Patents Examined by William E. Benston, Jr.
  • Medicinal aerosol formulations
    Patent number: 5695743
    Abstract: A self-propelling aerosol formulation which may be free from CFC's which comprises a medicament, 1,1,1,2-tetrafluoroethane, a surface active agent and at least one compound having a higher polarity than 1,1,1,2-tetrafluoroethane.
    Type: Grant
    Filed: March 4, 1993
    Date of Patent: December 9, 1997
    Assignee: Riker Laboratories, Inc.
    Inventors: Tarlochan S. Purewal, David J. Greenleaf
  • Coumarin spherules/beads having unique morphology
    Patent number: 5693342
    Abstract: Free-flowing, non-agglomerating and attrition resistant, substantially spherical solid beads/spherules of a coumarin compound, advantageously having a particle size ranging from 100 .mu.m to 2,000 .mu.m, a loose bulk density ranging from 0.25 to 0.8 and a compressive strength ranging from 500 to 10,000 N/m.sup.2, dissolve rapidly in ethanol and are conveniently prepared by prilling/fragmenting a melt of the coumarin compound into a stream of a cooling gas.
    Type: Grant
    Filed: March 16, 1995
    Date of Patent: December 2, 1997
    Assignee: Rhone-Poulenc Chimie
    Inventors: Eric Cervos, Pierre Labourt-Ibarre, Eraclis Statiotis
  • Pharmaceutical thermal infusion process
    Patent number: 5690959
    Abstract: A chewable tablet comprises a medicament dispersed in a chewable base, such as mannitol, together with an effervescent couple, such as citric acid--sodium bicarbonate. The combination of effervescence and chewability with optional flavorings improves the taste characteristics of the medicament in oral administration. A distintegrant such as microcrystalline cellulose may be added to give the patient the option of dispersing the tablet in water.
    Type: Grant
    Filed: May 4, 1995
    Date of Patent: November 25, 1997
    Assignee: SmithKline Beecham Corporation
    Inventors: Nageswara R. Palepu, Gopadi M. Venkatesh
  • Animal food supplement briquette
    Patent number: 5686111
    Abstract: There is disclosed an animal food supplement and a method and apparatus for preparing the same. The supplement is a high concentration vitamin/mineral supplement which is formed as a briquette by passing a mixture of the vitamin and minerals through a compacting step at a relatively low temperature.
    Type: Grant
    Filed: May 4, 1995
    Date of Patent: November 11, 1997
    Assignee: Concentres Scientifiques Belisle Inc.
    Inventor: Jacques Jalbert
  • Single dosage semi-solid topical pharmaceutical forms for transdermal therapy
    Patent number: 5686112
    Abstract: To improve the efficacy and tolerability of customary topical applications for transdermal systemically acting pharmaceutical substances, single dosage topical pharmaceutical forms which are therapeutically exactly ready-to-administer are formed from suitable semi-solid pharmaceutical forms. The topical single doses are specified pharmaceutically with respect to their dose, their topical spreading behaviour and their permeation properties. Several of the topically ready-to-administer single doses are in this case accommodated in a common commercial packaging container. Complex treatments can be developed by means of different individual dosages or alternatively active compound combinations. As pharmacological active compounds, steroids, peptides, various analgesics, local anaesthetics and non-steroidal antirheumatics are employed in particular.
    Type: Grant
    Filed: December 20, 1995
    Date of Patent: November 11, 1997
    Assignee: APL-American Pharmed Labs, Inc.
    Inventor: Rainer K. Liedtke
  • Chewable pharmaceutical tablets
    Patent number: 5686107
    Abstract: Formulations of chewable pharmaceutical tablets for delivery of prescription pharmaceutical actives, non-prescription pharmaceutical actives, or over-the-counter actives comprise as an excipient an aggregate of coprocessed microcrystalline cellulose and a galaotomannan. Addition of these excipients imparts improved smell, taste, texture, and mouthfeel to the finished product.
    Type: Grant
    Filed: January 30, 1995
    Date of Patent: November 11, 1997
    Assignee: FMC Corporation
    Inventors: Sheila Ratnaraj, William J. Reilly, Jr.
  • Gelatin coated medicament and process for making same
    Patent number: 5683717
    Abstract: This invention relates to coated medicaments and a process for providing spray coated gelatinous coverings for such medicaments. This invention is also directed to novel gelatinous compositions for spray coating tablets, caplets, pellets, granules and the like.
