Patents Examined by Lewis Gotts
  • Herbicidal 1-thiadiazolyl-5-carbamoyloxyimidazolidinones
    Patent number: 4023957
    Abstract: This invention discloses new compounds of the formula ##STR1## wherein R.sup.1 is selected from the group consisting of alkyl, alkenyl, haloalkyl, alkoxy, alkylthio, alkylsulfonyl and alkylsulfinyl; R.sup.2 is alkyl; R.sup.3 is selected from the group consisting of hydrogen and alkyl; Y is selected from the group consisting of oxygen and sulfur; and R.sup.4 is selected from the group consisting of hydrogen, alkyl, cycloalkyl and ##STR2## WHEREIN X is selected from the group consisting of alkyl, halogen, haloalkyl and alkoxy, and n is an integer from 0 to 5.
    Type: Grant
    Filed: September 10, 1975
    Date of Patent: May 17, 1977
    Assignee: Velsicol Chemical Corporation
    Inventor: John Krenzer
  • Use of dietary fructose in the control of human stress response
    Patent number: 4024250
    Abstract: Alleviation of physiologically-induced stress in the human body is provided through a dietary regimen including restriction of carbohydrate intake and administration of substantially pure fructose.
    Type: Grant
    Filed: September 10, 1975
    Date of Patent: May 17, 1977
    Inventor: J. Daniel Palm
  • Herbicidal mixed salts of magnesium
    Patent number: 4022610
    Abstract: This invention discloses mixed salts of magnesium having the empirical formula ##STR1## WHEREIN R is an organic acid radical of 7 to 20 carbon atoms; and n has an average value of from 0.5 to 1.5. The compounds of the above description are useful as herbicides.
    Type: Grant
    Filed: May 16, 1975
    Date of Patent: May 10, 1977
    Assignee: Velsicol Chemical Corporation
    Inventor: Takeo Hokama
  • Method for the preparation of salts of carbonic acid monoesters
    Patent number: 4022813
    Abstract: A method is disclosed for preparing salts of monoesters of the carbonic acid, the improvement consisting in that the alcohol corresponding to the monoester is reacted with carbon dioxide and a halide of a metal of the Groups IA, IIA, IIIA and IIB of the Periodic Table, the reaction being effected in the presence of a nitrogenous, aliphatic, aromatic or heterocyclic base.
    Type: Grant
    Filed: December 10, 1975
    Date of Patent: May 10, 1977
    Assignee: ANIC, S.p.A.
    Inventors: Carlo Neri, Gioacchino Cipriani
  • Iodine containing organic carbonates for use as radiographic agents
    Patent number: 4022814
    Abstract: Iodo-aryl carbonates, such as for example, p-iodo-benzyl carbonates, p-iodo-sec-phenethyl carbonates, p-iodo-phenethyl carbonates, p-iodo-phenyl carbonates, 3-(p-iodophenyl)propyl carbonates, 3-(p-iodophenyl)butyl carbonates, 2-(p-iodobenzyl)butyl carbonates and 2-(p-iodobenzyl)-n-hexyl carbonates, for use as radiographic media in connection with such techniques as x-ray applications including myelography, salpingography, lymphography and bronchography. An effective quantity of iodinated organic carbonate provides x-ray contrast, and the compounds of the invention may be characterized generally as carbonates having the general formula ##STR1## wherein R represents an alkyl group having from 4 to 10 carbon atoms and R' represents an iodinated phenyl linked to the ester oxygen through an alkyl chain consisting of 1 to 3 carbon atoms.
    Type: Grant
    Filed: April 22, 1976
    Date of Patent: May 10, 1977
    Assignee: Lafayette Pharmacal, Inc.
    Inventor: Barry N. Newton
  • Anticalculus composition
    Patent number: 4022880
    Abstract: This invention relates to an improved composition for inhibiting dental plaque and calculus formation, comprising zinc ions and a non-toxic, organoleptically acceptable antibacterial agent in an orally acceptable medium, and to a process for retarding the growth of dental plaque and calculus by application to the teeth of the above composition.
    Type: Grant
    Filed: August 11, 1975
    Date of Patent: May 10, 1977
    Assignee: Lever Brothers Company
    Inventors: Leonard J. Vinson, Lewis P. Cancro
  • N-.alpha.-chloroacetyl-N-(1,3-dioxolan-2-ylme thyl)-2-ethyl-6-methylaniline as a herbicide
    Patent number: 4022608
    Abstract: This invention discloses the compound N-.alpha.-chloroacetyl-N-(1,3-dioxolan-2-ylmethyl)-2-ethyl-6-methylaniline and its utility as a herbicide.
