Patents Examined by Lewis Gotts
  • Patent number: 4009211
    Abstract: Beta,beta-dialkylethylmercaptoethoxylate as new compounds.
    Type: Grant
    Filed: July 29, 1975
    Date of Patent: February 22, 1977
    Assignee: Gulf Research & Development Company
    Inventors: Anatoli Onopchenko, Johann G. D. Schulz
  • Patent number: 4009264
    Abstract: A complex of a polysaccharide or its derivative with reduced glutathione having in its infrared absorption spectrum no absorption peak at about 2500 cm.sup.-.sup.1 which appears in the infrared absorption spectrum of the reduced glutathione. The complex is prepared by reacting the polysaccharide or its derivative activated with an activating agent selected from cyanogen halides, organic cyanic acid esters and alkyl esters of halogenocarbonic acids, with the reduced glutathione at a pH of less than 7. The complex is especially useful for stabilizing thiol groups.
    Type: Grant
    Filed: April 1, 1975
    Date of Patent: February 22, 1977
    Assignee: Meito Sangyo Kabushiki Kaisha
    Inventor: Akihiro Mizutani
  • Patent number: 4008218
    Abstract: An 1-N-((S)-.alpha.-substituted-.omega.-aminoacyl)-neamine or -ribostamycin of the formula: ##STR1## wherein R is a hydrogen atom or .beta.-D-ribofuranosyl group of the formula ##STR2## and R.sub.3 is hydroxyl, amino-NH.sub.2 or acylamino group --NHR.sub.4 in which R.sub.4 is an acyl group, and n is a whole number of 1 to 4, may be produced by subjecting the corresponding O-((S)-.alpha.-substituted-.omega.-aminoacyl)-neamine or -ribostamycin of the formula ##STR3## or its hydroxyl-masked and amino-masked form, to the action of a basic medium to produce an acyl-migration product of the formula: ##STR4## and, optionally converting the amino-masking groups into hydrogen atoms and also the hydroxyl-masking group into hydrogen atom in a known manner if said amino-masking groups and said hydroxyl-masking groups are present in the acyl-migration product. The 1-N-((S)-.alpha.-substituted-.omega.
    Type: Grant
    Filed: March 19, 1975
    Date of Patent: February 15, 1977
    Assignee: Meiji Seiki Kaisha, Ltd.
    Inventors: Eiichi Akita, Tsutomu Tsuchiya, Shinichi Kondo, Shuntaro Yasuda, Sumio Umezawa, Hamao Umezawa
  • Patent number: 4008262
    Abstract: Water insoluble disperse dyes for aromatic polyester textile material are made by the reaction of an aldehyde intermediate derived from an .alpha.-(N-alkylanilino)-m-toluenesulfonamide, typified by .alpha.-(N-ethylanilino)-m-toluenesulfonamide, with a nitrile containing an active methylene group, such as malononitrile. This class of dyes, when appropriately dispersed, produces bright greenish-yellow dyeings on aromatic polyester fabrics with excellent substantivity, outstanding sublimation fastness, and excellent fastness to light. The dyes are applied to polyesters, such as polyethylene terephthalate, by carrier dyeing, pressure dyeing and thermofixation methods.
    Type: Grant
    Filed: February 12, 1976
    Date of Patent: February 15, 1977
    Assignee: American Color & Chemical Corporation
    Inventors: Edgar Earl Renfrew, Guido Ruggiero Lorenzo Genta
  • Patent number: 4008328
    Abstract: N-methyl-N-(3-trifluoromethylphenylsulfenyl)-carbonyloxime-carbamates of the formula ##STR1## in which R.sup.1 and R.sup.2 each independently is hydrogen, alkyl, alkenyl, alkynyl, alkoxy, alkylthio, alkoxycarbonyl, aminocarbonyl or alkylthioalkyl, or together are ##STR2## R.sub.3 is hydrogen or halogen, R.sub.4 is hydrogen or C.sub.1 -C.sub.4 alkyl, andX is oxygen or sulfur,Which possess insecticidal, acaricidal, nematicidal, fungicidal and bactericidal properties.
