Patents Examined by William E. Benston, Jr.
  • Compositions which contain active substances and are in the form of solid particles
    Patent number: 5641516
    Abstract: Compositions which contain active substances and are in the form of solid particles can be obtained by intimately mixing the active substance with a water-soluble melt composed ofa) 10-90% by weight of a water-soluble polymer A with a viscosity V.sub.a of 1,000-120,000 cps andb) 10-90% by weight of a water-soluble polymer B with a viscosity V.sub.b of 1-500 cpsas carrier substance, where the viscosities V.sub.a and V.sub.b are those of a 2% by weight aqueous solution at 20.degree. C., measured by the ASTM D 2363-72 capillary method (European Pharmacopoeia, Vol. III, p. 37), and processing the melt with shaping to give the particles.
    Type: Grant
    Filed: August 7, 1995
    Date of Patent: June 24, 1997
    Assignee: BASF Aktiengesellschaft
    Inventors: Sven Grabowski, Axel Sanner, Joerg Rosenberg
  • Cement bead composition for orthopaedic surgery and its manufacturing process
    Patent number: 5641514
    Abstract: The present invention relates to cement bead for orthopaedic surgery and its manufacturing process, embodying the cement beads for orthopaedic surgery manufactured from the mixture of antibiotics and cement which can be implanted into the dead space produced after the first saucerization on a patient with chronic osteomyelitis.
    Type: Grant
    Filed: January 30, 1995
    Date of Patent: June 24, 1997
    Inventor: Se Hyun Cho
  • Biocidal polymeric coating for heat exchanger coils
    Patent number: 5639464
    Abstract: A biocidal protective coating for heat exchanger coils formed by applying a polymeric composition containing an organic water resistant polymer that has associated with it an effective amount of a biocidal compound to inhibit corrosion, fouling, and biocidal buildup on the coils.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: June 17, 1997
    Assignee: Interface, Inc.
    Inventors: Claude E. Terry, Douglas E. Triestman, Daniel L. Price
  • Methods for the preparation of nucleic acids for in vivo delivery
    Patent number: 5639473
    Abstract: In accordance with the present invention, there are provided compositions useful for the in vivo delivery of a biologic, wherein the biologic is associated with a polymeric shell formulated from a biocompatible material. The biologic can be associated with the polymeric shell itself, and/or the biologic, optionally suspended/dispersed in a biocompatible dispersing agent, can be encased by the polymeric shell. In another aspect, the biologic associated with polymeric shell is administered to a subject, optionally dispersed in a suitable biocompatible liquid.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 17, 1997
    Assignee: Vivorx Pharmaceuticals, Inc.
    Inventors: Mark W. Grinstaff, Patrick Soon-Shiong, Michael Wong, Paul A. Sandford, Kenneth S. Suslick, Neil P. Desai
  • Biocidal polymeric coating for heat exchanger coils
    Patent number: 5635192
    Abstract: A biocidal protective coating for heat exchanger coils formed by applying a polymeric composition containing an organic water resistant polymer that has associated with it an effective amount of a biocidal compound to inhibit corrosion, fouling, and biocidal buildup on the coils.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: June 3, 1997
    Assignee: Interface, Inc.
    Inventors: Claude E. Terry, Douglas E. Triestman, Daniel L. Price
  • Methods for the preparation of blood substitutes for in vivo delivery
    Patent number: 5635207
    Abstract: In accordance with the present invention, there are provided compositions useful for the in vivo delivery of a biologic, wherein the biologic is associated with a polymeric shell formulated from a biocompatible material. The biologic can be associated with the polymeric shell itself, and/or the biologic, optionally suspended/dispersed in a biocompatible dispersing agent, can be encased by the polymeric shell. In another aspect, the biologic associated with polymeric shell is administered to a subject, optionally dispersed in a suitable biocompatible liquid.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 3, 1997
    Assignee: Vivorx Pharmaceuticals, Inc.
    Inventors: Mark W. Grinstaff, Patrick Soon-Shiong, Michael Wong, Paul A. Sandford, Kenneth S. Suslick, Neil P. Desai
  • Stabilized composition of levothyroxine sodium medication and method for its production
    Patent number: 5635209
    Abstract: The invention discloses a medication which requires the combination of levothyroxine sodium and potassium iodide, with the potassium iodide acting as a stabilizing excipient, the presence of which results in a more stable levothyroxine sodium medication and provides for longer shelf life of the medication. A method for manufacturing the disclosed medication is also provided.
    Type: Grant
    Filed: October 31, 1995
    Date of Patent: June 3, 1997
    Assignee: Vintage Pharmaceuticals, Inc.
