Patents Examined by Johnnie R. Brown
  • Patent number: 5271941
    Abstract: Antisense oligonucleotides of human regulatory subunit RI-alpha of cAMP-dependent protein kinases are disclosed along with pharmaceutical compositions containing these oligonucleotides as the active ingredients. These antisense oligonucleotides have been shown to inhibit the growth of several cancer cell lines including HL-60, human colon carcinoma LS-174T, neuroblastoma cells, breast cancer cells, and gastric carcinoma cells. In addition, these oligonucleotides can inhibit the growth of human colon carcinoma cells transplanted in athymic mice.
    Type: Grant
    Filed: May 20, 1991
    Date of Patent: December 21, 1993
    Inventor: Yoon S. Cho-Chung
  • Patent number: 5271936
    Abstract: Disclosed is a method of reducing the allergenicity of psyllium seed husks and psyllium seed husk-containing food additives. The method comprises subjecting ground psyllium seed husks to a wet heat treatment for a time and at a temperature and pressure sufficient to reduce the allergenicity of the psyllium seed husks. Psyllium seed husks alone can be subjected to the wet heat treatment to reduce its allergenicity and subsequently used as an ingredient to produce a psyllium-containing food additive or food product. Alternatively, psyllium seed husks can be mixed with one or more other ingredients of a food additive or food product and then subjected to the wet heat treatment during production of the food additive or food product.
    Type: Grant
    Filed: January 28, 1992
    Date of Patent: December 21, 1993
    Assignee: Kellogg Company
    Inventor: Richard D. Wullschleger
  • Patent number: 5270461
    Abstract: Benzoic acid esters of an ethoxylated methyl glucosides and of a propoxylated methyl glucosides exhibit enhanced characteristics that make these esters ideally suited for skin and hair care compositions. These esters demonstrate enhanced capabilities as foam boosters, emollients, conditioners, clarifiers, solubilizers, and carriers (diluents). In addition, oxybenzone, benzocaine, ibuprofin and dihydroxyacetone (DHA) can be solubilized by these esters. These esters have the ability to solubilize both hydrophilic and hydrophobic materials such as DHA. The benzoate esters have lower surface tensions than the glucam polyol molecules from which they were derived.
    Type: Grant
    Filed: November 19, 1991
    Date of Patent: December 14, 1993
    Assignee: Finetex, Inc.
    Inventors: Ismail I. Walele, Nicolas J. Scarangella, Anthony Ansaldi, Ann M. Andrews
  • Patent number: 5270304
    Abstract: The present invention concerns a therapeutic-prophylactic agent for ischemic diseases of the heart or brain, comprising as an active ingredient a 2-alkynyladenosine represented by the following formula: ##STR1## wherein n represents an integer of from 2 to 15.
    Type: Grant
    Filed: May 15, 1991
    Date of Patent: December 14, 1993
    Assignees: Yamasa Shoyu Kabushiki Kaisha, Toa Eiyo Ltd.
    Inventors: Kentaro Kogi, Toichi Abiru, Toyofumi Yamaguchi
  • Patent number: 5270446
    Abstract: A crosslinked product of a primary amino group-containing compound such as proteins, chitosan or a mixture thereof is disclosed. The product has a crosslinked structure formed by crosslinking with an iridoid compound, and the blue color developed by the crosslinking is decolorized. Also, a method for decolorization of the above crosslinked product is disclosed. The method comprises reacting a crosslinked product obtained by crosslinking a primary amino group-containing compound with an iridoid compound, with at least one decolorizing agent selected from the group consisting of an oxidizing agent, a reducing agent and a reductone. The decolorized product and the method for decolorization according to the present invention can be broadly applied in the fields of foodstuffs, cosmetics, pharmaceuticals and the like where blue tone coloration is undesirable.
    Type: Grant
    Filed: May 18, 1992
    Date of Patent: December 14, 1993
    Assignee: Suntory Limited
    Inventors: Nobuo Kyogoku, Keiko Harada
  • Patent number: 5268460
    Abstract: A method for obtaining a substantially biologically pure culture strain of Aureobasidium pullulans from a wild type strain by enriching the collected strain for organisms which grow as fungal yeastlike cells, growing colonies from isolated yeastlike cells and selecting those yeastlike cells which exhibit reduced pigmentation. Biologically pure culture strains obtained by the invention as well as methods for producing pullulan having decreased pigmentation and/or increased molecular weight are disclosed.
    Type: Grant
    Filed: October 16, 1991
    Date of Patent: December 7, 1993
    Assignees: Shin-Estu Bio, Inc., Shin-Etsu Chemical Co., Ltd.
    Inventors: Linda P. Thorne, Thomas J. Pollock, Richard W. Armentrout
  • Patent number: 5268467
    Abstract: Polysaccharides from the gum exudates of Astragalus species Tragacantha section plants are extracted and modified into water-soluble fractions free from small molecular impurities. Such polysaccharide fractions upon parenteral administration inhibit specific tumors and viruses in mammals away from the site of injection, presumably by immunostimulatory effects. These polysaccharide fractions show no toxicity upon parenteral administration.
