Patents Examined by Roy M. Punnoose
  • Patent number: 11662297
    Abstract: Aspects of the present disclosure include methods for flow cytometrically sorting a sample with particles, such as cells, based on order of identification. Methods according to certain embodiments include introducing the sample into a flow cytometer; flowing the introduced sample in a flow stream; irradiating the sample in the flow stream with a light source; detecting light from cells in the sample flowing in the flow stream; identifying phenotypes of cells in the sample flowing in the flow stream based on one or more data signals generated from the detected light; and dynamically sorting into partitions cells of the sample that have a phenotype of a collection of predetermined phenotypes based on order of identification. Systems for practicing the subject methods are also provided. Non-transitory computer readable storage mediums are also described.
    Type: Grant
    Filed: April 9, 2021
    Date of Patent: May 30, 2023
    Assignee: BECTON, DICKINSON AND COMPANY
    Inventors: David Alexander Roberts, Lingjie Wei, Peter Mage, Keegan Owsley
  • Patent number: 11662291
    Abstract: A feed validation measuring system for monitoring and controlling the quality of aquaculture feed, and a method for validating feed by utilizing such a system. The system includes the utilization of a high contrast surface, which receives a predetermined number of feed pellets and a measurement reference object, a lighting assembly to light the high contrast surface, a camera assembly to capture images of objects on the high contrast surface, and a software component which analyzes images and calculates the size of each of the predetermined number of feed pellets by referencing the size of the measurement reference object.
    Type: Grant
    Filed: June 18, 2021
    Date of Patent: May 30, 2023
    Assignee: ATLANTIC SAPPHIRE IP, LLC
    Inventor: Thue Holm
  • Patent number: 11644408
    Abstract: An optical cell for performing light spectroscopy (including absorbance, fluorescence and scattering measurements) on a liquid sample in microfluidic devices is disclosed. The optical cell comprises an inlaid sheet having an opaque material inlaid in a clear material, and a sensing channel that crosses the clear material and the opaque material provides a fluidic path for the liquid sample and an optical path for probe light. Integral optical windows crossing a clear-opaque material interface permit light coupling into and out of the sensing channel, and thus light transmission through the sensing channel is almost entirely isolated from background light interference. A microfluidic chip comprising one or more optical cells is also disclosed. The optical cells may have different lengths of sensing channels, and may be optically and fluidly coupled. A method of manufacturing an optical cell in a microfluidic chip is also disclosed.
    Type: Grant
    Filed: November 10, 2021
    Date of Patent: May 9, 2023
    Assignee: DARTMOUTH OCEAN TECHNOLOGIES INC.
    Inventors: Edward Arthur Luy, Sean Christopher Morgan, Vincent Joseph Sieben
  • Patent number: 11639947
    Abstract: A method of detecting a foreign object on a stage according to one aspect of the present disclosure includes acquiring first position information of a first pattern included in a first image in a reference state of a surface of the stage capable of attracting an object to be inspected; acquiring second position information of a second pattern included in a second image of the surface, the second image being obtained after obtaining the first image; and detecting one or more foreign objects on the surface by comparing the first position information and the second position information.
    Type: Grant
    Filed: December 9, 2020
    Date of Patent: May 2, 2023
    Assignee: Tokyo Electron Limited
    Inventors: Kenta Saiki, Takuya Ishida
  • Patent number: 11636587
    Abstract: There is provided a system and method of inspecting a specimen. The method includes obtaining a first image of an inspection area of a die of a semiconductor specimen and a group of reference images corresponding to a group of candidate reference units, obtaining a second image informative of one or more partitions of the inspection area respectively associated with one or more inspection algorithms, for each given pixel of the first image, determining location of one or more reference pixels thereof based on information of the second image, selecting, from the group of candidate reference units, one or more specific reference units actually required for inspecting the inspection area based on the determined location, and using one or more reference images corresponding to the selected reference units to inspect the first image, thereby providing an inspection result of the inspection area.
