Patents Examined by Johnnie R. Brown
  • Patent number: 5256775
    Abstract: A method is provided for making 3' and/or 5' end-capped oligonucleotides so as to render the oligonucleotide resistant to degradation by exonucleases. The exonuclease degradation resistance is provided by incorporating two or more phosphoramidate and phosphorocmonothioate and/or phosphorodithioate linkages at the 5' and/or 3' ends of the oligonucleotide, wherein the number of phosphoramidate linkages is less than a number which would interfere with hybridization to a complementary oligonucleotide strand and/or which would interfere with RNAseH activity when the oligonucleotide is hybridized to RNA.
    Type: Grant
    Filed: June 5, 1990
    Date of Patent: October 26, 1993
    Assignee: Gilead Sciences, Inc.
    Inventor: Brian C. Froehler
  • Patent number: 5256646
    Abstract: A novel antibiotic complex designated BU-4224V produced by fermentation of Kibdelosporangium albatum sp. nov. Strain R761-7. The complex may be separated chromatographically into bioactive components designated BU-4224V A, B.sub.1, B.sub.2, and C. The components BU-4224V B.sub.1 and B.sub.2 display both antiviral and antimicrobial activity, while component BU-4224V A has antimicrobial activity and component BU-4224V C has antiviral activity.
    Type: Grant
    Filed: July 27, 1990
    Date of Patent: October 26, 1993
    Assignee: Bristol-Myers Squibb Company
    Inventors: Mitsuaki Tsunakawa, Tetsuro Yamasaki, Koji Tomita, Osamu Tenmyo
  • Patent number: 5256651
    Abstract: Triple derivatives of polygalactomannan i.e., dialkylaminoalkyl ether-hydroxyalkyl ether - long aliphatic chain ether of polygalactomannan, are useful as thickening agents for aqueous fluids.
    Type: Grant
    Filed: May 27, 1992
    Date of Patent: October 26, 1993
    Assignee: Rhone-Poulenc, Inc.
    Inventors: Martha A. Phelps, Michael E. Morgan
  • Patent number: 5254540
    Abstract: Saccharide copolymers having antibacterial activity obtained by copolymerization of an oligosaccharide or polysaccharide with a nitrogen containing vinyl derivative, quaternarization of the obtained copolymer followed by oxidation of the oligosaccharide or polysaccharide monomer unit with formation of the corresponding dialdehyde.
    Type: Grant
    Filed: December 8, 1989
    Date of Patent: October 19, 1993
    Assignee: Etablissement Texcontor
    Inventor: Franco Conti
  • Patent number: 5254539
    Abstract: A method for tearing retroviral infections including acquired immune deficiency syndrome (AIDS) with 2',3'-dideoxyinosine or 2',3'-dideoxyadenosine is disclosed. This antiviral effect is irreversible with 2',3'-dideoxyinosine and 2',3'-dideoxyadenosine but reversible with 2',3'-dideoxyguanosine.
    Type: Grant
    Filed: February 28, 1991
    Date of Patent: October 19, 1993
    Assignee: U.S. Government, Dept. of Health and Human Services, c/o National Institutes of Health
    Inventors: Hiroaki Mitsuya, Samuel Broder
  • Patent number: 5252727
    Abstract: The heteropolysaccharide BM07, useful, e.g., as a thickening/stabilizing/suspending agent for a wide variety of industrial applications, is produced by fermenting a nutrient medium containing at least one source of assimilable carbon with a strain of Agrobacterium tumefaciens I-736 or mutant thereof.
    Type: Grant
    Filed: July 13, 1989
    Date of Patent: October 12, 1993
    Assignee: Rhone-Poulenc Chimie
    Inventors: Gabriel Ullmann, Alain Jarry
  • Patent number: 5252760
    Abstract: A method of phosphorylating a nucleoside or an oligonucleotide chain having a free 2', 3' or 5' hydroxyl moiety is provided. The method involves the use of a phosphorylating reagent which is selected such that the extent of phosphorylation can be monitored colorimetrically, easily and accurately. The phosphorylating reagent contains an aromatic species such as a dimethoxytrityl group that is cleavable with acid and colorimetrically detectable upon release.
