Patents Examined by Robert T. Crow
  • Method and system for multiplex genetic analysis
    Patent number: 9410889
    Abstract: The present disclosure provides apparatus, systems and method for detecting separately and substantially simultaneously light emissions from a plurality of localized light-emitting analytes. A system according to exemplary embodiments of the present disclosure comprises a sample holder having structures formed thereon for spatially separating and constraining a plurality of light-emitting analytes each having a single nucleic acid molecule or a single nucleic acid polymerizing enzyme, a light source configured to illuminate the sample holder, an optical assembly configured to collect and detect separately and substantially simultaneously light emissions associated with the plurality of light emitting analytes. The system may further include a computer system configured to analyze the light emissions to determine the structures or properties of a target nucleic acid molecule associated with each analyte.
    Type: Grant
    Filed: June 9, 2006
    Date of Patent: August 9, 2016
    Assignee: Applied Biosystem, LLC
    Inventors: Eric S. Nordman, Mark F. Oldham, Timothy Woudenberg
  • Methods and apparatus for detecting molecular interactions using FET arrays
    Patent number: 9404920
    Abstract: Methods and apparatuses relating to large scale FET arrays for analyte detection and measurement are provided. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes.
    Type: Grant
    Filed: January 9, 2014
    Date of Patent: August 2, 2016
    Assignee: Life Technologies Corporation
    Inventors: Jonathan Rothberg, Wolfgang Hinz
  • Bioagent detection systems, devices, and methods
    Patent number: 9393564
    Abstract: The present invention relates to portable systems and devices, and corresponding methods, for detecting bioagents. In particular, the present invention provides systems, devices, and methods that utilize one or more of a sample preparation component, sample analysis component employing broad range primers, and sample detection component.
    Type: Grant
    Filed: March 30, 2010
    Date of Patent: July 19, 2016
    Assignee: IBIS BIOSCIENCES, INC.
    Inventors: David J. Ecker, Steven A. Hofstadler, Rangarajan Sampath, Lawrence B. Blyn, Thomas A. Hall, Mark W. Eshoo
  • Synthesis of fluorescent noble metal nanoparticles
    Patent number: 9395371
    Abstract: A process for the production of fluorescent nanoparticles selected from noble metal or silica nanoparticles. Noble metals or silica nanoparticles provide a platform to which fluorophores and other detection molecules can be added. The fluorescent nanoparticles can be used as regents, diagnostic assays and in the tracking or targeting of tumors.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: July 19, 2016
    Inventors: Warren Chan, Steven Perrault, Leo Chou
  • System and method for temperature referencing for melt curve data collection
    Patent number: 9393566
    Abstract: The present invention relates to systems and methods of temperature referencing for melt curve data collection. More specifically, the present invention relates to systems and methods for collecting DNA melt curve data for a DNA sample and a temperature reference material.
    Type: Grant
    Filed: June 23, 2008
    Date of Patent: July 19, 2016
    Assignee: Canon U.S. Life Sciences, Inc.
    Inventors: Kenton C. Hasson, Hiroshi Inoue
  • Compositions and methods for performing a stringent wash step in hybridization applications
    Patent number: 9388456
    Abstract: The invention provides methods and compositions for performing a stringent wash step in a hybridization assay between at least one molecule and a target. The invention may, for example, eliminate the use of, or reduce the dependence on formamide in the stringent wash step. Compositions for use in the invention include an aqueous composition comprising at least one polar aprotic solvent in an amount effective to denature non-complementary sequences in a hybridization product.
    Type: Grant
    Filed: December 2, 2009
    Date of Patent: July 12, 2016
    Assignee: DAKO DENMARK A/S
    Inventor: Steen Hauge Matthiesen
  • Method and materials for isolation of nucleic acid materials
    Patent number: 9382532
    Abstract: A method for nucleic acid isolation comprising: receiving a binding moiety solution within a process chamber; mixing the binding moiety solution with a biological sample, within the process chamber, in order to produce a moiety-sample mixture; incubating the moiety-sample mixture during a time window, thereby producing a solution comprising a set of moiety-bound nucleic acid particles and a waste volume; separating the set of moiety-bound nucleic acid particles from the waste volume; washing the set of moiety-bound nucleic acid particles; and releasing a nucleic acid sample from the set of moiety-bound nucleic acid particles. The method preferably utilizes a binding moiety comprising at least one of poly(allylamine) and polypropylenimine tetramine dendrimer, both of which reversibly bind and unbind to nucleic acids based upon environmental pH.
    Type: Grant
    Filed: January 30, 2014
    Date of Patent: July 5, 2016
    Assignee: NeuMoDx Molecular, Inc.
