Patents Examined by William E. Benston, Jr.
  • Quick release coated preparation
    Patent number: 5578322
    Abstract: A coated preparation prepared by coating drug particles having a disagreeable taste with a mixture comprising a hydrophobic substance with a melting point of 45.degree. to 90.degree. C. and a surfactant with a lower melting point and heat treating the coating layer at a temperature ranging from around the melting point of the surfactant up to the melting point of the hydrophobic substance to modify the nature of the coating layer. This preparation can release the drug quickly which sufficiently suppressing the disagreeable taste.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: November 26, 1996
    Assignee: Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Hiroyoshi Shiozawa, Hiroya Sugao, Shigeru Yamazaki, Katsuhiko Yano
  • Peptide proteinaceous drug nasal powder composition
    Patent number: 5578324
    Abstract: A peptide proteinaceous drug nasal powder composition containing (i) an absorption accelerant comprised of a compound, or its salt, having in its molecule a group expressed by the formula (I): ##STR1## wherein, ##STR2## indicates a cyclohexane ring or a benzene ring which may be substituted at least one of its 3-position, 4-position, and 5-position and n is an integer of 1 to 3 and (ii) a therapeutically effective amount of a peptide proteinaceous drug.
    Type: Grant
    Filed: March 29, 1995
    Date of Patent: November 26, 1996
    Assignee: Teijin Limited
    Inventors: Masahiko Dohi, Yoshihisa Nishibe, Yuji Makino, Yoshiki Suzuki
  • Zeolite insecticide for termites
    Patent number: 5576007
    Abstract: The insecticide has little adverse effect on man or animals and presents little risk of environmental pollution, but eliminates harmful insects, such as termites, even when used over long periods of time without the insects acquiring resistance. The insecticide contains powdered zeolite, some of the particles of powdered zeolite having a diameter smaller than the distance between the body hairs of the insect which is to be killed.
    Type: Grant
    Filed: October 21, 1993
    Date of Patent: November 19, 1996
    Assignee: Kabushiki Kaisha Shikoku Sogo Kenkyusho
    Inventors: Satoshi Ikeda, Yoshiki Inoue, Naoaki Yamamoto
  • Intrabuccally dissolving compressed moldings and production process thereof
    Patent number: 5576014
    Abstract: Intrabuccally dissolving compressed moldings comprising a saccharide having low moldability having been granulated with a saccharide having high moldability. The moldings of the present invention show quick disintegration and dissolution in the buccal cavity and have an adequate hardness.
    Type: Grant
    Filed: February 1, 1995
    Date of Patent: November 19, 1996
    Assignee: Yamanouchi Pharmaceutical Co., Ltd
    Inventors: Takao Mizumoto, Yoshinori Masuda, Muneo Fukui
  • Redispersible nanoparticulate film matrices with protective overcoats
    Patent number: 5573783
    Abstract: A pharmaceutical film matrix comprising nanoparticles of a low solubility drug associated with a steric stabilizer and a film dispersing agent is coated on the surface of carrier particles and overcoated with a protective layer. Pharmaceutical compositions comprising the film matrix-coated carrier exhibit excellent bioavailability, are useful in methods of treating mammals and are extremely stable in that they are capable of being redispersed without extensive agglomeration into larger particles after being stored.
    Type: Grant
    Filed: February 13, 1995
    Date of Patent: November 12, 1996
    Assignee: Nano Systems L.L.C.
    Inventors: Mark A. Desieno, Gregg Stetsko
  • Pharmaceutical preparation for supplying fluoride ions
    Patent number: 5571532
    Abstract: Pharmaceutical preparation in tablet form for supplying fluoride ions for the treatment and prevention of losses of bone substance, including osteoporosis and alveolar bond damage, with a content of sodium fluorophosphate and substances for regulating the release of sodium fluorophosphate, the substances for the regulation of the sodium fluorophosphate release comprising a dual retardant system which consists of a retardant matrix in the tablet core and a retardant coating.
    Type: Grant
    Filed: September 20, 1993
    Date of Patent: November 5, 1996
    Assignee: Asta Medica Arzneimittal Ges. m.b.H.
    Inventors: Wolfram Tritthart, Rudiger Wolf
  • Organoleptically stable denture cleanser tablets
    Patent number: 5571519
    Abstract: Denture cleanser tablet compositions are disclosed which include a flavoring agent in one layer and a bleaching agent in a second layer. This arrangement avoids deterioration of the tablet flavor and taste during storage.
    Type: Grant
    Filed: December 13, 1994
    Date of Patent: November 5, 1996
    Assignee: Block Drug Company, Inc.