    Type: Grant
    Filed: December 17, 1975
    Date of Patent: May 10, 1977
    Assignee: Velsicol Chemical Corporation
    Inventors: Sidney B. Richter, John Krenzer
  • Eosinophilotactic tetrapeptides
    Patent number: 4021387
    Abstract: Two eosinophilotactic tetrapeptides of amino acid sequence Val-Gly-Ser-Glu and Ala-Gly-Ser-Glu have been isolated from extracts of human lung fragments. These tetrapeptides have been synthesized by solid phase peptide synthesis procedures and the synthetic and natural materials behaved similarly in analytical assays and bioassays. Novel N-terminal analogs have been prepared and have shown eosinophilotactic activity. Thus, the tetrapeptides disclosed herein have utility as therapeutic agents in the prophylaxis and/or treatment of parasitic diseases, anaphylaxis and bronchial asthma.
    Type: Grant
    Filed: November 19, 1975
    Date of Patent: May 3, 1977
    Assignee: President and Fellows of Harvard College
    Inventors: Edward J. Goetzl, K. Frank Austen
  • Method for reduction of sucrose loss during storage or sugar beets due to reduction in respiration and invert sugar formation
    Patent number: 4021231
    Abstract: Respiration of sucrose to carbon dioxide and water is reduced and the formation of invert sugar is inhibited in the storage of sugar beets which have had an effective amount of ethylene introduced into the ground near the roots of the growing plants.
    Type: Grant
    Filed: May 14, 1974
    Date of Patent: May 3, 1977
    Assignee: The Great Western Sugar Company
    Inventors: Arthur H. Freytag, Walter R. Akeson
  • Complement inhibitors
    Patent number: 4021545
    Abstract: Inulin poly(H-sulfate) and salts thereof useful as complement inhibitors.
    Type: Grant
    Filed: July 12, 1976
    Date of Patent: May 3, 1977
    Assignee: American Cyanamid Company
    Inventors: Vijay Gopalan Nair, Joseph Peter Joseph, Seymour Bernstein
  • Complement inhibitors
    Patent number: 4021544
    Abstract: Sulfated oligosaccharides of the maltose series useful as complement inhibitors.
    Type: Grant
    Filed: July 12, 1976
    Date of Patent: May 3, 1977
    Assignee: American Cyanamid Company
    Inventors: Vijay Gopalan Nair, Joseph Peter Joseph, Seymour Bernstein
  • Pro-drug forms of digoxin and method of preparing and using same
    Patent number: 4021546
    Abstract: There is provided, a novel pro-drug form of digoxin having the following formula: ##STR1## wherein R represents a member selected from the group consisting of a hydrogen atom, a residue of any naturally occurring amino acid, and a ##STR2## group, wherein X and Y, which may be the same or different, each represent a member selected from the group consisting of a methyl group and an ethyl group, or wherein X and Y may form a (CH.sub.2).sub.4 or (CH.sub.2).sub.5 heterocyclic ring with the N atom to which each of X and Y are attached, and a non-toxic inorganic or organic pharmaceutically acceptable acid addition salt thereof, with the proviso that:When R is a member other than a hydrogen atom, all of said R's must be the same member.These novel compounds will be cleaved in the bloodstream of a warm-blooded animal, thus delivering digoxin in a cardiotonic effective amount.
    Type: Grant
    Filed: March 8, 1976
    Date of Patent: May 3, 1977
    Assignee: Interx Research Corporation
    Inventor: Nicolae S. Bodor
  • Method of removing formyl groups from N-formyl-amino acid and N-formyl-peptide esters
    Patent number: 4021418
    Abstract: The masking N-formyl group of an N-formyl-amino acid ester or N-formyl-peptide ester is removed without major side reactions when the ester is reacted in an inert liquid medium with hydroxylamine of which at least 70% is present in the form of a salt with a strong acid, the remainder, if any, being present as the free base or the salt of a weak acid.
    Type: Grant
    Filed: November 26, 1975
    Date of Patent: May 3, 1977
    Assignee: Ajinomoto Co., Inc.
    Inventors: Tadashi Takemoto, Fusayoshi Kakizaki, Yasuo Ariyoshi, Ichiro Noda
  • 2,5-Dimethyl-1-pyrrole-lower-alkanecarboxamides
    Patent number: 4021566
    Abstract: 2,5-Dimethyl-1-pyrrole-lower-alkanecarboxamides, prepared by reaction of a 3-R.sub.3 -4-R.sub.4 -2,5-hexanedione with either an .omega.-amino-lower-alkanonitrile or an .omega.-amino-lower-alkanecarboxamide, and if appropriate, hydrolysis of the resulting 2,5-dimethyl-3-R.sub.3 -4-R.sub.4 -1-pyrrole-lower-alkano-nitrile, have anti-secretory and anti-ulcer activities.
    Type: Grant
    Filed: October 21, 1975
    Date of Patent: May 3, 1977
    Assignee: Sterling Drug Inc.
