Patents Examined by Emily R. Berkeley
  • Patent number: 10352917
    Abstract: The present invention provides a carboxylate-bridged binuclear iron-sulfur clusters fluorescent probe having the structure of Formula I. The preparation method comprises the following steps: anthracenylmethanamine and p-methoxycarbonylphenyl isocyanate have an addition reaction to get a substitutional methyl benzoate, which is hydrolyzed to get a corresponding carboxylic acid; react the resulting carboxylic acid with alkali to get carboxylate, and then coordinate with binuclear iron precursor to obtain the fluorescent probe. Compared with the prior art, the invention firstly provides the carboxylate-bridged binuclear iron-sulfur clusters of metal complex which similar to the central structure of bio-enzyme. The metal complex, as a fluorescent probe, has good selectivity to the fluorinion detection. The fluorescence titration experiment is simple and easy to operate and the fluorescence changes are sensitive.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: July 16, 2019
    Inventors: Yuhan Zhou, Jingping Qu, Xiaoliang Dong
  • Patent number: 10345318
    Abstract: A method is described for the diagnostic determination of the risk caused by an altered oxidative balance, comprising the photometric measurement of total cholesterol, hydroperoxides, and antioxidant capacity, on the basis of which the protective index, the oxidative index and the risk index caused by an altered oxidative balance (or ‘OBRI’) are calculated. This latter index has proved to be particularly dependable and reliable in determining the status of the oxidative balance in relation to cholesterol levels, being highly predictive of cardiovascular risk.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: July 9, 2019
    Assignee: H&D S.R.L.
    Inventor: Gabriele Callegari
  • Patent number: 10335784
    Abstract: A lab-on-chip-based system is described for the direct and multiple sampling, control of the volume, fluid filtration, biochemical reactions, sample transfer, and dried spot generation on the conventional and commercial cards for dried fluid spot. Within an all-in-one integrated holder, the invention allows the complete process required to ensure a quantitative analysis of blood, plasma or any other fluids, modification and enrichment of molecule subsets, and formation of a dried fluid spot on the specific spot location of a passive cellulose, non-cellulose, absorbent, or non-absorbent membrane material sampling.
    Type: Grant
    Filed: August 29, 2017
    Date of Patent: July 2, 2019
    Assignee: DBS System SA
    Inventors: Didier Maillefer, Julien Deglon, Aurelien Thomas, Julien Dumont
  • Patent number: 10317386
    Abstract: A method of measuring nitrate concentration in an aqueous sample includes mixing the aqueous sample with a water-soluble thioether chosen to reduce nitrate in the aqueous sample to nitrite in the presence of a water soluble catalyst, and a water soluble reagent system adapted to interact with nitrite to generate a color; measuring color generation, and correlating the color generation to nitrate concentration.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: June 11, 2019
    Assignee: HACH COMPANY
    Inventors: Darren Kent MacFarland, Angella Nicholle Greenawalt
  • Patent number: 10302535
    Abstract: A filtration device is disclosed for filtering debris from a biofluid sample. In at least one embodiment, the filtration device provides a collection container having a collection chamber defined by a flexible wall, a mouth fluidly communicating with the collection chamber and formed through the collection container at a top end, and a filter device defining a bottom to the collection chamber. A quantitative container has a quantitative chamber in fluid communication with the filter device with the filter device separating the collection chamber from the quantitative chamber. A biofluid sample is introduced into the collection chamber through the mouth, and when the mouth with a collection chamber cap, the flexible wall of the collection container is squeezed to reduce the volume of the collection chamber and force the biofluid sample through the filter device, the filtered biofluid sample thereafter being contained within the quantitative chamber.
    Type: Grant
    Filed: August 7, 2016
    Date of Patent: May 28, 2019
    Assignee: CellectGen, Inc.
    Inventors: Robert Gellibolian, Adam Markaryan
  • Patent number: 10295496
    Abstract: A biosensor system can comprise a sensor chip and a measurement device. The sensor chip comprises a capillary and electrodes disposed within the capillary. The height of the capillary is set to be less than the maximum value of the sum of the diffusion distance of an electron-transfer mediator and the diffusion distance of an analyte at the upper limit of the measurement guaranteed temperature of the biosensor system. The measurement device applies an open circuit voltage, a voltage that is lower than during concentration measurement, or the like to the electrodes of the sensor chip.
