Patents Examined by Emily R. Berkeley
  • Patent number: 10209194
    Abstract: A Raman scattering probe, and a method of making such a probe, uses a capsule of nanometric size, such as a nanotube, to which is coupled at least one Raman-active molecule. The Raman-active molecule may be encapsulated in, or attached on the exterior of, the capsule, and exhibits a Raman scattering response when the probe is illuminated by an excitation light beam. A functionalization chemical group that is attached to an exterior of the capsule provides a connection between the capsule and a target material. This functionalization may include a generic chemical functionalization that bonds with any of a plurality of secondary chemical groups each of which bonds directly with a different target. A method of using the probe for Raman spectroscopy or Raman imaging is also provided.
    Type: Grant
    Filed: June 22, 2016
    Date of Patent: February 19, 2019
    Inventors: Richard Martel, Nathalie Y-Wa Tang, Francois Raymond, Janie Cabana, Marc-Antoine Nadon
  • Patent number: 10208331
    Abstract: A bioparticle collection device and an aerosol collection system. The bioparticle collection device includes a collection medium including a plurality of fibers formed into a fiber mat and configured to collect bioparticles thereon, and includes a viability enhancing material provider disposed in a vicinity of the plurality of fibers and configured to provide a viability enhancing material to the collected bioparticles to maintain viability of the bioparticles collected by the fiber mat. The aerosol collection system includes an aerosol pumping device configured to entrain particles in an gas stream, an aerosol saturation device configured to saturate the particles in the gas stream with a biocompatible liquid, and an aerosol collection medium downstream from the aerosol saturation device and including a plurality of fibers formed into a fiber mat for collection of the saturated aerosol particles.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: February 19, 2019
    Assignee: Research Triangle Institute
    Inventors: David Samuel Ensor, Howard Jerome Walls, Karin K. Foarde
  • Patent number: 10203333
    Abstract: The invention relates to electronically neutral metal complexes as luminescent labels. The positive charge of the metal ion in the complex is neutralized by the negatively charged groups that are covalently linked to the nitrogen-containing diimine ligands, such as 2,2-bipyridine, 1,10-phenanthroline and their derivatives. The electronic neutrality reduces the impact of the metal complexes on the biological and/or biochemical activities of the labeled biomolecules, while the intensity of luminescent emission under electrochemical excitation is enhanced. These luminescent metal complex labels are useful in bioanalytic methodology development, with luminescence as the signal modality, such as electrochemiluminescence.
    Type: Grant
    Filed: June 18, 2014
    Date of Patent: February 12, 2019
    Assignee: Rubipy Scientific, Inc.
    Inventors: Ming Zhou, Linpo Yu
  • Patent number: 10203319
    Abstract: The invention relates to a process for determining the degree of branching of modified polymers wherein the polymers are modified in the sense that their degree of branching after polymerization was increased once more, wherein the modified polymers are treated with a polar transformation mixture comprising a compound of general formula (I) R1—S—S—R1?? (I) wherein the Mooney viscosity (ML 1+4 at 100° C.) of the polymers is determined before and after the treatment with the polar transformation mixture and the degree of branching is determined.
    Type: Grant
    Filed: October 9, 2014
    Date of Patent: February 12, 2019
    Inventors: Heike Kloppenburg, Alicia Le-Sattler
  • Patent number: 10175175
    Abstract: Novel Zr-based metal-organic framework (MOF) chemosensors useful for detection, recognition, removal, and separation of heavy metals are provided. Also provided are methods for preparation of the chemosensors and processes for detection, recognition, removal, and separation of heavy metals using the chemosensors.
    Type: Grant
    Filed: February 11, 2014
    Date of Patent: January 8, 2019
    Inventors: Hassan Azzazy, Ahmed Shahat, Hassan M. A. Hassan
  • Patent number: 10168284
    Abstract: A method of analyzing a sample to be tested to determine the presence of or to quantify an analyte in the sample, employing a reaction which produces a reaction medium derived from the sample and which possesses fluorescence properties, the reaction medium being located within a well, the reaction medium and the well forming an analysis assembly which possesses fluorescent properties in response to illumination by a light source producing a light signal, the light source being movable along a surface S1 of the well.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: January 1, 2019
    Assignee: Biomerieux
    Inventors: Bruno Colin, Laurent Drazek, Frédéric Pinston
  • Patent number: 10145826
    Abstract: The present invention is generally in the field of measuring and indicating techniques and relates to a time-temperature indicator and methods of manufacturing and use thereof. More specifically, the time-temperature indicator comprises a time temperature indicator comprising at least one metal layer or metal containing layer and in direct contact to the metal layer or to the metal containing layer at least one doped polymer layer, wherein the dopant is an acid, a base or a salt or a photolatent acid or a photolatent base which dopant is added to the polymer, and/or at least one polymer layer wherein a polymer is functionalized with acidic or latent acidic or basic or latent basic groups; or a time temperature indicator comprising at least one polymer layer containing metal particles and a photolatent acid or a photolatent base, or at least one polymer layer containing metal particles wherein the polymer is functionalized with latent acidic or latent basic groups.