    Type: Grant
    Filed: December 30, 2020
    Date of Patent: April 25, 2023
    Assignee: Applied Materials Israel Ltd.
    Inventors: Dan Koronel, Liat Shalom Mermelstein
  • Patent number: 11635376
    Abstract: An apparatus related method for measuring a property of a target material. The system may include a pump device that generates a pump beam. A modulation device may receive the pump beam and generate a modulated pump beam by modulating an intensity amplitude of the pump beam, which may be directed to the target material. A probe device may generate a probe beam, which is directed to the target material. A part of the probe beam may be reflected off of the target material, and has similar frequency characteristic as the modulated pump beam. A detection device may detect the reflected probe beam and produce a signal. An analyzing device may receive the signal and calculate the target material property by comparing the modulated frequency characteristics of the signal to those of the pump beam. At least one of the pump and the probe beams may be infrared light.
    Type: Grant
    Filed: January 20, 2021
    Date of Patent: April 25, 2023
    Assignee: University of Virginia Patent Foundation
    Inventors: Brian M. Foley, John T. Gaskins, Patrick E. Hopkins
  • Patent number: 11630051
    Abstract: A method for inverting aerosol components using a LiDAR ratio and a depolarization ratio, includes: S1. identifying sand dust, a spherical aerosol and a mixture of the sand dust and the spherical aerosol based on a depolarization ratio; S2. calculating a proportion of the sand dust in the mixture of the sand dust and the spherical aerosol; and S3. identifying soot and a water-soluble aerosol in the spherical aerosol based on a LiDAR ratio. In the present disclosure, only a wavelength with a polarization channel is needed, to identify the aerosol components, achieving high accuracy with low detection costs.
    Type: Grant
    Filed: April 7, 2022
    Date of Patent: April 18, 2023
    Assignee: INSTITUTE OF ATMOSPHERIC PHYSICS, CHINESE ACADEMY OF SCIENCES
    Inventors: Ting Yang, Zifa Wang, Futing Wang, Xi Chen, Haibo Wang, Hongyi Li
  • Patent number: 11629957
    Abstract: A surveying apparatus has a combined structure of a total station and a laser scanner. The surveying apparatus includes a point cloud data acquiring unit, an abnormal part detecting unit, an abnormal part position acquiring unit, and an automatic sighting controller. The point cloud data acquiring unit acquires first point cloud data and second point cloud data obtained by laser scanning that is performed on an object to be inspected at a time interval. The abnormal part detecting unit calculates a difference between the first and second point cloud data to detect a part of the object to be inspected, at which position information varies, as a detailed-inspection target part. The abnormal part position acquiring unit acquires a position of the detailed-inspection target part. The automatic sighting controller controls to make the total station sight the detailed-inspection target part, based on the position of the detailed-inspection target part.
    Type: Grant
    Filed: June 30, 2020
    Date of Patent: April 18, 2023
    Assignee: Topcon Corporation
    Inventor: You Sasaki
  • Patent number: 11629954
    Abstract: An apparatus for measuring a surface topography of a patient's teeth may include an optical probe, a light source configured to generate incident light, and focusing optics configured to focus one or more wavelengths of the incident light to a fixed focal position external to the optical probe, wherein the fixed focal position is fixed relative to the optical probe. The apparatus may further include a light sensor configured to measure a characteristic of returned light generated by illuminating the patient's teeth with the incident light and a processing unit operable to determine the surface topography of the patient's teeth based on the measured characteristic of the returned light.
    Type: Grant
    Filed: July 28, 2021
    Date of Patent: April 18, 2023
    Assignee: Align Technology, Inc.
    Inventors: Erez Lampert, Adi Levin, Tal Verker
  • Patent number: 11625820
    Abstract: A method, a non-transitory computer readable medium, and a system for evaluating an inspection algorithm for inspecting a semiconductor specimen.
    Type: Grant
    Filed: May 28, 2020
    Date of Patent: April 11, 2023
    Assignee: Applied Materials Israel Ltd.
