Patents Examined by Robert T. Crow
  • Method for nucleic acid detection using voltage enhancement
    Patent number: 9551026
    Abstract: Methods are provided for carrying out DNA sequencing on a device having upper and lower conductive layers separated by an insulative layer. Holes in the upper conductive layer create discrete attachment sites for DNA fragments. Voltage is applied to the surface to control affinity between the attachment sites and the DNA fragments, and to compact the DNA fragments for discrete optical detection.
    Type: Grant
    Filed: December 27, 2011
    Date of Patent: January 24, 2017
    Assignee: Complete Genomincs, Inc.
    Inventors: Andres Fernandez, Bryan Staker, Radoje Drmanac
  • Process for drying of BIBW2992, of its salts and of solid pharmaceutical formulations comprising this active ingredient
    Patent number: 9545381
    Abstract: The present invention relates to a drying process of BIBW 2992 or the salts thereof, preferably the dimaleate salt, as well as of solid pharmaceutical formulations comprising BIBW2992 or a salt thereof, and to pharmaceutical compositions comprising BIBW 2992 or a salt thereof as the active product ingredient, characterized by a water activity of the formulation of not more than 0.20 or a water content (Karl-Fischer) of not more than 4.2%.
    Type: Grant
    Filed: July 5, 2010
    Date of Patent: January 17, 2017
    Assignee: Boehringer Ingelheim International GmbH
    Inventor: Albert Barta
  • Method and materials for isolation of nucleic acid materials
    Patent number: 9540636
    Abstract: A method for nucleic acid isolation comprising: receiving a binding moiety solution within a process chamber; mixing the binding moiety solution with a biological sample, within the process chamber, in order to produce a moiety-sample mixture; incubating the moiety-sample mixture during a time window, thereby producing a solution comprising a set of moiety-bound nucleic acid particles and a waste volume; separating the set of moiety-bound nucleic acid particles from the waste volume; washing the set of moiety-bound nucleic acid particles; and releasing a nucleic acid sample from the set of moiety-bound nucleic acid particles. The method preferably utilizes a binding moiety comprising at least one of poly(allylamine) and polypropylenimine tetramine dendrimer, both of which reversibly bind and unbind to nucleic acids based upon environmental pH.
    Type: Grant
    Filed: June 6, 2016
    Date of Patent: January 10, 2017
    Assignee: NeuMoDx Molecular, Inc.
    Inventors: Sundaresh Brahmasandra, Michelle Mastronardi, Elizabeth Craig, Maureen Carey
  • Nanoscale field-effect transistors for biomolecular sensors and other applications
    Patent number: 9541522
    Abstract: The present invention generally relates to nanoscale wires, including to nanoscale wires used as sensors. In some cases, the nanoscale wires may be used to directly determine analytes, even within relatively complicated environments such as blood, unlike many prior art techniques. In some aspects, the nanoscale wire form at least a portion of the gate of a field-effect transistor, and in certain aspects, different periodically-varying voltages or other electrical signals may be applied to the field-effect transistor. For example, in one set of embodiments, sinusoidally-varying voltages of different frequencies may be applied to the nanoscale wire and the source electrode of the field-effect transistor. The electrical conductance or other properties of the nanoscale wire in response to the periodically-varying voltages may then be determined and used to determine binding of the species.
    Type: Grant
    Filed: September 12, 2013
    Date of Patent: January 10, 2017
    Assignee: President and Fellows of Harvard College
    Inventors: Charles M. Lieber, Hwan Sung Choe, Xueliang Liu
  • Ruggedized apparatus for analysis of nucleic acid and proteins
    Patent number: 9523656
    Abstract: The invention provides methods and systems for ruggedizing a nucleic acid analyzing apparatus. The ruggedized apparatus can be used reliably and effectively in uncontrolled environments, such as, for example at a crime scene to collect and analyze forensic data, as well as in semi-controlled environments, such as, for example at a point of care location.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: December 20, 2016
    Assignee: NetBio, Inc.