    Type: Grant
    Filed: April 20, 2015
    Date of Patent: December 4, 2018
    Inventors: Dietrich Haarer, Tal Gueta-Neyroud, Husein Salman
  • Patent number: 10139263
    Abstract: An analytical system includes a laser disposed to direct light toward a microfluidic feature disposed in a feature layer of a multiple layer test cartridge, a sensor to receive reflections from capping layers disposed about the microfluidic feature in the feature layer, and a controller to determine a depth of the microfluidic feature as a function of the received reflections.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: November 27, 2018
    Assignee: Honeywell International Inc.
    Inventor: Tzu-Yu Wang
  • Patent number: 10132791
    Abstract: A device and system for automatic handling of a sensor strip by a part of a meter that includes a sensor strip having a first section, a second section, and an intermediate section. The sensor strip includes at least a first opening about a first end thereof and a second opening about a second end thereof. A meter part includes a pair of pivoting catches configured to engage and grasp a sensor strip from a container containing a plurality of sensor strips. The sensor strip may thus be removed from a container for testing without need for manual handling of the strip by a user.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: November 20, 2018
    Assignee: Ascensia Diagnostics Care Holdings AG
    Inventor: Steven C. Charlton
  • Patent number: 10126304
    Abstract: The present disclosure relates to compositions and methodology for revealing binding sites between proteins, proteins and nucleic acids, or proteins and small molecules. The disclosure provides rapid and direct positive identification and sequencing of the contact region between such molecules, and can be applied to individual interacting pairs, as well as large-scale or global interactions.
    Type: Grant
    Filed: January 15, 2014
    Date of Patent: November 13, 2018
    Assignee: George Mason Research Foundation, Inc.
    Inventors: Alessandra Luchini, Lance Liotta, Virginia Espina
  • Patent number: 10119918
    Abstract: Compositions are provided comprising: 1) a solid metal oxide support having surface hydroxyl groups; 2) a silyl-containing compound bound to the solid metal oxide support through a silanol bond with the surface hydroxyl groups; and 3) a bis(glyoxime)-transition metal complex bound to the solid metal oxide support. These compositions can be used to make a colorimetric relative humidity-indicating sensor. A method of adjusting the colorimetric response of a moisture-indicating composition and a method of detecting moisture are also provided.
    Type: Grant
    Filed: November 14, 2013
    Date of Patent: November 6, 2018
    Assignee: 3M Innovative Properties Company
    Inventors: Myungchan Kang, Evan Koon Lun Yuuji Hajime
  • Patent number: 10105707
    Abstract: A container for selective transport of samples of biological material or of biological origin suitable for containing at least a fluid or liquid and/or for containing at least a portion of a collecting device, the container having a selective passage portion configured to prevent exit of a fluid or liquid from the container, through the passage portion, at least in at least an operating sealed condition defined at least by a rest state of the container or by a first value of mechanical shaking of the container and/or by a first value of relative centrifugal force to which the container is subjected, and configured selectively to enable exit of the fluid or liquid from the container, across the passage portion, at least in an operating passage condition, defined at least by a corresponding second state of mechanical shaking of the container and/or wherein the container is subjected to a corresponding second relative centrifugal force.
    Type: Grant
    Filed: November 17, 2011
    Date of Patent: October 23, 2018
    Assignee: Copan Italia S.p.A.
    Inventor: Daniele Triva
  • Patent number: 10106684
    Abstract: Fluorescent Schiff base compounds comprising a xanthene dye based moiety and an alkyl imidazole moiety. Methods of assessing these fluorescent Schiff base compounds as fluorescent probes for metal ions in Cu2+ chemosensing applications, methods of preparing the fluorescent Schiff base compounds and methods of detecting Cu2+ ions with the same are also provided.
    Type: Grant
    Filed: March 9, 2018
    Date of Patent: October 23, 2018
    Assignee: King Fahd University of Petroleum and Minerals
    Inventor: Aasif Helal
  • Patent number: 10107756
    Abstract: A method of fluorometrically detecting the concentration of chemical components in oxidizing formulations is disclosed. In a particular embodiment the detection is of the stabilizing component of picolinic acid, present in such formulations, although any component which fluoresces may be detected. According to the invention sample preparation of the oxidizing formulation includes adding to said sample an excess of reducing agent to bind peracid, and in the case of picolinic acid, adding to said sample an excess of terbium chloride. The sample then is subjected to radiation to induce fluorescence and the concentration of said chemical component is determined by a linear relationship between fluorescence emitted and the concentration of the target chemical.
    Type: Grant
    Filed: January 12, 2016
    Date of Patent: October 23, 2018
    Assignee: Ecolab USA Inc.