    Type: Grant
    Filed: February 24, 1975
    Date of Patent: February 15, 1977
    Assignee: Bayer Aktiengesellschaft
    Inventors: Peter Siegle, Engelbert Kuhle, Ingeborg Hammann, Wolfgang Behrenz, Bernhard Homeyer
  • Patent number: 4008362
    Abstract: An 1-N-((S)-.alpha.-substituted-.omega.-aminoacyl)-neamine or -ribostamycin of the formula ##STR1## wherein R is a hydrogen atom or .beta.-D-ribofuranosyl group of the formula ##STR2## and R.sub.3 is hydroxyl, amino-NH.sub.2 or acylamino group --NHR.sub.4 in which R.sub.4 is an acyl group, and n is a whole number of 1 to 4, may be produced by subjecting the corresponding O-((S)-.alpha.-substituted-.omega.-aminoacyl)-neamine or -ribostamycin of the formula ##STR3## or its hydroxyl-masked and maino-masked form, to the action of a basic medium to produce an acyl-migration product of the formula: ##STR4## and, optionally converting the amino-masking groups into hydrogen atoms and also the hydroxyl-masking group into hydroge atom in a known manner if said amino-masking groups and said hydroxyl-masking groups are present in the acyl-migration product. The 1-N-((S)-.alpha.-substituted-.omega.
    Type: Grant
    Filed: August 21, 1973
    Date of Patent: February 15, 1977
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Eiichi Akita, Tsutomu Tsuchiya, Shinichi Kondo, Shuntaro Yasuda, Sumio Umezawa, Hamao Umezawa
  • Patent number: 4008069
    Abstract: Certain noxious weeds, particularly yellow foxtail (Setaria glanca) and beggarweed (Desmodium torguosum) are combated in a number of crops by preemergent application of a synergistic combination of preferably about two parts by weight of N-benzyl-N-isopropylpivalamide with one part by weight of 2-cyclopropanecarboxamide-5-(2-chloro-1,1-dimethylethyl)-1,3,4-thiadiazole . Synergistic interaction of the two compounds is graphically illustrated by isobole charts of application rates which produce severe injury to specific weeds.
    Type: Grant
    Filed: September 13, 1972
    Date of Patent: February 15, 1977
    Assignee: Gulf Research & Development Company
    Inventor: James L. Ahle
  • Patent number: 4008209
    Abstract: The novel nonapeptide amide derivatives of the formula(Pyr)Glu-His-Trp-Ser-R.sub.1 -R.sub.2 -R.sub.3 -Arg-Pro-NH-R.sub.4wherein R.sub.1 is Tyr or Phe; R.sub.2 is D-Leu, D-Ile, D-Nle, D-Val, D-NVa, D-Abu, .alpha.-Aibu, D-Phe, D-Phg, D-Ser, D-Thr or D-Met; R.sub.3 is Leu, Ile or Nle and R.sub.4 is alkyl of 1 to 3 carbon atoms which may be substituted with hydroxyl group have a strong ovulation inducing activity.
    Type: Grant
    Filed: July 11, 1975
    Date of Patent: February 15, 1977
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Masahiko Fujino, Tsunehiko Fukuda, Susumu Shinagawa
  • Patent number: 4007195
    Abstract: Heterocyclic substituted fluoran compounds of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 independently of the other, represent hydrogen, alkyl with 1 to 4 carbon atoms, nitro or halogen orR.sub.2 and R.sub.3 together complete a condensed carbocyclic ring,X.sub.1 and X.sub.2 independently of the other, represent hydrogen, alkyl with 1 to 12 carbon atoms, alkenyl with at most 12 carbon atoms, alkoxyalkyl with 2 to 8 carbon atoms, alkoxycarbonylalkyl with 3 to 9 carbon atoms cycloalkyl with 5 or 6 carbon atoms, acyl having 1 to 12 carbon atoms, or optionally substituted benzyl, phenyl or naphthyl, andThe nitrogen ring A represents a heterocyclic radical which optionally includes a further hetero atom as a ring member and the benzene ring B may be further substituted by nitro or 1 to 4 halogen atoms. These fluorans compounds are particularly useful as color formers which give intense dark green, grey black or red colors when they are brought into contact with an electron-accepting co-reactant.