    Inventors: Joseph Synodis, Robert C. Gasman, Frank Mazzella
  • Elongated, divisible tablet
    Patent number: 5562920
    Abstract: Elongated, divisible tablet especially for pharmaceutical applications which, when the underside of the tablet is rested on a flat support, touches the support with two zones protruding from both ends of the underside of the tablet but not with the intervening zone wherein the protruding zones are formed as bulges. Such a tablet can be easily divided into two halves with one hand and picked up from a support. In addition it is easily manufactured.
    Type: Grant
    Filed: March 1, 1995
    Date of Patent: October 8, 1996
    Assignee: Boehringer Manheim GmbH
    Inventors: Fritz Demmer, Rolf-Dieter Gabel, Walter Preis
  • Opacifier for water-based compositions
    Patent number: 5562898
    Abstract: An opacifier comprising an amine including at least one carbon chain of at least 16 carbon atoms or a fancy amidoamine having an alkyl group including at least about thirteen carbon atoms, and a suitable acid is disclosed. The opacifier is a salt of the long-chain amine and effectively opacifies, or pearlizes, water-based compositions, such as hair treating compositions, like shampoos, conditioners, conditioning shampoos and antidandruff shampoos; and skin treating compositions, like conditioners, moisturizers and topical medicaments.
    Type: Grant
    Filed: September 28, 1994
    Date of Patent: October 8, 1996
    Assignee: Helene Curtis, Inc.
    Inventors: Teresa J. Dowell, Gerald P. Newell, Eugene Zeffren
  • Process for conditioning of water-soluble substances
    Patent number: 5562923
    Abstract: A process for providing water-soluble micronized pharmaceutically acceptable inhalable substances, which can be produced, stored and used while maintaining the aerodynamic properties required for inhalation of the pharmaceutically acceptable substances. This process is carried out by the steps of reducing, if necessary, the residual water from the micronized substance by drying at an elevated temperature and/or vacuum; conditioning the dried, micronized pharmaceutically acceptable inhalable substances with a solvent; and eliminating residual solvent by storing under dry conditions as, e.g., in a vacuum or by purging with a dry, inert gas.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 8, 1996
    Assignee: Aktiebolaget Astra
    Inventors: Jan W. Trofast, Eva A. Trofast, Edib Jakupovic, Katarina U. Bystrom
  • Treatment of sinus headache
    Patent number: 5562908
    Abstract: The present invention contemplates nasal compositions effective for relieving mammalian sinus headache associated with inflamed or congested turbinates, or both, accompanied by localized pain perceived on the septum, containing an anaesthetically effective amount of a non-addictive, rapidly absorbable anaesthetic component such anaesthetic being the sole active ingredient in the composition or being combined with a decongestant of the sympathomimetic amine class.
    Type: Grant
    Filed: July 1, 1994
    Date of Patent: October 8, 1996
    Assignee: Warner-Lambert Company
    Inventor: Navin M. Geria
  • Microprecipitation of nanoparticulate pharmaceutical agents
    Patent number: 5560932
    Abstract: This invention describes the preparation of nanoparticulate pharmaceutical agent dispersion via a process that comprises the dissolution of the said pharmaceutical agent in an alkaline solution and then neutralizing the said solution with an acid in the presence of a suitable surface-modifying, surface-active agent to form a fine particle dispersion of the said pharmaceutical agent. This can be preferably followed by steps of diafiltration clean-up of the dispersion and then concentration of it to a desired level. This process of dispersion preparation leads to microcrystalline particles of Z-average diameters smaller than 400 nm as measured by photon correlation spectroscopy. Various modification of precipitation schemes are described, many of which are suitable for large-scale manufacture of these agent dispersions.
    Type: Grant
    Filed: January 10, 1995
    Date of Patent: October 1, 1996
    Assignee: Nano Systems L.L.C.
    Inventors: Pranab Bagchi, Piotr H. Karpinski, Gregory L. McIntire
  • Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor
    Patent number: 5560933
    Abstract: In accordance with the present invention, there are provided compositions for the in vivo delivery of substantially water insoluble pharmacologically active agents (such as the anticancer drug taxol) in which the pharmacologically active agent is delivered in a soluble form or in the form of suspended particles. In particular, the soluble form may comprise a solution of pharmacologically active agent in a biocompatible dispersing agent contained within a protein walled shell. Alternatively, the protein walled shell may contain particles of taxol. In another aspect, the suspended form comprises particles of pharmacologically active agent in a biocompatible aqueous liquid.
    Type: Grant
    Filed: March 29, 1995
    Date of Patent: October 1, 1996
    Assignee: VivoRx Pharmaceuticals, Inc.
