Patents Examined by Emily R. Berkeley
  • Patent number: 10845361
    Abstract: Disclosed herein is a formulation for detecting a species indicative of a disease in a patient. The formulation comprises a mercury-containing reagent which, when contacted with a fluid sample from the patient, colourimetrically indicates whether the fluid sample contains the species. The mercury-containing reagent is contained within a non-flowing carrier which, upon exposure to the fluid sample, causes rapid mixing of substantially all of the mercury-containing reagent and the fluid sample.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: November 24, 2020
    Inventors: Allan J Chisholm, Nicolas De Luca
  • Patent number: 10845346
    Abstract: Compositions, kits, and methods of using the kits and compositions to determine the hardness of and/or magnesium concentration in a solution are described. The kit can include a lyophilized composition that has an absorbance at a detectable wavelength in response to the hardness of the solution and or the concentration of magnesium in the solution.
    Type: Grant
    Filed: May 26, 2016
    Date of Patent: November 24, 2020
    Assignee: WATER LENS, LLC
    Inventors: Justin M. Dragna, Adam Garland, Tyler West
  • Patent number: 10835148
    Abstract: Particular aspects of the invention are methods for assaying metabolite levels in samples from a patient during pregnancy using nuclear magnetic resonance and direct flow injection mass spectrometry. In various methods, the assayed metabolites may be acylcarnitine or one or more of C3-OH (hydroxypropionylcarnitine), C5-OH (C3DC), C10, C5:1-DC (glutaconylcarnitine), C14:1-OH (hydroxytetradecenoylcarnitine) and C14:2-OH. One or more methods also may include measuring nuchal translucency of the fetus. Other methods relate to predicting fetal congenital heart defects in a fetus.
    Type: Grant
    Filed: November 25, 2014
    Date of Patent: November 17, 2020
    Assignee: Bioscreening & Diagnostics LLC
    Inventors: Ray O. Bahado-Singh, Kypros Nicolaides
  • Patent number: 10830677
    Abstract: A filtration device is disclosed for filtering debris from a biofluid sample. In at least one embodiment, the filtration device provides a collection container having a collection chamber defined by a flexible wall, a mouth fluidly communicating with the collection chamber and formed through the collection container at a top end, and a filter device defining a bottom of the collection chamber. A quantitative container has a quantitative chamber in fluid communication with the filter device with the filter device separating the collection chamber from the quantitative chamber. A biofluid sample is introduced into the collection chamber through the mouth, and when the mouth with a collection chamber cap, the flexible wall of the collection container is squeezed to reduce the volume of the collection chamber and force the biofluid sample through the filter device, the filtered biofluid sample thereafter being contained within the quantitative chamber.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: November 10, 2020
    Assignee: CellectGen, Inc.
    Inventors: Robert Gellibolian, Adam Markaryan
  • Patent number: 10830764
    Abstract: Various techniques are provided to determine the presence of trace chemicals corresponding to various materials of interest. In one example, a method includes providing a chemical reporter of a chemical detector. The chemical reporter includes protonated 2-[5-methoxy-2-(4-phenyl-quinoline-2yl)-phenyl]-ethanol. A vapor-phase amine compound is subsequently received at the chemical reporter. The chemical detector then detects a response of the chemical reporter to the amine compound to determine whether materials of interest are present. Additional methods and related devices are also provided.
    Type: Grant
    Filed: December 14, 2017
    Date of Patent: November 10, 2020
    Assignee: FLIR Detection, Inc.
    Inventors: Lara B. Wald, Steven L. Keen
  • Patent number: 10825669
    Abstract: A metabolized product ion spectrum is produced for a metabolized version of a known compound using tandem mass spectrometry. Metabolized structures are inferred from the metabolized product ion spectrum. An unmetabolized product ion spectrum is received for an unmetabolized version of the known compound and unmetabolized structures are inferred from the unmetabolized product ion spectrum. Each of the metabolized structures is compared to the unmetabolized structures, producing matched and unmatched structures. For each unmatched structure, a biotransformation repository is searched for modifications and each unmatched structure and the modifications found are again compared to the unmetabolized structures, producing modified matched structures. For each atomic index of the known compound, an unmodified specificity is calculated from the matched structures, a modified intensity specificity is calculated from the modified matched structures, and a score is calculated from the specificities.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: November 3, 2020
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Eva Duchoslav, Pui Yee Iris Shek, Alina Dindyal-Popescu
  • Patent number: 10816478
    Abstract: Luminescent lanthanide complexes comprising a triazine-based ligand capable of selective detection of urinary polyamines and their methods of use in detecting and quantifying urinary polyamines as well as prostate cancer biomarkers, such as spermine. The detection of the urinary polyamines can be accomplished using colorimetric methods such as, with an ultraviolet-visible spectrometer.