    Inventor: Malcolm Rice Bell
  • 3.beta.-(.alpha.-L-althromethylosyl)-14.beta.-hydroxy-bufa-4,20,22-trieno lide and acylated derivatives thereof
    Patent number: 4021547
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are hydrogen or carboxylic acyl, particularly acetyl, benzoyl or p-nitro-benzoyl; the compounds are useful as cardiotonics.
    Type: Grant
    Filed: January 21, 1976
    Date of Patent: May 3, 1977
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Walter Losel, Werner Traunecker, Wolfgang Hoefke
  • Reagents used in the radioimmunoassay of digoxin
    Patent number: 4021535
    Abstract: The derivatives of digoxin useful in the radioimmunoassay of digoxin having the following formulae: ##STR1## where R is a carboxylic acid ester. These derivatives are formed by the following process: (1) reacting the carboxylic acid in the presence of trifluoroacetic anhydride with a solution of digoxin in an inert, nonaqueous solvent medium, (2) adding water so as to form the above derivatives, (3) purifying the above derivatives from other constituents of the reaction mixture and (4) radio-labeling these derivatives for use as a labeled hapten in the radioimmunoassay of digoxin.The preferred carboxylic acids are imidazoleacetic acid and p-hydroxyphenylpropionic acid. The preferred radioactive isotope is .sup.125 I.
    Type: Grant
    Filed: January 14, 1975
    Date of Patent: May 3, 1977
    Assignee: Beckman Instruments, Inc.
    Inventor: Alan J. Polito
  • Herbicides
    Patent number: 4021226
    Abstract: New and valuable herbicide based on 1-phenyl-4-amino-5-chloro (or -5-bromo)-pyridazone-(6) in the form of an aqueous suspension.
    Type: Grant
    Filed: October 8, 1975
    Date of Patent: May 3, 1977
    Assignee: BASF Aktiengesellschaft
    Inventors: Helmut Preugschas, Ewald Daubach, Roman Fischer, Manfred Herrmann
  • 2-Methoxy-benzamide derivatives
    Patent number: 4021567
    Abstract: The invention provides novel 2-methoxy-benzamide derivatives of the formula: ##STR1## in which n is 1 or 2; R.sub.1 represents a cycloalkyl-alkyl radical of formula:(CH.sub.2).sub.m -CH-A- ,a phenylalkyl radical of formula ##STR2## (in which m is an integer from 2 to 5, A is a linear or branched alkylene chain of 1 to 4 carbon atoms, and R.sub.4 is hydrogen, halogen, especially fluorine or chlorine, trifluoromethyl, or alkyl or alkoxy of 1 to 3 carbon atoms), CNCH.sub.2 -CH.sub.2 -, CH.tbd.C-CH.sub.2 -, ##STR3## R.sub.2 is either chlorine, SO.sub.2 R.sub.5 (in which R.sub.5 is alkyl of 1 to 4 carbon atoms), or SO.sub.2 NR.sub.6 R.sub.7 (in which, R.sub.6 and R.sub.7, which are identical or different, represent, independently of one another, hydrogen or alkyl of 1 to 4 carbon atoms); and R.sub.
    Type: Grant
    Filed: December 16, 1975
    Date of Patent: May 3, 1977
    Assignee: Synthelabo
    Inventors: Jean-Pierre Kaplan, Bernard Michel Raizon, Daniel Charles Leon Obitz, Philippe Michel Jacques Manoury, Henry Najer, Maurice Jalfre, Don Pierre Rene Lucien Giudicelli
  • Process for disguising saline taste of pharmaceuticals and product thereof
    Patent number: 4021543
    Abstract: Glucose polymers having an average chain length of 3 - 8 units are added to an electrolyte solution which normally has a saline taste in an amount to substantially disguise the saline taste of the electrolyte solution. Preferably, the polymer is added in an amount in the range of 15% to 50% by weight and the electrolyte solution contains the usual chloride salts of calcium, magnesium and potassium with the solution having a pH in the range of 3 - 6.
    Type: Grant
    Filed: March 28, 1975
    Date of Patent: May 3, 1977
    Assignee: Abbott Laboratories
    Inventor: Gene Darrell McKay
  • Preparation of a hepatitis B immune globulin and use thereof as a prophylactic material
    Patent number: 4021540
    Abstract: A method for producing a novel immunizing agent is described. The immunizing agent is anti-HB.sub.s gamma globulin essentially free of fibrinogen, plasminogen, 19 S globulin and lipids found to be effective in immunizing against hepatitis B virus disease. The method of producing this material involves fractionation of human plasma utilizing selective solvent and control of pH, temperature and ionic strength.
    Type: Grant
    Filed: July 28, 1975
    Date of Patent: May 3, 1977
    Assignee: Ortho Diagnostics Inc.
    Inventors: William Pollack, Albert McKee