Patents Examined by J. R. Brown
  • Patent number: 4871835
    Abstract: Analogs of hGH having the activity of naturally occurring hGH and a similar amino acid sequence varying from the sequence of natural hGh by the addition of one or more amino acids, e.g. methione or methionine-leucine, to the N-terminus of natural hGH have been produced, recovered and purified. Such analogs may be incorporated into pharmaceutical compositions and administered to a subject to increase the level of hGH in the subject.Analogs of hGH which comprise the amino acid sequence of natural hGH from the N-terminus of which one or more amino acids have been deleted, e.g. Met.sup.14 hGh, have been produced, recovered and purified. Such analogs may be incorporated into pharmaceutical compositions and administered to a subject to lower the level of hGH in the subject.A plasmid has been constructed which directs the expression of an analog of hGH having the amino acid sequence methionine-leucine added to the N-terminus of natural hGH.
    Type: Grant
    Filed: January 14, 1985
    Date of Patent: October 3, 1989
    Assignee: Bio-Technology General Corp.
    Inventors: Haim Aviv, Marian Gorecki, Avigdor Levanon, Amos Oppenheim, Tikva Vogel, Pinhas E. Zeelon, Menachem Zeevi
  • Patent number: 4801583
    Abstract: The oligosaccharides of the invention contain or are constituted by a tetrasaccharide enchainment of the formula: ##STR1## in which R.sub.1 represents an organic anion, R.sub.2 is identical to R.sub.1 or represents a hydrogen atom, N.sub.1 and N.sub.2 represent a functional amino group.
    Type: Grant
    Filed: May 15, 1985
    Date of Patent: January 31, 1989
    Assignee: Choay S.A.
    Inventors: Maurice Petitou, Jean-Claude Lormeau, Jean Choay, Jean-Claude Jacquinet, Pierre Sinay
  • Patent number: 4795743
    Abstract: As new 2'-deamino-2'-hydroxyistamycin B.sub.o derivatives are provided four compounds, namely 2'-deamino-2'-hydroxyistamycin B; 2'-deamino-2'-hydroxy-3-O-demethylistamycin B; 4-N-(.beta.-alanyl)-2'-deamino-2'-hydroxyistamycin B.sub.o ; and 4-N-(.beta.-alanyl)-2'-deamino-2'-hydroxy-3-O-demethylistamycin B.sub.o which all exhibit high antibacterial activity and low acute toxicity in combination. These new compounds are useful as antibacterial agent.
    Type: Grant
    Filed: March 4, 1987
    Date of Patent: January 3, 1989
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
    Inventors: Yoshiro Okami, Shinichi Kondo, Daishiro Ikeda, Hamao Umezawa, deceased
  • Patent number: 4795808
    Abstract: The present invention relates to anthracycline derivatives and a process for their preparation. The compounds are distinguished by a high cytostatic activity and can therefore be used as medicaments with an anti-tumor action.
    Type: Grant
    Filed: November 24, 1986
    Date of Patent: January 3, 1989
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Hans G. Berscheid, Dirk Bottger, Hans P. Kraemer
  • Patent number: 4795630
    Abstract: There is disclosed a method for manufacturing a toothpaste containing an abrasive, a humectant, a binder, a surfactant and water comprising steps of:mixing the binder, part of the humectant and a small amount of water to prepare a liquid dispersion where the binder is slightly swollen,mixing the thus prepared liquid of the slightly swollen binder with the abrasive, the surfactant, the remaining humectant and the remaining water, andperforming a final stage where the binder is completely swollen and dissolved to prepare a toothpaste.
    Type: Grant
    Filed: June 19, 1986
    Date of Patent: January 3, 1989
    Assignee: Lion Corporation
    Inventors: Haruo Okouchi, Shoji Konishi
  • Patent number: 4794178
    Abstract: Organic compounds labeled with no-carrier-added fluorine 18 are processed yield a compound having a formula in the form of .sup.18 F-R through a nucleophilic substitution reaction. The process has a series of steps. The first step of the process relates to providing an organic compound having a formula of X-R. X is the nucleophilic leaving group in the substitution action, and R is a preferred substituted hydrocarbon structure being selected from aliphatic, alicyclic, heterocyclic aliphatic, carbocyclic and heterocyclic aromatic structures. The X-R compounds with acid hydrogen are excluded. The next step is to bring the organic compound X-R into contact with fluoride ions which are present in a solvent. These fluoride ions are essentially carrier free .sup.18 F ions. The organic compound is brought into contact with the fluoride ions in an apparatus to produce a reaction.