    Type: Grant
    Filed: September 12, 2016
    Date of Patent: May 21, 2019
    Inventor: Motonori Uchiyama
  • Patent number: 10294252
    Abstract: The present disclosure provides a new series of compounds exhibiting high fluorescence quantum yields in the solid state. In one embodiment, the compounds include a series of 2,3,4,5-tetraphenylgermoles with the same or different 1,1-substituents. In another embodiment, substituted germafluorenes, germa-fluoresceins/rhodamines, and germapins are described. These germanium heterocycles possess ideal photophysical and thermostability properties, which makes them excellent candidates for chemical or biological sensors, host materials for electroluminescent devices and solar cells, and emissive and for electron-transport layer components in organic light emitting diode devices.
    Type: Grant
    Filed: June 11, 2013
    Date of Patent: May 21, 2019
    Assignee: The Curators of the University of Missouri
    Inventors: Janet Braddock-Wilking, Teresa Lynn Bandrowsky, James Bryan Carroll, II
  • Patent number: 10288606
    Abstract: The present invention provides an analysis method for simultaneously detecting or quantifying plural species of target substances by measuring the light emission from plural carriers within a single container from outside of the container, these carriers comprising a plurality of substances that are respectively immobilized thereon for capturing the plural species of target substances, wherein the light emission from a desired carrier is selectively received by measuring the emission from the carriers through an optical filter.
    Type: Grant
    Filed: October 21, 2013
    Date of Patent: May 14, 2019
    Inventors: Takaki Sugimoto, Tetsuya Ueda, Shuichi Kobayashi, Hideji Tajima
  • Patent number: 10267775
    Abstract: The present specification discloses methods for determining the presence one or more analytes in a test sample, materials useful to perform the disclosed methods, and kits comprising reagents useful to practice the disclosed methods.
    Type: Grant
    Filed: May 30, 2015
    Date of Patent: April 23, 2019
    Assignee: TECAN SP, INC.
    Inventors: Qi Huang, Philip A. Dimson, Karsten R. Liegmann
  • Patent number: 10246557
    Abstract: Disclosed is a curable sealant composition including: (i) a thiol-terminated prepolymer and/or monomers thereof, wherein the thiol-terminated prepolymer is a polythioether or a polysulfide; (ii) an “ene” crosslinker having a molecular weight of about 100 to about 5000; and (iii) a pH indicator molecule including a quantum dot functionalized with a pH-responsive ligand. Methods for determining a sufficient cure state of a composition by combining the thiol-terminated prepolymer and/or monomers thereof and the “ene” crosslinker with a pH indicator molecule, including a quantum dot functionalized with a pH-responsive ligand, and (ii) then subjecting a resultant mixture of (i) to curing conditions until the mixture changes its color are also disclosed.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: April 2, 2019
    Inventors: Katherine L. Frank, Andrew M. Zweig
  • Patent number: 10239056
    Abstract: A micro flow channel chip having high shape accuracy is provided. A micro flow channel chip includes a base material 12 having a groove 121 formed on one surface; and a resin film 14 joined to the surface of the base material 12 so as to cover the groove 121 of the base material 12, in which the resin film 14 contains a (meth)acrylic resin (A), and the (meth)acrylic resin (A) contains a structural unit (A1) represented by Formula (1). (In Formula (1), R1 and R2 each independently represent a hydrogen atom, a methyl group, an ethyl group, or a propyl group; and R3 represents an alkyl group having 3 to 6 carbon atoms).
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: March 26, 2019
    Inventor: Hirohito Taniguchi
  • Patent number: 10239055
    Abstract: The present invention relates to a pipette comprising a tip removal mechanism adapted for lifting an inner mechanism of the pipette with regard to a body of the pipette when the user presses the tip removal button. The present invention further relates to a method for disengaging a disposable tip attached to a tip cone of a pipette of the present invention, and to a method for pipetting with a pipette according to the present invention.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: March 26, 2019
    Inventor: Ville Juhani Hintikka
  • Patent number: 10227287
    Abstract: Described is a method of detecting and/or determining levels of incorporation of monolignol ferulate conjugate esters into lignin by derivatizing the lignin, reductively cleaving the lignin, labeling the cleavage products, and then detecting cleavage products derived from monolignol ester conjugates via differential attachment of the label.
    Type: Grant
    Filed: December 31, 2015
    Date of Patent: March 12, 2019
    Inventors: John Ralph, Steven D Karlen, Fachuang Lu, Dharshana Padmakshan
  • Patent number: 10207229
    Abstract: The disclosure relates to a process and related article for functionalizing a porous membrane by contacting the membrane with a polyacid polymer at low pH to stably adsorb a polyacid layer on the membrane pore surface. The resulting functionalized membrane is characterized by a high density of free acid groups, resulting in a higher specific capacity for its intended application. The process allows functionalization of porous membranes in a very simple, one-step process. Such functional membranes may find multiple uses, including rapid, selective binding of proteins for their purification or immobilization.
