Abstract: A 2-thio-6-chlorouracil having the formula: ##STR1## wherein R.sub.1, R.sub.3 and R.sub.5 are the same or different and represent an alkyl, aryl or aralkyl group. R.sub.1 can also be hydrogen or an alkenyl group. These compounds are useful as inhibitors of the enzyme, alcohol dehydrogenase.

Abstract: New compounds are derived from intra-molecular and inter-molecular, in the case of a polymer, sulphur bridged hydrocarbon rings containing from 6 to 12 carbon atoms. The hydrocarbon ring is preferably 1,5-cyclooctadiene. The compounds also contain the residue of an alkyl, alkenyl or aralkyl xanthate and may also contain the residue of a further nucleophilic group. The new compounds are useful in lubricating oil compositions. The compositions may also contain other conventional lubricant additives.

Abstract: Compounds of the formula 1 or 1a ##STR1##HSCH.sub.2 CH(R)CO--Lys--Asn--Phe--Phe--Trp--Lys--Thr--Phe--Thr--Ser--NHCH.sub.2 CH.sub.2 SH (1a)In which R is hydrogen or NHR.sup.1 in which R.sup.1 is lower aliphatic acyl containing from 1 - 6 carbon atoms or benzoyl, and pharmaceutically acceptable salts thereof are disclosed. The compounds of formulae 1 and 1a are useful for the management of diabetes and the treatment of acromegaly in mammals. Methods for their use also are disclosed.

Abstract: Gas-free paste or gel dentifrices are made by a process which includes producing a degassed gel of a gelling agent in a polyhydric alcohol, and admixing it with other dentifrice constituents, including powdered light weight polishing agent, under vacuum. Preferably, the powdered polishing agent is degassed in a vacuum hopper, before addition to the gel base in a mixer. Where no vacuum hopper or similar facilities are available, however, powdered polishing agent may be added to the gel in a suitable mixer with adequate head space and any gas present is removed from it by vacuum while it is resting on the surface of the gel, after which the polishing agent is mixed in with the gel.

Abstract: A method is disclosed for the preparation of thiocarbamic acid esters by reacting an aminic compound with carbon monoxide and an organic disulphide. Elemental selenium is used as the catalyst, possibly supplemented by a tertiary amine. The temperature and pressure ranges are comparatively wide.

Abstract: Tetrahydro-1,3-thiazinium salts of the formula ##STR1## where X is an anion, R.sup.2 hydrogen or hydroxyl, and R and R.sup.1 are alkyl, hydroxyl substituted alkyl, or a heterocyclic ring, are prepared by reacting a secondary amine with formaldehyde and a 3-halopropanethiol. The salts are useful as pesticides and as sensitizers for photographic silver halide emulsions.

Abstract: This invention relates to highly fluorinated diazides of the formula N.sub.3 CH.sub.2 (CF.sub.2).sub.x CH.sub.2 N.sub.3 wherein x is a positive integer from 2 to 12; to the preparation of these diazides by the reaction of excess sodium azide with a ditosylate of the formula C.sub.7 H.sub.7 SO.sub.3 CH.sub.2 (CF.sub.2).sub.x CH.sub.2 O.sub.3 SC.sub.7 H.sub.7 wherein x has the same meaning given above; and to the synthesis of highly fluorinated primary diamines of the formula H.sub.2 NCH.sub.2 (CF.sub.2).sub.x CH.sub.2 NH.sub.2 wherein x has the same meaning given above by catalytic hydrogenation of said diazides.

Abstract: A polypeptide of the formula:X.sub.1 --Tyr--Ser--X.sub.2 --X.sub.3 --His--Phe--Arg--Trp--Gly--Lys--Pro--Val--Gly--(Lys).sub.n --Ywherein X.sub.1 is .alpha.-aminoisobutyric acid, .beta.-alanine, L-serine, D-serine, glycine, D-alanine, .gamma.-aminobutyric acid or sarcosine residue; X.sub.2 is L-methionine, L-norleucine, L-isoleucine or L-norvaline residue; X.sub.3 is L-glutamic acid or L-glutamine residue; n is an integer of 5-10; and Y is --R.sub.1, ##STR1## wherein R.sub.1 is hydroxy or lower alkoxy having 1-5 carbon atoms; R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are each hydrogen or lower alkyl having 1-5 carbon atoms; m is an integer of 1-10 and Y is a group bound to the carbonyl group of the C-terminal lysine residue; non-toxic acid addition salts thereof; and complexes thereof; being useful as a medicament owing to their strong adrenal-stimulating activity with protracted action and little side effects.

Abstract: A polypeptide of the formula:X.sub.1 -Tyr-Ser-X.sub.2 -X.sub.3 -His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-(Lys).sub.n -Ywherein X.sub.1 is .alpha.-aminoisobutyric acid, .beta.-alanine, L-serine, glycine, D-serine, D-alanine, .gamma.-aminobutyric acid or sarcosine residue; X.sub.2 is L-methionine, L-norleucine, L-isoleucine or L-norvaline residue; X.sub.3 is L-glutamic acid or L-glutamine residue; n is an integer of 1-4 and Y is a group of ##STR1## which is linked to the carbonyl group of the C-terminal lysine residue, wherein R.sub.1 and R.sub.2 are each hydrogen or the same or different lower alkyl having 1-5 carbon atoms, and R.sub.1 and R.sub.2, when taken together with or without another hetero atom, form a substituted or unsubstituted nitrogen containing heterocyclic ring, with the proviso that a peptide when X.sub.1 is a .alpha.-aminoisobutyric acid or D-serine, R.sub.1 and R.sub.