    Type: Grant
    Filed: March 8, 1990
    Date of Patent: December 7, 1993
    Inventor: Anthony J. Verbiscar
  • Patent number: 5268365
    Abstract: The invention provides a method of stimulating the immune function with the aid of a nucleobase source, the use of nucleobase sources for immunostimulation and compositions comprising such nucleobase sources. The invention also provides the use of nuclobase source for the maintenance of the immune function in the presense of protein depletion or protein starvation.
    Type: Grant
    Filed: September 27, 1991
    Date of Patent: December 7, 1993
    Inventors: Frederick B. Rudolph, Charles T. Van Buren
  • Patent number: 5268462
    Abstract: Oleandomycin oximes ##STR1## wherein R.sup.1 stands for hydrogen or --CH.sub.3, R.sup.2 stands for --CH.sub.3 or hydrogen or R.sup.1 and R.sup.2 stand together for an epoxide group or for .dbd.CH.sub.2, R.sup.3 stands for --OH, whereas the line stands for a single or a double bond, a process for the preparation thereof and their use in antimicrobial agents.
    Type: Grant
    Filed: March 14, 1991
    Date of Patent: December 7, 1993
    Assignee: Pliva Farmaceutska
    Inventors: Gorjana Lazarevski, Slobodan Djokic
  • Patent number: 5264564
    Abstract: Oligonucleotide analogs wherein one or more phosphodiester linkages between adjacent nucleotides are replaced by an formacetal/ketal type linkage are resistant to nucleases and do not need to exhibit the diastereomerism characteristic of many other oligonucleotide analogs, and thus are capable of strong hybridization to target RNA or DNA. These oligonucleotide analogs are useful in therapies which modulate gene expression using "antisense" or other specifically binding oligomers.
    Type: Grant
    Filed: July 30, 1990
    Date of Patent: November 23, 1993
    Assignee: Gilead Sciences
    Inventor: Mark Matteucci
  • Patent number: 5264562
    Abstract: Oligonucleotide analogs wherein one or more phosphodiester linkages between adjacent nucleotides are replaced by an formacetal/ketal type linkage are resistant to nucleases and do not need to exhibit the diastereomerism characteristic of many other oligonucleotide analogs, and thus are capable of strong hybridization to target RNA or DNA. These oligonucleotide analogs are useful in therapies which modulate gene expression using "antisense" or other specifically binding oligomers.
    Type: Grant
    Filed: April 24, 1991
    Date of Patent: November 23, 1993
    Assignee: Gilead Sciences, Inc.
    Inventor: Mark Matteucci
  • Patent number: 5264566
    Abstract: A method is provided for the high fidelity, rapid and economical in vitro synthesis of oligonucleotides. Nucleoside H-phosphonates are condensed in seriatim using a dehydrating agent to produce a poly (nucleoside H-phosphonate). The product is oxidized to yield the desired oligonucleotide. A novel reagent is provided for multiple nucleoside additions in single cycles.
    Type: Grant
    Filed: April 26, 1990
    Date of Patent: November 23, 1993
    Assignee: Genentech, Inc.
    Inventors: Brian C. Froehler, Mark D. Matteucci
  • Patent number: 5264561
    Abstract: The instant invention is drawn to a method for manufacturing 2',3'-dideoxy-2',3'-didehydronucleoside compounds by reacting a ribonucleoside derivative wherein the hydroxyl in the 5'-position of the furanose ring of said ribonucleoside is protected by a silyl protective group, with an acid anhydride such as acetic anhydride in the presence of a catalyst such as hydrous zirconium oxide, and then subjecting the reaction product to decarboxylation. The decarboxylation can be effected by heating the reaction product. This method can be performed in a single step, and requires no reagents which are expensive or chemicals which should be handled with care. Hence, it serves to manufacture 2',3'-dideoxy-2',3'-didehydronucleosides easily at low cost.
    Type: Grant
    Filed: March 20, 1992
    Date of Patent: November 23, 1993
    Assignees: Japan Tobacco Inc., Yuki Gosei Kogyo Co, Ltd.
    Inventors: Takashi Ebata, Hajime Matsushita, Nobuhiro Mizutani, Junji Ohki, Junko Tanaka, Hiromi Kaibara, Kazuo Itoh
  • Patent number: 5262531
    Abstract: 2'-deoxy-.beta.-adenosine can be industrially and easily obtained without using expensive or dangerous materials by the process of the present invention, which comprises the steps of: preparing a salt of adenine from adenine, allowing to condense the salt with a derivative of pentofuranose to isolate a derivative of adenine, and then eliminating the protecting groups.
    Type: Grant
    Filed: June 30, 1989
    Date of Patent: November 16, 1993
    Assignees: Japan Tobacco, Inc., Yuki Gosei Kogyo, Co. Ltd.
