Patents Examined by Donald B. Moyer
  • Anti-leishmanial pharmaceutical formulations
    Patent number: 4594241
    Abstract: Antimony-containing anti-leishmaniasis drugs are encapsulated in a lipid based liposomal formulation having a weight ratio of lipid to encapsulated antimony-containing drug of 1:1.6 to 1:0.25 and a salt concentration in the continuous aqueous phase which is at least isotonic with human blood. Such formulations are found to have a leakage rate of initially encapsulated antimony-containing drug of less than 50% by weight after storage at 25.degree. C. for 6 weeks from encapsulation and hence provide storage stable formulations which can be used effectively after prolonged storage without refrigeration in tropical climates. The anti-parasital activity of the liposomal formulations has been found greater than that of corresponding aqueous formulations.
    Type: Grant
    Filed: November 5, 1984
    Date of Patent: June 10, 1986
    Assignee: Burroughs Wellcome Co.
    Inventor: Leburu S. Rao
  • Method of reducing dental plaque formation with products for human or animal consumption using isomaltulose sucrose substitute
    Patent number: 4587119
    Abstract: Isomaltulose is of use as a whole or partial replacement for sucrose in products for human or animal consumption.
    Type: Grant
    Filed: December 14, 1984
    Date of Patent: May 6, 1986
    Assignee: Tate & Lyle Public Limited Company
    Inventors: Christopher Bucke, Peter S. J. Cheetham
  • Process for pasteurizing fibronectin
    Patent number: 4585654
    Abstract: A process for heating and simultaneously agitating a plasma protein solution in the presence of a polyol, a surface active agent and a chelating agent. Said process inactivates viruses in said solution while preserving the physical and biological properties of said plasma protein.
    Type: Grant
    Filed: December 21, 1984
    Date of Patent: April 29, 1986
    Assignee: Armour Pharmaceutical Co.
    Inventors: Ricardo H. Landaburu, Godfrey W. Amphlett, Roy E. Branson, Arthur B. Shaw
  • Immune stimulation
    Patent number: 4571336
    Abstract: Immunostimulatory peptide is isolated from bovine thymus tissue and is useful to treat mammals and birds at risk from viral or fungal infections or other trauma.
    Type: Grant
    Filed: January 25, 1985
    Date of Patent: February 18, 1986
    Assignee: Endorphin, Inc.
    Inventors: John C. Houck, Leonard M. Patt
  • Process for the preparation of vinylphosphonic acid dichloride and 2-chloroethanephosphonic acid dichloride
    Patent number: 4548762
    Abstract: A process for the preparation of vinylphosphonic acid dichloride and 2-chloroethanephosphonic acid dichloride, wherein 2-chloroethanephosphonic acid derivatives containing 2-chloroethyl ester groups, as produced in the Arbusow rearrangement of tris-chloroethyl phosphite, are heated to 150.degree. to 230.degree. C. in a first stage, and, in a second stage, the residual reaction mixture is reacted with phosgene at 90.degree.-200.degree. C., in the presence of basic catalysts or of alkali metal salts as catalysts, and in the presence of phosphonic acid dichlorides.
    Type: Grant
    Filed: February 4, 1983
    Date of Patent: October 22, 1985
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Hans-Jerg Kleiner, Walter Dursch
  • Crosslinked, porous polymers for controlled drug delivery
    Patent number: 4548990
    Abstract: A controlled-release, drug-delivery composition which comprises (A) a crosslinked copolymer, capable of swelling in ethanol to give a swollen copolymer containing at least 40% by weight of ethanol, and capable of swelling in water to give a swollen copolymer containing no more than 20% by weight of water, where the swelling ratio (% ethanol: % water) is 2:1 to 22:1, which comprises the copolymerization product of (a) 50 to 99% by weight of said copolymer of a water-insoluble monoolefinic monomer or (a) with 0 to 45% by weight of total monomers of a water-soluble monoolefinic monomer, with (b) 50 to 1% by weight, but not more than 20 mol % of a divinyl or polyvinyl crosslinking agent; and (B) an effective amount of a pharmaceutical medicament is useful for the controlled and prolonged release of drugs when taken orally.
    Type: Grant
    Filed: August 15, 1983
    Date of Patent: October 22, 1985
    Assignee: Ciba-Geigy Corporation
    Inventors: Karl F. Mueller, Sonia J. Heiber
  • Synthetic calcitonin-gene-related peptides for lowering blood pressure or gastric acid secretion in mammals
    Patent number: 4530838
    Abstract: CGRP (calcitonin-gene-related peptide) has the formula: ##STR1## A related peptide has the residue Lys instead of Glu in the 35-position. CGRP or this homolog or pharmaceutically acceptable salts thereof, dispersed in a pharmaceutically acceptable liquid or solid carrier, can be administered to mammals, including humans, to influence memory, mood and pain appreciation and to achieve a substantial lowering of blood pressure or gastric acid secretion over an extended period of time. They also may be administered to affect ingestion behavior, taste and sensory perception.