    Inventors: John Wilhelm Bolduc, Eugene Tokhtuev, Anatoly Skirda, Anna Pilipchenko, Justin Scott Valenstein, Amanda Bakken, Stacy Fawbush, Jeffrey S. Hutchison
  • Patent number: 10107809
    Abstract: A method is provided for of preparing a glass bead mixture using inert nanoparticles to improve flow rates of the glass beads for purposes of manufacturing an immunodiagnostic test element, such as a column agglutination test cassette. The immunodiagnostic test element includes a plurality of test columns including an aqueous reagent in each test column.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: October 23, 2018
    Inventors: Jonathan Burr Crowther, Amy Louise Surowitz, Anna Krystyna Luczak
  • Patent number: 10078091
    Abstract: A method, a labeling reagent, sets of labeling reagents, and labeling techniques are provided for the analysis of ketosterol biomarkers such as bile acid precursors from human plasma, serum or whole blood. This method is used for new born screening for Cerebrotendinous Xanthomatosis (CTX). Methods for labeling, analyzing, and quantifying ketosterol biomarkers are also disclosed as are methods that also use mass spectrometry.
    Type: Grant
    Filed: May 17, 2013
    Date of Patent: September 18, 2018
    Assignees: DH Technologies Development Pte. Ltd., Oregon Health and Science University
    Inventors: Andrea DeBarber, Subhasish Purkayastha, Robert D. Steiner, Michal Weinstock
  • Patent number: 10072191
    Abstract: A de/anti-icer composition comprises one or more de/anti-icer moieties and a marker material, the marker material being selected such that, after application of the de/anti-icer composition to a traveled surface, the amount of the marker material at or on the traveled surface at a given time correlates to the amount of said one or more de/anti-icer moieties on the said surface at such time. The presence of the marker material enables the user readily to determine the concentration of the de/anti-icer moiety or the freezing point of liquid on the traveled surface. Methods of using such compositions for concentration and/or freezing point determination of de/anti-icer materials applied to traveled surfaces are described, together with systems and kits of parts utilizing such compositions.
    Type: Grant
    Filed: June 24, 2013
    Date of Patent: September 11, 2018
    Inventor: Alistair McConnell
  • Patent number: 10067114
    Abstract: In a method of resolving a contribution ratio to soil contamination by a plurality of polluters through a sequential extraction scheme and a stable isotope analysis scheme, Pb stable isotopes are eluted at 5 types of “cation exchange fraction”, “carbonate fraction”, “iron-oxide and manganese hydroxide-fraction”, “organic matters and sulfide fraction”, and “residual fraction” existing at other types and separated from each other in each step. The Pb stable isotopes obtained in each step are analyzed. The contribution ratio to soil contamination by the polluters is resolved through a predetermined resolving equation using the content of a Pb stable isotope in each step based on the content ratio of the Pb stable isotopes. The Pb stable isotopes are 206Pb and 207Pb.
    Type: Grant
    Filed: December 28, 2015
    Date of Patent: September 4, 2018
    Inventor: Pyeong-Koo Lee
  • Patent number: 10060892
    Abstract: A compound, or a protonate or salt thereof, having a formula I of: wherein Y represents an optionally substituted aromatic group; n is 1 or 2; a is 0 to 4; R1 and R2 are each independently H; optionally substituted alkyl; optionally substituted aralkyl; acyl; phosphonyl; —SO2R12; —C(O)R13; —C(O)OR14; —C(O)NR15R16; —C(O)CH2R17; or —C(S)—NR18R19; —S(O)R20; or —SO2NR21R22, wherein R12-R22 are each independently H, optionally substituted alkyl, optionally substituted aralkyl, optionally substituted aryl, or —C(O)R23, wherein R23 is H, optionally substituted alkyl, optionally substituted aralkyl, or optionally substituted aryl; and each R3 is independently optionally substituted alkyl, halogen, optionally substituted alkoxy, optionally substituted carboxyl, amide; amino; or nitro.
    Type: Grant
    Filed: December 11, 2014
    Date of Patent: August 28, 2018
    Assignee: University of Oregon
    Inventors: Michelle Watt, Darren W. Johnson, Michael M. Haley
  • Patent number: 10058864
    Abstract: A microfluidic structure in which a plurality of chambers arranged at different positions are connected in parallel and into which a fixed amount of fluid may be efficiently distributed without using a separate driving source, and a microfluidic device having the same. The microfluidic device includes a platform having a center of rotation and including at least one microfluidic structure. The microfluidic structure includes a sample supply chamber configured to accommodate a sample, a plurality of first chambers arranged in a circumferential direction of the platform at different distances from the center of rotation of the platform, and a plurality of siphon channels, each of the siphon channels being connected to a corresponding one of the first chambers.
    Type: Grant
    Filed: July 20, 2015
    Date of Patent: August 28, 2018
    Inventor: Beom Seok Lee