Abstract: Citraconic anhydride is made by the vanadium-catalyzed gas-phase air oxidation of mesityl oxide at about 200-500.degree.C. and atmospheric pressure with a contact time of less than 1 second. Preferred catalysts are vanadium oxide and vanadate salts. Preferred O.sub.2 /mesityl oxide molar ratios are about 10:1 to 100:1.
Abstract: Viscous polybutenes of number average molecular weight (M.sub.n) in the range of about 300 to about 3000 have improved reactivity with intramolecular anhydrides of unsaturated aliphatic dicarboxlyic acids when such polybutenes contain rather small amounts, i.e., 5 to 200 ppm, of halogenated, preferably chlorinated and/or brominated aliphatic or aromatic hydrocarbons. Preference is given to such halogen containing compounds having a sufficient vapor pressure at a temperature in the range of 100.degree. to 300.degree.C to be substantially completely removed at absolute pressures in the range of 5 to 760 mm Hg.
Abstract: (3-amino-2-hydroxy propyloxy) thiochromans of the formula ##SPC1##Wherein A is hydrogen or halogen, R.sub.1 is hydrogen or lower alkyl, and R.sub.2 is lower alkyl or cyclo lower alkyl.These compounds possess cardiovascular properties and may be used as blockers of cardiac .beta. adrenergic receptors.
Abstract: High purity citraconic acid is prepared in good yield by the thermolysis, in the presence of a catalyst, of citramalic acid, 3-methylmalic acid, paraconic acid, mesaconic acid and mixtures thereof.
Abstract: A new class of 2,3-benzoxazepine compounds of the formula ##SPC1##In the formula, R is heterocyclic acyl or heterocyclic acetyl. The compounds have central nervous system and anti-inflammatory activity.
Type:
Grant
Filed:
November 14, 1974
Date of Patent:
June 1, 1976
Assignee:
Gruppo Lepetit S.p.A.
Inventors:
Giorgio Pifferi, Amedeo Omodei-Sale', Pietro Consonni
Abstract: A process is provided for the preparation of 2-chloropyridine by the liquid phase hydrogenolysis of 2,6-dichloropyridine in the presence of a selected transition metal catalyst and a strong base.
Abstract: Novel compounds, N-acetyl-polychlorobenzamides, are prepared by treating corresponding polychlorobenzonitrile compounds with acetic acid in a closed reactor at an elevated temperature above the boiling point of the acetic acid. These new compounds have been found to be useful biological chemicals, particularly in controlling undesirable vegetation, and also useful as chemical intermediates.
Abstract: The disclosure relates to new 2-aryloxymethylmorpholine derivatives which possess antidepressant properties, and to processes for the manufacture of the said morpholine derivatives, to pharmaceutical compositions containing them, and to a method of preventing or relieving depression in warm-blooded animals including man. Typical of the morpholine derivatives disclosed is 2-(o-ethoxyphenoxymethyl)morpholine.
Type:
Grant
Filed:
September 27, 1974
Date of Patent:
May 25, 1976
Assignee:
Imperial Chemical Industries Limited
Inventors:
Keith Blakeney Mallion, Ralph William Turner, Alexander Henry Todd
Abstract: Compounds of the formula: ##SPC1##Wherein R.sub.1 and R.sub.2 are the same or different and are hydrogen, alkyl of from 1 to 6 carbon atoms, inclusive, or phenyl; R.sub.3 is hydrogen, alkyl of from 1 to 8 carbon atoms, inclusive, phenyl, or benzyl; R.sub.4 is hydrogen or alkyl of from 1 to 6 carbon atoms, inclusive, and R.sub.3 and R.sub.4 can be joined together to form a heterocyclic ring selected from the group consisting of morpholine, pyrrolidine or piperidine; X is oxygen or sulfur; A and B are the same or different, and are hydrogen, alkyl of from 1 to 6 carbon atoms inclusive, cycloalkyl of from 3 to 7 carbon atoms, inclusive, haloalkyl, and halogen; Z is an alkyl group of from 1 to 6 carbon atoms, inclusive, or a cycloalkyl group of from 3 to 7 carbon atoms provided that when A and B are halogen, Z is located at the 4 or 5 positions.
