Patents Examined by Donald B. Moyer
  • Effective hormonal peptides: D-3-Pal.sup.6 -LHRH
    Patent number: 4642332
    Abstract: Two sets of hormonal peptides are synthesized which are super agonists of the luteinizing hormone releasing hormone (LHRH). Chronic administration results in the inhibition of LHRH which is responsible for stimulating cell growth in the testes. One peptide has the D(dextro)-form of a monoheterocyclic amino acid in position six (D-3-pyridyl-alanine) while the other peptide has a bi-heterocyclic amino acid in that same position (.beta.-(3-quinolyl)-D-.alpha.-alanine. Both peptides are less metabolically reactive than those in the prior art and yet both peptides are significantly more potent than LHRH itself.
    Type: Grant
    Filed: April 26, 1985
    Date of Patent: February 10, 1987
    Assignee: The Board of Regents, The University of Texas System
    Inventors: Karl Folkers, Xu Jie-Cheng, Cyril Y. Bowers
  • Plant protection method
    Patent number: 4640836
    Abstract: A trypsin inhibitor derived from the cowpea Vigna unguiculata or similar plant is used to protect another plant or a part thereof from attack by a pest of that plant. The plant protected may in particular be cotton or a cereal crop and particular pests from which the plant is protected are bollworms of the genus Heliothis.
    Type: Grant
    Filed: August 13, 1984
    Date of Patent: February 3, 1987
    Assignee: Agricultural Genetics Company, Limited
    Inventors: Donald Boulter, Angharad M. R. Gatehouse, John A. Gatehouse, Roger B. Cox
  • [16,19-Di-alanine] calcitonin
    Patent number: 4639509
    Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which have an alanine in positions 16 and 19 instead of the natural leucine or phenylalanine found in those positions. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.
    Type: Grant
    Filed: March 28, 1985
    Date of Patent: January 27, 1987
    Assignee: Armour Pharmaceutical Company
    Inventors: Ronald C. Orlowski, Glenn L. Stahl, Robert L. Colescott
  • Des-19-leucine-calcitonin analogs
    Patent number: 4639511
    Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which do not have a leucine in position 19. The position 19 leucine is omitted. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.
    Type: Grant
    Filed: November 12, 1985
    Date of Patent: January 27, 1987
    Assignee: Armour Pharmaceutical Company
    Inventors: Ronald C. Orlowski, Jay K. Seyler
  • Pharmaceutical composition useful for inhibiting platelet aggregation
    Patent number: 4621076
    Abstract: A pharmaceutical composition comprising an amount, effective for inhibiting platelet aggregation, of guanosine monophosphate represented by the following formula ##STR1## wherein one of X, Y and Z represents a H.sub.2 PO.sub.3 group and the remaining two of these represent a hydrogen atom,or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable diluent or carrier.
    Type: Grant
    Filed: February 15, 1985
    Date of Patent: November 4, 1986
    Assignee: Meito Sangyo Kabushiki Kaisha
    Inventors: Fumio Kuzuya, Kyoji Kito, Hisaaki Uchida
  • Non-irritating pyrethroid formulations in vegetable oils and tall oils
    Patent number: 4617318
    Abstract: Liquid pesticidal compositions comprising pyrethroid solutions in vegetable oils, fatty acids, mixtures of fatty acids, tall oils, and mixtures of vegetable oils with fatty acids and tall oils. Pyrethroid pesticidal solutions may optionally contain anionic, non-ionic surfactants, and mixtures thereof. A method of application is also described. These compositions are less irritating to mammalian ocular tissues than are similar conventional formulations.
    Type: Grant
    Filed: September 25, 1981
    Date of Patent: October 14, 1986
    Assignee: American Cyanamid Company
    Inventor: Abdel H. Marei
  • Growth hormone release factor analogs
    Patent number: 4617149
    Abstract: A class of compounds having growth hormone releasing activity is described. These compounds have the formula H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser- Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-X-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-A rg-Gly-Ala-Arg-Ala-Arg-Leu-Y in which Y is OH or NH.sub.2 and X is selected from the group consisting of Met(O), Met(S-Me), Hse, Gln, Asn, Ser, Thr, Leu, Ile, Ala, Gly, Pro, Val, Phe, Trp, Tyr, Cys, Lys, Arg, His, Glu, and Asp.