    Type: Grant
    Filed: August 30, 2016
    Date of Patent: February 19, 2019
    Inventors: Merlin L. Bruening, Gregory L. Baker, Somnath Bhattacharjee, Yiding Ma
  • Patent number: 10209194
    Abstract: A Raman scattering probe, and a method of making such a probe, uses a capsule of nanometric size, such as a nanotube, to which is coupled at least one Raman-active molecule. The Raman-active molecule may be encapsulated in, or attached on the exterior of, the capsule, and exhibits a Raman scattering response when the probe is illuminated by an excitation light beam. A functionalization chemical group that is attached to an exterior of the capsule provides a connection between the capsule and a target material. This functionalization may include a generic chemical functionalization that bonds with any of a plurality of secondary chemical groups each of which bonds directly with a different target. A method of using the probe for Raman spectroscopy or Raman imaging is also provided.
    Type: Grant
    Filed: June 22, 2016
    Date of Patent: February 19, 2019
    Inventors: Richard Martel, Nathalie Y-Wa Tang, Francois Raymond, Janie Cabana, Marc-Antoine Nadon
  • Patent number: 10208331
    Abstract: A bioparticle collection device and an aerosol collection system. The bioparticle collection device includes a collection medium including a plurality of fibers formed into a fiber mat and configured to collect bioparticles thereon, and includes a viability enhancing material provider disposed in a vicinity of the plurality of fibers and configured to provide a viability enhancing material to the collected bioparticles to maintain viability of the bioparticles collected by the fiber mat. The aerosol collection system includes an aerosol pumping device configured to entrain particles in an gas stream, an aerosol saturation device configured to saturate the particles in the gas stream with a biocompatible liquid, and an aerosol collection medium downstream from the aerosol saturation device and including a plurality of fibers formed into a fiber mat for collection of the saturated aerosol particles.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: February 19, 2019
    Assignee: Research Triangle Institute
    Inventors: David Samuel Ensor, Howard Jerome Walls, Karin K. Foarde
  • Patent number: 10203333
    Abstract: The invention relates to electronically neutral metal complexes as luminescent labels. The positive charge of the metal ion in the complex is neutralized by the negatively charged groups that are covalently linked to the nitrogen-containing diimine ligands, such as 2,2-bipyridine, 1,10-phenanthroline and their derivatives. The electronic neutrality reduces the impact of the metal complexes on the biological and/or biochemical activities of the labeled biomolecules, while the intensity of luminescent emission under electrochemical excitation is enhanced. These luminescent metal complex labels are useful in bioanalytic methodology development, with luminescence as the signal modality, such as electrochemiluminescence.
    Type: Grant
    Filed: June 18, 2014
    Date of Patent: February 12, 2019
    Assignee: Rubipy Scientific, Inc.
    Inventors: Ming Zhou, Linpo Yu
  • Patent number: 10203319
    Abstract: The invention relates to a process for determining the degree of branching of modified polymers wherein the polymers are modified in the sense that their degree of branching after polymerization was increased once more, wherein the modified polymers are treated with a polar transformation mixture comprising a compound of general formula (I) R1—S—S—R1?? (I) wherein the Mooney viscosity (ML 1+4 at 100° C.) of the polymers is determined before and after the treatment with the polar transformation mixture and the degree of branching is determined.
    Type: Grant
    Filed: October 9, 2014
    Date of Patent: February 12, 2019
    Inventors: Heike Kloppenburg, Alicia Le-Sattler
  • Patent number: 10175175
    Abstract: Novel Zr-based metal-organic framework (MOF) chemosensors useful for detection, recognition, removal, and separation of heavy metals are provided. Also provided are methods for preparation of the chemosensors and processes for detection, recognition, removal, and separation of heavy metals using the chemosensors.
    Type: Grant
    Filed: February 11, 2014
    Date of Patent: January 8, 2019
    Inventors: Hassan Azzazy, Ahmed Shahat, Hassan M. A. Hassan
  • Patent number: 10168284
    Abstract: A method of analyzing a sample to be tested to determine the presence of or to quantify an analyte in the sample, employing a reaction which produces a reaction medium derived from the sample and which possesses fluorescence properties, the reaction medium being located within a well, the reaction medium and the well forming an analysis assembly which possesses fluorescent properties in response to illumination by a light source producing a light signal, the light source being movable along a surface S1 of the well.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: January 1, 2019
    Assignee: Biomerieux
    Inventors: Bruno Colin, Laurent Drazek, Frédéric Pinston