    Type: Grant
    Filed: December 2, 1994
    Date of Patent: November 4, 1997
    Assignees: Pharmacia & Upjohn Company, L. Perrigo Company
    Inventor: Robert Wu-wei Shen
  • Medicinal aerosol formulations
    Patent number: 5683677
    Abstract: A self-propelling aerosol formulation which may be free from CFC's which comprises a medicament, 1,1,1,2-tetrafluoroethane, a surface active agent and at least one compound having a higher polarity than 1,1,1,2-tetrafluoroethane.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: November 4, 1997
    Assignee: Riker Laboratories, Inc.
    Inventors: Tarlochan S. Purewal, David J. Greenleaf
  • Orally-administered dosage form for animals, preparation method therefor and uses thereof
    Patent number: 5683722
    Abstract: A dosage form for orally administering chemical or medicinal substances such as vitamins, trace elements, amino acids, nutritive substances, vaccines, etc., to domestic or wild animals, and a method for preparing same, are disclosed. Said dosage form includes: a porous water-soluble central core containing binders selected from polypeptides, polysaccharides, polymers and colloids, and/or diluents selected from polyols, metal oxides, carbonates, phosphates and microcrystalline cellulose, and an effective amount of at least one bioactive substance; and a palatable hydrophobic outer layer containing at least one lipid substance selected from fatty alcohols, fatty acids, glycerol esters, hydrogenated oils, waxes, paraffin, lanolin, coconut oil and fatty acid salts; a polymeric agent for modulating the disintegration and adhesion of said outer layer, and natural or synthetic palatable substances.
    Type: Grant
    Filed: August 1, 1996
    Date of Patent: November 4, 1997
    Assignee: Virbac S.A.
    Inventors: Guy Derrieu, Andre Aubert, Bernard Raynier, Carolin L. Schumacher
  • Galenic preparation of therapeutic composition comprising aspirin
    Patent number: 5683721
    Abstract: Mecidinal specialty in galenic presentation and constituted in particular by a pastille, granule, pill, tablet or the like, adapted to be sucked by the user or with sublingual administration. At least one active product in microdispersed form within the substrate. Method of presenting a therapeutical composition for internal use, particularly for administration per os, in galenic presentation, and containing at least one active principle in solid form adsorbed on a substrate. The active product is distributed therein in the state of finely dispersed microparticles.
    Type: Grant
    Filed: July 17, 1995
    Date of Patent: November 4, 1997
    Inventors: Philippe Perovitch, Marc Maury
  • Delayed release microtablet of .beta.-phenylpropiophenone derivatives
    Patent number: 5681588
    Abstract: A cylindrical delayed release tablet with a convex or flat upper side and lower side is provided, along with a method for its production and a gelatin capsule containing 3-200 tablets of the same having identical or different release rates, wherein the tablet if made of .beta.-phenylpropiophenone derivatives of the formula I as active ingredient ##STR1## where R is n-propyl or 1,1-dimethylpropyl, and their pharmacologically acceptable salts, wherein the tablet has a height and diameter that are both, independently of one another, 1-3 mm, the active ingredient content is in the range from 81-99.
    Type: Grant
    Filed: October 3, 1995
    Date of Patent: October 28, 1997
    Assignee: Knoll Aktiengesellschaft
    Inventors: Karl Kolter, Helmut Fricke, Volker Buehler, Herbert Mueller-Peltzer
  • Medicinal aerosol formulations
    Patent number: 5681545
    Abstract: A self-propelling aerosol formulation which may be free from CFC's comprises a medicament, 1,1,1,2-tetrafluoroethane, a surface active agent and at least one compound having a higher polarity than 1,1,1,2-tetrafluoroethane.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: October 28, 1997
    Assignee: Riker Laboratories, Inc.
    Inventors: Tarlochan S. Purewal, David J. Greenleaf
  • Porous material product and process
    Patent number: 5681572
    Abstract: A method of preparing a device of a selected material to have pores and pore interconnections of predetermined sizes and shapes includes the steps of forming a selectively removable open-celled porous mold form of particles which adhere to one another, with the particles corresponding to the predetermined pore sizes and shapes, and interconnections between the particles which bind them together in the form in which the connections correspond to the predetermined sizes and shapes of the pore connections. Also included are the steps of filling the vacancies between the particles and connections of the form with the selected material, and then removing the form to leave the selected material. The resulting device is at least partly porous, the pores and pore interconnections corresponding in size and shape to the particles and connections respectively.
    Type: Grant
    Filed: November 22, 1993
    Date of Patent: October 28, 1997
    Inventor: William J. Seare, Jr.
  • Time-release delivery matrix composition and corresponding controlled-release compositions
    Patent number: 5676972
    Abstract: A composition is provided for use as a matrix for controlled-release compositions. Such compositions utilize an active ingredient dispersed in a matrix. Active ingredients include, for example, pharmaceuticals and agricultural agents. The matrix is a blend of a poly(hydroxyethyl) methacrylate, polyethylene glycol and a time-release extending agent which is a low molecular weight polymer having hydrophilic and hydrophobic side groups, such as diblock or triblock poly(ethylene oxide propyleneoxide).
