Abstract: A method to correct measurement error in a resonance energy-transfer assay, including exciting anti-Stokes photoluminescent donors with at least one wavelength of light which is greater than an emission wavelength of acceptor molecules; measuring emission at the acceptor's emission wavelength and which differs from the donor's emission wavelength in at least two different time windows; a first time window within the time window defined by the excitation light pulse and a second non-overlapping time window which follows the first time window; and correcting the emission signal, which includes signals originating from non-radiative and radiative energy transfer, within the first time window by estimating the ratio of the signals from non-radiative and radiative energy transfer or the signal originating from radiative energy transfer using at least one emission signal measured in the second time window.

Abstract: A detection device comprising a substrate comprising a plurality of objects of which properties are changed due to the contact with a target substance, means for bringing the target substance into contact with the objects, and means for detecting a change in properties of the objects caused when the target substance is brought into contact with the objects, based on light output when the objects are irradiated with light, wherein the plurality of the objects are located in the direction in which the light for irradiation travels, and the detecting means is means for detecting the change in the properties based on the summation of light output from the plurality of the objects upon irradiation with light.

Abstract: An exemplary embodiment includes an apparatus having an energy source for selectively directing a first energy toward a first material. The at least a portion of the first energy excites a preselected second material to an excited state where at least two photons of the first energy are absorbed by the molecule of the second material causing the molecule to emit a second energy at about a predetermined wavelength. The apparatus also includes a control system for directing the first energy toward the first material. The apparatus also includes a detector for detecting at least a portion of the emitted second energy when the detector is more than about 40 meters from the molecule.

Abstract: An information processing apparatus includes a unit configured to acquire spectral data of ambient light to be estimated, a unit configured to receive spectral data and ambient light type information of a plurality of reference ambient light conditions, a comparison unit configured to compare the spectral data of the ambient light to be estimated with the spectral data of the plurality of reference ambient light conditions, and an estimation unit configured to estimate an ambient light type of the spectral data of the ambient light to be estimated from the ambient light type information of the reference ambient light based on a result of comparison provided by the comparison unit.

Abstract: Embodiments include an apparatus including a color sensor including a transmitter portion and a receiver portion, the transmitter portion including a light source operable to generate and transmit a light having a particular range of wavelengths, the receiver portion including a first detector operable to receive a first portion of the light emitted from the transmitter portion and to measure a luminance of the received first portion of the emitted light, and a second detector including a polarization filter, the second detector operable to receive a second portion of the light emitted from the transmitter after the second portion has passed through the polarization filter, and operable to measure a pure color of the received second portion of transmitted light.

Abstract: A system and method to predict the progression of disease of a test sample. A group of known biological samples is provided. Each known biological sample has an associated known outcome including a non-diseased sample or a diseased sample. A Raman data set is obtained for each known biological sample. Each Raman data set is analyzed to identify a diseased or non-diseased reference Raman data set depending on whether respective biological sample is the non-diseased sample or the diseased sample. A first database is generated where the first database contains reference Raman data sets for all diseased samples. A second database is generated where the second database contains reference Raman data sets for all non-diseased samples. A test Raman data set of a test biological sample is received, where the test biological sample has an unknown disease status. A diagnostic is provided as to whether the test sample is a non-diseased sample or a diseased sample.

Abstract: A measuring device for optical and spectroscopic examination of a sample includes a housing, a first light source, a window, an optical spectrometer with a dispersive element and a number of detector elements and which can record light from the first light source which is indirectly reflected by the sample and reenters the housing through the window, an electronic camera whose incidence opening is directed onto the sample, through the window, and an electronic evaluation device which is connected to an image sensor of the camera and to the detector elements. The camera may be assigned a second light source.

Abstract: The present invention is to present a cell analyzer capable of measuring cells which are approximately 20 to 100 ?m in size with high precision via flow cytometry. The cell analyzer 10 comprises: a flow cell 51 in which a measurement sample including a measurement target cell flows; a light source part 53 for irradiating a light on the measurement sample flowing in the flow cell 51; an optical system 52 for forming a beam spot on the measurement sample flowing in the flow cell 51, the beam spot having a diameter of 3˜8 ?m in a flow direction of the measurement sample and a diameter of 300˜600 ?m in a direction perpendicular to the flow direction of the measurement sample; and a light receiving part 55, 58, 59 for receiving a light from the measurement sample.

Abstract: An apparatus for determining location of at least one inclusion in a gemstone having a first refractive index, comprising: a container adapted for containing a material having a second refractive index, a holder operative to support a gemstone in the material when the container contains the material; an illuminator positioned and adapted to illuminate said gemstone when disposed within said material in said container, with illumination at which said gemstone and said material have their respective first and second indices; a detector that detects illumination from the illuminated gemstone and said material and produces signals responsive thereto; a controller that receives the signals and is operative to determine a location of an inclusion in the gemstone based on the signals; and a system, operative to reduce the presence within said material, at least when the gemstone is disposed therein, of any substance other than inclusions, having a third refractive index.

Abstract: A spectrophotometer is provided capable of reducing the influence of the vibration as much as possible when a wavelength dispersion element is rotationally driven and capable of increasing the analysis accuracy. When a fluorescence signal is obtained from the fluorescence detector, the central control unit A/D converts the fluorescence signal at sampling intervals of T1 for vibration convergence determination, and provides the result data to the data processor (S1). At the timing of performing the vibration convergence determination (S2), the data processor performs a predetermined signal processing to the digital signals obtained (S3), and determines whether all the data that have been obtained within a given period of time from the latest data are equal to or smaller than a specified value (S4). If all the data are equal to or smaller than the specified value, it is determined that the diffraction grating's vibration is converged, and the vibration convergence determination operation is terminated.