    Inventors: Pieter J. Groenewoud, Hai Wang
  • Beads having a core coated with an antifungal and a polymer
    Patent number: 5633015
    Abstract: The present invention is concerned with beads comprising a 25-30 mesh core, a coating of a hydrophilic polymer and an antifungal agent, and a seal outer coating layer; pharmaceutical dosage forms comprising said beads and a method of preparing said beads. Preferred antifungal agents are lipophilic azole antifungals, such as itraconazole and saperconazole.
    Type: Grant
    Filed: March 13, 1995
    Date of Patent: May 27, 1997
    Inventors: Paul M. V. Gilis, Valentin F. V. De Conde, Roger P. G. Vandecruys
  • Medicaments for beneficial insects and method
    Patent number: 5631024
    Abstract: There are disclosed therapeutic microcapsules for beneficial insects having a non-toxic matrix with a medicament for treating a beneficial insect disorder substantially uniformly distributed therethrough and therapeutic compositions in which the microcapsules are in a carrier. Also disclosed is the method of treating beneficial insect disorders with such microcapsules and compositions.
    Type: Grant
    Filed: May 22, 1995
    Date of Patent: May 20, 1997
    Assignee: Enviroquest, Ltd.
    Inventors: Sherrene D. Kevan, Peter G. Kevan, Jack D. Trevino
  • Method for making freeze dried drug dosage forms
    Patent number: 5631023
    Abstract: The present invention discloses an improved technique for preparing a rapidly dispersing pharmaceutic tablet of a granular therapeutic agent which has both relatively low solubility and relatively large particle size. Xanthan gum is added to a liquid admixture of solvent, carrier components, and the granular therapeutic agent. The xanthan gum not only facilitates suspension of the granular therapeutic agent in the liquid admixture, but, more surprisingly, does so without adversely effecting the dispersion qualities and texture of the tablet in the patient's mouth upon administration.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: May 20, 1997
    Assignee: R.P. Scherer Corporation
    Inventors: Patrick Kearney, Sang K. Wong
  • Micellar nanoparticles
    Patent number: 5629021
    Abstract: The present invention relates to micellar nanoparticles and methods of their production. Micellar nanoparticles are made by hydrating a mixture of an oil, a stabilizer/surfactant, and an alcoholic initiator with an aqueous solution. These micellar nanoparticles are normally less than 100 nanometers in diameter. The micellar nanoparticles are particularly advantageous in delivering materials such as estradiol topically through the skin because their small size allows easy penetration.
    Type: Grant
    Filed: January 31, 1995
    Date of Patent: May 13, 1997
    Assignee: Novavax, Inc.
    Inventor: D. Craig Wright
  • Infusion preparation
    Patent number: 5626880
    Abstract: Disclosed is an infusion preparation for nutrient supply use. It comprises a sugar, amino acids, electrolytes and a fat emulsion. It has an excellent shelf life without causing precipitation, denaturation and the like in spite of the simultaneous presence of these components. Also disclosed is a container filled with infusion liquids comprising a first and a second compartments separated from each other by a separation means, wherein an infusion liquid containing a fat emulsion and a sugar is included in the first compartment and another infusion liquid containing amino acids and electrolytes is included in the second compartment. Further disclosed are an infusion preparation comprising a fat emulsion and a sugar, and an infusion preparation comprising amino acids and electrolytes.
    Type: Grant
    Filed: January 22, 1996
    Date of Patent: May 6, 1997
    Assignee: The Green Cross Corporation
    Inventors: Tadaaki Inoue, Hideto Kodaira, Yoshihito Nawa, Ryoichiro Murashima, Shunichi Abe, Kazumasa Yokoyama
  • Controlled release pharmaceutical tablet having lenticular form
    Patent number: 5626874
    Abstract: Controlled release pharmaceutical tablet having a lenticular form consisting of three layers of which the central one or core (a) contains the active principle and the two outer layers or barriers (b) and (c) comprise gellable and/or erodible polymeric material, said barrier layers being equal or different among themselves for composition and/or thickness, while the central layer has a limited external annular surface exposed to the dissolution medium, through which the active principle is released.
    Type: Grant
    Filed: November 30, 1994
    Date of Patent: May 6, 1997
    Assignee: Ekita Investments N.V.
    Inventors: Ubaldo Conte, Aldo La Manna, Lauretta Maggi
  • Pharmaceutical soft capsules containing lysine clonixinate and a process for their preparation
    Patent number: 5626872
    Abstract: A soft gelatin capsule with a filling including lysine clonixinate as an active ingredient and in a hydrophilic matrix and with a shell comprising gelatin, a plasticizer and sorbitol, wherein the plasticizer in many instances will be glycerol but may comprise the sorbitol alone. The presence of sorbitol in the gelatin capsule of a lysine clonixinate dosage form imparts unexpectedly good drug release and stability thereto.