    Inventors: Sundaresh Brahmasandra, Michelle Mastronardi, Elizabeth Craig, Maureen Carey
  • Methods of constructing libraries of genetic packages that collectively display the members of a diverse family of peptides, polypeptides or proteins
    Patent number: 9382535
    Abstract: Methods useful in constructing libraries that collectively display members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods. Methods of screening those libraries and the peptides, polypeptides or proteins identified by such screens.
    Type: Grant
    Filed: February 28, 2006
    Date of Patent: July 5, 2016
    Assignee: Dyax Corp.
    Inventors: Robert C. Ladner, Edward H. Cohen, Horacio G. Nastri, Kristin L. Rookey, Rene Hoet
  • Apparatus for high throughput sequencing of nucleic acids
    Patent number: 9382585
    Abstract: A scalable reaction and detection system for automated high throughput sequencing of nucleic acids involving a combination of chemical processes and observation processes independent of the chemistry processes. Discrete functional units may be configured in a manner that allows the system to interchangeably utilize different sequencing reaction components in conjunction with discrete apparatus components for optical image collection and/or analysis.
    Type: Grant
    Filed: October 30, 2008
    Date of Patent: July 5, 2016
    Assignee: Complete Genomics, Inc.
    Inventor: Arnold Oliphant
  • Stable nanoreporters
    Patent number: 9376712
    Abstract: The present invention relates to compositions and methods for detection and quantification of individual target molecules in biomolecular samples. In particular, the invention relates to improved, stable nanoreporter probes that are capable of binding to and identifying target molecules based on the probes' uniquely detectable signal. Methods for identifying target-specific sequences for inclusion in the probes are also provided, as are methods of making and using such probes. Polynucleotide sequences of certain nanoreporter components are also provided. The probes can be used in diagnostic, prognostic, quality control and screening applications.
    Type: Grant
    Filed: August 1, 2013
    Date of Patent: June 28, 2016
    Assignee: NanoString Technologies, Inc.
    Inventors: Philippa Jane Webster, Timothy Dahl
  • Nanoreporters and methods of manufacturing and use thereof
    Patent number: 9371563
    Abstract: The present invention relates to compositions and methods for detection and quantification of individual target molecules in biomolecular samples. In particular, the invention relates to coded, labeled probes that are capable of binding to and identifying target molecules based on the probes' label codes. Methods of making and using such probes are also provided. The probes can be used in diagnostic, prognostic, quality control and screening applications.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: June 21, 2016
    Assignees: NanoString Technologies, Inc., The Institute for Systems Biology
    Inventors: Gary K. Geiss, Sean M. Ferree, Philippa Jane Webster, Krassen M. Dimitrov
  • Histological specimen treatment apparatus and method
    Patent number: 9366605
    Abstract: Method and apparatus for processing tissue specimens against decomposition, putrefaction and autolysis which use a simple three step procedure in a single vessel or container. First, the specimens are saturated with a solvent mixture of a ketone and a hydrocarbon, e.g., an Acetone/Hexane or an Acetone/Xylene mixture, to dissolve lipids and other cellular solutes. The container is then flooded with melted Paraffin. In a last step, the solvent mixture is vaporized and evacuated from the container, allowing the melted Paraffin to replace the vaporized solvent and impregnate the specimens. Raw, i.e., non-processed and non-burred specimens up to 5 mm thick can be processed in about 60 minutes. A solvent regenerator distills the evacuated solvent; and converts vent waste gases into carbon dioxide and water through a thermocatalytic oxidizer.
    Type: Grant
    Filed: February 14, 2012
    Date of Patent: June 14, 2016
    Inventor: Steven Paul Wheeler
  • Plant volatiles
    Patent number: 9364002
    Abstract: The present invention provides compounds and compositions for attracting or repelling sap-sucking insects, such as whitefly, as well as methods for using such compositions.
    Type: Grant
    Filed: September 25, 2008
    Date of Patent: June 14, 2016
    Assignee: Keygene N.V.
    Inventors: Petronella Martina Bleeker, Kai Ament, Paul Johan Diergaarde, Michiel Theodoor Jan De Both, Robert Cornelis Schuurink
  • Pre-mix composition for cattle
    Patent number: 9364483
    Abstract: The present invention concerns a premix composition for feeding cattle, comprising: a) a premix carrier having an overall particle size comprised between 300 and 400 ?m, b) zilpaterol, and c) a surface agent. The present invention is also related to a method of increasing the rate of weight gain in cattle, comprising the administration to the cattle of feed additives consisting of a premix composition such as described, over a period of at least two weeks.