Abstract: Detection sensitivity is improved by increasing the amount of light of beams that irradiate a sample cell without causing saturation of a detector with ultraviolet beams or visible beams. This spectrophotometer includes a sample cell, which stores a sample to be measured, a visible light source and an ultraviolet light source each for supplying an incident beam that enters the sample, a spectroscope, which disperses a beam that has passed through the sample, an optical detector, which detects beams dispersed from such beam (spectrum), and a dichroic element which reflects or transmits ultraviolet beams from the ultraviolet light source and which transmits or reflects visible beams from the visible light source. Optics are configured such that ultraviolet beams and visible beams that have passed through or have been reflected by the dichroic element enter the sample cell.

Abstract: A hyperspectral reflectance and fluorescence line-scan imaging system is used for on-line quality and safety inspection of agricultural commodities. The system simultaneously acquires hyperspectral/multispectral combinations of both fluorescence and reflectance images of the agricultural commodities.

Abstract: A method of calibrating an absorption spectroscopy measurement wherein the calibration method includes projecting laser light through a sample of a first quantity of a gas of interest and a second irrelevant quantity of a spectroscopically identical or similar gas (10). The first and second spectroscopic absorptions of the laser light are measured over specific first and second absorption lines. A functional relationship is determined between the first and second measured spectroscopic absorptions and two unknown variables. The function relationships may then be simultaneously solved to determine one or both unknown variables and thereby obtain a measurement relating to the first quantity of the gas of interest, calibrated for the second irrelevant quantity of gas.

Abstract: In apparatus for performing Surface Enhanced Raman Spectroscopy (SERS), rather than applying a sample to be analyzed to an SERS active substrate, the SERS active substrate is applied to the sample using an inkjet nozzle to apply a substance containing a colloidal metal, such as silver, to the sample. The prepared sample is then analyzed with a Raman spectrometer in a conventional fashion.

Abstract: The invention concerns a spectrograph with a tilted detector window comprising a light source (1), an entrance slit (3), a grating (4), a detector (5) comprising a window through which the light beam diffracted by the grating (4) is transmitted, a part of the diffracted light beam generating reflections on the window or between the window and sensitive surface of the detector (5) and at least a means for inclining able to avoid interference spectra. According to the invention, the at least a means for inclining able to avoid interference spectra comprises the detector window (6, 11) which is an inclined detector window (11).

Abstract: A method of analyzing an effect of a first substance on the behavior of a second substance comprises exposing a test material to the first substance, performing a first surface enhanced Raman spectroscopy analysis of the test material while it is exposed to the first substance, exposing the test material to the first substance and to the second substance, and performing a second surface enhanced Raman spectroscopy analysis of the test material while it is exposed to the first substance and to the second substance. Results of the first and second analyses are compared to identify a change in the behavior of the first substance.

Abstract: Application of digital light processor (DLP) systems in monochromator, spectrophotometer or the like systems to mediate selection of individual wavelengths, and/or to image elected regions of a sample in an imaging ellipsometer, imaging polarimeter, imaging reflectometer, imaging spectrophotometer, and/or to provide chopped beams.

Abstract: A system (200) and method (800) for determining whether a sample object (203) has a color that is within a predetermined range is provided. The system (200) includes a light source (201) capable of projecting lights having different light wavelength spectrum upon the sample object (203). A controller (222) causes the light source (201) to project a first light wavelength spectrum upon the sample object (203), then another, then another, and so forth. While each light is projecting upon the object, a monochromatic image capture device (202) captures an image having luminous intensity information. The luminous intensity information, or a subset thereof selected by an image selection tool (232) is then compared to the statistical range, which is derived from a plurality of images taken of a reference object (403).

Abstract: An image scanning apparatus has an organic CMOS image sensor mounted in a base, and a photoreceptive surface of the image sensor is exposed on a top side of the base. A subject is placed directly on the photoreceptive surface, and the subject and the photoreceptive surface are covered up with a cover light-tightly. Thus the image sensor detects only chemiluminescent light from the subject. As for a fluorochrome-labeled subject, the subject placed directly on the photoreceptive surface is irradiated with excitation light from a light source mounted in the cover. The image sensor is provided with a filter for blocking the excitation light from its photoelectric conversion layers, so the image sensor detects only fluorescent rays generated from the excited fluorochrome-labeled subject. The image scanning apparatus needs no redundant space in perpendicular direction to the photoreceptive surface.

Abstract: A system and method for full width scanning color analysis of a printed media sheet are disclosed. The full width array spectrophotometer system includes one or more substantially linear elongated illumination arrays of closely spaced multiple illumination sources. The sources include sets of illumination sources, including a first set of different color illumination sources and a second set including one or more UV-emitting illumination sources. The sets are arranged to span a printer paper path or other object path to illuminate a band extending transversely across a printed print media sheet or other object moving in the path. A full width array light imaging sensor includes an elongated array of multiple closely spaced photodetectors for detecting plural colors and is positioned adjacent to and extending substantially parallel to the linear array(s) to receive radiation reflected from the transverse illuminated band.