    Inventors: Eugene Tan, Heung Chuan Lam, Gregory John Kellogg
  • Method and system for directing a localized biological response to an implant
    Patent number: 9517023
    Abstract: The invention provides methods for directing a localized biological response of a mammalian body to an implant disposed within the body. In one embodiment, a delivery system is positioned outside the body and adjacent to the implant within the body. The delivery system comprises a first tissue response modifier effective for directing a localized biological response of the body to the implant. The tissue response modifier is nonsurgically delivered from the delivery system into the body in a quantity effective to direct the localized biological response of the body to the implant. The invention also provides an implant system for long-term use comprising an implant and nonsurgical means for delivering a tissue response modifier through the epidermis of the body, the tissue response modifier effective for directing a localized biological response of the body to the implant.
    Type: Grant
    Filed: May 27, 2010
    Date of Patent: December 13, 2016
    Assignee: Profusa, Inc.
    Inventors: William A. McMillan, Natalie Wisniewski
  • Sodium nitrite-containing pharmaceutical compositions
    Patent number: 9504709
    Abstract: Provided herein are pharmaceutically acceptable sodium nitrite and pharmaceutical compositions thereof. Also provided herein are methods for determining the total non-volatile organic carbon in a sodium nitrite-containing sample. Further provided herein are methods for producing pharmaceutically acceptable sodium nitrite. Still further provided herein are methods of treatment comprising the administration of pharmaceutically acceptable sodium nitrite.
    Type: Grant
    Filed: February 8, 2016
    Date of Patent: November 29, 2016
    Assignee: Hope Medical Enterprises, Inc.
    Inventors: Craig Sherman, Anthony James Lepine, Catherine Marie Smith, Kevin Robert Wirtz, Erich Schulze
  • Devices and methods for microarray selection
    Patent number: 9493822
    Abstract: The present invention relates to a device for the specific selection of target molecules, wherein immobilized capture molecules can be organized in a microarray in the form of spots or lines. In a further aspect the present invention relates to a method of specifically selecting target molecules in a reaction zone, as well as the use of such a device for specifically selecting target molecules, e.g. for target enrichment, or microarray based genome selection (MGS).
    Type: Grant
    Filed: August 26, 2010
    Date of Patent: November 15, 2016
    Assignee: KONINKLIJKE PHILIPS ELECTRONICS N.V.
    Inventors: Pieter Jan Van Der Zaag, Harma Feitsma, Jacob Marinus Jan Den Toonder, Reinhold Wimberger-Friedl
  • Gastric resistant pharmaceutical or nutraceutical formulation comprising one or more salts of alginic acid
    Patent number: 9492394
    Abstract: The invention relates to a gastric resistant pharmaceutical or nutraceutical composition, comprising a core, comprising a pharmaceutical or nutraceutical active ingredient and a gastric resistant coating layer onto the core, wherein the release of the pharmaceutical or nutraceutical active ingredient is not more than 15% under in-vitro conditions at pH 1.2 for 2 hours in medium according to USP with and without the addition of 40% (v/v) ethanol, wherein the gastric resistant coating layer comprises 10 to 100% by weight of one or more salts of alginic acid with a viscosity of 30 to 720 cP of a 1% aqueous solution.
    Type: Grant
    Filed: April 13, 2011
    Date of Patent: November 15, 2016
    Assignee: Evonik Roehm GmbH
    Inventors: Shraddha Ashok Bodinge, Priyanka Bansilal Haksar, Seema Yashwant Gawde, Hemant Karbhari Pagar, Hans-Ulrich Petereit
  • Preparation of bee venom with allergenic components removed
    Patent number: 9492486
    Abstract: Disclosed is a method for manufacturing a separated and purified bee venom (separated PBV) not possessing allergy-triggering effects by reducing or eliminating allergy-inducing components contained in a bee venom via ultrafiltration, thereby producing a PVB with desirable pharmacological effects while fundamentally blocking allergies that may be induced by the same.