    Type: Grant
    Filed: December 12, 1994
    Date of Patent: May 6, 1997
    Assignee: Roemmers S.A.I.C.F.
    Inventor: Carlos E. M. V asquez
  • Porous product mold form
    Patent number: 5624674
    Abstract: The present invention is directed to apparatus and methods for forming open-cell porous mold forms to mold porous devices having substantially continuously interconnected pores. The mold form is made from selected material comprising particles having predetermined sizes and shapes which is capable of forming a stable mold form under selected conditions. The particles are treated such that the particles are manipulable into a mass of continuously interconnected particles defining continuously interconnected pores and connecting interstices within the mass. The formed mass is made into a predetermined shape and solidified to form a mold form.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 29, 1997
    Inventor: William J. Seare, Jr.
  • Feed additives for fattening pigs, feed for fattening pigs, and method of fattening pigs
    Patent number: 5624686
    Abstract: Feeding fattening pigs a feed additive which contains as an active ingredient active folic acid (in the form of leucovorin, H.sub.2 -folic acid, a liver powder, disrupted cells of a microorganism or a cell extract of a microorganism), or a feed for fattening pigs and lactating sows which contains such an additive, either directly orally or via breast milk, is effective for increasing the amount of a reduced form of folic acid in the plasma of the fattening pigs and improving the efficiency of fattening.
    Type: Grant
    Filed: March 10, 1995
    Date of Patent: April 29, 1997
    Assignee: Ajinomoto Co., Inc.
    Inventors: Minoru Shimoda, Ei-ichi Kokue
  • Dosage forms of risedronate
    Patent number: 5622721
    Abstract: The present invention is directed to a novel enteric-coated oral dosage form of a risedronate active ingredient comprised of a safe and effective amount of a pharmaceutical composition which is comprised of a risedronate active ingredient and pharmaceutically-acceptable excipients. Said dosage forms prohibit the exposure of the risedronate active ingredient to the epithelial and mucosal tissues of the buccal cavity, pharynx, esophagus, and stomach and thereby protects said tissues from erosion, ulceration or other like irritation. Accordingly, the said dosage forms effect the delivery to the lower gastrointestinal tract of said human or other mammal of a safe and effective amount of the risedronate active ingredient, and substantially alleviate the esophagitis or esophageal irritation which occasionally accompanies the oral administration of risedronate active ingredients.
    Type: Grant
    Filed: September 14, 1994
    Date of Patent: April 22, 1997
    Assignee: The Procter & Gamble Company
    Inventors: Richard J. Dansereau, Russell Y. Mosher, Douglas W. Axelrod, William K. Sietsema
  • Process for stabilizing gelatin products
    Patent number: 5620704
    Abstract: Process for the manufacturing of gelatin products with improved stability against storage under hot and humid conditions and/or aldehydes characterized in that at least one additive, preferred glutamic acid, tryptophan, or nitrilotrismethylene phosphonic acid or a mixture thereof is incorporated into the gelatin before forming the final product as usual as well as the gelatin compositions used and the products obtained by the process.
    Type: Grant
    Filed: November 7, 1994
    Date of Patent: April 15, 1997
    Assignee: Warner-Lambert Company
    Inventors: Dominique Cade, Nicolas Madit
  • Spherical granule, production method thereof and medicinal preparation using said granule
    Patent number: 5618562
    Abstract: The spherical granules useful as a precipient for medicines and foods, and a production method thereof. A spherical granule comprises 95% by weight or more of lactose, and has a long diameter/short diameter ratio of 1.2 or less, and, when aggregated, a bulk density of 0.7 g/ml or more and an angle of repose of 35.degree. or less. The spherical granule is produced by feeding lactose particles into a granulating and coating apparatus equipped with a horizontal rotary disk having a smooth surface to contact with the granules, and by spraying lactose solution while the above-mentioned rotary disk is rotated.
    Type: Grant
    Filed: October 17, 1995
    Date of Patent: April 8, 1997
    Assignee: Freund Industrial Co., Ltd.
    Inventors: Hiroshi Saito, Toshio Mikami, Nagayoshi Myo
  • Process and product for attracting animals and covering human scent
    Patent number: 5618548
    Abstract: An improved animal lure and cover scent process and product employs a combustible absorbent material impregnated with an aromatic substance having fragrance attractive to an animal, with the absorbent material being of restricted combustibility such that the absorbent material tends to smoke without producing a flame as it burns, the smoke entraining the fragrance with it as it travels through the air. The combustible absorbent material of the present invention is in the form of an incense stick wherein a cellulosic material formed from sawdust is coated on one end of a combustible bamboo stick. A weather shield protects the incense stick from wind and rain.
    Type: Grant
    Filed: June 14, 1994
    Date of Patent: April 8, 1997
    Inventor: Richard A. Dawson