    Inventor: Ilya Blayvas
  • Patent number: 11624694
    Abstract: The invention relates to a method for examining a liquid which contains at least one cell and/or at least one particle using a first and a second measurement signal emanating from a liquid region, wherein the method has the following steps: (a) reading the first measurement signal and analysing the first measurement signal; and (b) determining based on the analysed first measurement signal (15) whether a detection of the second measurement signal (20) is carried out and a reading of the detected second measurement signal is completed, or whether a reading of the detected second measurement signal (20) is completed, or whether a reading of the detected second measurement signal (20) is interrupted.
    Type: Grant
    Filed: February 4, 2019
    Date of Patent: April 11, 2023
    Assignee: cytena GmbH
    Inventors: Jonas Schöndube, Lena Lautscham
  • Patent number: 11619574
    Abstract: The inventive concept relates to a device for detecting particles in air, said device comprising a receiver for receiving a flow of air comprising particles, a sample carrier, and a particle capturing arrangement. The particle capturing arrangement is configured to separate the particles from the flow of air for and to collect a set of particles on a surface of the sample carrier. The device further comprises a light source configured to illuminate the particles on the sample carrier, such that an interference pattern is formed by interference between light being scattered by the particles and non-scattered light from the light source. The device further comprises an image sensor configured to detect the interference pattern. The device further comprises a cleaner configured for cleaning the surface of the sample carrier for enabling re-use of the surface for collection of a subsequent set of particles.
    Type: Grant
    Filed: December 18, 2020
    Date of Patent: April 4, 2023
    Assignee: IMEC VZW
    Inventors: Geert Vanmeerbeeck, Ziduo Lin, Abdulkadir Yurt, Richard Stahl
  • Patent number: 11609175
    Abstract: The present invention falls within the field of medical apparatuses. Disclosed are a method and a device for identifying platelet aggregation, and a flow cytometer, which are used for accurately giving an alarm about a platelet aggregation during blood cell analysis.
    Type: Grant
    Filed: December 18, 2019
    Date of Patent: March 21, 2023
    Assignee: SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.
    Inventors: Guanzhen Wang, Bo Ye, Jiantao Di
  • Patent number: 11609176
    Abstract: Methods for evaluating performance a diode laser are provided. In embodiments, methods include receiving a laser beam profile of a diode laser, determining first, second and third laser beam widths at first, second and third laser intensities, respectively, for the laser beam profile, computing a first ratio between the second and third laser beam widths, computing a second ratio between the first and second laser beam widths, evaluating laser performance based on the first and second ratios, and outputting a determination regarding the suitability of the laser for use in a flow cytometry setting. Devices for practicing the subject methods are also provided, and include first and second stages configured to receive a diode laser and beam profiler, respectively. Aspects of the invention further include flow cytometers incorporating a diode laser that has been evaluated by the subject method.
    Type: Grant
    Filed: May 12, 2021
    Date of Patent: March 21, 2023
    Assignee: BECTON, DICKINSON AND COMPANY
    Inventors: An-Dien Nguyen, Waheed Amiri, David J. Gianduzzo
  • Patent number: 11598713
    Abstract: Provided are a particle size measurement method, a particle size measurement apparatus, and a particle size measurement program in which a needless measurement time period is omitted by setting an appropriate measurement time period in accordance with a particle size to be measured. The particle size measurement method includes: a test measurement step; an autocorrelation function calculation step; a setting step of setting a part of a plurality of measurement timings set in advance as measurement timings to be used for main measurement, based on a time period required until an autocorrelation function falls below a predetermined threshold value and a preliminary time period set and added to the time period; a main measurement step of measuring a main measurement intensity of scattered light during a main measurement time period; and a particle size calculation step of calculating a particle size of a sample.
    Type: Grant
    Filed: April 2, 2021
    Date of Patent: March 7, 2023
    Assignee: OTSUKA ELECTRONICS CO., LTD.
    Inventor: Ikuo Wakayama
  • Patent number: 11598712
    Abstract: A cell evaluation system includes physical measurement unit, a database, and evaluation unit. The evaluation unit refers to a relevance stored in the database, searches reference measurement information based on measurement information of a cell newly measured via the physical measurement unit, and evaluates the cell with biological measurement information associated with the searched reference measurement information.