    Type: Grant
    Filed: September 21, 1983
    Date of Patent: October 14, 1986
    Assignee: Eli Lilly and Company
    Inventors: Richard D. DiMarchi, Carl J. Shaar
  • Compositions for the post-treatment of seborrheal, acneiform processes and a process for the preparation thereof
    Patent number: 4614652
    Abstract: The invention relates to a cosmetic composition for the post-treatment of seborrheal, acneiform processes, characterized by containing(i) an extract of dried chamomile (Matricaria chamomilla) and dried St. John's wort (Hypericum perforatum) in apple brandy and/or gooseberry brandy,(ii) an extract of propolis in apple brandy and/or gooseberry brandy, and(iii) a known ceratoplastic agent.
    Type: Grant
    Filed: September 17, 1984
    Date of Patent: September 30, 1986
    Assignee: Delta Vas-, Muanyag- ES Szolgaltato Ipari Szovetkezet
    Inventors: Gabriella Valyi, Eva Kutassy
  • Peptide having immunopotentiating activity similar to thymosin alpha.sub.1
    Patent number: 4614731
    Abstract: A new biologically active polypeptide hormone has been isolated from calf thymosin fraction 5 and has been given the designation thymosin alpha.sub.11. The peptide contains seven additional amino acid residues at the carboxy terminus when compared to thymosin alpha.sub.1. Thymosin alpha.sub.11 is one of several peptides present in thymosin fraction 5 which participate in the regulation, differentiation and function of thymic dependent lymphocytes (T cells). The new peptide is approxomately 16 times as potent in the protection of subject animals against opportunistic infections as thymosin fraction 5 and approximately equal in potency to thymosin alpha.sub.1.
    Type: Grant
    Filed: June 10, 1985
    Date of Patent: September 30, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Bernard L. Horecker
  • Pyridine-soluble extracts of microorganisms
    Patent number: 4613504
    Abstract: A purified pyridine-soluble extract of a microorganism is disclosed. The extract in a pharmaceutically acceptable medium is useful as an anti-animal tumor agent in the treatment of animals.
    Type: Grant
    Filed: November 13, 1984
    Date of Patent: September 23, 1986
    Assignee: Ribi ImmunoChem Research, Inc.
    Inventor: John L. Cantrell
  • Dentifrice composition
    Patent number: 4612189
    Abstract: Transparent and translucent dentifrice compositions improved in cleaning ability, stain removing ability and feeling are disclosed which comprise a mixture of an amorphous silica and an amorphous silicate containing at least 70% by weight of SiO.sub.2 which is partially inter-bonded with 1-10% by weight of an oxide of a metal selected from the group consisting of aluminum, magnesium and calcium and a transparent vehicle having substantially the same refractive index as that of the silica, the ratio of the silica to the silicate being in the range of 4:6 to 6:4 on a weight basis, the content of said mixture being in the range of 1 to 25% by weight of the composition, and the pH of the composition being in the range of 4.5 to 10.
    Type: Grant
    Filed: April 26, 1982
    Date of Patent: September 16, 1986
    Assignee: Lion Corporation
    Inventors: Masaaki Oyobe, Hiromichi Ichikawa, Tsutomu Maeyama
  • N-acyl derivatives of dipeptides, their preparation and their use in the therapy of disorders, and agents for this purpose
    Patent number: 4610818
    Abstract: N-acyl derivatives of dipeptides of the formulaX-CO-L-Leu-NH-CH.sub.2 -CO-Rwhere X and R have the meanings given in the description, are useful for the therapy of disorders.
    Type: Grant
    Filed: July 12, 1983
    Date of Patent: September 9, 1986
    Assignee: BASF Aktiengesellschaft
    Inventors: Hans P. Albrecht, Horst Kreiskott
  • Protective composition with penetrating carrier
    Patent number: 4610881
    Abstract: In a composition for application to a porous substrate, e.g. timber, to protect it e.g. from attack by insects or fungi, there is a protective substance, e.g. a boron-rich compound (containing at least 25% by weight B.sub.2 O.sub.3) in a liquid carrier which according to the invention is a hygroscopic liquid, preferably ethylene glycol. When applied to wood the composition with the glycol carrier penetrates the outer layers of the wood more rapidly than a comparable composition with water as carrier.
