
  • C2 substituted taxanes
    Patent number: 6649777
    Abstract: Taxane derivatives having alternative C2 substituents.
    Type: Grant
    Filed: December 12, 2001
    Date of Patent: November 18, 2003
    Assignee: Florida State University
    Inventors: Robert A. Holton, Chunlin Tao
  • Process for the epoxidation of olefins
    Patent number: 6646141
    Abstract: The present invention relates to a process for the working up of a product stream from the epoxidation of olefins that contains olefin, olefin oxide, water-miscible organic solvent and water, by separating this product stream into an overhead product containing olefin, olefin oxide and organic solvent, and into a bottom product containing organic solvent and water, wherein the separation takes place in a pre-evaporator with at most 5 theoretical separation stages, and 20 to 60% of the total amount of organic solvent introduced with the product stream is removed with the overhead product and the residue remains in the bottom product, as well as a process for the epoxidation of olefins that includes this working up stage.
    Type: Grant
    Filed: October 4, 2002
    Date of Patent: November 11, 2003
    Assignees: Degussa AG, UHDE GmbH
    Inventors: Willi Hofen, Georg Thiele, Alexander Möller
  • Process for producing propylene oxide
    Patent number: 6646138
    Abstract: A process for producing propylene oxide comprising the following steps: oxidation step: a step of obtaining isopropylbenzene hydroperoxide by oxidizing isopropylbenzene; epoxidation step: a step of obtaining propylene oxide and cumyl alcohol by reacting propylene with isopropylbenzene hydroperoxide obtained in the oxidation step; hydrogenolysis step: a step of obtaining isopropylbenzene by hydrogenolyzing cumyl alcohol obtained in the epoxidation step, and recycling this isopropylbenzene to the oxidation step as a raw material of the oxidation step; and organic acid removal step: a step of removing an organic acid out of the system in at least one point in said steps or between said steps.
    Type: Grant
    Filed: January 11, 2002
    Date of Patent: November 11, 2003
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Noriaki Oku, Tateo Seo
  • Process for the preparation of hydroxy substituted gamma butyrolactones
    Patent number: RE38324
    Abstract: Preparation of 4-hydroxy substituted butyrolactones is described. A process for the preparation of 3-hydroxybutyrolactone, 1.2.4-trihydroxybutane and 3,4-dihydroxy acid methyl ester from malic acid is particularly described. The preparation of 4-hydroxymethyl-4-hydroxybutyric acid -1-methyl ester and 4-hydroxymethyl butyrolactone is particularly described. The compounds are intermediates to various pharmaceutical and agricultural products.
    Type: Grant
    Filed: March 28, 2002
    Date of Patent: November 18, 2003
    Assignee: Board of Trustees of Michigan State University
    Inventor: Rawle I. Hollingworth