    Type: Grant
    Filed: July 8, 1983
    Date of Patent: July 23, 1985
    Assignee: The Salk Institute for Biological Studies
    Inventors: Ronald M. Evans, Larry Swanson, Wylie W. Vale, Jr., Michael G. Rosenfeld, Susan G. Amara, Marvin R. Brown, Jean E. F. Rivier
  • Method of producing human epidermal growth factor
    Patent number: 4528186
    Abstract: A method for producing a human epidermal growth factor in high yield and high purity by adding particles of an aluminum or magnesium silicate of the formula z.2 (or 6) SiO.sub.2.xH.sub.2 O where Z is Al.sub.2 O.sub.3 or 2MgO and x is the number of water molecules in each molecule of the compound, to human urine under neutral to acid conditions to adsorb the factor on the particles and then eluting the factor with an alkaline solution.
    Type: Grant
    Filed: June 9, 1983
    Date of Patent: July 9, 1985
    Assignee: Japan Chemical Research Co., Ltd.
    Inventors: Toyohiko Nishimura, Naomi Uchida, Hajime Hiratani
  • Method for purifying reaction products containing higher-alkyl glycosides
    Patent number: 4510306
    Abstract: The subject invention relates to the removal of residual higher alcohols which are present from the preparation of crude higher-alkyl glycosides. The residual higher alcohols are removed via vacuum distillation with a hydroxyl-containing solvent. The purified higher-alkyl glycosides are biodegradable nonionic surfactants which are soluble and stable in highly alkaline cleaning formulations used for bottle washing, metal cleaning, textile treatment and other applications.
    Type: Grant
    Filed: September 13, 1983
    Date of Patent: April 9, 1985
    Assignee: BASF Wyandotte Corporation
    Inventor: William K. Langdon
  • Pharmaceutical preparation containing purified fibronectin
    Patent number: 4478829
    Abstract: Disclosed are readily reconstitutable lyophilized fibronectin formulations containing fibronectin, a neutral salt, a carbohydrate and a surface active agent.
    Type: Grant
    Filed: March 30, 1984
    Date of Patent: October 23, 1984
    Assignee: Armour Pharmaceutical Company
    Inventors: Ricardo H. Landaburu, Robert H. Yue, David L. Farb, Bernard N. Violand
  • Process of preparing alkylsaccharides
    Patent number: 4465828
    Abstract: Hydroxy carboxylic acids minimize the formation of color bodies in processes for preparing and purifying alkylsaccharides when the temperature exceeds about 100.degree. C.
    Type: Grant
    Filed: February 17, 1984
    Date of Patent: August 14, 1984
    Assignee: The Procter & Gamble Company
    Inventors: Allen H. Rau, Donald T. Speckman
  • Oximes of 3'"-dehydrocardenolide tridigitoxosides
    Patent number: 4461763
    Abstract: The present invention provides 3'"-dehydrocardenolide tridigitoxoside oximes of the general formula: ##STR1## in which R.sub.1 is a hydrogen atom or an alkyl radical containing up to 3 carbon atoms, R.sub.2 is a hydrogen atom or a lower acyl or alkyl radical and R.sub.3 represents two hydrogen atoms, the group ##STR2## or the oximino group .dbd.NOR.sub.1, wherein R.sub.1 has the above-given meaning.The present invention also provides a process for the preparation of these oximes, as well as pharmaceutical compostions containing them which are useful for the treatment of cardiac insufficiency.
    Type: Grant
    Filed: November 5, 1982
    Date of Patent: July 24, 1984
    Assignee: Boehringer Mannheim GmbH
    Inventors: Wolfgang Schaumann, Fritz Kaiser, Wolfgang Voigtlander, Edgar Hoyer, Peter Neubert
  • Compounds having antibiotic activity, processes for their preparation, pharmaceutical compositions containing them and their use as medicaments
    Patent number: 4459291
    Abstract: New antibacterial compounds, DC--45--A.sub.1 and DC--45--A.sub.2 are produced by fermentation of a microorganism belonging to the genus Streptomyces. The antibiotics are accumulated in the culture liquor and are isolated therefrom. These compounds are also prepared by acid hydrolysis of known compounds, DC--45--A or DC--45--B.sub.2. DC--45--A.sub.2 is also prepared by acid hydrolysis of DC--45--A.sub.1.