    Type: Grant
    Filed: September 30, 1975
    Date of Patent: February 8, 1977
    Assignee: Ciba-Geigy AG
    Inventors: Robert Garner, Jean Claude Petitpierre
  • Patent number: 4007239
    Abstract: Novel aromatic diamines having the general formula ##STR1## WHEREIN N IS AN INTEGER OF FROM 2 TO 8, X is sulfur or oxygen, and R is an n-valent hydrocarbon radical which may be interrupted by O or S atoms and which is obtained by removing OH or SH groups from a polyol or polythiol having a molecular weight of less than 600, are prepared by reacting a compound having the formula (HX).sub.n R where X, n and R are as defined above with about n-equivalents of an isatoic acid anhydride in the presence of a strong base. The aromatic diamines of the invention are particularly useful as the active hydrogen containing component for reaction with polyisocyanates in the preparation of synthetic resins by the isocyanate-polyaddition process.
    Type: Grant
    Filed: October 6, 1975
    Date of Patent: February 8, 1977
    Assignee: Bayer Aktiengesellschaft
    Inventors: Johannes Blahak, Erwin Muller, Helmut Kleimann
  • Patent number: 4007260
    Abstract: Dental creams, particularly translucent dental creams, containing finely divided synthetic amorphous silica polishing agents, such polishing agents have an average refractive index of from about 1.410 to 1.440.
    Type: Grant
    Filed: July 18, 1975
    Date of Patent: February 8, 1977
    Assignee: Monsanto Company
    Inventor: Keun Y. Kim
  • Patent number: 4007213
    Abstract: Process for the manufacture of 1-(N-.beta.-cyanethylamino)-3-acylaminobenzenes of the formula (1) ##STR1## in which R.sub.1 represents hydrogen, methyl or alkoxy of 1 to 4 carbon atoms, R.sub.2 represents hydrogen, alkyl from 1 to 3 carbon atoms or phenyl, R.sub.3 represents hydrogen or alkyl from 1 to 3 carbon atoms, and n represents the integer 0 or 1, which comprises reacting 1 mole of an amino of the formula (2) ##STR2## in which R.sub.1, R.sub.2 and R.sub.3 are defined as above, with 1 to 1.75 moles of acrylonitrile between 70.degree. and 150.degree. C in water with the addition of 1 to 30% by weight of an organic carboxylic acid or carbonic acid, and oxethylating the compound at the said formula (1) obtained, if n stands for the integer 0, without or after isolation, with 1 to 10 moles of ethylene oxide between 50.degree. and 100.degree. C.
    Type: Grant
    Filed: April 27, 1976
    Date of Patent: February 8, 1977
    Assignee: Hoechst Aktiengesellschaft
    Inventor: Rudolf Schickfluss
  • Patent number: 4007223
    Abstract: Process of preparing a not discolored p-nitrobenzoic acid by oxidation of p-nitrotoluene with oxygen, which comprises contacting the oxygen with the p-nitrotoluene in an acetic acid reaction medium and in the presence of a cobalt-containing and bromine-containing catalyst at a temperature of 80.degree. to 150.degree. C. The cobalt is present as a cobalt salt in the amount of 0.01 to 0.1 moles per mole of p-nitrotoluene, and the amount of acetic acid is 3 to 15 moles per mole p-nitrotoluene.
    Type: Grant
    Filed: December 23, 1974
    Date of Patent: February 8, 1977
    Assignee: Dynamit Nobel Aktiengesellschaft
    Inventors: Marcel Feld, Hermann Richtzenhain
  • Patent number: 4007166
    Abstract: Meglumine complexes of fungicidal polyene macrolide antibiotics of the formula: ##STR1## wherein R is the remainder of a fungicidal polyene macrolide antibiotic.