    Type: Grant
    Filed: July 5, 1985
    Date of Patent: December 27, 1988
    Assignee: Kernforschungsanlage Julich Gesellschaft mit beschrankter Haftung
    Inventors: Heinrich H. Coenen, Kurt Hamacher, Manfred Schuller, Gerhard Stocklin, Bernd Klatte, Arndt Knochel
  • Patent number: 4794174
    Abstract: In accordance with this invention, there are provided 5'-deoxy-5'-substituted adenosines having the formula ##STR1## wherein X is a member selected from the group consisting of NH, NCH.sub.3, S, or ##STR2## n is an integer from 2-4; and Z is a member selected from the group consisting of: ##STR3## provided that when X is NH, S or CH.sub.3 --S .sym., then Z is not ONH.sub.2. These compounds show activity as inhibitors of AdoMet-DC.
    Type: Grant
    Filed: February 10, 1987
    Date of Patent: December 27, 1988
    Assignee: Southern Research Institute
    Inventor: John A. Secrist, III
  • Patent number: 4789663
    Abstract: A method of repairing bone defects by use of suspensions containing purified atelopeptide, reconstituted, fibrillar skin collagen or bone collagen powder or mixtures thereof is disclosed. The suspensions provide matrices for conductive growth of bone into the defect. The skin collagen may also be lyophilized and used in the form of mats.
    Type: Grant
    Filed: July 5, 1985
    Date of Patent: December 6, 1988
    Assignee: Collagen Corporation
    Inventors: Donald G. Wallace, Thomas L. Smestad, John M. McPherson, Karl A. Piez, Saeid Seyedin, Rosa Armstrong
  • Patent number: 4789737
    Abstract: An oligonucleotide derivative having an amino group protected with an eliminatable group bonded through a phosphate group and a spacer with an appropriate length to the 5'-end of an oligonucleotide protected suitably at the 3'-hydroxyl group and the base moiety of the nucleotide, and an immobilized oligonucleotide derivative having a Sepharose carrier bonded to the amino group in place of said protective group are disclosed. Methods for production of these derivatives are also disclosed.
    Type: Grant
    Filed: February 20, 1987
    Date of Patent: December 6, 1988
    Assignee: Wakunaga Seiyaku Kabushiki Kaisha
    Inventors: Kenichi Miyoshi, Toru Fuwa
  • Patent number: 4789735
    Abstract: The conjugate according to the invention is constituted by a wall adhesin of Streptococcus mutans, of a proteinic nature, capable of binding the components of saliva, or an active fraction of such a protein, covalently coupled to a Streptococcus mutans polysaccharide, or to a fraction of such a polysaccharide.Preferably, the adhesin is constituted by a single polypeptide chain having a molecular weight of about 74,000; it is common to the different serotypes of Streptococcus mutans where it has a crossed antigenicity; and it is capable of interacting with the salivary glycoproteins and polysaccharide derived from the same serotype of S. mutans, particularly serotype f.Use for the preparation of immunogenic compositions, particularly for the preparation of vaccines against dental caries.
    Type: Grant
    Filed: May 13, 1986
    Date of Patent: December 6, 1988
    Assignees: Universite Catholique de Louvain, Institut National de la Sante et de la Recherche Medicale
    Inventors: Robert Frank, Jean P. Klein, Fabienne Ackermans, Herve Bazin
  • Patent number: 4788179
    Abstract: A method of treating patients suffering from amyotrophic lateral sclerosis (ALS) by administering dipeptide derivatives of the formula ##STR1## wherein R.sub.1 is hydrogen, a lower alkyl group, cyclohexyl or benzyl; Z is one of the groups ##STR2## wherein if Z is a group (a), R.sub.2 and R.sub.3 together represent an additional bond between the carbon atoms bearing R.sub.2 and R.sub.3, or if Z is a group (b), R.sub.2 is hydrogen; R.sub.4 and R.sub.5 are hydrogen or lower alkyl, or R.sub.5 may also be phenyl; and R.sub.6 is hydrogen or methyl; hydrates or pharmaceutically acceptable acid additions salts thereof. Pharmaceutical compositions containing effective ALS symptom counteracting amounts of such dipeptide derivatives may be administered by infusion, injection, orally, rectally or percutaneously.
    Type: Grant
    Filed: December 11, 1985
    Date of Patent: November 29, 1988
    Assignee: Gruenenthal GmbH
    Inventors: Leopold Flohe, Hans Barth
  • Patent number: 4786719
    Abstract: A DNA sequence comprising a polynucleotide segment consisting of a DNA sequence (A) shown below and a DNA sequence complementary thereto: ##STR1## wherein A represents deoxyadenosine-5'-phosphate, C represents deoxycytidine-5'-phosphate, G represents deoxyguanosine-5'-phosphate, and T represents deoxythymidine-5'-phosphate.The DNA sequence provided by this invention is derived from a rearranged immunoglobulin heavy chain variable (V.sub.H) region gene taken from the mouse hybridoma NL-1 cells which produce an antibody capable of commonly recognizing surface antigens of various human acute lyphocytic leukemia cells. Accordingly, if, for example, it is combined with a heavy chain constant (C.sub.H) region gene, a heavy chain can be produced which can recognize commonly various human acute lymphocytic leukemia cells in combination with a proper light chain. This would serve for the diagnosis and treatment of human acute lymphocytic leukemia.