    Type: Grant
    Filed: July 21, 1982
    Date of Patent: July 10, 1984
    Assignee: Kyowa Hakko Kogyo Kabushiki Kaisha
    Inventors: Kunikatsu Shirahata, Takao Iida
  • Glycosides of vitamins A, E and K
    Patent number: 4457918
    Abstract: A water soluble vitamin compound of the formula selected from the group consisting of: ##STR1## wherein R.sup.1 is a straight or branched chain glycosidic residue containing 1-20 glycosidic units per residue, and R.sup.2 and R.sup.3 are hydrogen or R.sup.1, with the proviso that at least one of R.sup.2 or R.sup.3 is R.sup.1.
    Type: Grant
    Filed: May 12, 1982
    Date of Patent: July 3, 1984
    Assignee: The General Hospital Corporation
    Inventors: Michael F. Holick, Sally A. Holick
  • Nitrosourea derivatives
    Patent number: 4452814
    Abstract: Nitrosourea derivatives are provided which possess a high level of inhibitory activity against leukemia and tumors and which are therefore useful for pharmaceutical purposes. The compounds have the structure represented by formulae (I), (II) and (III): ##STR1## wherein R.sup.1, R.sup.2 and R.sup.4 may be the same or different and each represent a hydrogen atom or an alkyl, aryl, aralkyl, alkanoyl or a heterocyclic group; R.sup.3 represents the residual group on the .alpha.-carbon atom of an .alpha.-amino acid; n represents 2 or 3; X represents a halogen atom selected from chlorine, fluorine and bromine; and Ac represents an alkanoyl group.
    Type: Grant
    Filed: January 12, 1982
    Date of Patent: June 5, 1984
    Inventor: Tetsuo Suami
  • Medicated compound for treating diseases infected by virus of the herpes group
    Patent number: 4436732
    Abstract: A pharmaceutical composition for the treatment of diseases caused by a virus pertaining to the herpes group comprising an active principle: 2-C-.beta.-D-glucopyranosyl-1,3,6,7-tetraoxyxanthone of the formula: ##STR1## in combination with a pharmaceutical vehicle.
    Type: Grant
    Filed: October 26, 1981
    Date of Patent: March 13, 1984
    Inventors: Serafima A. Vichkanova, Ljudmila D. Shipulina, Vladimir I. Glyzin, Alexandr I. Bankovsky, Mikhail G. Pimenov, Klim I. Boryaev
  • Drug delivery system comprising a reservoir containing a plurality of tiny pills
    Patent number: 4434153
    Abstract: A delivery device is disclosed for delivering a beneficial drug to a biological environment of use. The device comprises a hydrogel reservoir containing tiny pills. The tiny pills comprise a wall surrounding a drug core.
    Type: Grant
    Filed: March 22, 1982
    Date of Patent: February 28, 1984
    Assignee: Alza Corporation
    Inventors: John Urquhart, Felix Theeuwes
  • Strong anion exchange composition and methods
    Patent number: 4430496
    Abstract: A strong anion exchange composition useful in monophosphate nucleotide isomer separations is comprised of an inert porous particle having a silyl alkyl ammonium compound fixedly attached by a covalent silicon-oxygen-silicon bond to the surface thereof. A process for synthesizing the strong anion exchange composition in an aqueous solvent is disclosed together with methods for separation of monophosphate nucleotide isomers, highly phophorylated nucleotides and aldopentose carbohydrates using a column packed with this strong anion exchange composition.
    Type: Grant
    Filed: March 16, 1982
    Date of Patent: February 7, 1984
    Assignee: Varian Associates, Inc.
    Inventor: Seth R. Abbott
  • Conversion of cellulosic fibers to mono-sugars and lignin
    Patent number: 4427584
    Abstract: A process which comprises a stepwise treatment of natural fibers with liquid or gaseous sulphur trioxide to cause decrystallization of the alpha-cellulose therein, followed by hydrolysis of the treated fibers to produce (1) an aqueous solution of hexose sugars which can be utilized as feedstock when using a yeast organism to produce ethanol, (2) pentose sugars that may be used as a syrup for feed to ruminants, and (3) a residual lignin fraction that may be used as fuel to energize said process.
    Type: Grant
    Filed: May 5, 1982
    Date of Patent: January 24, 1984
    Assignee: University of Florida
    Inventors: Ferdinand LeGrand, Seymour S. Block
  • Novel uracil derivatives, process for preparing the same and a pharmaceutical composition containing the same
    Patent number: 4415573
    Abstract: Novel uracil derivatives of the formula ##STR1## (wherein R.sub.1, R.sub.2 R.sub.3 and X are defined in the description) and their pharmaceutically acceptable salts, process for preparing the same and pharmaceutical composition containing the same are disclosed. The uracil derivatives have good antitumor activity and, therefore, are useful as antitumor preparation.
    Type: Grant
    Filed: August 10, 1981
    Date of Patent: November 15, 1983
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Kiyoshige Ochi, Katsuhito Miyamoto, Hiroki Mitsui, Yumiko Tsuruma, Isao Matsunaga, Takashi Matsuno, Shigeru Takanashi, Minoru Shindo