    Type: Grant
    Filed: February 16, 1995
    Date of Patent: October 14, 1997
    Assignee: The University of Akron
    Inventors: Vassilios Galiatsatos, Lubica Alabakovska
  • Medicinal aerosol formulations
    Patent number: 5674473
    Abstract: A self-propelling aerosol formulation which may be free from CFC's which comprises a medicament, 1,1,1,2-tetrafluoroethane, a surface active agent and at least one compound having a higher polarity than 1,1,1,2-tetrafluoroethane.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: October 7, 1997
    Assignee: Riker Laboratories, Inc.
    Inventors: Tarlochan S. Purewal, David J. Greenleaf
  • Method and product for dispensing medication for animals
    Patent number: 5674515
    Abstract: A food item and method for administering medication to a subject, particularly a dog wherein the food item is a short edible tube with an interior chamber having a closed end and open end providing that the medication may be inserted into the chamber through the open end of the tube and then the open end of the tube is pinched closed. The food item is composed of foodstuffs such as meats, a congealing agent, if necessary, such as flour and water, with a percentage of water selected to maintain a consistency of the foodstuff that maintains the shape of the tube in a handling operation yet is readily deformed by pinching the open end.
    Type: Grant
    Filed: September 12, 1994
    Date of Patent: October 7, 1997
    Inventor: Humphrey Erwin Wesenhagen
  • Infusion preparation comprising phospholipid
    Patent number: 5674527
    Abstract: Disclosed is an infusion preparation for nutrient supply use. It comprises a sugar, amino acids, electrolytes and a fat emulsion. It has an excellent shelf life without causing precipitation, denaturation and the like in spite of the simultaneous presence of these components. Also disclosed is a container filled with infusion liquids comprising a first and a second compartments separated from each other by a separation means, wherein an infusion liquid containing a fat emulsion and a sugar is included in the first compartment and another infusion liquid containing amino acids and electrolytes is included in the second compartment. Further disclosed are an infusion preparation comprising a fat emulsion and a sugar, and an infusion preparation comprising amino acids and electrolytes.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 7, 1997
    Assignee: The Green Cross Corporation
    Inventors: Tadaaki Inoue, Hideto Kodaira, Yoshihito Nawa, Ryoichiro Murashima, Shunichi Abe, Kazumasa Yokoyama
  • Method of treating pain by administering 24 hour oral opioid formulations
    Patent number: 5672360
    Abstract: Patients are treated with 24-hour oral sustained release opioid formulations which, upon administration, provide an initially rapid opioid absorption such that the minimum effective analgesic concentration of the opioid is more quickly achieved. These sustained release opioid formulations include an effective amount of at least one retardant material to cause said opioid analgesic to be released at a such a rate as to provide an analgesic effect after oral administration to a human patient for at least about 24 hours, and are characterized by providing an absorption half-life from 1 to about 8 hours. A method of titrating a human patient utilizing these sustained release opioid formulations is also disclosed.
    Type: Grant
    Filed: July 22, 1996
    Date of Patent: September 30, 1997
    Assignee: Purdue Pharma, L.P.
    Inventors: Richard S. Sackler, Robert F. Kaiko, Paul Goldenheim
  • Process of preparing microparticulate collagen, collagen-based products thereby and method of applying same
    Patent number: 5672336
    Abstract: There is disclosed a collagen preparation of improved adhesive properties and formed of microparticulate collagen of a particle size of from 0.5 to 2 .mu.m, preferably 0.5 to 1.0 .mu.m preferably submicrosized in a delivery system, such as an aerosol, and thus in sprayable form as a wound dressing alone, or with releasing drugs or other active agents. The microparticulate collagen is formed by ball milling collagen for a time sufficient to form the microparticulate collagen having a particle size of from 0.5 to 2 .mu.m, preferably 0.5 to 1 .mu.m.
    Type: Grant
    Filed: October 7, 1994
    Date of Patent: September 30, 1997
    Inventor: Vinay K. Sharma
  • Process for the production of medicament formulations
    Patent number: 5670167
    Abstract: A medicament compact is produced by placing loose powdered medicament in a mould having a longitudinal axis where a mandrel is positioned along the longitudinal axis of the mould compressing the medicament when a force parallel to the longitudinal axis is applied. The frictional force between the medicament and the mould and the frictional force between the medicament and the mandrel are opposite.
    Type: Grant
    Filed: June 17, 1996
    Date of Patent: September 23, 1997
    Assignee: Fisons plc
    Inventors: Clive Roland Sleath, Paul Manuel Anson, Hugh William Dyson