    Type: Grant
    Filed: October 24, 1985
    Date of Patent: November 22, 1988
    Assignee: Teijin, Limited
    Inventors: Akira Kudo, Yushi Nishimura, Yataro Ichikawa, Takeshi Watanabe
  • Patent number: 4786723
    Abstract: Novel 7-hydroxyguanine compounds of the formula: ##STR1## wherein R is hydrogen atom or hydroxy, and a salt thereof, which have excellent anti-tumor activity, process for preparing the compounds, and anti-tumor agent containing said compound as an active ingredient.
    Type: Grant
    Filed: March 27, 1986
    Date of Patent: November 22, 1988
    Assignee: Kanegafuchi Chemical Industry Co., Ltd.
    Inventors: Mikio Kitahara, Kiyoto Ishii, Hajime Kawaharada, Kiyoshi Watanabe
  • Patent number: 4783483
    Abstract: Alkenes of the formula (I) and epoxides (II) used to make them are useful as anti-inflammatory and antiallergic pharmaceuticals: ##STR1## wherein R.sup.1 =H or CH.sub.3 ; R.sup.2 =phenyl, substituted phenyl, benzyl or a cysteinyl moiety; R.sup.4 and R.sup.5 =alkyl; n=O or 1; and R.sup.3 is as described.
    Type: Grant
    Filed: December 29, 1986
    Date of Patent: November 8, 1988
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Michael P. Ferro, Michael P. Wachter
  • Patent number: 4783470
    Abstract: Anticoagulant is derived from hematin on standing in a slightly alkaline medium and may be isolated therefrom.
    Type: Grant
    Filed: January 14, 1986
    Date of Patent: November 8, 1988
    Assignee: The Rockefeller University
    Inventor: Robert L. Jones
  • Patent number: 4783484
    Abstract: A pharmaceutical composition combines a physiologically acceptable carrier with substantially uniformly sized particles of an organoiodide or organobromide which is solid at physiological tempertures, has a solubility in blood serum of less that one part per ten thousand, and has a mean particle diameter of from about 0.01 microns to about 4 microns. The method of the invention involves administering to a patient an effective amount of such particles.
    Type: Grant
    Filed: October 5, 1984
    Date of Patent: November 8, 1988
    Assignee: University of Rochester
    Inventors: Michael R. Violante, Roy T. Steigbigel
  • Patent number: 4783444
    Abstract: The present invention relates to ophthalmological pharmaceutical compositions comprising (benzothiadiazine, benzamide and benzenesulfonyl)phenyl-substituted carboxyalkyl dipeptide compounds and to methods for using said composition in reducing intraocular pressure, e.g., in the treatment of glaucoma.
    Type: Grant
    Filed: April 4, 1986
    Date of Patent: November 8, 1988
    Assignee: Schering Corporation
    Inventors: Robert Watkins, Ronald J. Doll, Bernard R. Neustadt, Elizabeth M. Smith, Charles V. Magatti, Elijah H. Gold
  • Patent number: 4782136
    Abstract: Synthetic peptide compounds are provided which are capable of producing antibodies binding to the lactate dehydrogenase enzyme of human serum (LDH-C.sub.4). The peptide compounds comprise antigenic sequences of human LDH-C.sub.4. The peptide compounds can be used to prepare vaccines for reducing the fertility of women.
    Type: Grant
    Filed: December 1, 1986
    Date of Patent: November 1, 1988
    Assignee: Northwestern University
    Inventors: Erwin Goldberg, Jose L. Millan
  • Patent number: 4782141
    Abstract: This invention relates to salts of primycin formed with an organic acid--preferably a C.sub.1-16 aliphatic carboxylic acid, a halogenated carboxylic acid, an aliphatic dicarboxylic acid, an aromatic carboxylic acid, a substituted aromatic carboxylic acid or an organic sulfonic acid--or an inorganic acid--preferably a hydrohalogenic acid.There is furtheron provided a process for the preparation of new primycin salts which comprises reacting a suspension of primycin sulfate formed with an aliphatic alcohol containing 1-4 carbon atoms with a barium salt.The new primycin salts of the present invention possess excellent antibiotic properties.
    Type: Grant
    Filed: July 2, 1985
    Date of Patent: November 1, 1988
    Assignee: Chinoin Gyogyszer ES Vegyeszeti Termekek Gyara RT.
    Inventors: Gyula Dekany, Judit Frank
  • Patent number: 4780479
    Abstract: Derivatives of carbonyl-group containing behavior modifying compounds, in which said carbonyl group has been converted to a photolabile group which regenerates the carbonyl group on exposure to radiation, are of value in various methods for the control of animal, and in particular insect, species.
    Type: Grant
    Filed: January 14, 1987
    Date of Patent: October 25, 1988
    Assignee: National Research Development Corporation
    Inventors: John A. Pickett, Ewen D. M. Macaulay