    Type: Grant
    Filed: August 18, 1987
    Date of Patent: October 12, 1993
    Assignee: Chiron Corporation
    Inventors: Michael S. Urdea, Thomas Horn
  • Patent number: 5250672
    Abstract: A polysaccharide chemically joined to a nitroxyl spin label (NSL) compound has use for the preparation of an NMR diagnostic composition. An agent for modifying H.sub.2 O relaxation times in NMR diagnosis may comprise a polysaccharide to which is chemically linked both an NSL compound and an organic complexing agent to which is complexed a paramagnetic metal ion, such as Gd(III) or Cu(II). Polysaccharides include dextran, starch and cellulose. The preferred NSL compound is 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl.
    Type: Grant
    Filed: June 30, 1987
    Date of Patent: October 5, 1993
    Assignee: Guerbet S.A.
    Inventors: Peter J. Sadler, Charles T. Harding
  • Patent number: 5250673
    Abstract: Novel 2'-deoxy-5-substituted uridine derivative represented by the general formula, ##STR1## wherein R.sub.1 is a hydrogen atom, a benzoyl group or a tetrahydrofuranyl group; R.sub.2 is a fluorine atom or a trifluoromethyl group; and any one of R.sub.3 and R.sub.4 is a hydrogen atom and the other one is an alkyl group having 1 to 10 carbon atoms, an alkenyl group having 2 to 6 carbon atoms, a benzyl group having as the substituents selected from the group consisting of a halogen atom, an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms and a nitro group, or an alkyl group having 1 to 3 carbon atoms having one or two phenyl groups as the substituents.The novel 2'-deoxy-5-substituteduridine derivative possesses excellent antitumor activity with less toxicity, thus it is useful as antitumor agent.
    Type: Grant
    Filed: October 17, 1989
    Date of Patent: October 5, 1993
    Assignee: Taiho Pharmaceutical Company, Ltd.
    Inventors: Setsuro Fujii, Jun-ichi Yamashita, Hiroshi Matsumoto, Setsuo Takeda, Tadafumi Terada, Mitsugi Yasumoto, Norio Unemi
  • Patent number: 5250518
    Abstract: The invention relates to O-methyl derivatives of azithromycin A of the formula (I) ##STR1## wherein Ia R.sup.1 =R.sup.2 =CO.sub.2 CH.sub.2 C.sub.6 H.sub.5, R.sup.3 =CH.sub.3, R.sup.4 =R.sup.5 =HIb R.sup.1 =R.sup.2 =CO.sub.2 CH.sub.2 C.sub.6 H.sub.5, R.sup.3 =R.sup.4 =CH.sub.3, R.sup.5 =HIc R.sup.1 =R.sup.2 =CO.sub.2 CH.sub.2 C.sub.6 H.sub.5, R.sup.3 =R.sup.5 =H, R.sup.4 =C.sub.3Id R.sup.1 =R.sup.2 =CO.sub.2 CH.sub.2 C.sub.6 H.sub.5, R.sup.3 =R.sup.4 =R.sup.5 =CH.sub.3Ie R.sup.1 =R.sup.2 =R.sup.4 =R.sup.5 =H, R.sup.3 =CH.sub.3If R.sup.1 =R.sup.2 =R.sup.5 =H, R.sup.3 =R.sup.4 =CH.sub.3Ig R.sup.1 =R.sup.2 =R.sup.3 =R.sup.5 =H, R.sup.4 =CH.sub.3Ih R.sup.1 =R.sup.2 =H, R.sup.3 =R.sup.4 =R.sup.5 =CH.sub.3Ii R.sup.1 =R.sup.4 =R.sup.5 =H, R.sup.2 =R.sup.3 =CH.sub.3Ij R.sup.1 =R.sup.5 =H, R.sup.2 =R.sup.3 =R.sup.4 =CH.sub.3Ik R.sup.1 =R.sup.3 =R.sup.5 =H, R.sup.2 =R.sup.4 =CH.sub.3Il R.sup.1 =H, R.sup.2 =R.sup.3 =R.sup.4 =R.sup.5 =CH.sub.