Abstract: Poly[2-hydroxyethylene(dimethyliminio)ethylene(dimethyliminio)methylene dichloride] prepared by the reaction of N, N, N', N'-tetramethylethylenediamine with hydrochloric acid and epichlorohydrin is useful as an algicide.

Abstract: The tripeptide derivatives of formula 1H--L--Pro--N(R.sup.1)CH(R.sup.2)CO--Y--R.sup.3 (1)in which R.sup.1 is hydrogen, lower alkyl or NR.sup.4 R.sup.5 wherein R.sup.4 and R.sup.5 each are lower alkyl, R.sup.2 is hydrogen or lower alkyl, R.sup.3 is amino, lower alkylamino, di(lower)alkylamino or amino(lower)alkylamino and Y is one of the amino acid residues Gly or D-Ala with the proviso that when R.sup.1 is NR.sup.4 R.sup.5 wherein R.sup.4 and R.sup.5 are as defined herein and R.sup.2 and Y are as defined herein, R.sup.3 is lower alkylamino, di(lower)alkylamino or amino(lower)alkylamino, and a method for their preparation are disclosed. The tripeptide derivatives of formula 1 possess central nervous system activity and methods for their use are given.

Abstract: The decapeptide [D-Phe.sup.6 ]-LH-RH, salts thereof, and intermediates used for the synthesis thereof are disclosed. The decapeptide has potent LH- and FSH-releasing hormone properties.

Abstract: There is provided a method for the preemergence and postemergence control of undesirable plant species by the application of a herbicidally effective amount of a 1,2,4-trialkyl disubstituted pyrazolium salt to the foliage of said undesirable plant species, and to soil containing seeds thereof.

Abstract: The invention provides a novel therapeutic composition comprising a pharmaceutically acceptable carrier containing a therapeutically effective amount of an ethereal monosubstitution of a monosaccharide derivative having the general formula S-O-Y, wherein S is the residue of the monosaccharide derivative selected from the group consisting of pentoses, hexoses and heptoses as single or polysubstituted acetals, ketals or esters and Y is selected from the group consisting of cyclic monovalent nitrogen-containing organic radicals and residua and monovalent organic radicals and residua having the general formula ##STR1## wherein R.sub.1 is a divalent organic radical having a linear carbon chain length of about 1-7 carbon atoms and R.sub.2 and R.sub.3 are selected from the group consisting of --H, --OH, --SH; halogen and monovalent organic radicals and residua having a linear carbon chain length of about 1-7 carbon atoms.

Abstract: This invention relates to the control of bindweed by applying to the locus of the bindweed a compound selected from compounds having the following formula: ##STR1## wherein R.sub.1 and R.sub.2 independently can be alkyl of 1 to 3 carbon atoms or allyl.

Abstract: Aminoalkylated hydroxyphenylated lignosulfonate is described. The composition is prepared by reacting a hydroxyphenylated lignosulfonate with a nitrogen compound and an aldehyde.

Abstract: This patent describes the catalytic promotion of the reaction of oxirane-containing compounds with carboxylic acid compounds at high, ambient, and low temperature. Specifically, this patent describes the method of reacting oxirane-containing compounds with carboxyl-containing compounds, preferably at temperatures at or around ambient, in the presence of active chromium III tricarboxylate salts which have unoccupied coordination sites. More specifically this patent describes the preparation of catalytically active chromium III-tricarboxylates from normally catalytically inactive chromium III tri-carboxylate hydrates. These compounds are powerful catalysts for the reactions of oxirane compounds with both organic carboxylic acids and cyclic primary imides.

Abstract: Compounds having the formula ##STR1## in which R.sub.1 is lower alkyl, cycloalkyl, or cycloalkyl-alkyl, and R.sub.2 is hydrogen or lower alkoxy. These compounds are selectively useful in controlling insects.

Abstract: This invention relates to a method of controlling bindweed by applying to the locus of the bindweed an effective amount of at least one compound of the formula ##STR1## wherein R.sub.1 is alkyl of 1 to 3 carbon atoms or allyl; and M is hydrogen, ammonium, sodium, lithium, or potassium.

Abstract: Polycarboxy-oxyalkylene polyester-ether polyol intermediates useful in the production of polyurethane products and methods of making the intermediates and polyurethane products are described. The polyol intermediates are made from lignin by reacting lignin with maleic anhydride, substituted maleic anhydride, or mixtures thereof to form carboxylated lignin maleic anhydride copolymers. These copolymers are then reacted with an oxyalkylating medium with or without prior hydrolysis to form the polyol intermediates. These polyester-ether polyol intermediates are then reacted with an isocyanate medium having an isocyanate with at least 2 NC0 groups per molecule to produce polyurethane products with or without simultaneous foaming.