    Inventors: Patrick Soon-Shiong, Neil P. Desai, Mark W. Grinstaff, Paul A. Sandford, Kenneth S. Suslick
  • Method for preparing aqueous emulsion for coating solid pharmaceutical preparations
    Patent number: 5560930
    Abstract: A method permits the easy preparation of an aqueous emulsion for coating solid pharmaceutical preparations through emulsification in water without addition of additives such as emulsifying agents, polymerization initiators, chain transfer agents, salts and plasticizers. A cellulosic polymer is dissolved in an organic solvent miscible in water in any rate or a mixed solvent comprising the organic solvent and water to give a polymer solution. The polymer solution is mixed with water to disperse the solution in water and thereafter the organic solvent is removed to form an aqueous emulsion for coating solid pharmaceutical preparations. If ethyl cellulose is used as a coating base, ethyl cellulose is first dissolved in a non-hydrophilic solvent to give a non-hydrophilic solution thereof.
    Type: Grant
    Filed: December 21, 1994
    Date of Patent: October 1, 1996
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Naosuke Maruyama, Hiroyasu Kokubo, Yoshiaki Kawashima
  • Process for the production of an S-ibuprofen-containing tablet
    Patent number: 5560926
    Abstract: The invention relates to a process for the production of a tablet containing S-ibuprofen which rapidly releases the active compound, and to S-ibuprofen-containing tablets prepared by this process.
    Type: Grant
    Filed: October 7, 1994
    Date of Patent: October 1, 1996
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Hermann Franz, Hans Peter Weckenmann
  • Combined personal cleansing and moisturizing compositions
    Patent number: 5560918
    Abstract: The present invention relates to compositions which provide both a skin cleansing and skin moisturizing benefit from the same product. These compositions provide improved lathering and cleansing characteristics, are extremely mild to the skin, and deliver a moisturizing agent to the skin. These compositions comprise at least one anionic surfactant, a dispersed, insoluble oil phase, at least one additional surfactant, an optional suspending agent, and water. This invention also relates to methods for providing combined cleansing and moisturization, and to methods for delivering these compositions as a foam.
    Type: Grant
    Filed: May 9, 1995
    Date of Patent: October 1, 1996
    Assignee: Richardson-Vicks Inc.
    Inventors: Susan C. Wivell, George E. Deckner
  • Pharmaceutical and other dosage forms
    Patent number: 5558880
    Abstract: A fast dissolving, solid dosage form defined by a matrix containing gelatin, pectin and/or soy fiber protein and one or more amino acids having from about 2 to 12 carbon atoms is disclosed.
    Type: Grant
    Filed: April 28, 1994
    Date of Patent: September 24, 1996
    Assignee: Janssen Pharmaceutica Inc.
    Inventors: Dilip J. Gole, R. Saul Levinson, Paul K. Wilkinson, J. Desmond Davies
  • Biocidal self adhesive and process for producing the same, as well as self-adhesive article and application thereof
    Patent number: 5554376
    Abstract: An self-adhesive article which is produced by forming an adhesive layer from an adhesive consisting essentially of a polymer of which is soluble in or swellable by an iso-thiocyanate, impregnating the adhesive layer with an iso-thiocyanate to provide a biocidal self-adhesive, and applying the biocidal self-adhesive to at least one surface of a base material. A high concentration of the iso-thiocyanate can be held in the adhesive layer, and the self-adhesive article is put to uses intended for the purpose of providing bactericidal, fungicidal and microbiocidal effects in building and food-related fields and the like.
    Type: Grant
    Filed: March 13, 1995
    Date of Patent: September 10, 1996
    Assignee: The Green Cross Corporation
    Inventors: Yasushi Sekiyama, Yuichi Mizukami, Shuzo Nakagawa, Hideaki Okabe, Kazuya Katoh, Hiroshi Nagaki
  • High dose formulations of mycophenolate mofetil and mycophenolic acid
    Patent number: 5554384
    Abstract: Mycophenolate mofetil and mycophenolic acid can be conveniently manufactured into high dose oral formulations by the hot melt filling of a supercooled mycophenolate mofetil or mycophenolic acid liquid into a pharmaceutical dosage form. High dose oral pharmaceutical formulations and manufacturing methods therefor are disclosed.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: September 10, 1996
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Glenn J. Samuels, Jung-Chung Lee, Charles Lee, Stephen Berry, Paul J. Jarosz
  • Surface modified NSAID nanoparticles
    Patent number: 5552160
    Abstract: Dispersible particles consisting essentially of a crystalline NSAID having a surface modifier adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than about 400 nm. Pharmaceutical compositions containing the particles exhibit reduced gastric irritation following oral administration and/or hastened onset of action.
    Type: Grant
    Filed: March 13, 1995
    Date of Patent: September 3, 1996
    Assignee: NanoSystems L.L.C.
    Inventors: Gary G. Liversidge, Philip Conzentino, Jr., Kenneth C. Cundy, Pramod P. Sarpotdar