    Type: Grant
    Filed: April 16, 2018
    Date of Patent: October 27, 2020
    Assignee: New Life Medicine Technology Company Limited
    Inventor: Ka Leung Wong
  • Patent number: 10809241
    Abstract: Apparatuses and methods of measuring a hydrogen diffusivity of a metal structure including during operation of the metal structure, are provided. A hydrogen charging surface is provided at a first location on an external surface of the structure. In addition, a hydrogen oxidation surface is provided at a second location adjacent to the first location on the external surface of the structure. Hydrogen flux is generated and directed into the metal surface at the charging surface. At least a portion of the hydrogen flux generated by the charging surface is diverted back toward the surface. A transient of the diverted hydrogen fluxes measured, and this measurement is used to determine the hydrogen diffusivity of the metal structure in service.
    Type: Grant
    Filed: May 10, 2019
    Date of Patent: October 20, 2020
    Inventors: Abderrazak Traidia, Mohammed Alshahrani, Sebastien A. Duval
  • Patent number: 10802033
    Abstract: A method is provided for measuring status parameters of a fluid contained in a container (10). The container (10) is configured for single use and has a wall on which a sensor-carrier plate is fixed in a fluid-tight manner. The plate carries sensors (S1-S5) that are in operative contact with the internal chamber of the container (10) and connected for data exchange (14) with an external control unit (16) that receives and processes the measurement data from the sensors (S1-S5). The sensor plate also carries a temporarily inactive duplicate (D1-D5) of at least one of the sensors (S1-S5) that is activated if measurement data of the sensor (S1-S5) is classified as atypical in the context of an integrity or plausibility test carried out by the external control unit (16).
    Type: Grant
    Filed: April 27, 2016
    Date of Patent: October 13, 2020
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Mario Becker, Gerhard Greller, Christian Grimm, Thorsten Adams, Lars Boettcher, Henry Weichert
  • Patent number: 10786177
    Abstract: Various devices are disclosed for measuring the concentration of an analyte, such as acetone, in a breath sample. The disclosed devices include a disposable cartridge containing a reactive material that extracts the analyte from a breath sample passed through the cartridge. In some embodiments, the cartridge contains a solid, porous structure (such as a disk, bowl or puck) that contains the reactive material. The porous structure may be created by mixing reactive particles with resin particles, and then using a sintering process to transform the mixture into a solid structure. Also disclosed are devices for routing a breath sample through the cartridge during exhalation, and for analyzing a reaction in the cartridge to measure a concentration of the analyte.
    Type: Grant
    Filed: May 16, 2019
    Date of Patent: September 29, 2020
    Assignee: Invoy Holdings Inc.
    Inventors: Lubna M. Ahmad, Zachary B. Smith, Salman A. Ahmad, Connie Kim
  • Patent number: 10786811
    Abstract: The present invention relates to methods of detecting one or more targets of interest in a sample. In one instance, the target can be correlated to an active infection (e.g., by a virus and/or a bacterium). Methods can include treating the sample with a dissociation agent, thereby releasing the target of interest for more accurate detection (e.g., by use of a sedimentation-based centrifugal microfluidic devices). Also described herein are microfluidic devices and systems for use with a dissociation agent.
    Type: Grant
    Filed: October 17, 2017
    Date of Patent: September 29, 2020
    Assignees: National Technology & Engineering Solutions of Sandia, LLC
    Inventors: Chung-Yan Koh, Anup K. Singh, Julia Litvinov
  • Patent number: 10787551
    Abstract: Cross-linked polymer networks that are at least partially conjugated (e.g., phenylene vinylene polymer networks). The cross-linked polymer networks may be thin-films disposed on a substrate. The cross-linked polymer network may be covalently bonded to the substrate. The cross-linked polymer networks can be used, for example, in methods of detecting explosives (e.g., RDX (cyclotrimethylenetrinitramine)) and degradation products thereof.
    Type: Grant
    Filed: February 28, 2014
    Date of Patent: September 29, 2020
    Assignee: Cornell University
    Inventors: William R. Dichtel, Deepti Gopalakrishnan
  • Patent number: 10782239
    Abstract: Embodiments of the present disclosure pertain to methods of monitoring an environment for the presence of a solvent by: (i) exposing the environment to a luminescent compound, where the relative luminescence emission intensity of the luminescent compound changes upon interaction with the solvent; and (ii) monitoring a change in the relative luminescence emission intensity of the luminescent compound, where the absence of the change indicates the absence of the solvent from the environment, and where the presence of the change indicates the presence of the solvent in the environment. The luminescent compounds include a phosphorous atom with one or more carboxyl groups, where the carboxyl groups are coordinated with one or more metallic ions (e.g., lanthanide ions and yttrium ions). The present disclosure also pertains to sensors for monitoring an environment for the presence of a solvent, where the sensors include one or more of the aforementioned luminescent compounds.