    Type: Grant
    Filed: June 20, 2014
    Date of Patent: June 14, 2016
    Assignee: LABORATORIOS VIRBAC
    Inventors: Jose Manuel Monroe Monroy, Luis Gerardo Estrella Parraga, Laurent Angeli
  • Biologic sample collection devices and methods of production and use thereof
    Patent number: 9359600
    Abstract: Collection devices and kits for biological sample collection include a biologic sample collection device having a hydrophilic swab matrix that includes a modified polycaprolactone (PCL). Methods of production and use thereof are also described herein. The biologic sample collection devices, kits and methods described herein are used to collect a biologic sample (e.g., blood, buccal cells, etc.) and to enable extraction of nucleic acids (e.g., DNA) from that biologic sample so that the nucleic acids can be analyzed (e.g., sequencing and subsequent analyses of DNA).
    Type: Grant
    Filed: April 18, 2014
    Date of Patent: June 7, 2016
    Assignee: Diomics Corporation
    Inventors: Jeff Morhet, Thomas Kindt, Franco Ferrari, Vasana Maneeratana, Frederic Zenhausern
  • Capture based nucleic acid detection
    Patent number: 9353404
    Abstract: The present invention relates to methods and kits useful for the detection of a target nucleotide sequence in a sample. In general, the methods of the present invention are predicated on the target-mediated capture of a nuclease into a complex wherein the extent of complex formation, as measured by nuclease activity, is positively correlated with the presence of the target nucleic acid in the sample.
    Type: Grant
    Filed: September 16, 2011
    Date of Patent: May 31, 2016
    Assignee: Australian Centre for Plant Functional Genomics Pty Ltd
    Inventor: Stephen John Fletcher
  • Polynucleotides and related nanoassemblies, structures, arrangements, methods and systems
    Patent number: 9340416
    Abstract: A linker polynucleotide for attaching a nanomaterial to a polynucleotidic platform and related nanoassemblies, arrangements, structures, methods and systems.
    Type: Grant
    Filed: August 12, 2009
    Date of Patent: May 17, 2016
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Hareem T. Maune, Si-Ping Han, Robert D. Barish, Marc W. Bockrath, William A. Goddard, III, Paul W. K. Rothemund, Erik Winfree
  • Method of designing addressable array suitable for detection of nucleic acid sequence differences using ligase detection reaction
    Patent number: 9340834
    Abstract: The present invention is directed to a method of designing a plurality of capture oligonucleotide probes for use on a support to which complementary oligonucleotide probes will hybridize with little mismatch, where the plural capture oligonucleotide probes have melting temperatures within a narrow range. The present invention further relates to an oligonucleotide array comprising of a support with the plurality of oligonucleotide probes immobilized on the support, a method of using the support to detect single-base changes, insertions, deletions, or translocations in a plurality of target nucleotide sequences, and a kit for such detection, which includes the support on which the oligonucleotides have been immobilized.
    Type: Grant
    Filed: July 22, 2013
    Date of Patent: May 17, 2016
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Francis Barany, Monib Zirvi, Norman P. Gerry, Reyna Favis, Richard Kliman
  • Immunohistochemistry detection method
    Patent number: 9340824
    Abstract: The invention provides compositions and methods for the detection of targets in a sample; in particular, an immunohistochemistry (IHC) sample. Probes and detectable labels may be provided in multiple layers in order to increase the flexibility of a detection system, and to allow for amplification to enhance the signal from a target. The layers may be created by incorporating probes and detectable labels into larger molecular units that interact through nucleic acids base-pairing, including peptide-nucleic acid (PNA) base-pairing. Optional non-natural bases allow for degenerate base pairing schemes. The compositions and methods are compatible with immunohistochemistry (IHC), but also could be used in immunocytochemistry (ICC), in situ hybridization (ISH), flow cytometry, enzyme immuno-assays (EIA), enzyme linked immuno-assays (ELISA), blotting methods (e.g.
    Type: Grant
    Filed: April 14, 2014
    Date of Patent: May 17, 2016
    Assignee: DAKO Denmark A/S
    Inventors: Lars Winther, Jesper Lohse, Susanne Gabs, Kenneth Heesche Petersen
  • Delivery carrier
    Patent number: 9333177
    Abstract: The present invention relates to a novel liquid delivery carrier comprising a specific grade of glyceryl caprylate and PEG-40 hydrogenated castor oil in particular amounts. This carrier can be loaded with slightly or poorly water soluble substances and filled into hard gelatin capsule shells for final administration to a subject. Also disclosed are filling compositions comprising such delivery carrier and hard gelatin capsules filled with the carrier and the composition of the invention. The delivery carrier of the invention proved to be compatible with both the hard gelatin capsule shells and the substances loaded into it.
    Type: Grant
    Filed: October 26, 2010
    Date of Patent: May 10, 2016
    Assignee: Capsugel Belgium NV
    Inventors: David Delmarre, Marie-Sophie Lina Martina, Jan Emiel Godelieve Vertommen