Patents Examined by Robert T. Crow
  • Sensor arrays and nucleic acid sequencing applications
    Patent number: 9695472
    Abstract: Embodiments of the present invention provide devices methods for sequencing DNA using arrays of reaction regions containing electronic sensors to monitor changes in solutions contained in the reaction regions. Test and fill reaction schemes are disclosed that allow DNA to be sequenced. By sequencing DNA using parallel reactions contained in large arrays, DNA can be rapidly sequenced.
    Type: Grant
    Filed: November 19, 2010
    Date of Patent: July 4, 2017
    Assignee: INTEL CORPORATION
    Inventors: Xing Su, Kai Wu
  • Compositions and methods for target delivering a bioactive agent to aquatic organisms
    Patent number: 9693552
    Abstract: Biodegradable and nutritionally attractive composition comprising biocidal or antibiotic compounds and/or microbes having bio-adhesion and controlled buoyancy properties are selectively fed to an aquatic organism in open or closed water-bodies, and bioactive components are released upon contact with mucosal tissues such as gill, skin or along the digestive tract of the selected aquatic organism.
    Type: Grant
    Filed: February 21, 2013
    Date of Patent: July 4, 2017
    Assignee: ADVANCED BIONUTRITION CORPORATION
    Inventors: Moti Harel, Brian Carpenter, Pete Schmalz
  • Sodium nitrite-containing pharmaceutical compositions
    Patent number: 9687505
    Abstract: Provided herein are pharmaceutically acceptable sodium nitrite and pharmaceutical compositions thereof. Also provided herein are methods for determining the total non-volatile organic carbon in a sodium nitrite-containing sample. Further provided herein are methods for producing pharmaceutically acceptable sodium nitrite. Still further provided herein are methods of treatment comprising the administration of pharmaceutically acceptable sodium nitrite.
    Type: Grant
    Filed: August 29, 2016
    Date of Patent: June 27, 2017
    Assignee: Hope Medical Enterprises, Inc.
    Inventors: Craig Sherman, Anthony James Lepine, Catherine Marie Smith, Kevin Robert Wirtz, Erich Schulze
  • Sodium nitrite-containing pharmaceutical compositions
    Patent number: 9687506
    Abstract: Provided herein are pharmaceutically acceptable sodium nitrite and pharmaceutical compositions thereof. Also provided herein are methods for determining the total non-volatile organic carbon in a sodium nitrite-containing sample. Further provided herein are methods for producing pharmaceutically acceptable sodium nitrite. Still further provided herein are methods of treatment comprising the administration of pharmaceutically acceptable sodium nitrite.
    Type: Grant
    Filed: August 30, 2016
    Date of Patent: June 27, 2017
    Assignee: Hope Medical Enterprises, Inc.
    Inventors: Craig Sherman, Anthony James Lepine, Catherine Marie Smith, Kevin Robert Wirtz, Erich Schulze
  • Control of enzyme translocation in nanopore sequencing
    Patent number: 9678056
    Abstract: The invention relates to devices and methods for nanopore sequencing. Methods for controlling translocation of through the nanopore are disclosed. The rate of transport of the template nucleic acids through the nanopore can be controlled using a translocating enzyme having two slow kinetic steps. The translocating enzyme and reaction conditions can be selected such that the translocating enzyme exhibits two kinetic steps wherein each of the kinetic steps has a rate constant, and the ratio of the rate constants of the kinetic steps is from 10:1 to 1:10. The invention also provides for using the signals from n-mers to provide sequence information, for example where the system has less than single base resolution. The invention includes arrays of nanopores having incorporated electronic circuits, for example, in CMOS.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: June 13, 2017
    Assignee: Pacific Biosciense of California, Inc.
    Inventors: Stephen Turner, Benjamin Flusberg
  • Chemical sensor, chemical sensor module, biomolecule detection apparatus, and biomolecule detection method
    Patent number: 9670532
    Abstract: A chemical sensor including a substrate, an on-chip lens layer, and a flattening layer. On the substrate, a plurality of photodiodes are formed and arranged in a planar form. The on-chip lens layer collects incident light to the photodiodes and is provided on the substrate. The flattening layer covers and planarizes the on-chip lens to form a probe holding surface for holding a probe material.
    Type: Grant
    Filed: October 11, 2012
    Date of Patent: June 6, 2017
    Assignee: SONY CORPORATION
    Inventors: Nobuyuki Matsuzawa, Kensaku Maeda, Yusuke Moriya, Ken Ozawa
  • Multifunctional topical formulation for the treatment of acne vulgaris and other skin conditions
    Patent number: 9662341
    Abstract: A two-part aqueous composition for treating skin ailments, such as acne vulgaris, includes an acidic part having salicylic acid and an ?-hydroxy acid, and an alkaline part having an alkaline nitrite salt. The ?-hydroxy acid is preferably glycolic acid, lactic acid, malic acid, mandelic acid or a combination thereof. The alkaline nitrite salt is preferably sodium nitrite. The acidic part and the alkaline part are an acidic aqueous solution and an alkaline aqueous solution, respectively, which may either be mixed with one another then applied to an affected portion of a patient's skin or, alternatively, may be sequentially applied to the affected portion of the patient's skin, preferably within 15 minutes of one another.