    Type: Grant
    Filed: June 7, 2013
    Date of Patent: November 15, 2016
    Assignee: CHUNG JIN BIOTECH CO., LTD
    Inventors: Chang Zhe Shen, Ha Young Won, Seung Ju Kim, Choul Goo Kim, Ji Yeon Lee, Yeon Hee Shin, Seon Young Lee, Jung Keun Park, Eui Kyung Kim
  • Using a field effect device for identifying translocating charge-tagged molecules in a nanopore sequencing device
    Patent number: 9488636
    Abstract: A detector apparatus includes a field-effect transistor configured to undergo a change in amplitude of a source-to-drain current when at least a portion of a charge-tagged molecule translocates through the nanopore. In some implementations, the field-effect transistor is a carbon nanotube field effect transistor and the nanopore is located in a membrane. In other implementations, the field-effect transistor is a carbon nanotube field effect transistor and the nanopore is implemented in the form of a nano-channel in a semiconductor layer.
    Type: Grant
    Filed: June 22, 2015
    Date of Patent: November 8, 2016
    Assignee: California Institute of Technology
    Inventors: Andres Jaramillo-Botero, William A. Goddard, III
  • Pheromone compositions and their use to modify behavior in different vertebrate species
    Patent number: 9480688
    Abstract: A composition comprising Androstenone is described for the modification of undesirable or harmful stress-related behaviors or other behaviors or physiology in a variety of vertebrate species, as well as methods of using the compositions in vertebrates from a species different than the species in which the Androstenone is a naturally occurring pheromone.
    Type: Grant
    Filed: August 14, 2015
    Date of Patent: November 1, 2016
    Assignee: Sergeant's Pet Care Products, Inc.
    Inventors: Mark Levin, John J. McGlone
  • Second harmonic imaging nanoprobes and techniques for use thereof
    Patent number: 9476830
    Abstract: Second harmonic nanoprobes for imaging biological samples and a method of using such probes to monitor the dynamics of biological process using a field resonance enhanced second harmonic (FRESH) technique are provided. The second harmonic generating (SHG) nanoprobes are comprised of various kinds of nanocrystals that do not possess an inversion symmetry and therefore are capable of generating second harmonic signals that can then be detected by conventional two-photon microscopy for in vivo imaging of biological processes and structures such as cell signaling, neuroimaging, protein conformation probing, DNA conformation probing, gene transcription, virus infection and replication in cells, protein dynamics, tumor imaging and cancer therapy evaluation and diagnosis as well as quantification in optical imaging.
    Type: Grant
    Filed: November 21, 2007
    Date of Patent: October 25, 2016
    Assignee: California Institute of Technology
    Inventors: Periklis Pantazis, Ye Pu, Demetri Psaltis, John H. Hong, Scott E. Fraser
  • DNA glycosylase/lyase and AP endonuclease substrates
    Patent number: 9469867
    Abstract: A new class of nucleic acid substrates for AP endonucleases and members of the glycosylase/lyase family of enzymes is described. Representatives of each family, the enzymes Nfo and fpg, respectively, cleave nucleic acid backbones at positions in which a base has been replaced by a linker to which a variety of label moieties may be attached. The use of these synthetic substrates embedded within oligonucleotides is of utility in a number of applications.
    Type: Grant
    Filed: May 18, 2010
    Date of Patent: October 18, 2016
    Assignee: Alere San Diego, Inc.
    Inventors: Olaf Piepenburg, Niall A. Armes
  • Bionematicide composition and method for controlling phytopathogenic nematodes using the same
    Patent number: 9468215
    Abstract: The present invention relates to the field of biotechnology, and particularly relates to a bionematicide composition broad spectrum action on phytopathogenic nematodes which comprises one or more bacterial strains isolated from Chilean soil belonging to the genus Bacillus, and the method of use of this composition for the protection of plants against nematode attack.