    Type: Grant
    Filed: July 18, 1991
    Date of Patent: October 5, 1993
    Assignee: Pliva Farmaceutska, Kemijska, Prehrambena I Kozmeticka
    Inventors: Gabrijela Kobrehel, Slobodan Djokic, Gorjana Lazarevski
  • Patent number: 5248771
    Abstract: Reacting [.sup.* X]X- with YVaraU in the presence of a cuprous ion catalyst under anaerobic and reducing conditions produces [.sup.* X]XVaraU, where .sup.* X is a radioactive halogen, Y is a second halogen, X and Y are different halogens, and XVaraU is 1-(.beta.-D-arabinofuranosyl)-5(E)-(2-halogenovinyl) uracil, the halogen of which is X. The reaction produces an effective administrable form of [.sup.* X]XVaraU for use in diagnosis and treatment of herpes virus infections.
    Type: Grant
    Filed: June 26, 1991
    Date of Patent: September 28, 1993
    Assignee: Triumf
    Inventor: Hayes Dougan
  • Patent number: 5248770
    Abstract: This application discloses probes for adenosine receptors which are functionalized congeners of the following compound: ##STR1## wherein R is --CH.sub.2 --C(O)--R' or ##STR2## These probes bind to A.sub.2 and A.sub.3 adenosine receptors and aid in quantifying and characterizing the receptors. The compounds may be labeled, for example with fluorescent compounds or radioactive compounds, or unlabeled.
    Type: Grant
    Filed: December 19, 1988
    Date of Patent: September 28, 1993
    Assignee: The United States of America, as represented by the Department of Health and Human Services
    Inventors: Kenneth A. Jacobson, John W. Daly, Kenneth L. Kirk
  • Patent number: 5248669
    Abstract: This invention relates to a method for inhibiting or suppressing in an animal the contraction of vessels lined with endothelial tissue, which contractions are caused by anoxia or hypoxia. The method comprises administering to such an animal an effective therapeutic (contraction-inhibiting) amount of an avermectin class antibiotic such as ivermectin or a derivative thereof for a time period sufficient to inhibit or suppress said contractions.
    Type: Grant
    Filed: December 17, 1991
    Date of Patent: September 28, 1993
    Inventor: Samir Amer
  • Patent number: 5248670
    Abstract: Antisense oligonucleotides are disclosed having a length of 15-30 nucleotides containing the CAT sequence and hybridizable to herpes simplex virus type I gene UL13, UL39, or UL40. These antisense oligomers inhibit the replication of the virus at least three-fold. Pharmaceutical compositions containing these oligonucleotides as the active ingredients are also disclosed.
    Type: Grant
    Filed: February 26, 1990
    Date of Patent: September 28, 1993
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Kenneth G. Draper, David J. Ecker, Christopher K. Mirabelli, Stanley T. Crooke
  • Patent number: 5248672
    Abstract: This invention relates to novel polysubstituted benzimidazole nucleosides and compositions and their use in the treatment of viral infections, particulary those caused by human cytomegalovirus and herpes simplex virus. Such substituted compounds exhibit antiviral properties superior to their parent compounds and low leveSPONSORSHIPThis invention was made with government support under Contract No. NO1 Al 42554 and NO1 Al 72641 awarded by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health. The government has certain rights in this invention.
    Type: Grant
    Filed: November 1, 1990
    Date of Patent: September 28, 1993
    Assignee: The Regents of the University of Michigan
    Inventors: Leroy B. Townsend, John C. Drach
  • Patent number: 5246924
    Abstract: The present invention relates to a composition for, and a method of, treating a hepatitis viral infection in a subject using 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-ethyluracil [FEAU].