Abstract: Process for the manufacture of 2-ethyl-pyridine from 2-methyl-pyridine and methanol in the gaseous phase with a catalyst consisting essentially of silicon dioxide and oxides of metals of the second and/or third main group or subgroup and/or the fifth main group of the periodic system of elements at elevated temperatures.
Abstract: Novel tetrahydrofuran derivatives of the formula ##EQU1## wherein R is a branched or linear alkyl of 1 to 10 carbon atoms and R.sub.1 is alkyl of 1 to 5 carbon atoms and X is selected from the group consisting of chlorine, bromine, --OH and alkylcarbonyloxy of 2 to 5 carbon atoms useful as insecticides and their preparation.
Type:
Grant
Filed:
February 3, 1975
Date of Patent:
May 18, 1976
Assignee:
Roussel Uclaf
Inventors:
Daniel Hainaut, Jean-Pierre Demoute, Pierre Girault
Abstract: Compounds represented by the following formula ##EQU1## wherein A is a substituted or unsubstituted heterocyclic radical and T is a C.sub.2 -C.sub.5 alkyl, alkenyl, cyclopropylmethyl, cyclobutylmethyl or cyclopentyl groupA process for their preparation and novel intermediates therefor are disclosed. These compounds are useful antibiotics.
Type:
Grant
Filed:
August 2, 1974
Date of Patent:
May 11, 1976
Assignee:
Hoffmann-La Roche Inc.
Inventors:
Andre Furlenmeier, Peter Quitt, Karl Vogler, Paul Lanz
Abstract: A process for producing a substituted tetrahydrofuran which comprises contacting an epoxide with molecular hydrogen and a Group VIII metal hydrogenation catalyst at a temperature between 50.degree. and 250.degree.C and a pressure between 10 and 5000 psig, wherein the contacting is carried out in the liquid phase and in the presence of a protonic acid, and the epoxide has the formula ##EQU1## wherein R.sup.1 is a methyl, ethyl, propyl or butyl group and wherein R.sup.2 is hydrogen, methyl, ethyl, propyl or butyl.
Abstract: Viscous polybutenes of number average molecular weight (M.sub.n) in the range of about 300 to about 3000 have improved reactivity with intramolecular anhydrides of unsaturated aliphatic dicarboxylic acids when such polybutenes contain rather small amounts, i.e., 5 to 200 ppm, of halogenated, preferably chlorinated and/or brominated carboxylic or sulfonic acid. Preference is given to such halogen containing compounds having a sufficient vapor pressure at a temperature in the range of 100.degree. to 300.degree.C to be substantially completely removed at absolute pressures in the range of 5 to 760 mm Hg. Use of such polybutenes containing such halogenated compounds in the addition reaction with said unsaturated anhydrides can reduce formation of undesired tarry product resulting from polymerization and/or thermal decomposition of the unsaturated anhydrides and enhance yield of desired alkenyl-substituted anhydride.
Abstract: Tetra-(alkylsulphamoyl)-copper phthalocyanines of the formula ##EQU1## WHEREIN CuPc denotes a copper phthalocyanine radical, R.sub.1, R.sub.2 and R.sub.3 denote alkyl radicals with a total of 7 - 12 C atoms, R.sub.4, R.sub.5 and R.sub.6 denote alkyl radicals with a total of 11 - 13 C atoms and n denotes 0 - 4 have a good solubility an alcohol and are particularly suitable for dyeing alcoholic solutions of film-forming polymers.
Abstract: Improved process for the preparation of copper phthalocyanine in pigmentary form by viscous salt milling crude copper phthalocyanine in the presence of an organic conditioning agent and FeCl.sub.3 followed by acid extraction. This process requires substantially less energy than conventional viscous salt milling and produces a highly dispersible, very strong .beta.-phase copper phthalocyanine which is useful as a pigment in a variety of applications.
Abstract: This invention relates to therapeutically active 2,5-furane derivatives, wherein the substituent in the 2-position is a lower alkyl group or a group ROOC--(CH.sub.2).sub.7 --, in which R is hydrogen or lower alkyl, the 5-substituent being an alkyl or alkylene group of 4 to 13 carbon atoms, which may be substituted with an oxygen atom, a hydroxy group or a lower alkyl group at the third carbon atom, counted from the furane ring, and to the production thereof.