    Type: Grant
    Filed: April 24, 1974
    Date of Patent: February 8, 1977
    Inventors: Valter Osvaldovich Kulbakh, Tatyana Mikhailovna Kokushina, Irina Kondratievna Lagert, Georgy Avxentievich Mikhailets, Galina Vasilievna Kholodova, Oleg Nikolaevich Ekzemplyarov, Ruvim Bentsionovich Zelmanov, Leonid Borisovich Sokolov, Evgeny Davidovich Etingov, Irina Mikhailovna Lushitskaya
  • Patent number: 4006133
    Abstract: New derivatives of the antibiotic butirosin A having the formula: ##STR1## in which R is a radical of formula (II): ##STR2## and pharmaceutically acceptable acid addition salts thereof. The butirosin A derivatives of formula (I) can be prepared by reduction of a 5"-azido compound having the formula (III): ##STR3## in which R' is the same groups R or a group which, on reduction, gives a group of formula (II).The butirosin A derivatives of general formula (I) and pharmaceutically acceptable acid addition salts thereof are active against a broad spectrum of Gram-positive and Gram-negative bacteria, including some butirosin-resistant strains.
    Type: Grant
    Filed: October 18, 1974
    Date of Patent: February 1, 1977
    Assignee: Sankyo Company Limited
    Inventors: Eiji Ohki, Hiromichi Saeki, Shinichi Sugawara
  • Patent number: 4006225
    Abstract: Everninomicin antibiotics having a nitro function, e.g. everninomicin B, everninomicin C, and everninomicin D, upon treatment with aluminum amalgam in aqueous alkanol are converted to a mixture of at least two reduction products having antibacterial activity, said reduction products being an everninomicin having a nitroso function and an everninomicin having a hydroxylamino function. The nitrosoeverninomicins are also prepared by treating the corresponding hydroxylaminoeverninomicin with an oxidizing reagent selected from the group consisting of aerial oxidation in alkaline solution, and an alkali metal hypobromite in an aprotic solvent. The everninomicin reduction products and salts thereof are described as well as nitrone derivatives of the hydroxylaminoeverninomicins and salts thereof, all of which possess antibacterial activity. A preferred compound is hydroxylaminoeverninomicin D, particularly the sodium salt thereof.
    Type: Grant
    Filed: April 21, 1975
    Date of Patent: February 1, 1977
    Assignee: Schering Corporation
    Inventors: Ashit K. Ganguly, Olga Sarre
  • Patent number: 4006223
    Abstract: Pharmaceutical compositions comprising an .alpha..sub.1 glycoproteic complex, a lipoprotic complex, a kalikrein-inhibitor polypeptide, thiaminediphosphate and L-tryptophan are disclosed. The compositions may be administered to afflicted man and animals to treat radiation disease without prior and exact determination of the time of exposure to the radiation.
    Type: Grant
    Filed: December 16, 1974
    Date of Patent: February 1, 1977
    Assignee: Spitalul Clinic Filantropia Bucuresti
    Inventors: Irina Chitulescu, Octav Costachel
  • Patent number: 4006134
    Abstract: Calcium sucrose phosphate is manufactured in a unit operating on a semi-continuous principle by circulating a lime-sugar slurry continuously at a high rate from a holding vessel through a heat exchanger as precooler, a cooled scraped-wall reactor into which phosphorus oxychloride is injected and then back to the holding vessel. The serious problem of gel formation of the reaction mixture on cooling surfaces is obviated by this circulation technique.
    Type: Grant
    Filed: January 9, 1976
    Date of Patent: February 1, 1977
    Assignee: Imperial Chemical Industries Limited
    Inventor: John Whetstone
  • Patent number: 4006161
    Abstract: Thio-substituted 2-oxoindolines have the formula ##SPC1##In which one of R or R.sub.1 is hydrogen and the other is R.sub.2 --S--, in which R.sub.2 is C.sub.1 -C.sub.3 alkyl, benzyl, halobenzyl, nitrobenzyl, C.sub.1 -C.sub.3 alkylbenzyl, or phenyl. These compounds are active in relieving a condition associated with anxiety, tension, or like emotional disturbances.
    Type: Grant
    Filed: December 26, 1973
    Date of Patent: February 1, 1977
    Assignee: Eli Lilly and Company
    Inventors: Richard E. Holmes, Glen P. Jourdan
  • Patent number: 4006188
    Abstract: Novel aliphatic di- and tri-olefinic acids, esters, thio S-acids, S-thioates, ketones and amides, intermediates therefor, and the control of insects therewith.
    Type: Grant
    Filed: April 30, 1976
    Date of Patent: February 1, 1977
    Assignee: Zoecon Corporation
    Inventors: Clive A. Henrick, Jeffery N. Labovitz