    Type: Grant
    Filed: May 10, 2016
    Date of Patent: September 22, 2020
    Assignee: Board of Regents, The University of Texas System
    Inventor: Simon M. Humphrey
  • Patent number: 10768115
    Abstract: The present disclosure includes discloses a method for analyzing a multi-component gas sample using spectroscopy in combination with the measurement of extrinsic or intrinsic properties of the gas sample. The results of the spectroscopic analysis and the measurement are combined to quantify a gas component unseen by the spectroscopic analysis.
    Type: Grant
    Filed: December 4, 2017
    Date of Patent: September 8, 2020
    Assignee: Kaiser Optical Systems Inc.
    Inventors: Joseph B. Slater, James M. Tedesco, Francis Esmonde-White
  • Patent number: 10761050
    Abstract: A molecular detection apparatus according to an embodiment includes: a distributor which ionizes a target containing substances to be detected, applies voltage to ionized substances, and extracts the substances to be detected according to a time-of-flight based on the speed; a detector which detects the substance to be detected dropped from the distributor; and a discriminator which discriminates the substance to be detected. The detector includes: a plurality of detection units including field effect transistors using graphene layers; and a plurality of organic probes which are provided on the graphene layers, and at least some of which have different bond strengths with the substances to be detected. The substance to be detected is discriminated depending on a signal pattern based on intensity differences of the detection signals generated by differences in the bond strengths between the organic probes and the substances to be detected.
    Type: Grant
    Filed: August 24, 2017
    Date of Patent: September 1, 2020
    Inventors: Ko Yamada, Hirohisa Miyamoto, Norikazu Osada, Mitsuhiro Oki, Yasuko Noritomi
  • Patent number: 10761083
    Abstract: The invention generally relates to a sample dispenser including an internal standard and methods of use thereof.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: September 1, 2020
    Assignee: Purdue Research Foundation
    Inventors: Zheng Ouyang, He Wang, Nicholas E. Manicke, Robert Graham Cooks, Qian Yang, Jiangjiang Liu
  • Patent number: 10753915
    Abstract: A method for analyzing and quantifying a panel of drugs in a clinical sample comprises: trapping a first portion of drug parent compounds and their metabolites on a first chromatographic column; trapping a second portion of the drug parent compounds and their metabolites on a second chromatographic column; separately eluting the first and second portions of the drug parent compounds and their metabolites from the first and second chromatographic columns; detecting concentrations of each of the drug parent compounds and metabolites eluted from each of the first and second chromatographic columns with a detector; and summing the detected concentration of each drug parent compound together with the detected concentrations of all of its respective analytes so as to derive a respective total concentration of each drug in the sample.
    Type: Grant
    Filed: July 27, 2016
    Date of Patent: August 25, 2020
    Assignee: Thermo Finnigan LLC
    Inventors: Joseph Herman, Sarah J. Fair, Dayana Argoti
  • Patent number: 10746639
    Abstract: A method of extracting an analyte from a sample is described. The sample is added to a sample container. A liquid solvent and a gas are added into the sample container. The addition of the gas is controlled to establish an elevated pressure within the sample container. The liquid solvent is heated to an elevated temperature that is below the boiling temperature of the liquid solvent at the elevated pressure. A type of gas is used that does not transition to a supercritical fluid at the elevated temperature and pressure used in the extraction process. The analyte can dissolve from the solid sample into the liquid solvent. Next, at least a portion of the liquid solvent containing the dissolved analyte can be removed from the sample container for subsequent analysis.
    Type: Grant
    Filed: August 10, 2016
    Date of Patent: August 18, 2020
    Assignee: Dionex Corporation
    Inventors: Kannan Srinivasan, SM Rahmat Ullah
  • Patent number: 10746662
    Abstract: A method and system incorporating a process for analyzing a sample to be tested to determine the presence of or to quantify an analyte in the sample. The process employs a reaction which produces a reaction medium derived from the sample that possesses fluorescence properties, in response to illumination by a light source. The process includes illuminating the sample and detecting a fluorescent signal, introducing the reaction medium, and illuminating the sample and detecting a second fluorescent signal from the sample. The process further includes processing the two signals to determine which portion of the fluorescent signal is produced solely by the reaction medium.
    Type: Grant
    Filed: December 6, 2018
    Date of Patent: August 18, 2020
    Assignee: BIOMERIEUX
    Inventors: Bruno Colin, Laurent Drazek, Frederic Pinston
  • Patent number: 10750577
    Abstract: A fluidic chip comprising: a sealing layer having an upper surface and a lower surface; and a formed part comprising a generally planar body having a lower surface sealed with the upper surface of the sealing layer, the generally planar body having a number of through holes and a number of wells in fluid communication with the number of through holes, wherein together with the upper surface of the sealing layer, the number of through holes and the number of wells respectively define a number of fluid inlets and a number of fluid chambers in fluid connection with each other in the fluidic chip.
    Type: Grant
    Filed: October 7, 2017
    Date of Patent: August 18, 2020
    Assignee: CELL ID PTE LTD
    Inventor: Lye Hock Sim