    Inventors: Hiroshi Kawakami, Hajime Matsushita, Hajima Yoshikoshi, Kazuo Itoh, Yoshitake Naoi
  • Patent number: 5262530
    Abstract: A method and system for polynucleotide synthesis are provided which employ solid phase synthesis on a nonswellable porous polystyrene support by phosphoramidite or hydrogen phosphonate chemistries. The polystyrene support gives rise to fewer tritylated failure sequences caused by chain growth from extraneous support sites, and allows lower amounts of monomer reactants to be used to achieve equal or better coupling efficiencies as those achieveable with CPG. The method and system also employ nucleoside intermediates whose exocyclic amines are protected by base-labile groups which permit simultaneous cleavage and deprotection of the completed polynucleotide chain in the presence of the solid phase support. This latter feature allows practical automation of both the synthesis and purification of polynucleotides.
    Type: Grant
    Filed: July 27, 1990
    Date of Patent: November 16, 1993
    Assignee: Applied Biosystems, Inc.
    Inventors: William A. Andrus, Christie D. McCollum, Gerald Zon
  • Patent number: 5262401
    Abstract: A porphycene having the structure ##STR1## wherein each R.sup.1 is, independently, (a) --(CH.sub.2).sub.n --X, where n= 1-4, X is OR.sup.2 and R.sup.2 is C.sub.1-6 alkyl, aralkyl or aryl; CN; OH; OSO.sub.2 R.sup.2 ; NH.sub.2 ; NHR.sup.2 ; NR.sup.2.sub.2 ; SH; SR.sup.2 ; S(O).sub.1-2 R.sup.2 ; COOH; CO.sub.2 R.sup.2 ; C(O)NH.sub.2 ; C(O)NHR.sup.2 ; C(O)NR.sup.2.sub.2 ; halogen; or CHO;(b) --(CH.sub.2).sub.m CH.dbd.CH.sub.2 where m is 0-2; or(c) --(CH.sub.2).sub.n --O--G where G is a mono- or oligosaccharide;(d) --(CH.sub.2).sub.2n --X, where X is an amino acid, oligopeptide covalently bonded by an ether-, ester- or amine-bond or --Y--(CH.sub.2).sub.n -porphycene.sup.2 (porphycene.sup.2 being a compound of the same structure and Y is a direct bond; --O--; or --CH.dbd.CH.sub.2); or(e) where one, two or three of the substituents R.sup.1 are C.sub.1-6 alkyl or aryl and the remaining substituents are as above under (a)-(d), and salts and metal complexes thereof.
    Type: Grant
    Filed: April 29, 1992
    Date of Patent: November 16, 1993
    Assignee: Cytopharm, Inc.
    Inventors: Emanuel Vogel, Clemens Richert, Thomas Benninghaus, Martin Muller, Alexander D. Cross
  • Patent number: 5262536
    Abstract: Fluorescent reagents possessing an activated phosphate for the convenient covalent coupling to the 5'-hydroxyl of oligonucleotides. A class of 5'-fluorescence-tagged oligonucleptides is also disclosed.
    Type: Grant
    Filed: December 5, 1990
    Date of Patent: November 16, 1993
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Frank W. Hobbs, Jr.
  • Patent number: 5260426
    Abstract: The invention relates to antibacterial pseudo-primycin complexes of formula (I) ##STR1## to the components and acid addition salts thereof, as well as to the preparation of these compounds and to the pharmaceutical compositions containing said compounds as active ingredient.In the formula (I) R.sup.1 is butyl, pentyl or hexyl, R.sup.2 is hydrogen, hydroxyl or O-arabinose and X is organic or inorganic acid ion.
    Type: Grant
    Filed: March 24, 1992
    Date of Patent: November 9, 1993
    Assignee: Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T.
    Inventors: Gyula Dekany, Judit Frank, Istvan Pelczer, Gabor Kulcsar, Eniko Schreiner
  • Patent number: 5260425
    Abstract: The invention relates to new anthracycline derivatives having cytostatic activity and the general formula I, ##STR1## which can optionally also be in the form of an acid addition salt of physiologically acceptable inorganic or organic acids, where R.sup.1 is hydrogen or a hydroxyl group, R.sup.2 is hydrogen, a hydroxyl or a methoxy group, R.sup.3 is hydrogen or a hydroxyl group, R.sup.4 is hydrogen or a hydroxyl group, R.sup.5 hydrogen, a hydroxyl or a methoxycarbonyl group, R.sup.6 is CH.sub.2 CH.sub.3, COCH.sub.3, COCH.sub.2 OH, CHOHCH.sub.3 or CHOHCH.sub.2 OH and R.sup.
    Type: Grant
    Filed: June 2, 1989
    Date of Patent: November 9, 1993
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Peter Hermentin, Ernst Raab, Cenek Kolar, Manfred Gerken, Dieter Hoffmann, Hans P. Kraemer, Ulrich Stache
  • Patent number: 5260432
    Abstract: A novel gamma retinoic acid receptor is disclosed. The novel receptor is encoded for by cDNA carried on plasmid pGEM-hRAR.gamma., which has been deposited with the American Type Culture Collection for patent purposes. Chimeric receptor proteins are also disclosed. The chimera contain at least one functional domain from the new gamma retinoic acid receptor.
    Type: Grant
    Filed: June 22, 1989
    Date of Patent: November 9, 1993
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Fumimaro Takaku, Takashi Ishikawa, Michio Imawari, Ronald M. Evans, Kazuhiko Umesono