    Type: Grant
    Filed: March 28, 2016
    Date of Patent: May 30, 2017
    Assignee: Kantian Sciences Corporation
    Inventor: Robert D. Kross
  • Integrated optoelectronic read head and fluidic cartridge useful for nucleic acid sequencing
    Patent number: 9650669
    Abstract: A detection apparatus having a read head including a plurality of microfluorometers positioned to simultaneously acquire a plurality of the wide-field images in a common plane; and (b) a translation stage configured to move the read head along a substrate that is in the common plane. The substrate can be a flow cell that is included in a cartridge, the cartridge also including a housing for (i) a sample reservoir; (ii) a fluidic line between the sample reservoir and the flow cell; (iii) several reagent reservoirs in fluid communication with the flow cell, (iv) at least one valve configured to mediate fluid communication between the reservoirs and the flow cell; and (v) at least one pressure source configured to move liquids from the reservoirs to the flow cell. The detection apparatus and cartridge can be used together or independent of each other.
    Type: Grant
    Filed: July 18, 2014
    Date of Patent: May 16, 2017
    Assignee: Illumina, Inc.
    Inventors: Dale Buermann, John A. Moon, Bryan Crane, Mark Wang, Stanley S. Hong, Jason Harris, Matthew Hage, Mark J. Nibbe
  • Modified sophorolipids as oil solubilizing agents
    Patent number: 9650405
    Abstract: A method for the development of a library of modified sophorolipids using a wide-range of chemical and enzyme catalyst tools to identify modified sophorolipids that can be used in pure form, as mixtures with other modified sophorolipids, as mixtures with natural sophorolipids, as mixtures with modified and natural sophorolipids, and as mixtures with other compounds known by one skilled in the art for use in the dispersion, solubilization or emulsification of various oil types and nutraceuticals, and modified sophorolipids for use in dispersion, solubilization or emulsification processes.
    Type: Grant
    Filed: May 27, 2013
    Date of Patent: May 16, 2017
    Assignee: Synthezyme, LLC
    Inventors: Richard A. Gross, Thavasi Rengathavasi, Amanda Koh, Yifeng Peng
  • Method for producing an aqueous stable chlorine dioxide solution
    Patent number: 9630841
    Abstract: The invention relates to a method for producing an ultrapure, aqueous, long-term- and storage-stable, and thus transportable chlorine dioxide solution, comprising the steps of providing chlorite, providing peroxodisulfate, and combining chlorite and peroxodisulfate in an aqueous system and in a molar ratio of peroxodisulfate to chlorite [S2O82?]/[ClO2?] of greater than 1, forming the aqueous chlorine dioxide solution, wherein no additional buffer is added to produce the aqueous chlorine dioxide solution. The invention further relates to a corresponding chlorine dioxide solution, to the use of said chlorine dioxide solution, and to a device for producing the chlorine dioxide solution.
    Type: Grant
    Filed: December 22, 2011
    Date of Patent: April 25, 2017
    Assignee: A.P.F. AQUA SYSTEM AG
    Inventor: Helmut Uhlmann
  • Cell analysis apparatus and cell analysis method
    Patent number: 9625388
    Abstract: A cell analysis apparatus that can accurately distinguish between an aggregating cell and a non-aggregating cell is provided.
    Type: Grant
    Filed: April 19, 2010
    Date of Patent: April 18, 2017
    Assignee: SYSMEX CORPORATION
    Inventors: Masaki Ishisaka, Kazuki Kishi, Masakazu Fukuda
  • Ruggedized apparatus for analysis of nucleic acid and proteins
    Patent number: 9606083
    Abstract: The invention provides methods and systems for ruggedizing a nucleic acid analyzing apparatus. The ruggedized apparatus can be used reliably and effectively in uncontrolled environments, such as, for example at a crime scene to collect and analyze forensic data, as well as in semi-controlled environments, such as, for example at a point of care location.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: March 28, 2017
    Assignee: NETBIO, INC.
    Inventors: Eugene Tan, Heung Chuan Lam, Gregory John Kellogg
  • Device and methods for molecular analysis
    Patent number: 9605298
    Abstract: Systems and methods are provided for high speed sorting of objects in a continuous body of fluid. The object can be analyzed within one or more interrogation volumes that allow for simultaneous or time-correlated measurement of the object's properties. A processor can interpret the properties of the object and then measured and then direct the object to one of a plurality of downstream flow paths. In some embodiments, the sorting of the object is based on two or more properties of the object. The sorting process can be repeated to create a network of sorting events.