    Type: Grant
    Filed: January 30, 2014
    Date of Patent: October 18, 2016
    Assignee: BIO INSUMOS NATIVA SpA
    Inventors: Paulo Escobar Valdes, Eduardo Donoso Cuevas, Gustavo Lobos Prats
  • Nutrition with non-viable and non-digestible oligosaccharide
    Patent number: 9456629
    Abstract: An infant and/or toddler nutrition comprising non-viable Bifidobacterium breve and a non-digestible oligosaccharide and its use are disclosed.
    Type: Grant
    Filed: June 13, 2008
    Date of Patent: October 4, 2016
    Assignee: N.V. NUTRICIA
    Inventors: Sander Hougee, Adrianus Johannes Maria Vriesema, Johan Garssen, Jan Knol
  • Method of detecting nucleic acids, method of optically observing sample and fluorescent substance
    Patent number: 9459213
    Abstract: [Object] A method of detecting nucleic acids easily without requiring complicated operations such as mixing of liquids and cleaning within micro-scale flow channels. [Solving Means] A method of detecting nucleic acids including the steps of bringing a sample containing the nucleic acids into contact with copper, and detecting fluorescence emitted from the sample is provided. According to the method of detecting nucleic acids, only by bringing the sample containing nucleic acids into contact with copper, the fluorescence derived from the composite of the nucleic acids and copper can be easily detected.
    Type: Grant
    Filed: November 4, 2011
    Date of Patent: October 4, 2016
    Assignee: Sony Corporation
    Inventor: Nao Nitta
  • Lysis buffers for extracting nucleic acids
    Patent number: 9447409
    Abstract: The present teachings relate to the extraction of nucleic acid from solid materials. Provided are useful compositions, methods and kits for obtaining nucleic acids from a solid biological sample or an adhesive material having a biological material adherent or embedded within the adhesive substrate. The extracted nucleic acid can be used in downstream applications such as genotyping, detection, quantification, and identification of the source of the biological material.
    Type: Grant
    Filed: September 14, 2010
    Date of Patent: September 20, 2016
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: James Stray, Jason Yingjie Liu, Maxim Brevnov, Jaiprakash Shewale, Allison Holt
  • Method of patterning self-organizing material, patterned substrate of self-organizing material and method of producing the same, and photomask using patterned substrate of self-organizing material
    Patent number: 9429845
    Abstract: A method for performing micro fabrication includes using, as a photomask, a self-organizing material-patterned substrate which is soluble in an organic solvent. A method for emitting light includes emitting the light in a pattern of a nucleic acid which is a self-organizing material immobilized on a self-organizing material-patterned substrate. An immobilization layer containing a binding material capable of binding to a self-organizing material is formed on a substrate. Then this immobilization layer is patterned by transferring a protrusion and recess pattern formed in a mold thereto by the imprint process. The self-organizing material is supplied onto the side having the protrusion and recess pattern of the immobilization layer transferred thereto.
    Type: Grant
    Filed: May 20, 2013
    Date of Patent: August 30, 2016
    Assignee: Japan Science and Technology Agency
    Inventors: Toshihito Ohtake, Ken-ichiro Nakamatsu, Shinji Matsui, Hitoshi Tabata, Tomoji Kawai
  • Compositions and methods for preparing oligonucleotide solutions
    Patent number: 9416411
    Abstract: The present invention is directed to methods and compositions for generating a pool of oligonucleotides. The invention finds use in preparing a population or subpopulations of oligonucleotides in solution. The pool of oligonucleotides finds use in a variety of nucleic acid detection and/or amplification assays.
    Type: Grant
    Filed: January 16, 2014
    Date of Patent: August 16, 2016
    Assignee: Illumina, Inc.
    Inventors: John R. Stuelpnagel, Mark Chee