    Type: Grant
    Filed: May 2, 2018
    Date of Patent: March 7, 2023
    Assignees: THINKCYTE, INC., THE UNIVERSITY OF TOKYO
    Inventors: Masashi Ugawa, Yoko Kawamura, Sadao Ota
  • Patent number: 11592564
    Abstract: A system of generating a three-dimensional (3D) scan of an environment includes multiple 3D scanners including a first 3D scanner at respective first and second positions. The system further includes a controller coupled to the 3D scanners via a common communications network. The first scanner and second scanner transmit a subset of data to the controller while acquiring a set of 3D coordinates. The controller registers the subsets of data to each other while the sets of 3D coordinates is being acquired.
    Type: Grant
    Filed: June 22, 2021
    Date of Patent: February 28, 2023
    Assignee: FARO TECHNOLOGIES, INC.
    Inventors: Daniel Pompe, Manuel Caputo, José Gerardo Gómez Méndez, Zia ul Azam, Louis Bergmann, Daniel Flohr, Oliver Zweigle
  • Patent number: 11579062
    Abstract: The invention provides an optical particle sensor (1) comprising: at least one light source (2, 2r, 2g, 2b) configured to emit light rays (20), at least one channel (3) intended to receive a fluid transporting at least one particle (30), and to at least partially receive the light rays (20) emitted by the at least one source (2, 2r, 2g, 2b), such that said light rays (20) are partially scattered by the at least one particle (30), at least one photodetector (4) capable of receiving said scattered light rays (20), said sensor (1) being characterised in that the at least one source (2, 2r, 2g, 2b) has an emission face (21) facing one side (D) of the sensor and in that the at least one photodetector (4) has a receiving face (41) facing the same side (D) of the sensor (1), such that the light rays received by the at least one photodetector are light rays (20b) backscattered by the at least one particle (30), for at least 90% of them.
    Type: Grant
    Filed: June 30, 2021
    Date of Patent: February 14, 2023
    Assignee: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
    Inventors: Tony Maindron, Salim Boutami, Christophe Kopp
  • Patent number: 11573167
    Abstract: A particle analyzer, comprising a source of a substantially nondiffracting light beam; a flow path configured to produce in a flowcell a ribbon-like core stream having a specific cross-sectional aspect ratio; the flowcell being configured to expose a segment of the core stream to the light beam; a detector configured to receive a signal resulting from an interaction of a particle in the core stream with the light beam; a first sorting actuator connected with the flowcell, downstream of the exposed segment of core stream; a plurality of sorting channels in fluid connection with the flow path and downstream of the first actuator; the actuator having multiple actuation states, each state configured to direct at least one part of the core stream to a corresponding channel; a second sorting actuator connected with the flowcell, opposite the first actuator, and operable in coordination with the first actuator.
    Type: Grant
    Filed: June 14, 2021
    Date of Patent: February 7, 2023
    Assignee: Kinetic River Corp.
    Inventor: Giacomo Vacca
  • Patent number: 11567178
    Abstract: The laser distance measuring device includes: a laser light emission unit for emitting laser light; a scanning mechanism for scanning the laser light by changing an output angle thereof; a light receiving unit for receiving reflected light of the laser light from an object, to thereby output a light reception signal; a light-detector control circuit for causing the light receiving unit to output the reception signal after setting a light receiving sensitivity for the reflected light at the time when the output angle is small, higher than a light receiving sensitivity for the reflected light at the time when the output angle is large; and a distance calculation unit for calculating, based on the reception signal, a distance to the object. This enhances the distance measuring capability in both cases of measuring a short distance and a long distance.
    Type: Grant
    Filed: March 27, 2020
    Date of Patent: January 31, 2023
    Assignee: Mitsubishi Electric Corporation
    Inventors: Shohei Tsukamoto, Hiroshi Sakanoue, Masaharu Imaki