    Type: Grant
    Filed: August 6, 2010
    Date of Patent: March 28, 2017
    Assignee: Cornell University
    Inventors: Harold G. Craighead, Benjamin R. Cipriany, Stephen Levy, Paul Soloway
  • Sodium nitrite-containing pharmaceutical compositions
    Patent number: 9597354
    Abstract: Provided herein are pharmaceutically acceptable sodium nitrite and pharmaceutical compositions thereof. Also provided herein are methods for determining the total non-volatile organic carbon in a sodium nitrite-containing sample. Further provided herein are methods for producing pharmaceutically acceptable sodium nitrite. Still further provided herein are methods of treatment comprising the administration of pharmaceutically acceptable sodium nitrite.
    Type: Grant
    Filed: November 19, 2014
    Date of Patent: March 21, 2017
    Assignee: Hope Medical Enterprises, Inc.
    Inventors: Craig Sherman, Anthony James Lepine, Catherine Marie Smith, Kevin Robert Wirtz, Erich Schulze
  • G-quadruplex binding assays and compounds therefor
    Patent number: 9598719
    Abstract: The present invention provides methods for assaying binding of compounds to G-quadruplex structures. Also provided are methods for screening candidate compounds for use as modulators of G-quadruplex activity, and methods for screening candidate compounds for telomerase inhibitory activity. The invention further provides novel compounds useful in the assays of the invention.
    Type: Grant
    Filed: April 25, 2014
    Date of Patent: March 21, 2017
    Inventor: Lesley Davenport
  • Tyrosine derivatives and compositions comprising them
    Patent number: 9585841
    Abstract: Provided herein are methods comprising providing a tyrosine derivative and a solid particulate material (and, optionally, melanin) and applying force to said tyrosine derivative and said solid particulate material for a time and under conditions effective to impregnate at least one of said tyrosine derivative and said solid particulate material with the other of said tyrosine derivative and said solid particulate material. The invention also provides compositions comprising at least one of a tyrosine derivative impregnated with a solid particulate material and a solid particulate material impregnated with a tyrosine derivative.
    Type: Grant
    Filed: October 24, 2013
    Date of Patent: March 7, 2017
    Assignee: Tyme, Inc.
    Inventor: Steven Hoffman
  • Diagnostic and sample preparation devices and methods
    Patent number: 9580742
    Abstract: Contemplated methods and devices are drawn to preparation and analysis of analytes from biological samples. In a preferred embodiment the analytes are nucleic acids that are both released from biological compartment present in the sample and fragmented through the use of a voltage potential applied to a pair of electrodes. The nucleic acids thus prepared are subsequently characterized.
    Type: Grant
    Filed: March 12, 2012
    Date of Patent: February 28, 2017
    Inventors: Shana O. Kelley, Susan Bortolin, Reginald James McKenzie Orton, Stefan Christopher Wiechula
  • Metallic nanoparticle synthesis with carbohydrate capping agent
    Patent number: 9581590
    Abstract: The disclosure relates to metal nanoparticle compositions and their methods of formation and use, in particular gold nanoparticles (AuNP) and gold-coated magnetic nanoparticles. Compositions according to the disclosure include aqueous suspensions of metal nanoparticles that are stabilized with one or more carbohydrate capping agents and/or that are functionalized with one or more binding pair members for capture/detection of a target analyte. The nanoparticle suspensions are stable for extended periods and can be functionalized as desired at a later point in time, typically prior to use in an assay for the detection of a target biological analyte. The stable nanoparticle suspension can be formed by the aqueous reduction of oxidized metal precursors at non-acidic pH values in the presence of a carbohydrate-based capping agent such as dextrin or other oligosaccharides.
    Type: Grant
    Filed: November 7, 2012
    Date of Patent: February 28, 2017
    Assignee: BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
    Inventors: Evangelyn C. Alocilja, Michael J. Anderson, Edith Torres-Chavolla
  • Animal attractant system
    Patent number: 9565855
    Abstract: Animal attractant compositions, devices, systems and methods that can be deployed to attract game animals, such as deer by stimulating several of the animal's senses to attract animals to a desired location. The invention can use a combination of ultraviolet brighteners for visual interest and one or more of deer urine based scents, foods, mineral or salt. The invention capitalizes on the link between many animals' ability to see ultraviolet light with their desire to visualize urine territory markers left by other animals of the same species.
    Type: Grant
    Filed: October 9, 2015
    Date of Patent: February 14, 2017
    Assignee: Thought Streams, LLC
    Inventors: Todd Kuhn, Joseph J. Gizdic, III
  • Method for nucleic acid detection using voltage enhancement
    Patent number: 9551026
    Abstract: Methods are provided for carrying out DNA sequencing on a device having upper and lower conductive layers separated by an insulative layer. Holes in the upper conductive layer create discrete attachment sites for DNA fragments. Voltage is applied to the surface to control affinity between the attachment sites and the DNA fragments, and to compact the DNA fragments for discrete optical detection.
    Type: Grant
    Filed: December 27, 2011
    Date of Patent: January 24, 2017
    Assignee: Complete Genomincs, Inc.
    Inventors: Andres Fernandez, Bryan Staker, Radoje Drmanac