    Type: Grant
    Filed: February 12, 1982
    Date of Patent: September 9, 1986
    Inventor: Carl C. Bechgaard
  • N-acyl derivatives of peptides, their preparation and their use in the treatment of disorders, and agents for this purpose
    Patent number: 4610817
    Abstract: Novel N-acyl derivatives of peptides related to L-pro-L-leu-gly-NH.sub.2, melanocyte stimulating hormone-release inhibiting factor (MIF), and therapeutic compositions which are useful for the treatment of depression.
    Type: Grant
    Filed: July 12, 1983
    Date of Patent: September 9, 1986
    Assignee: BASF Aktiengesellschaft
    Inventors: Hans P. Albrecht, Horst Kreiskott
  • Method of treating cachexia
    Patent number: 4608256
    Abstract: An inorganic health preservative for treating cachexia to improve the physical constitution of humans which is prepared by mixing 8 parts by weight of crystalline ferrous sulfate heptahydrate, which is a by-product of manufacturing titanium-white, with 1 to 2 parts by weight of fine powder of flyash, which is a by-product in a steam power station, drying the mixture for about one hour at a temperature of from 65.degree. to 85.degree. C. to obtain shattered granules, and pulverizing mechanically said shattered granules into a finely powered substance, having the degree of pulverization of about 100 Tyler mesh.
    Type: Grant
    Filed: March 29, 1985
    Date of Patent: August 26, 1986
    Inventor: Chukei Komakine
  • Calcitonin analogs
    Patent number: 4604236
    Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which do not have a serine in position 13. The position 13 serine is omitted. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.
    Type: Grant
    Filed: March 18, 1985
    Date of Patent: August 5, 1986
    Inventors: Ronald C. Orlowski, Jay K. Seyler
  • Analogs of calcitonin
    Patent number: 4604238
    Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which have a shorter amino acid chain than natural calcitonins and are also substitution analogs of the natural calcitonins. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.
    Type: Grant
    Filed: December 10, 1984
    Date of Patent: August 5, 1986
    Assignee: Armour Pharmaceutical Company
    Inventors: Ronald C. Orlowski, Jay K. Seyler, Glenn L. Stahl
  • Pharmaceutical preparations of pinacidal
    Patent number: 4600577
    Abstract: New pharmaceutical preparation containing pinacidil (N"-cyano-N-4-pyridyl-N'-1,2,2-trimethylpropylguanidine) in slow-release form, providing more uniform absorption rates and resulting blood levels when administered to the individual patients.
    Type: Grant
    Filed: January 23, 1984
    Date of Patent: July 15, 1986
    Assignee: Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselkab)
    Inventor: Erik J. Didriksen
  • Sustained release breath freshener, mouth and palate coolant wafer composition and method of use
    Patent number: 4597959
    Abstract: A cosmetic breath freshener composition, in wafer form, having slow release comprising a multiplicity of microencapsulated liquid droplets of flavoring material contained in a base or carrier. The microcapsules are soluble in the saliva in the mouth to release the flavoring material at sustained rate. The base has an adhesive therein so that the formed wafer can be placed on the lower or upper gums of the user, thus being activated by the saliva in the mouth causing the capsules to release the flavoring material at a sustained rate for long periods of time in the mouth to mask bad breath and also offering a cool feel effect in the mouth of the user.
    Type: Grant
    Filed: April 30, 1982
    Date of Patent: July 1, 1986
    Inventor: Arthur Barr
  • Rumen-stable pellets
    Patent number: 4595584
    Abstract: Disclosed is a composition adapted for use in coating pellets orally administrable to ruminants which protects the core material in the rumen and releases it in the abomasum comprising a film-forming polymeric material, a hydrophobic material dispersed in said polymeric material, and a physiologically acceptable flake material dispersed in said polymeric material, the flake material having been treated by bringing the particles into rubbing contact with the hydrophobic material so that the surface of the particles of flake material become hydrophobic.
    Type: Grant
    Filed: January 7, 1985
    Date of Patent: June 17, 1986
    Assignee: Eastman Kodak Company
    Inventors: Stephen H. W. Wu, M. Akram Sandhu