    Type: Grant
    Filed: May 6, 1991
    Date of Patent: September 21, 1993
    Assignees: Sloan-Kettering Institute for Cancer Research, Institut National de la Sante et de la Recherche Medicale
    Inventors: Jack J. Fox, Kyoichi A. Watanabe, Carlos Lopez, Christian G. Trepo
  • Patent number: 5246922
    Abstract: The present invention relates to a N.sup.6,N.sup.6 -disubstituted-cyclic adenosine-3',5'-monophosphate represented by the formula ##STR1## wherein R represents a linear alkyl group having 3 or more carbon atoms or a branched alkyl group having 4 or more carbon atoms, an aralkyl group or an alkenyl group; A.sup..sym. represents a hydrogen ion, an alkali metal ion, an alkaline earth metal ion, an ammonium ion or an organoammonium ion, or a salt thereof, and a cardiac composition comprising it as an effective component, and further includes a process for preparing a compound represented by the formula ##STR2## wherein R.sub.1 represents an alkyl group, an aralkyl group or an alkenyl group and A.sup..sym. has the same meanings as defined above, or a salt thereof, characterized in that a 2'-O-protected-cyclic adenosine-3',5'-monophosphate represented by the formula ##STR3## wherein Y represents a protecting group and A.sup..sym.
    Type: Grant
    Filed: August 23, 1990
    Date of Patent: September 21, 1993
    Assignee: Kikkoman Corporation
    Inventors: Shigehiro Kataoka, Nobuyuki Yamaji, Motohiko Kato, Shoichi Imai
  • Patent number: 5244880
    Abstract: The invention relates to novel stable aqueous primycin solutions containing 0.5 to 1.75% by mass/volume of primycin sulfate or 2.5 to 9% by mass/volume of a complex of primycin N-methylpyrrolidone and 2 to 15% by mass/volume of pyroglutamic acid, preferably L-pyroglutamic acid or a soluble salt, preferably the sodium salt thereof as calculated for the volume of the solution to be prepared and 40 to 60% by volume of isopropanol as calculated for the volume of the solution to be prepared as well as water in an amount adding up to 100%. The stable, aqueous primycin solutions are topical antibiotics.
    Type: Grant
    Filed: February 11, 1992
    Date of Patent: September 14, 1993
    Assignee: Chinoin Gyogyszer- es Vegyeszeti Termekek Gyara
    Inventors: Peter Szentmiklosi, Tamas Szuts, Gyorgy Hidasi, Istvan Juhasz
  • Patent number: 5243042
    Abstract: The invention relates to antibacterially active 5-amino-3-(.beta.-D-ribofuranosyl)imidazo[4,5-d][1,3]thiazin-7(3H)-one, also referred to as 1-thiaguanosine, a composition and method comprising the same and processes and intermediates for the preparation of 1-thiaguanosine and 5-amino-3-(.beta.-D-ribofuranosyl)imidazo[4,5-d][1,3]oxazin-7(3H)-one, also referred to as oxanosine, a known compound.
    Type: Grant
    Filed: August 2, 1990
    Date of Patent: September 7, 1993
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Kin-Chun Luk, Dennis D. Keith
  • Patent number: RE34387
    Abstract: A method of increasing the rate of repletion of purine nucleotide pools in tissue deficient in the nucleotides, which comprises administering to a human or animal a therapeutically effective amount of 5-amino-4-imidazolecarboxamide riboside, 5-amino-4-imidazolecarboxamide, or a pharmaceutically acceptable salt thereof sufficient to increase the rate of the repletion is disclosed along with pharmaceutical compositions useful for carrying out the method of the invention.
    Type: Grant
    Filed: March 11, 1988
    Date of Patent: September 21, 1993
    Assignee: Duke University
    Inventors: Edward W. Holmes, Judith L. Swain